CA2294709C - Compositions and methods for enhancing delivery of therapeutic agents to cells - Google Patents

Compositions and methods for enhancing delivery of therapeutic agents to cells Download PDF

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Publication number
CA2294709C
CA2294709C CA2294709A CA2294709A CA2294709C CA 2294709 C CA2294709 C CA 2294709C CA 2294709 A CA2294709 A CA 2294709A CA 2294709 A CA2294709 A CA 2294709A CA 2294709 C CA2294709 C CA 2294709C
Authority
CA
Canada
Prior art keywords
compound
gene
agent
composition according
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2294709A
Other languages
English (en)
French (fr)
Other versions
CA2294709A1 (en
Inventor
Heidrun Engler
Tattanahalli L. Nagabhushan
Stephen Kenneth Youngster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Canji Inc
Merck Sharp and Dohme LLC
Original Assignee
Canji Inc
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canji Inc, Schering Corp filed Critical Canji Inc
Publication of CA2294709A1 publication Critical patent/CA2294709A1/en
Application granted granted Critical
Publication of CA2294709C publication Critical patent/CA2294709C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2294709A 1997-07-08 1998-07-08 Compositions and methods for enhancing delivery of therapeutic agents to cells Expired - Fee Related CA2294709C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/889,355 US7002027B1 (en) 1996-01-08 1997-07-08 Compositions and methods for therapeutic use
US08/889,355 1997-07-08
PCT/US1998/014241 WO1999002191A1 (en) 1997-07-08 1998-07-08 Compositions and methods for enhancing delivery of therapeutic agents to cells

Publications (2)

Publication Number Publication Date
CA2294709A1 CA2294709A1 (en) 1999-01-21
CA2294709C true CA2294709C (en) 2010-05-11

Family

ID=25394956

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2294709A Expired - Fee Related CA2294709C (en) 1997-07-08 1998-07-08 Compositions and methods for enhancing delivery of therapeutic agents to cells

Country Status (20)

Country Link
US (3) US7002027B1 (https=)
EP (2) EP2106807B1 (https=)
JP (2) JP4460148B2 (https=)
KR (1) KR100691572B1 (https=)
AR (1) AR016312A1 (https=)
AT (2) ATE434448T1 (https=)
AU (1) AU774338B2 (https=)
CA (1) CA2294709C (https=)
CY (1) CY1109367T1 (https=)
DE (2) DE69840932D1 (https=)
DK (1) DK1011733T3 (https=)
ES (2) ES2328094T3 (https=)
HU (1) HUP0002683A3 (https=)
IL (1) IL133929A0 (https=)
MY (1) MY138257A (https=)
NZ (1) NZ502060A (https=)
PT (1) PT1011733E (https=)
TW (1) TW490306B (https=)
WO (1) WO1999002191A1 (https=)
ZA (1) ZA986003B (https=)

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US20040014709A1 (en) * 1996-01-08 2004-01-22 Canji, Inc. Methods and compositions for interferon therapy
US5789244A (en) * 1996-01-08 1998-08-04 Canji, Inc. Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems
US7002027B1 (en) * 1996-01-08 2006-02-21 Canji, Inc. Compositions and methods for therapeutic use
EP1070047A2 (en) 1998-04-08 2001-01-24 Celltech Chiroscience Limited Lipids
ES2745068T3 (es) * 2001-12-20 2020-02-27 Merck Sharp & Dohme Composiciones de SYN3 y métodos
JP2007526219A (ja) * 2003-06-04 2007-09-13 カンジ，インコーポレイテッド トランスフェクション薬剤
US7355056B2 (en) * 2003-06-04 2008-04-08 Canji, Inc. Transfection agents
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
CA2548100C (en) * 2003-12-10 2015-03-24 Canji, Inc. Methods and compositions for treatment of interferon-resistant tumors
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US8716021B2 (en) * 2005-09-07 2014-05-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of replicators to prevent gene silencing
US20110071100A1 (en) * 2008-05-05 2011-03-24 Tiltan Pharma Ltd. Sulfobetaines for cancer, obesity, macular degeneration, neurodegenerative diseases
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
US20130079382A1 (en) 2009-10-12 2013-03-28 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
US20120147800A1 (en) * 2010-12-10 2012-06-14 Minyoung Park Power management in a wireless network having stations with different power capabilities
US20120237492A1 (en) 2011-02-18 2012-09-20 Kythera Biopharmaceuticals, Inc. Treatment of submental fat
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
US10492104B2 (en) * 2016-03-10 2019-11-26 Cable Television Laboratories, Inc. Latency reduction in wireless service
WO2026077967A1 (en) 2024-10-08 2026-04-16 Ferring International Center Sa Method for making syn3

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US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US6207454B1 (en) 1989-10-16 2001-03-27 Amgen Inc. Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
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US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5120316A (en) 1990-09-28 1992-06-09 Akzo N.V. Urethral catheter and catheterization process
WO1992006180A1 (en) 1990-10-01 1992-04-16 University Of Connecticut Targeting viruses and cells for selective internalization by cells
NZ240846A (en) * 1990-12-06 1994-04-27 Hoechst Ag Dimeric bile acid derivatives; preparatory processes and pharmaceutical compositions
DE69233725T2 (de) 1991-06-28 2009-02-12 The Regents Of The University Of Michigan, Ann Arbor Verwendung von DNA oder RNA zur Herstellung eines Medikaments zur Behandlung von Tumoren
JPH06509578A (ja) 1991-07-26 1994-10-27 ユニバーシティ・オブ・ロチェスター 悪性細胞利用による癌治療法
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US5795870A (en) * 1991-12-13 1998-08-18 Trustees Of Princeton University Compositions and methods for cell transformation
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US5602023A (en) 1992-03-24 1997-02-11 Csatary; Laszlo K. Pharmaceutical product containing live, stabilized virus for the therapy of viral and malignant diseases and process for preparing the same
DK0636028T3 (da) 1992-04-03 2004-07-12 Univ California Selvorganiserende polynucleotidleveringssystem omfattende et amfipatisk kationisk peptid
JPH07505773A (ja) 1992-04-03 1995-06-29 ヤング　アレキサンダー　ティー 標的化されたウイルスベクターを用いた遺伝子治療
US5334761A (en) 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
WO1994006923A1 (en) 1992-09-24 1994-03-31 The University Of Connecticut Modification of a virus to redirect infectivity and enhance targeted delivery of polynucleotides to cells
US5656609A (en) 1992-09-24 1997-08-12 University Of Connecticut Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine
US5346701A (en) 1993-02-22 1994-09-13 Theratech, Inc. Transmucosal delivery of macromolecular drugs
WO1995002698A1 (en) 1993-07-12 1995-01-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5804566A (en) * 1993-08-26 1998-09-08 The Regents Of The University Of California Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
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US5789244A (en) 1996-01-08 1998-08-04 Canji, Inc. Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems
US7002027B1 (en) 1996-01-08 2006-02-21 Canji, Inc. Compositions and methods for therapeutic use
US6392069B2 (en) 1996-01-08 2002-05-21 Canji, Inc. Compositions for enhancing delivery of nucleic acids to cells
US20040014709A1 (en) 1996-01-08 2004-01-22 Canji, Inc. Methods and compositions for interferon therapy
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US6938069B1 (en) * 2000-03-18 2005-08-30 Computing Services Support Solutions Electronic meeting center
ES2745068T3 (es) 2001-12-20 2020-02-27 Merck Sharp & Dohme Composiciones de SYN3 y métodos
KR100499787B1 (ko) 2002-11-29 2005-07-07 인티그런트 테크놀로지즈(주) 스위치 모드 동작을 하는 선형성이 우수한 광대역 가변이득 증폭기
JP2007526219A (ja) 2003-06-04 2007-09-13 カンジ，インコーポレイテッド トランスフェクション薬剤
US7355056B2 (en) 2003-06-04 2008-04-08 Canji, Inc. Transfection agents
WO2004108898A2 (en) 2003-06-04 2004-12-16 Canji, Inc. Transfection agents
CA2548100C (en) 2003-12-10 2015-03-24 Canji, Inc. Methods and compositions for treatment of interferon-resistant tumors

Also Published As

Publication number Publication date
JP2010070565A (ja) 2010-04-02
HUP0002683A2 (hu) 2000-12-28
DK1011733T3 (da) 2009-09-28
US7538093B2 (en) 2009-05-26
EP1011733A1 (en) 2000-06-28
IL133929A0 (en) 2001-04-30
ES2328094T3 (es) 2009-11-06
CA2294709A1 (en) 1999-01-21
ATE497786T1 (de) 2011-02-15
AU774338B2 (en) 2004-06-24
DE69842133D1 (de) 2011-03-24
AU8390198A (en) 1999-02-08
MY138257A (en) 2009-05-29
US20060199782A1 (en) 2006-09-07
US8022044B2 (en) 2011-09-20
DE69840932D1 (de) 2009-08-06
US7002027B1 (en) 2006-02-21
HK1028961A1 (en) 2001-03-16
CY1109367T1 (el) 2014-07-02
US20100028431A1 (en) 2010-02-04
AR016312A1 (es) 2001-07-04
JP4460148B2 (ja) 2010-05-12
EP1011733A4 (en) 2004-09-29
TW490306B (en) 2002-06-11
WO1999002191A1 (en) 1999-01-21
JP2001509492A (ja) 2001-07-24
ATE434448T1 (de) 2009-07-15
KR100691572B1 (ko) 2007-03-12
ZA986003B (en) 1999-01-28
KR20010021620A (ko) 2001-03-15
HK1134025A1 (en) 2010-04-16
NZ502060A (en) 2003-01-31
EP2106807B1 (en) 2011-02-09
EP2106807A1 (en) 2009-10-07
PT1011733E (pt) 2009-09-15
HUP0002683A3 (en) 2005-09-28
EP1011733B1 (en) 2009-06-24
ES2362027T3 (es) 2011-06-27

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Legal Events

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Effective date: 20160708