TWI273103B - N-[5-[[[5-alkyl-2-oxazolyl methyl]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases - Google Patents
N-[5-[[[5-alkyl-2-oxazolyl methyl]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases Download PDFInfo
- Publication number
- TWI273103B TWI273103B TW089126788A TW89126788A TWI273103B TW I273103 B TWI273103 B TW I273103B TW 089126788 A TW089126788 A TW 089126788A TW 89126788 A TW89126788 A TW 89126788A TW I273103 B TWI273103 B TW I273103B
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- TW
- Taiwan
- Prior art keywords
- methyl
- thiazolyl
- thio
- oxazolyl
- dimethylethyl
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title description 4
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title description 2
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title description 2
- 108091007914 CDKs Proteins 0.000 title 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 87
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Classifications
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
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- Hematology (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/464,511 US6262096B1 (en) | 1997-11-12 | 1999-12-15 | Aminothiazole inhibitors of cyclin dependent kinases |
| US61662700A | 2000-07-26 | 2000-07-26 |
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| TWI273103B true TWI273103B (en) | 2007-02-11 |
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| TW089126788A TWI273103B (en) | 1999-12-15 | 2000-12-14 | N-[5-[[[5-alkyl-2-oxazolyl methyl]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
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| EP (1) | EP1240166B1 (https=) |
| JP (1) | JP2003516987A (https=) |
| KR (1) | KR100738132B1 (https=) |
| CN (1) | CN1433416A (https=) |
| AR (1) | AR026974A1 (https=) |
| AT (1) | ATE289306T1 (https=) |
| AU (1) | AU783719B2 (https=) |
| BR (1) | BR0016424A (https=) |
| CA (1) | CA2394552A1 (https=) |
| CO (1) | CO5261565A1 (https=) |
| CZ (1) | CZ20022015A3 (https=) |
| DE (1) | DE60018205T2 (https=) |
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| EG (1) | EG24168A (https=) |
| ES (1) | ES2236034T3 (https=) |
| HK (1) | HK1049661B (https=) |
| HU (1) | HUP0301032A3 (https=) |
| IL (2) | IL149755A0 (https=) |
| MX (1) | MXPA02005870A (https=) |
| MY (1) | MY125768A (https=) |
| NO (1) | NO323726B1 (https=) |
| NZ (1) | NZ519120A (https=) |
| PE (1) | PE20011026A1 (https=) |
| PL (1) | PL364921A1 (https=) |
| PT (1) | PT1240166E (https=) |
| RU (1) | RU2002119016A (https=) |
| TW (1) | TWI273103B (https=) |
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Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262096B1 (en) | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US6414156B2 (en) | 1998-10-21 | 2002-07-02 | Bristol-Myers Squibb Company | Process for preparing azacycloalkanoylaminothiazoles |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
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