TWI312679B - Carbamate compounds for use in preventing or treating neurodegenerative disorders - Google Patents

Carbamate compounds for use in preventing or treating neurodegenerative disorders Download PDF

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Publication number
TWI312679B
TWI312679B TW091103504A TW91103504A TWI312679B TW I312679 B TWI312679 B TW I312679B TW 091103504 A TW091103504 A TW 091103504A TW 91103504 A TW91103504 A TW 91103504A TW I312679 B TWI312679 B TW I312679B
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TW
Taiwan
Prior art keywords
group
formula
disease
injury
ministry
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Application number
TW091103504A
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English (en)
Chinese (zh)
Inventor
R Plata-Salaman Carlos
Zhao Boyu
E Twyman Roy
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of TWI312679B publication Critical patent/TWI312679B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/325Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
TW091103504A 2001-02-27 2002-02-27 Carbamate compounds for use in preventing or treating neurodegenerative disorders TWI312679B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27168201P 2001-02-27 2001-02-27
US10/081,764 US20020165273A1 (en) 2001-02-27 2002-02-21 Carbamate compounds for use in preventing or treating neurodegenerative disorders

Publications (1)

Publication Number Publication Date
TWI312679B true TWI312679B (en) 2009-08-01

Family

ID=26765943

Family Applications (1)

Application Number Title Priority Date Filing Date
TW091103504A TWI312679B (en) 2001-02-27 2002-02-27 Carbamate compounds for use in preventing or treating neurodegenerative disorders

Country Status (26)

Country Link
US (3) US20020165273A1 (https=)
EP (1) EP1383489B1 (https=)
JP (1) JP4276840B2 (https=)
KR (1) KR100910928B1 (https=)
CN (1) CN1235579C (https=)
AR (1) AR035756A1 (https=)
AT (1) ATE361745T1 (https=)
BR (1) BR0207645A (https=)
CA (1) CA2439295C (https=)
CY (1) CY1106753T1 (https=)
CZ (1) CZ301203B6 (https=)
DE (1) DE60220043T2 (https=)
DK (1) DK1383489T3 (https=)
ES (1) ES2284845T3 (https=)
HU (1) HUP0303264A3 (https=)
IL (2) IL157591A0 (https=)
MX (1) MXPA03007718A (https=)
MY (1) MY138156A (https=)
NO (1) NO20033798L (https=)
NZ (1) NZ527990A (https=)
PL (1) PL364680A1 (https=)
PT (1) PT1383489E (https=)
RS (1) RS51055B (https=)
RU (1) RU2300373C2 (https=)
TW (1) TWI312679B (https=)
WO (1) WO2002067925A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033092A1 (en) * 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Chroman derivatives
DK1809273T3 (da) * 2004-09-16 2010-08-02 Janssen Pharmaceutica Nv Anvendelse af 2-phenyl-1,2-ethandiol-(di)carbamater til behandling af epileptogenese
BRPI0516112A (pt) * 2004-10-15 2008-08-26 Janssen Pharmaceutica Nv métodos para neuroproteção
US20070021500A1 (en) * 2005-07-12 2007-01-25 Twyman Roy E Methods for neuroprotection
ES2385087T3 (es) * 2005-07-26 2012-07-18 Sk Biopharmaceuticals Co., Ltd Procedimientos para tratar trastornos relacionados con sustancias
JP2010505856A (ja) * 2006-10-06 2010-02-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ (s)−(+)−2−(2−クロロフェニル)−2−ヒドロキシ−エチルカルバメートの新規結晶
EP2081648A2 (en) * 2006-10-30 2009-07-29 Janssen Pharmaceutica, N.V. Carbamate compounds for use in treating depression
BRPI0718323A2 (pt) * 2006-10-31 2013-11-26 Janssen Pharmaceutica Nv Tratamento de transtornos invasivos do desenvolvimento.
CN104628603B (zh) * 2010-07-02 2017-08-15 比皮艾思药物研发有限公司 苯基氨基甲酸酯化合物及含有苯基氨基甲酸酯化合物的肌肉松弛剂
US9018253B2 (en) 2010-07-02 2015-04-28 Bio-Pharm Solutions Co., Ltd. Phenylcarbamate compound and muscle relaxant containing the same
US8609849B1 (en) 2010-11-30 2013-12-17 Fox Chase Chemical Diversity Center, Inc. Hydroxylated sulfamides exhibiting neuroprotective action and their method of use
US20130060024A1 (en) * 2011-09-07 2013-03-07 Satori Pharmaceuticals, Inc. Compounds useful for treating neurodegenerative disorders
MX353024B (es) 2011-12-27 2017-12-18 Bio Pharm Solutions Co Ltd Compuestos de fenil carbamato para uso en la prevencion o tratamiento de epilepsia.
CN105189451A (zh) * 2013-03-12 2015-12-23 比皮艾思药物研发有限公司 氨基甲酸苯酯化合物和包含该化合物的用于预防或治疗神经性毒气引起的疾病的组合物
CN109939092B (zh) 2013-03-12 2022-03-22 比皮艾思药物研发有限公司 用于预防或治疗小儿癫痫和癫痫相关综合征的苯基氨基甲酸酯化合物
WO2017150903A1 (en) 2016-02-29 2017-09-08 Bio-Pharm Solutions Co., Ltd. Sulfamate derivative compounds, processes for preparing them and their uses
EP3556365B1 (en) * 2016-12-14 2025-07-02 SK Biopharmaceuticals Co., Ltd. Use of carbamate compound for prevention, alleviation, or treatment of demyelinating disease
ES2978226T3 (es) * 2018-09-21 2024-09-09 Sk Biopharmaceuticals Co Ltd Compuesto de carbamato y uso de la formulación que lo comprende para prevenir, aliviar o tratar el trastorno de estrés agudo o el trastorno de estrés postraumático
KR20230044274A (ko) * 2020-08-31 2023-04-03 (주)바이오팜솔루션즈 신경퇴행성 질환의 예방 또는 치료용 페닐 알킬 카바메이트 화합물
KR20230051206A (ko) 2020-09-10 2023-04-17 (주)바이오팜솔루션즈 정신질환 치료 또는 완화용 설파메이트 유도체 화합물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313692A (en) * 1958-04-21 1967-04-11 Armour Pharma Method of inducing calming and muscle relaxation with carbamates
US3278380A (en) * 1962-02-06 1966-10-11 Armour Pharma Methods of calming employing diphenyl hydroxy carbamate compounds
US3265728A (en) * 1962-07-18 1966-08-09 Armour Pharma Substituted phenethyl carbamates
US5474990A (en) * 1989-10-20 1995-12-12 Olney; John W. Barbiturates as safening agents in conjunction with NMDA antagonists
CN1109880A (zh) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3,4-二氢-2h-1,4-苯并噁嗪衍生物、制备及其应用
US5492930A (en) * 1994-04-25 1996-02-20 Schering Corporation Method and formulation for treating CNS disorders
US5698588A (en) * 1996-01-16 1997-12-16 Yukong Limited Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
US5728728A (en) * 1996-04-10 1998-03-17 Kozachuk; Walter E. Methods of providing neuroprotection
US6232434B1 (en) * 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
KR100886578B1 (ko) * 2001-02-27 2009-03-05 오르토-맥네일 파마슈티칼, 인코퍼레이티드 카바메이트 화합물을 포함하는 정신증 장애 예방용 또는 치료용 약제학적 조성물
ES2262801T3 (es) * 2001-02-27 2006-12-01 Ortho-Mcneil Pharmaceutical, Inc. Uso de un compuesto de carbamato para la prevencion o el tratamiento de trastorno bipolar.
PT1411917E (pt) * 2001-02-27 2007-09-17 Ortho Mcneil Pharm Inc ''compostos carbamatos para utilização na prevenção ou tratamento de distúrbios do movimento''

Also Published As

Publication number Publication date
EP1383489B1 (en) 2007-05-09
ES2284845T3 (es) 2007-11-16
US20040171679A1 (en) 2004-09-02
US20090005442A1 (en) 2009-01-01
CZ301203B6 (cs) 2009-12-09
JP2004523555A (ja) 2004-08-05
NO20033798L (no) 2003-09-26
HUP0303264A2 (hu) 2004-01-28
PT1383489E (pt) 2007-06-21
RU2300373C2 (ru) 2007-06-10
JP4276840B2 (ja) 2009-06-10
RS51055B (sr) 2010-10-31
BR0207645A (pt) 2004-12-28
MXPA03007718A (es) 2004-11-12
CN1235579C (zh) 2006-01-11
WO2002067925A1 (en) 2002-09-06
DK1383489T3 (da) 2007-08-06
NO20033798D0 (no) 2003-08-26
US20020165273A1 (en) 2002-11-07
ATE361745T1 (de) 2007-06-15
CN1503667A (zh) 2004-06-09
PL364680A1 (en) 2004-12-13
EP1383489A1 (en) 2004-01-28
IL157591A0 (en) 2004-03-28
DE60220043T2 (de) 2008-01-10
HK1060516A1 (en) 2004-08-13
CA2439295C (en) 2010-05-25
NZ527990A (en) 2006-01-27
RU2003128982A (ru) 2005-03-10
HUP0303264A3 (en) 2012-07-30
IL157591A (en) 2009-12-24
AR035756A1 (es) 2004-07-07
KR100910928B1 (ko) 2009-08-06
CY1106753T1 (el) 2012-05-23
CZ20032313A3 (cs) 2004-08-18
RS67403A (sr) 2006-12-15
DE60220043D1 (de) 2007-06-21
MY138156A (en) 2009-04-30
HK1065486A1 (en) 2005-02-25
CA2439295A1 (en) 2002-09-06
KR20030076714A (ko) 2003-09-26

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