NZ502891A - Rapidly disintegrating tablets comprising methylcellulose and an edible calcium salt - Google Patents
Rapidly disintegrating tablets comprising methylcellulose and an edible calcium saltInfo
- Publication number
- NZ502891A NZ502891A NZ502891A NZ50289198A NZ502891A NZ 502891 A NZ502891 A NZ 502891A NZ 502891 A NZ502891 A NZ 502891A NZ 50289198 A NZ50289198 A NZ 50289198A NZ 502891 A NZ502891 A NZ 502891A
- Authority
- NZ
- New Zealand
- Prior art keywords
- methylcellulose
- tablet
- tablet according
- calcium phosphate
- sodium
- Prior art date
Links
- 229920000609 methyl cellulose Polymers 0.000 title claims abstract description 91
- 239000001923 methylcellulose Substances 0.000 title claims abstract description 89
- 159000000007 calcium salts Chemical class 0.000 title claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 89
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims abstract description 27
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 23
- 235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 14
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 235000010981 methylcellulose Nutrition 0.000 claims description 86
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 78
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 70
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 70
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 69
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 63
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 62
- 229940069328 povidone Drugs 0.000 claims description 47
- 235000019359 magnesium stearate Nutrition 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 37
- 229920003109 sodium starch glycolate Polymers 0.000 claims description 37
- 239000008109 sodium starch glycolate Substances 0.000 claims description 37
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 37
- 235000011468 Albizia julibrissin Nutrition 0.000 claims description 35
- 239000003795 chemical substances by application Substances 0.000 claims description 25
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims description 24
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 23
- 239000008187 granular material Substances 0.000 claims description 23
- 239000000080 wetting agent Substances 0.000 claims description 21
- 229920002472 Starch Polymers 0.000 claims description 16
- 229940032147 starch Drugs 0.000 claims description 16
- 239000008107 starch Substances 0.000 claims description 16
- 235000019698 starch Nutrition 0.000 claims description 16
- 239000000314 lubricant Substances 0.000 claims description 14
- 239000011230 binding agent Substances 0.000 claims description 13
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 11
- 229920002261 Corn starch Polymers 0.000 claims description 11
- 239000011575 calcium Substances 0.000 claims description 11
- 229910052791 calcium Inorganic materials 0.000 claims description 11
- 239000008120 corn starch Substances 0.000 claims description 11
- 239000003085 diluting agent Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 9
- 241000124008 Mammalia Species 0.000 claims description 8
- 241000416162 Astragalus gummifer Species 0.000 claims description 7
- 229920001615 Tragacanth Polymers 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 235000010487 tragacanth Nutrition 0.000 claims description 7
- 239000000196 tragacanth Substances 0.000 claims description 7
- 229940116362 tragacanth Drugs 0.000 claims description 7
- 206010010774 Constipation Diseases 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 5
- 239000007884 disintegrant Substances 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229920001817 Agar Polymers 0.000 claims description 4
- 240000008886 Ceratonia siliqua Species 0.000 claims description 4
- 235000013912 Ceratonia siliqua Nutrition 0.000 claims description 4
- 244000303965 Cyamopsis psoralioides Species 0.000 claims description 4
- 235000015125 Sterculia urens Nutrition 0.000 claims description 4
- 240000001058 Sterculia urens Species 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000008272 agar Substances 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 229960000913 crospovidone Drugs 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 239000001814 pectin Substances 0.000 claims description 4
- 235000010987 pectin Nutrition 0.000 claims description 4
- 229920001277 pectin Polymers 0.000 claims description 4
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 4
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 239000007916 tablet composition Substances 0.000 claims description 4
- -1 veegum Polymers 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims description 3
- 229920000881 Modified starch Polymers 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- 239000001506 calcium phosphate Substances 0.000 claims 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 3
- 235000011010 calcium phosphates Nutrition 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- 240000007472 Leucaena leucocephala Species 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 229940080313 sodium starch Drugs 0.000 claims 2
- 240000005852 Mimosa quadrivalvis Species 0.000 claims 1
- 229940099112 cornstarch Drugs 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 63
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract description 27
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 87
- 238000009472 formulation Methods 0.000 description 48
- 241001070944 Mimosa Species 0.000 description 34
- 239000004615 ingredient Substances 0.000 description 28
- 229920003108 Methocel™ A4M Polymers 0.000 description 27
- 235000000346 sugar Nutrition 0.000 description 20
- 229920003084 Avicel® PH-102 Polymers 0.000 description 15
- 239000000975 dye Substances 0.000 description 13
- 229920003086 cellulose ether Polymers 0.000 description 12
- 238000004040 coloring Methods 0.000 description 11
- 239000002253 acid Substances 0.000 description 10
- 229960005069 calcium Drugs 0.000 description 9
- 239000000843 powder Substances 0.000 description 8
- 239000002245 particle Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 239000008141 laxative Substances 0.000 description 4
- 230000002475 laxative effect Effects 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 239000008142 bulk forming laxative Substances 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- FXPVUWKFNGVHIZ-UHFFFAOYSA-L disodium;dodecyl sulfate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O FXPVUWKFNGVHIZ-UHFFFAOYSA-L 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 239000007894 caplet Substances 0.000 description 2
- 229940081970 citrucel Drugs 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- CYPFMVTZEDNCQV-UHFFFAOYSA-L magnesium;octadecanoate;dihydrate Chemical compound O.O.[Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CYPFMVTZEDNCQV-UHFFFAOYSA-L 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 239000007968 orange flavor Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- BDJMTDLZGXLFNI-UHFFFAOYSA-M sodium dodecyl sulfate dihydrate Chemical compound O.O.[Na+].CCCCCCCCCCCCOS([O-])(=O)=O BDJMTDLZGXLFNI-UHFFFAOYSA-M 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- 241000220479 Acacia Species 0.000 description 1
- 241001550224 Apha Species 0.000 description 1
- 239000004150 EU approved colour Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000009478 high shear granulation Methods 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5689997P | 1997-08-22 | 1997-08-22 | |
| US8766298P | 1998-06-02 | 1998-06-02 | |
| PCT/US1998/017405 WO1999009958A1 (en) | 1997-08-22 | 1998-08-21 | Rapidly disintegrating methylcellulose tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ502891A true NZ502891A (en) | 2002-06-28 |
Family
ID=26735831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ502891A NZ502891A (en) | 1997-08-22 | 1998-08-21 | Rapidly disintegrating tablets comprising methylcellulose and an edible calcium salt |
Country Status (16)
| Country | Link |
|---|---|
| US (9) | US6350469B1 (enExample) |
| EP (1) | EP1005329A4 (enExample) |
| JP (1) | JP2001513545A (enExample) |
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-
1998
- 1998-08-18 AR ARP980104076A patent/AR017512A1/es unknown
- 1998-08-19 CO CO98047418A patent/CO4960651A1/es unknown
- 1998-08-20 MY MYPI98003811A patent/MY128046A/en unknown
- 1998-08-20 MY MYPI20034998A patent/MY135183A/en unknown
- 1998-08-21 EP EP98944489A patent/EP1005329A4/en active Pending
- 1998-08-21 BR BR9811980-0A patent/BR9811980A/pt not_active Application Discontinuation
- 1998-08-21 NZ NZ502891A patent/NZ502891A/en unknown
- 1998-08-21 EA EA200000246A patent/EA004803B1/ru not_active IP Right Cessation
- 1998-08-21 AU AU92022/98A patent/AU741326B2/en not_active Ceased
- 1998-08-21 CN CN988102943A patent/CN1215833C/zh not_active Expired - Fee Related
- 1998-08-21 US US09/485,627 patent/US6350469B1/en not_active Expired - Lifetime
- 1998-08-21 CN CN2004100115143A patent/CN1660054A/zh active Pending
- 1998-08-21 KR KR1020007001825A patent/KR100743767B1/ko not_active Expired - Fee Related
- 1998-08-21 KR KR1020077007455A patent/KR20070040424A/ko not_active Ceased
- 1998-08-21 TW TW087113834A patent/TWI222869B/zh not_active IP Right Cessation
- 1998-08-21 JP JP2000507349A patent/JP2001513545A/ja active Pending
- 1998-08-21 WO PCT/US1998/017405 patent/WO1999009958A1/en not_active Ceased
- 1998-08-21 CA CA002301135A patent/CA2301135C/en not_active Expired - Fee Related
- 1998-08-21 KR KR1020077027417A patent/KR20070116291A/ko not_active Ceased
- 1998-08-21 PL PL98338858A patent/PL338858A1/xx unknown
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2001
- 2001-12-19 US US10/024,807 patent/US20020086052A1/en not_active Abandoned
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2003
- 2003-06-19 US US10/464,968 patent/US20030215505A1/en not_active Abandoned
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2004
- 2004-11-19 US US10/993,984 patent/US20050089565A1/en not_active Abandoned
- 2004-11-19 US US10/993,983 patent/US20050089564A1/en not_active Abandoned
- 2004-11-19 US US10/993,458 patent/US20050089561A1/en not_active Abandoned
- 2004-11-19 US US10/993,272 patent/US20050089560A1/en not_active Abandoned
- 2004-11-19 US US10/993,547 patent/US7125562B2/en not_active Expired - Lifetime
- 2004-11-19 US US10/993,550 patent/US20050089563A1/en not_active Abandoned
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