JP2001509492A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2001509492A5 JP2001509492A5 JP2000501781A JP2000501781A JP2001509492A5 JP 2001509492 A5 JP2001509492 A5 JP 2001509492A5 JP 2000501781 A JP2000501781 A JP 2000501781A JP 2000501781 A JP2000501781 A JP 2000501781A JP 2001509492 A5 JP2001509492 A5 JP 2001509492A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- hexose
- composition
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 31
- 238000000034 method Methods 0.000 description 29
- 239000000203 mixture Substances 0.000 description 18
- 125000000837 carbohydrate group Chemical group 0.000 description 17
- 239000003795 chemical substances by application Substances 0.000 description 16
- 230000002708 enhancing effect Effects 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 8
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 7
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 7
- 239000013598 vector Substances 0.000 description 5
- 239000013603 viral vector Substances 0.000 description 5
- 125000002091 cationic group Chemical group 0.000 description 4
- 150000002402 hexoses Chemical group 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- PFZUIDNKXWIWBG-KBALINIXSA-N CCCC(C)C(CCC1C(C(C2)[C@@](C)(CC[C@H](C3)O)C3C3)[C@@H]3O)[C@@]1(C)[C@H]2O Chemical compound CCCC(C)C(CCC1C(C(C2)[C@@](C)(CC[C@H](C3)O)C3C3)[C@@H]3O)[C@@]1(C)[C@H]2O PFZUIDNKXWIWBG-KBALINIXSA-N 0.000 description 2
- ZAJHJDBGYZOQBF-NDRAZTMQSA-N CCCC(C)C(CCC1C([C@H](C)C2)C(C3)[C@@](C)(CC4)C2C[C@@H]4O)[C@@]1(C)[C@H]3O Chemical compound CCCC(C)C(CCC1C([C@H](C)C2)C(C3)[C@@](C)(CC4)C2C[C@@H]4O)[C@@]1(C)[C@H]3O ZAJHJDBGYZOQBF-NDRAZTMQSA-N 0.000 description 2
- 201000000582 Retinoblastoma Diseases 0.000 description 2
- 108700025701 Retinoblastoma Genes Proteins 0.000 description 2
- 230000031018 biological processes and functions Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000003232 mucoadhesive effect Effects 0.000 description 2
- 150000002972 pentoses Chemical class 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 150000004043 trisaccharides Chemical class 0.000 description 2
- 206010005003 Bladder cancer Diseases 0.000 description 1
- ATCGTYXFBXLXBJ-GJYGINKKSA-N CCCC(C)C(CCC1C(CC2)C(C3)[C@@](C)(CC4)C2C[C@@H]4OC)[C@@]1(C)[C@H]3OC Chemical compound CCCC(C)C(CCC1C(CC2)C(C3)[C@@](C)(CC4)C2C[C@@H]4OC)[C@@]1(C)[C@H]3OC ATCGTYXFBXLXBJ-GJYGINKKSA-N 0.000 description 1
- 0 CCCC(C)C(CCC1C2[C@@](C)CC(C[C@@](CC3)O*)[C@@]3(C)C2C2)[C@@]1(C)[C@]2OC Chemical compound CCCC(C)C(CCC1C2[C@@](C)CC(C[C@@](CC3)O*)[C@@]3(C)C2C2)[C@@]1(C)[C@]2OC 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 108050002653 Retinoblastoma protein Proteins 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 150000002772 monosaccharides Chemical group 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 108700025694 p53 Genes Proteins 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/889,355 US7002027B1 (en) | 1996-01-08 | 1997-07-08 | Compositions and methods for therapeutic use |
| US08/889,355 | 1997-07-08 | ||
| PCT/US1998/014241 WO1999002191A1 (en) | 1997-07-08 | 1998-07-08 | Compositions and methods for enhancing delivery of therapeutic agents to cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009293390A Division JP2010070565A (ja) | 1997-07-08 | 2009-12-24 | 治療用薬剤の細胞への送達を増強するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001509492A JP2001509492A (ja) | 2001-07-24 |
| JP2001509492A5 true JP2001509492A5 (https=) | 2006-01-05 |
| JP4460148B2 JP4460148B2 (ja) | 2010-05-12 |
Family
ID=25394956
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000501781A Expired - Fee Related JP4460148B2 (ja) | 1997-07-08 | 1998-07-08 | 治療用薬剤の細胞への送達を増強するための組成物および方法 |
| JP2009293390A Withdrawn JP2010070565A (ja) | 1997-07-08 | 2009-12-24 | 治療用薬剤の細胞への送達を増強するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009293390A Withdrawn JP2010070565A (ja) | 1997-07-08 | 2009-12-24 | 治療用薬剤の細胞への送達を増強するための組成物および方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7002027B1 (https=) |
| EP (2) | EP2106807B1 (https=) |
| JP (2) | JP4460148B2 (https=) |
| KR (1) | KR100691572B1 (https=) |
| AR (1) | AR016312A1 (https=) |
| AT (2) | ATE434448T1 (https=) |
| AU (1) | AU774338B2 (https=) |
| CA (1) | CA2294709C (https=) |
| CY (1) | CY1109367T1 (https=) |
| DE (2) | DE69840932D1 (https=) |
| DK (1) | DK1011733T3 (https=) |
| ES (2) | ES2328094T3 (https=) |
| HU (1) | HUP0002683A3 (https=) |
| IL (1) | IL133929A0 (https=) |
| MY (1) | MY138257A (https=) |
| NZ (1) | NZ502060A (https=) |
| PT (1) | PT1011733E (https=) |
| TW (1) | TW490306B (https=) |
| WO (1) | WO1999002191A1 (https=) |
| ZA (1) | ZA986003B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6392069B2 (en) * | 1996-01-08 | 2002-05-21 | Canji, Inc. | Compositions for enhancing delivery of nucleic acids to cells |
| US20040014709A1 (en) * | 1996-01-08 | 2004-01-22 | Canji, Inc. | Methods and compositions for interferon therapy |
| US5789244A (en) * | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
| US7002027B1 (en) * | 1996-01-08 | 2006-02-21 | Canji, Inc. | Compositions and methods for therapeutic use |
| EP1070047A2 (en) | 1998-04-08 | 2001-01-24 | Celltech Chiroscience Limited | Lipids |
| ES2745068T3 (es) * | 2001-12-20 | 2020-02-27 | Merck Sharp & Dohme | Composiciones de SYN3 y métodos |
| JP2007526219A (ja) * | 2003-06-04 | 2007-09-13 | カンジ,インコーポレイテッド | トランスフェクション薬剤 |
| US7355056B2 (en) * | 2003-06-04 | 2008-04-08 | Canji, Inc. | Transfection agents |
| US7790039B2 (en) * | 2003-11-24 | 2010-09-07 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for stem cell enrichment |
| CA2548100C (en) * | 2003-12-10 | 2015-03-24 | Canji, Inc. | Methods and compositions for treatment of interferon-resistant tumors |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| US8716021B2 (en) * | 2005-09-07 | 2014-05-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of replicators to prevent gene silencing |
| US20110071100A1 (en) * | 2008-05-05 | 2011-03-24 | Tiltan Pharma Ltd. | Sulfobetaines for cancer, obesity, macular degeneration, neurodegenerative diseases |
| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| US20120147800A1 (en) * | 2010-12-10 | 2012-06-14 | Minyoung Park | Power management in a wireless network having stations with different power capabilities |
| US20120237492A1 (en) | 2011-02-18 | 2012-09-20 | Kythera Biopharmaceuticals, Inc. | Treatment of submental fat |
| US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
| US10492104B2 (en) * | 2016-03-10 | 2019-11-26 | Cable Television Laboratories, Inc. | Latency reduction in wireless service |
| WO2026077967A1 (en) | 2024-10-08 | 2026-04-16 | Ferring International Center Sa | Method for making syn3 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554386A (en) | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US6207454B1 (en) | 1989-10-16 | 2001-03-27 | Amgen Inc. | Method for enhancing the effciency of gene transfer with stem cell factor (SCF) polypeptide |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5120316A (en) | 1990-09-28 | 1992-06-09 | Akzo N.V. | Urethral catheter and catheterization process |
| WO1992006180A1 (en) | 1990-10-01 | 1992-04-16 | University Of Connecticut | Targeting viruses and cells for selective internalization by cells |
| NZ240846A (en) * | 1990-12-06 | 1994-04-27 | Hoechst Ag | Dimeric bile acid derivatives; preparatory processes and pharmaceutical compositions |
| DE69233725T2 (de) | 1991-06-28 | 2009-02-12 | The Regents Of The University Of Michigan, Ann Arbor | Verwendung von DNA oder RNA zur Herstellung eines Medikaments zur Behandlung von Tumoren |
| JPH06509578A (ja) | 1991-07-26 | 1994-10-27 | ユニバーシティ・オブ・ロチェスター | 悪性細胞利用による癌治療法 |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US5521291A (en) | 1991-09-30 | 1996-05-28 | Boehringer Ingelheim International, Gmbh | Conjugates for introducing nucleic acid into higher eucaryotic cells |
| US6013638A (en) | 1991-10-02 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung |
| US5795870A (en) * | 1991-12-13 | 1998-08-18 | Trustees Of Princeton University | Compositions and methods for cell transformation |
| AU3434393A (en) | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
| US5602023A (en) | 1992-03-24 | 1997-02-11 | Csatary; Laszlo K. | Pharmaceutical product containing live, stabilized virus for the therapy of viral and malignant diseases and process for preparing the same |
| DK0636028T3 (da) | 1992-04-03 | 2004-07-12 | Univ California | Selvorganiserende polynucleotidleveringssystem omfattende et amfipatisk kationisk peptid |
| JPH07505773A (ja) | 1992-04-03 | 1995-06-29 | ヤング アレキサンダー ティー | 標的化されたウイルスベクターを用いた遺伝子治療 |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| WO1994006923A1 (en) | 1992-09-24 | 1994-03-31 | The University Of Connecticut | Modification of a virus to redirect infectivity and enhance targeted delivery of polynucleotides to cells |
| US5656609A (en) | 1992-09-24 | 1997-08-12 | University Of Connecticut | Method of enhancing and/or prolonging expression of gene introduced into a cell using colchicine |
| US5346701A (en) | 1993-02-22 | 1994-09-13 | Theratech, Inc. | Transmucosal delivery of macromolecular drugs |
| WO1995002698A1 (en) | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US5804566A (en) * | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| JPH07109983A (ja) | 1993-10-13 | 1995-04-25 | Nippondenso Co Ltd | スクロール型圧縮機 |
| DE69431959T2 (de) | 1993-10-15 | 2003-11-06 | Cytrx Corp | Therapeutische abgabesysteme und verfahren für ihre verwendung |
| US6210939B1 (en) | 1993-10-25 | 2001-04-03 | Canji, Inc. | Recombinant adenoviral vector and methods of use |
| EP1637608B1 (en) | 1993-10-25 | 2009-07-22 | CANJI, Inc. | Recombinant adenoviral vector and methods of use |
| US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5552309A (en) | 1994-09-30 | 1996-09-03 | Indiana University Foundation | Use of polyols for improving the introduction of genetic material into cells |
| US7163925B1 (en) | 1995-07-17 | 2007-01-16 | Board Of Regents, The University Of Texas System | p16 expression constructs and their application in cancer therapy |
| AU6600396A (en) * | 1995-07-28 | 1997-02-26 | David E. Kohne | Method for enhancing chemiluminescence |
| US5789244A (en) | 1996-01-08 | 1998-08-04 | Canji, Inc. | Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems |
| US7002027B1 (en) | 1996-01-08 | 2006-02-21 | Canji, Inc. | Compositions and methods for therapeutic use |
| US6392069B2 (en) | 1996-01-08 | 2002-05-21 | Canji, Inc. | Compositions for enhancing delivery of nucleic acids to cells |
| US20040014709A1 (en) | 1996-01-08 | 2004-01-22 | Canji, Inc. | Methods and compositions for interferon therapy |
| US5671110A (en) | 1996-01-23 | 1997-09-23 | Oneac Corporation | Ground skew protection method and apparatus |
| US6283940B1 (en) * | 1997-08-29 | 2001-09-04 | S. Grant Mulholland | Catheter |
| US6938069B1 (en) * | 2000-03-18 | 2005-08-30 | Computing Services Support Solutions | Electronic meeting center |
| ES2745068T3 (es) | 2001-12-20 | 2020-02-27 | Merck Sharp & Dohme | Composiciones de SYN3 y métodos |
| KR100499787B1 (ko) | 2002-11-29 | 2005-07-07 | 인티그런트 테크놀로지즈(주) | 스위치 모드 동작을 하는 선형성이 우수한 광대역 가변이득 증폭기 |
| JP2007526219A (ja) | 2003-06-04 | 2007-09-13 | カンジ,インコーポレイテッド | トランスフェクション薬剤 |
| US7355056B2 (en) | 2003-06-04 | 2008-04-08 | Canji, Inc. | Transfection agents |
| WO2004108898A2 (en) | 2003-06-04 | 2004-12-16 | Canji, Inc. | Transfection agents |
| CA2548100C (en) | 2003-12-10 | 2015-03-24 | Canji, Inc. | Methods and compositions for treatment of interferon-resistant tumors |
-
1997
- 1997-07-08 US US08/889,355 patent/US7002027B1/en not_active Expired - Fee Related
-
1998
- 1998-07-07 MY MYPI98003070A patent/MY138257A/en unknown
- 1998-07-07 ZA ZA986003A patent/ZA986003B/xx unknown
- 1998-07-08 AT AT98934359T patent/ATE434448T1/de active
- 1998-07-08 DE DE69840932T patent/DE69840932D1/de not_active Expired - Lifetime
- 1998-07-08 KR KR1020007000178A patent/KR100691572B1/ko not_active Expired - Fee Related
- 1998-07-08 CA CA2294709A patent/CA2294709C/en not_active Expired - Fee Related
- 1998-07-08 ES ES98934359T patent/ES2328094T3/es not_active Expired - Lifetime
- 1998-07-08 EP EP09008139A patent/EP2106807B1/en not_active Expired - Lifetime
- 1998-07-08 JP JP2000501781A patent/JP4460148B2/ja not_active Expired - Fee Related
- 1998-07-08 AU AU83901/98A patent/AU774338B2/en not_active Ceased
- 1998-07-08 ES ES09008139T patent/ES2362027T3/es not_active Expired - Lifetime
- 1998-07-08 DK DK98934359T patent/DK1011733T3/da active
- 1998-07-08 AT AT09008139T patent/ATE497786T1/de not_active IP Right Cessation
- 1998-07-08 HU HU0002683A patent/HUP0002683A3/hu unknown
- 1998-07-08 IL IL13392998A patent/IL133929A0/xx unknown
- 1998-07-08 DE DE69842133T patent/DE69842133D1/de not_active Expired - Lifetime
- 1998-07-08 EP EP98934359A patent/EP1011733B1/en not_active Expired - Lifetime
- 1998-07-08 NZ NZ502060A patent/NZ502060A/en not_active IP Right Cessation
- 1998-07-08 AR ARP980103311A patent/AR016312A1/es unknown
- 1998-07-08 PT PT98934359T patent/PT1011733E/pt unknown
- 1998-07-08 WO PCT/US1998/014241 patent/WO1999002191A1/en not_active Ceased
-
1999
- 1999-01-11 TW TW087111049A patent/TW490306B/zh not_active IP Right Cessation
-
2006
- 2006-02-21 US US11/359,997 patent/US7538093B2/en not_active Expired - Fee Related
-
2009
- 2009-04-13 US US12/422,807 patent/US8022044B2/en not_active Expired - Fee Related
- 2009-09-15 CY CY20091100949T patent/CY1109367T1/el unknown
- 2009-12-24 JP JP2009293390A patent/JP2010070565A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001509492A5 (https=) | ||
| US8367631B2 (en) | Pharmaceutical composition which improves in vivo gene transfer | |
| US9987232B2 (en) | Dissolution aids for oral peptide delivery comprising a biguanide | |
| US20030229040A1 (en) | Cationic liposomal delivery system and therapeutic use thereof | |
| JP2024019727A5 (https=) | ||
| JP2021523916A (ja) | メッセンジャーrnaの皮下送達 | |
| US6559129B1 (en) | Cationic liposomal delivery system and therapeutic use thereof | |
| JP2010070565A5 (https=) | ||
| CN1198675A (zh) | 含有hgf基因的药物 | |
| US7303762B2 (en) | Absorption enhancers | |
| CA2294709A1 (en) | Compositions and methods for enhancing delivery of therapeutic agents to cells | |
| JPH0747543B2 (ja) | アシアロ糖蛋白抱合薬剤 | |
| US20110045061A1 (en) | Gene therapy for diabetic ischemic disease | |
| JP2006523662A (ja) | Bht、bhaまたは没食子酸プロピルなどの吸収促進剤 | |
| TW200930811A (en) | Transfection reagent and method for enhancing transfection efficiency | |
| JP2003528138A5 (https=) | ||
| JPWO2022235935A5 (https=) | ||
| Sewell et al. | Optimizing suicide gene therapy for head and neck cancer | |
| JPWO2001032220A1 (ja) | 糖尿病性虚血性疾患遺伝子治療 | |
| EP4630562A1 (en) | Nucleic acid based cancer vaccine and methods thereof | |
| CN112316153A (zh) | 一种抗肿瘤的药物组合物及其应用 | |
| CN117159725B (zh) | 通过dna水凝胶促进小分子药物结晶达到缓释效果的方法 | |
| JP2003531181A (ja) | 核酸を細胞に投与するための粒状複合体 | |
| JP4831551B2 (ja) | 非虚血性心筋障害に対する医薬 | |
| JP2003531181A6 (ja) | 核酸を細胞に投与するための粒状複合体 |