TW490306B - Compositions and methods for enhancing delivery of therapeutic agents to cells - Google Patents
Compositions and methods for enhancing delivery of therapeutic agents to cells Download PDFInfo
- Publication number
- TW490306B TW490306B TW087111049A TW87111049A TW490306B TW 490306 B TW490306 B TW 490306B TW 087111049 A TW087111049 A TW 087111049A TW 87111049 A TW87111049 A TW 87111049A TW 490306 B TW490306 B TW 490306B
- Authority
- TW
- Taiwan
- Prior art keywords
- group
- compound
- hexose
- patent application
- scope
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract description 8
- 238000000034 method Methods 0.000 title abstract description 3
- 230000002708 enhancing effect Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title description 4
- 229940124597 therapeutic agent Drugs 0.000 title description 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 29
- 125000000837 carbohydrate group Chemical group 0.000 description 8
- 125000002091 cationic group Chemical group 0.000 description 3
- 150000002972 pentoses Chemical class 0.000 description 2
- 101150033766 Syn3 gene Proteins 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 150000002402 hexoses Chemical group 0.000 description 1
- 125000000625 hexosyl group Chemical group 0.000 description 1
- 150000002772 monosaccharides Chemical group 0.000 description 1
- 230000003232 mucoadhesive effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/889,355 US7002027B1 (en) | 1996-01-08 | 1997-07-08 | Compositions and methods for therapeutic use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW490306B true TW490306B (en) | 2002-06-11 |
Family
ID=25394956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW087111049A TW490306B (en) | 1997-07-08 | 1999-01-11 | Compositions and methods for enhancing delivery of therapeutic agents to cells |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7002027B1 (https=) |
| EP (2) | EP2106807B1 (https=) |
| JP (2) | JP4460148B2 (https=) |
| KR (1) | KR100691572B1 (https=) |
| AR (1) | AR016312A1 (https=) |
| AT (2) | ATE434448T1 (https=) |
| AU (1) | AU774338B2 (https=) |
| CA (1) | CA2294709C (https=) |
| CY (1) | CY1109367T1 (https=) |
| DE (2) | DE69840932D1 (https=) |
| DK (1) | DK1011733T3 (https=) |
| ES (2) | ES2328094T3 (https=) |
| HU (1) | HUP0002683A3 (https=) |
| IL (1) | IL133929A0 (https=) |
| MY (1) | MY138257A (https=) |
| NZ (1) | NZ502060A (https=) |
| PT (1) | PT1011733E (https=) |
| TW (1) | TW490306B (https=) |
| WO (1) | WO1999002191A1 (https=) |
| ZA (1) | ZA986003B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6392069B2 (en) * | 1996-01-08 | 2002-05-21 | Canji, Inc. | Compositions for enhancing delivery of nucleic acids to cells |
| US20040014709A1 (en) * | 1996-01-08 | 2004-01-22 | Canji, Inc. | Methods and compositions for interferon therapy |
| US5789244A (en) * | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
| US7002027B1 (en) * | 1996-01-08 | 2006-02-21 | Canji, Inc. | Compositions and methods for therapeutic use |
| EP1070047A2 (en) | 1998-04-08 | 2001-01-24 | Celltech Chiroscience Limited | Lipids |
| ES2745068T3 (es) * | 2001-12-20 | 2020-02-27 | Merck Sharp & Dohme | Composiciones de SYN3 y métodos |
| JP2007526219A (ja) * | 2003-06-04 | 2007-09-13 | カンジ，インコーポレイテッド | トランスフェクション薬剤 |
| US7355056B2 (en) * | 2003-06-04 | 2008-04-08 | Canji, Inc. | Transfection agents |
| US7790039B2 (en) * | 2003-11-24 | 2010-09-07 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for stem cell enrichment |
| CA2548100C (en) * | 2003-12-10 | 2015-03-24 | Canji, Inc. | Methods and compositions for treatment of interferon-resistant tumors |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US8716021B2 (en) * | 2005-09-07 | 2014-05-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of replicators to prevent gene silencing |
| US20110071100A1 (en) * | 2008-05-05 | 2011-03-24 | Tiltan Pharma Ltd. | Sulfobetaines for cancer, obesity, macular degeneration, neurodegenerative diseases |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| US20120147800A1 (en) * | 2010-12-10 | 2012-06-14 | Minyoung Park | Power management in a wireless network having stations with different power capabilities |
| US20120237492A1 (en) | 2011-02-18 | 2012-09-20 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| US10492104B2 (en) * | 2016-03-10 | 2019-11-26 | Cable Television Laboratories, Inc. | Latency reduction in wireless service |
| WO2026077967A1 (en) | 2024-10-08 | 2026-04-16 | Ferring International Center Sa | Method for making syn3 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554386A (en) | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US6207454B1 (en) | 1989-10-16 | 2001-03-27 | Amgen Inc. | Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5120316A (en) | 1990-09-28 | 1992-06-09 | Akzo N.V. | Urethral catheter and catheterization process |
| WO1992006180A1 (en) | 1990-10-01 | 1992-04-16 | University Of Connecticut | Targeting viruses and cells for selective internalization by cells |
| NZ240846A (en) * | 1990-12-06 | 1994-04-27 | Hoechst Ag | Dimeric bile acid derivatives; preparatory processes and pharmaceutical compositions |
| DE69233725T2 (de) | 1991-06-28 | 2009-02-12 | The Regents Of The University Of Michigan, Ann Arbor | Verwendung von DNA oder RNA zur Herstellung eines Medikaments zur Behandlung von Tumoren |
| JPH06509578A (ja) | 1991-07-26 | 1994-10-27 | ユニバーシティ・オブ・ロチェスター | 悪性細胞利用による癌治療法 |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US5521291A (en) | 1991-09-30 | 1996-05-28 | Boehringer Ingelheim International, Gmbh | Conjugates for introducing nucleic acid into higher eucaryotic cells |
| US6013638A (en) | 1991-10-02 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung |
| US5795870A (en) * | 1991-12-13 | 1998-08-18 | Trustees Of Princeton University | Compositions and methods for cell transformation |
| AU3434393A (en) | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
| US5602023A (en) | 1992-03-24 | 1997-02-11 | Csatary; Laszlo K. | Pharmaceutical product containing live, stabilized virus for the therapy of viral and malignant diseases and process for preparing the same |
| DK0636028T3 (da) | 1992-04-03 | 2004-07-12 | Univ California | Selvorganiserende polynucleotidleveringssystem omfattende et amfipatisk kationisk peptid |
| JPH07505773A (ja) | 1992-04-03 | 1995-06-29 | ヤング アレキサンダー ティー | 標的化されたウイルスベクターを用いた遺伝子治療 |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| WO1994006923A1 (en) | 1992-09-24 | 1994-03-31 | The University Of Connecticut | Modification of a virus to redirect infectivity and enhance targeted delivery of polynucleotides to cells |
| US5656609A (en) | 1992-09-24 | 1997-08-12 | University Of Connecticut | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine |
| US5346701A (en) | 1993-02-22 | 1994-09-13 | Theratech, Inc. | Transmucosal delivery of macromolecular drugs |
| WO1995002698A1 (en) | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US5804566A (en) * | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| JPH07109983A (ja) | 1993-10-13 | 1995-04-25 | Nippondenso Co Ltd | スクロール型圧縮機 |
| DE69431959T2 (de) | 1993-10-15 | 2003-11-06 | Cytrx Corp | Therapeutische abgabesysteme und verfahren für ihre verwendung |
| US6210939B1 (en) | 1993-10-25 | 2001-04-03 | Canji, Inc. | Recombinant adenoviral vector and methods of use |
| EP1637608B1 (en) | 1993-10-25 | 2009-07-22 | CANJI, Inc. | Recombinant adenoviral vector and methods of use |
| US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5552309A (en) | 1994-09-30 | 1996-09-03 | Indiana University Foundation | Use of polyols for improving the introduction of genetic material into cells |
| US7163925B1 (en) | 1995-07-17 | 2007-01-16 | Board Of Regents, The University Of Texas System | p16 expression constructs and their application in cancer therapy |
| AU6600396A (en) * | 1995-07-28 | 1997-02-26 | David E. Kohne | Method for enhancing chemiluminescence |
| US5789244A (en) | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
| US7002027B1 (en) | 1996-01-08 | 2006-02-21 | Canji, Inc. | Compositions and methods for therapeutic use |
| US6392069B2 (en) | 1996-01-08 | 2002-05-21 | Canji, Inc. | Compositions for enhancing delivery of nucleic acids to cells |
| US20040014709A1 (en) | 1996-01-08 | 2004-01-22 | Canji, Inc. | Methods and compositions for interferon therapy |
| US5671110A (en) | 1996-01-23 | 1997-09-23 | Oneac Corporation | Ground skew protection method and apparatus |
| US6283940B1 (en) * | 1997-08-29 | 2001-09-04 | S. Grant Mulholland | Catheter |
| US6938069B1 (en) * | 2000-03-18 | 2005-08-30 | Computing Services Support Solutions | Electronic meeting center |
| ES2745068T3 (es) | 2001-12-20 | 2020-02-27 | Merck Sharp & Dohme | Composiciones de SYN3 y métodos |
| KR100499787B1 (ko) | 2002-11-29 | 2005-07-07 | 인티그런트 테크놀로지즈(주) | 스위치 모드 동작을 하는 선형성이 우수한 광대역 가변이득 증폭기 |
| JP2007526219A (ja) | 2003-06-04 | 2007-09-13 | カンジ，インコーポレイテッド | トランスフェクション薬剤 |
| US7355056B2 (en) | 2003-06-04 | 2008-04-08 | Canji, Inc. | Transfection agents |
| WO2004108898A2 (en) | 2003-06-04 | 2004-12-16 | Canji, Inc. | Transfection agents |
| CA2548100C (en) | 2003-12-10 | 2015-03-24 | Canji, Inc. | Methods and compositions for treatment of interferon-resistant tumors |
-
1997
- 1997-07-08 US US08/889,355 patent/US7002027B1/en not_active Expired - Fee Related
-
1998
- 1998-07-07 MY MYPI98003070A patent/MY138257A/en unknown
- 1998-07-07 ZA ZA986003A patent/ZA986003B/xx unknown
- 1998-07-08 AT AT98934359T patent/ATE434448T1/de active
- 1998-07-08 DE DE69840932T patent/DE69840932D1/de not_active Expired - Lifetime
- 1998-07-08 KR KR1020007000178A patent/KR100691572B1/ko not_active Expired - Fee Related
- 1998-07-08 CA CA2294709A patent/CA2294709C/en not_active Expired - Fee Related
- 1998-07-08 ES ES98934359T patent/ES2328094T3/es not_active Expired - Lifetime
- 1998-07-08 EP EP09008139A patent/EP2106807B1/en not_active Expired - Lifetime
- 1998-07-08 JP JP2000501781A patent/JP4460148B2/ja not_active Expired - Fee Related
- 1998-07-08 AU AU83901/98A patent/AU774338B2/en not_active Ceased
- 1998-07-08 ES ES09008139T patent/ES2362027T3/es not_active Expired - Lifetime
- 1998-07-08 DK DK98934359T patent/DK1011733T3/da active
- 1998-07-08 AT AT09008139T patent/ATE497786T1/de not_active IP Right Cessation
- 1998-07-08 HU HU0002683A patent/HUP0002683A3/hu unknown
- 1998-07-08 IL IL13392998A patent/IL133929A0/xx unknown
- 1998-07-08 DE DE69842133T patent/DE69842133D1/de not_active Expired - Lifetime
- 1998-07-08 EP EP98934359A patent/EP1011733B1/en not_active Expired - Lifetime
- 1998-07-08 NZ NZ502060A patent/NZ502060A/en not_active IP Right Cessation
- 1998-07-08 AR ARP980103311A patent/AR016312A1/es unknown
- 1998-07-08 PT PT98934359T patent/PT1011733E/pt unknown
- 1998-07-08 WO PCT/US1998/014241 patent/WO1999002191A1/en not_active Ceased
-
1999
- 1999-01-11 TW TW087111049A patent/TW490306B/zh not_active IP Right Cessation
-
2006
- 2006-02-21 US US11/359,997 patent/US7538093B2/en not_active Expired - Fee Related
-
2009
- 2009-04-13 US US12/422,807 patent/US8022044B2/en not_active Expired - Fee Related
- 2009-09-15 CY CY20091100949T patent/CY1109367T1/el unknown
- 2009-12-24 JP JP2009293390A patent/JP2010070565A/ja not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GD4A | Issue of patent certificate for granted invention patent | ||
| MM4A | Annulment or lapse of patent due to non-payment of fees |