TWI258466B - Process for the preparation of amino-pyrrolidine derivatives - Google Patents
Process for the preparation of amino-pyrrolidine derivatives Download PDFInfo
- Publication number
- TWI258466B TWI258466B TW092120682A TW92120682A TWI258466B TW I258466 B TWI258466 B TW I258466B TW 092120682 A TW092120682 A TW 092120682A TW 92120682 A TW92120682 A TW 92120682A TW I258466 B TWI258466 B TW I258466B
- Authority
- TW
- Taiwan
- Prior art keywords
- amino
- pyrrolidine derivatives
- preparation
- derivatives
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Description
I258466
如申請專利範圍第1或2項之方法，其中使用zi為芊氧基 羰基之式II之起始化合物。 如申睛專利範圍第1或2項之方法，其中式Π之起始化合 物係與羥基胺鹽酸鹽反應。 如申請專利範圍第1或2項之方法，其中式IV之中間體係 與二·第三丁基碳酸氫鹽反應。 如申請專利範圍第1或2項之方法，其中式V之中間體之 第二3-氨基之去保護係藉催化脫氫用鈀/炭完成。 如申請專利範圍第1或2項之方法，其中反應在1至5 0巴之 壓力下實施。 如申請專利範圍第1或2項之方法，其中式I之3-氨基-吡咯 喊進一步加工至式A之乙烯基吡咯烷酮-頭孢菌素衍生物
Y表示C Η或氮； R1表示氫或氨基保護基；及 *表示對掌性之中心。 1〇·如申請專利範圍第1項之方法，用於製造式A-ι之 (6R，7R)-7-[(Z)-2-(5-氨基-[1，2,4]嘧二唑-3-基）-2-羥基亞 胺基-乙醯基氨基]-8-氧基_3-[(E)-(R)-2-氧基-[1，3，]二吡 86674-950807.doc 1258466 . 咯啶基-3-基二烯甲基]-5-噻-1-氮雜-雙環[4.2.0]辛-2-稀 -2-羧酸
86674-950807.doc -4-
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02016944 | 2002-08-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200403222A TW200403222A (en) | 2004-03-01 |
| TWI258466B true TWI258466B (en) | 2006-07-21 |
Family
ID=31197783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092120682A TWI258466B (en) | 2002-08-01 | 2003-07-29 | Process for the preparation of amino-pyrrolidine derivatives |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6872836B2 (zh) |
| EP (1) | EP1546096B1 (zh) |
| JP (1) | JP4368304B2 (zh) |
| KR (1) | KR100919145B1 (zh) |
| CN (1) | CN1297539C (zh) |
| AT (1) | ATE338747T1 (zh) |
| AU (1) | AU2003258536C1 (zh) |
| BR (1) | BR0313355B1 (zh) |
| CA (1) | CA2491133C (zh) |
| CY (1) | CY1105781T1 (zh) |
| DE (1) | DE60308204T2 (zh) |
| DK (1) | DK1546096T3 (zh) |
| ES (1) | ES2271652T3 (zh) |
| HK (1) | HK1080472A1 (zh) |
| MX (1) | MXPA05001150A (zh) |
| PT (1) | PT1546096E (zh) |
| TW (1) | TWI258466B (zh) |
| WO (1) | WO2004013097A1 (zh) |
| ZA (1) | ZA200500290B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006022045A (ja) * | 2004-07-08 | 2006-01-26 | Kaneka Corp | 光学活性１−ｔ−ブトキシカルボニル−３−アミノピロリジン塩の単離精製方法 |
| EP1818411A1 (en) * | 2006-02-13 | 2007-08-15 | Lonza AG | Process for the preparation of optically active chiral amines |
| EP1897956A1 (en) * | 2006-09-06 | 2008-03-12 | Lonza AG | Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase |
| CN101955457A (zh) * | 2010-09-21 | 2011-01-26 | 海门慧聚药业有限公司 | 光学活性3-氨基吡咯烷、3-氨基哌啶烷及其衍生物的一种通用制备方法 |
| CN103373953A (zh) * | 2012-04-26 | 2013-10-30 | 上海阳帆医药科技有限公司 | 3-氨基哌啶及其光学异构体的制备方法 |
| CN103570601B (zh) * | 2012-07-20 | 2016-03-30 | 重庆博腾制药科技股份有限公司 | 一种光学活性药物中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4916141A (en) * | 1989-03-28 | 1990-04-10 | Warner-Lambert Company | (S)-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid |
| DE3910920A1 (de) * | 1989-04-05 | 1990-10-11 | Bayer Ag | Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren |
| JPH04346971A (ja) * | 1991-05-21 | 1992-12-02 | Fujisawa Pharmaceut Co Ltd | ピロリジン化合物またはその塩の製造法 |
| EP1138672A1 (en) * | 1998-01-12 | 2001-10-04 | Basilea Pharmaceutica AG | Process for the preparation of 3-amino-pyrrolidine derivatives |
-
2003
- 2003-07-24 CA CA002491133A patent/CA2491133C/en not_active Expired - Fee Related
- 2003-07-24 EP EP03766281A patent/EP1546096B1/en not_active Expired - Lifetime
- 2003-07-24 PT PT03766281T patent/PT1546096E/pt unknown
- 2003-07-24 CN CNB038185032A patent/CN1297539C/zh not_active Expired - Fee Related
- 2003-07-24 DK DK03766281T patent/DK1546096T3/da active
- 2003-07-24 AU AU2003258536A patent/AU2003258536C1/en not_active Ceased
- 2003-07-24 AT AT03766281T patent/ATE338747T1/de active
- 2003-07-24 BR BRPI0313355-9B1A patent/BR0313355B1/pt not_active IP Right Cessation
- 2003-07-24 DE DE60308204T patent/DE60308204T2/de not_active Expired - Lifetime
- 2003-07-24 WO PCT/EP2003/008132 patent/WO2004013097A1/en active IP Right Grant
- 2003-07-24 MX MXPA05001150A patent/MXPA05001150A/es active IP Right Grant
- 2003-07-24 JP JP2004525302A patent/JP4368304B2/ja not_active Expired - Fee Related
- 2003-07-24 ES ES03766281T patent/ES2271652T3/es not_active Expired - Lifetime
- 2003-07-29 US US10/629,483 patent/US6872836B2/en not_active Expired - Fee Related
- 2003-07-29 TW TW092120682A patent/TWI258466B/zh not_active IP Right Cessation
- 2003-12-22 US US10/743,365 patent/US7064199B2/en not_active Expired - Fee Related
-
2005
- 2005-01-12 ZA ZA200500290A patent/ZA200500290B/en unknown
- 2005-01-19 KR KR1020057001035A patent/KR100919145B1/ko not_active IP Right Cessation
-
2006
- 2006-01-10 HK HK06100357A patent/HK1080472A1/xx not_active IP Right Cessation
- 2006-11-14 CY CY20061101653T patent/CY1105781T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE338747T1 (de) | 2006-09-15 |
| PT1546096E (pt) | 2006-12-29 |
| MXPA05001150A (es) | 2005-05-16 |
| US6872836B2 (en) | 2005-03-29 |
| AU2003258536C1 (en) | 2009-12-17 |
| CN1671658A (zh) | 2005-09-21 |
| AU2003258536B2 (en) | 2009-06-25 |
| US7064199B2 (en) | 2006-06-20 |
| DE60308204D1 (de) | 2006-10-19 |
| TW200403222A (en) | 2004-03-01 |
| KR20050023444A (ko) | 2005-03-09 |
| DK1546096T3 (da) | 2006-11-20 |
| CA2491133A1 (en) | 2004-02-12 |
| CN1297539C (zh) | 2007-01-31 |
| BR0313355B1 (pt) | 2014-04-22 |
| EP1546096B1 (en) | 2006-09-06 |
| US20040034236A1 (en) | 2004-02-19 |
| EP1546096A1 (en) | 2005-06-29 |
| BR0313355A (pt) | 2005-07-12 |
| JP2006506337A (ja) | 2006-02-23 |
| US20040127703A1 (en) | 2004-07-01 |
| AU2003258536A1 (en) | 2004-02-23 |
| JP4368304B2 (ja) | 2009-11-18 |
| HK1080472A1 (en) | 2006-04-28 |
| ZA200500290B (en) | 2005-11-14 |
| KR100919145B1 (ko) | 2009-09-28 |
| CA2491133C (en) | 2009-09-01 |
| CY1105781T1 (el) | 2011-02-02 |
| DE60308204T2 (de) | 2007-08-23 |
| WO2004013097A1 (en) | 2004-02-12 |
| ES2271652T3 (es) | 2007-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |