TWI222869B - Rapidly disintegrating methylcellulose tablets - Google Patents
Rapidly disintegrating methylcellulose tablets Download PDFInfo
- Publication number
- TWI222869B TWI222869B TW087113834A TW87113834A TWI222869B TW I222869 B TWI222869 B TW I222869B TW 087113834 A TW087113834 A TW 087113834A TW 87113834 A TW87113834 A TW 87113834A TW I222869 B TWI222869 B TW I222869B
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- Taiwan
- Prior art keywords
- patent application
- item
- scope
- sodium
- lozenge
- Prior art date
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- 229920000609 methyl cellulose Polymers 0.000 title claims abstract description 58
- 239000001923 methylcellulose Substances 0.000 title claims abstract description 57
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 70
- 239000000203 mixture Substances 0.000 claims description 60
- 235000010981 methylcellulose Nutrition 0.000 claims description 55
- 239000003826 tablet Substances 0.000 claims description 47
- 239000007937 lozenge Substances 0.000 claims description 43
- 238000009472 formulation Methods 0.000 claims description 38
- 235000019359 magnesium stearate Nutrition 0.000 claims description 35
- 239000002245 particle Substances 0.000 claims description 35
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 30
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 30
- 229920002472 Starch Polymers 0.000 claims description 26
- 229940032147 starch Drugs 0.000 claims description 26
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- 235000019698 starch Nutrition 0.000 claims description 26
- 239000002253 acid Substances 0.000 claims description 22
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- 239000001913 cellulose Substances 0.000 claims description 21
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- 239000008187 granular material Substances 0.000 claims description 17
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 17
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 17
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 16
- 159000000007 calcium salts Chemical class 0.000 claims description 15
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 14
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 12
- 229910052791 calcium Inorganic materials 0.000 claims description 12
- 229940023144 sodium glycolate Drugs 0.000 claims description 12
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 9
- 150000004683 dihydrates Chemical class 0.000 claims description 8
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- 229920003109 sodium starch glycolate Polymers 0.000 claims description 8
- 239000008109 sodium starch glycolate Substances 0.000 claims description 8
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 8
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- 239000000080 wetting agent Substances 0.000 claims description 6
- 239000007884 disintegrant Substances 0.000 claims description 5
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- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
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- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
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- 235000019792 magnesium silicate Nutrition 0.000 claims description 2
- 229960002366 magnesium silicate Drugs 0.000 claims description 2
- 229910052919 magnesium silicate Inorganic materials 0.000 claims description 2
- ZADYMNAVLSWLEQ-UHFFFAOYSA-N magnesium;oxygen(2-);silicon(4+) Chemical compound [O-2].[O-2].[O-2].[Mg+2].[Si+4] ZADYMNAVLSWLEQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
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- 235000010487 tragacanth Nutrition 0.000 claims description 2
- 239000000196 tragacanth Substances 0.000 claims description 2
- 229940116362 tragacanth Drugs 0.000 claims description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 2
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims 2
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims 2
- 244000215068 Acacia senegal Species 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 229940057948 magnesium stearate Drugs 0.000 claims 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
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- 235000011152 sodium sulphate Nutrition 0.000 claims 1
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- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 11
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- 230000006835 compression Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- SYJFEGQWDCRVNX-UHFFFAOYSA-N diquat Chemical compound C1=CC=[N+]2CC[N+]3=CC=CC=C3C2=C1 SYJFEGQWDCRVNX-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- NDORGWUNFGHGKU-UHFFFAOYSA-N dodecanoic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(O)=O NDORGWUNFGHGKU-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 description 1
- 230000003636 fecal output Effects 0.000 description 1
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- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
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- 239000010452 phosphate Substances 0.000 description 1
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- 238000012545 processing Methods 0.000 description 1
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- 229910052702 rhenium Inorganic materials 0.000 description 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
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- AEJSFQAWBLGTTK-UHFFFAOYSA-M sodium dodecanoic acid hydrogen carbonate Chemical compound C([O-])(O)=O.[Na+].C(CCCCCCCCCCC)(=O)O AEJSFQAWBLGTTK-UHFFFAOYSA-M 0.000 description 1
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- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| US5689997P | 1997-08-22 | 1997-08-22 | |
| US8766298P | 1998-06-02 | 1998-06-02 |
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| TWI222869B true TWI222869B (en) | 2004-11-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW087113834A TWI222869B (en) | 1997-08-22 | 1998-08-21 | Rapidly disintegrating methylcellulose tablets |
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| AR016827A1 (es) | 1997-08-22 | 2001-08-01 | Smithkline Beecham Corp | PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA |
| AR017512A1 (es) * | 1997-08-22 | 2001-09-12 | Smithkline Beecham Corp | Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas |
| US7022683B1 (en) * | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
| US6607749B1 (en) | 1998-09-08 | 2003-08-19 | Smithkline Beecham Corporation | Lipstatin derivative-soluble fiber tablets |
| FR2795962B1 (fr) * | 1999-07-08 | 2003-05-09 | Prographarm Laboratoires | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif |
| FR2798289B1 (fr) * | 1999-09-15 | 2004-12-31 | Cll Pharma | Formes galeniques a delitement rapide en bouche et leur procede de preparation |
| WO2001045647A2 (de) * | 1999-12-20 | 2001-06-28 | Henkel Kommanditgesellschaft Auf Aktien | Tablettierung verdickender systeme |
| ATE366602T1 (de) | 1999-12-20 | 2007-08-15 | Henkel Kgaa | Festförmiges färbemittel für keratinfasern |
| DE19961910A1 (de) | 1999-12-20 | 2001-06-21 | Henkel Kgaa | Färbemittel |
| EP1239816B1 (de) | 1999-12-20 | 2007-11-21 | Henkel Kommanditgesellschaft auf Aktien | Festförmiges färbemittel für keratinfasern |
| US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
| US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
| US7670612B2 (en) * | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
| CA2499977A1 (en) * | 2002-09-28 | 2004-04-08 | Mcneil-Ppc, Inc. | Edible solid composition and dosage form |
| US7232577B2 (en) * | 2002-10-21 | 2007-06-19 | L. Perrigo Company | Readily dispersible dietary fiber composition |
| US20040197284A1 (en) * | 2003-04-04 | 2004-10-07 | Frederic Auguste | Cosmetic composition comprising a volatile fatty phase |
| MXPA06000702A (es) * | 2003-07-23 | 2006-04-11 | Perrigo L Co | Composicion que contiene fibra celulosica. |
| FR2858556B1 (fr) * | 2003-08-06 | 2006-03-10 | Galenix Innovations | Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation |
| JP2005272408A (ja) * | 2004-03-26 | 2005-10-06 | Tendou Seiyaku Kk | 緩下剤 |
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| US7767248B2 (en) * | 2007-02-02 | 2010-08-03 | Overly Iii Harry J | Soft chew confectionary with high fiber and sugar content and method for making same |
| KR100895942B1 (ko) * | 2007-05-08 | 2009-05-07 | 조선대학교산학협력단 | 생약 추출물을 함유하는 구강 내 속붕해성 제제 조성물 및그의 제조 방법 |
| WO2009021127A2 (en) * | 2007-08-07 | 2009-02-12 | Neurogen Corporation | Controlled released compositions |
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| BR112012010170A2 (pt) * | 2009-10-28 | 2016-04-12 | Mcneil Ppc Inc | composições de revestimento para desintegração/dissolução rápida |
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| US10166219B2 (en) * | 2012-07-27 | 2019-01-01 | Redhill Bipharma Ltd. | Formulations and methods of manufacturing formulations for use in colonic evacuation |
| US10806743B1 (en) * | 2017-05-12 | 2020-10-20 | Braintree Laboratories, Inc. | Method of administering lactitol to reduce plasma concentration of lactitol |
| KR20210092613A (ko) | 2020-01-16 | 2021-07-26 | 안정오 | 은 생리대 제조방법 |
| IT202100016784A1 (it) * | 2021-06-25 | 2022-12-25 | Natural Way Laboratories Srl | Composizione per il rilascio di ioni Magnesio |
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| TW355683B (en) * | 1994-02-17 | 1999-04-11 | Janssen Pharmaceutica Nv | Composition containing micronized nebivolol |
| JPH07267850A (ja) | 1994-03-28 | 1995-10-17 | Eisai Co Ltd | 不快味を防止した医薬組成物及びその製造方法 |
| US5543099A (en) * | 1994-09-29 | 1996-08-06 | Hallmark Pharmaceutical, Inc. | Process to manufacture micronized nifedipine granules for sustained release medicaments |
| GB9501127D0 (en) * | 1995-01-20 | 1995-03-08 | Wellcome Found | Tablet |
| US8071128B2 (en) * | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| AU8699298A (en) * | 1997-08-11 | 1999-03-01 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
| AR017512A1 (es) * | 1997-08-22 | 2001-09-12 | Smithkline Beecham Corp | Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas |
| AR016827A1 (es) * | 1997-08-22 | 2001-08-01 | Smithkline Beecham Corp | PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA |
-
1998
- 1998-08-18 AR ARP980104076A patent/AR017512A1/es unknown
- 1998-08-19 CO CO98047418A patent/CO4960651A1/es unknown
- 1998-08-20 MY MYPI98003811A patent/MY128046A/en unknown
- 1998-08-20 MY MYPI20034998A patent/MY135183A/en unknown
- 1998-08-21 EP EP98944489A patent/EP1005329A4/en active Pending
- 1998-08-21 BR BR9811980-0A patent/BR9811980A/pt not_active Application Discontinuation
- 1998-08-21 NZ NZ502891A patent/NZ502891A/en unknown
- 1998-08-21 EA EA200000246A patent/EA004803B1/ru not_active IP Right Cessation
- 1998-08-21 AU AU92022/98A patent/AU741326B2/en not_active Ceased
- 1998-08-21 CN CN988102943A patent/CN1215833C/zh not_active Expired - Fee Related
- 1998-08-21 US US09/485,627 patent/US6350469B1/en not_active Expired - Lifetime
- 1998-08-21 CN CN2004100115143A patent/CN1660054A/zh active Pending
- 1998-08-21 KR KR1020007001825A patent/KR100743767B1/ko not_active Expired - Fee Related
- 1998-08-21 KR KR1020077007455A patent/KR20070040424A/ko not_active Ceased
- 1998-08-21 TW TW087113834A patent/TWI222869B/zh not_active IP Right Cessation
- 1998-08-21 JP JP2000507349A patent/JP2001513545A/ja active Pending
- 1998-08-21 WO PCT/US1998/017405 patent/WO1999009958A1/en not_active Ceased
- 1998-08-21 CA CA002301135A patent/CA2301135C/en not_active Expired - Fee Related
- 1998-08-21 KR KR1020077027417A patent/KR20070116291A/ko not_active Ceased
- 1998-08-21 PL PL98338858A patent/PL338858A1/xx unknown
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2001
- 2001-12-19 US US10/024,807 patent/US20020086052A1/en not_active Abandoned
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2003
- 2003-06-19 US US10/464,968 patent/US20030215505A1/en not_active Abandoned
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2004
- 2004-11-19 US US10/993,984 patent/US20050089565A1/en not_active Abandoned
- 2004-11-19 US US10/993,983 patent/US20050089564A1/en not_active Abandoned
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- 2004-11-19 US US10/993,272 patent/US20050089560A1/en not_active Abandoned
- 2004-11-19 US US10/993,547 patent/US7125562B2/en not_active Expired - Lifetime
- 2004-11-19 US US10/993,550 patent/US20050089563A1/en not_active Abandoned
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