JP2006523662A - Bht、bhaまたは没食子酸プロピルなどの吸収促進剤 - Google Patents
Bht、bhaまたは没食子酸プロピルなどの吸収促進剤 Download PDFInfo
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- JP2006523662A JP2006523662A JP2006506134A JP2006506134A JP2006523662A JP 2006523662 A JP2006523662 A JP 2006523662A JP 2006506134 A JP2006506134 A JP 2006506134A JP 2006506134 A JP2006506134 A JP 2006506134A JP 2006523662 A JP2006523662 A JP 2006523662A
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- aromatic alcohol
- analogs
- derivatives
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Abstract
Description
(a)活性を有する巨大分子成分;および
(b)ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ならびにそれらの類似体および誘導体から選択された芳香族アルコール吸収促進剤であって、活性巨大分子成分の重量と等しいかそれより多く存在する芳香族アルコール吸収促進剤。
(a)活性を有する巨大分子成分;および
(b)没食子酸プロピル、ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ならびにそれらの類似体および誘導体から選択された芳香族アルコール吸収促進剤、および
(c)該芳香族アルコール吸収促進剤の水性溶媒中への溶解性を増大させることのできる可溶化助剤であって、活性巨大分子成分の重量と等しいかそれより多く存在する芳香族アルコール吸収促進剤。
1. インスリン;カルシトニン;ヒト血清アルブミン;成長ホルモン;成長ホルモン放出因子;ガラニン;副甲状腺ホルモン;キノゲン(kinogen)、プロトロンビン、フィブリノゲン、第VII因子、第VIII因子、または第IX因子などの血液凝固タンパク質;エリスロポエチンおよびEPO疑似体;GCSFおよびGMCSFを含むコロニー刺激因子;血小板由来成長因子;上皮成長因子;線維芽細胞増殖因子;トランスフォーミング成長因子;GLP-1;GAG;サイトカイン;インスリン様成長因子;骨および軟骨誘導因子;神経栄養因子;IL-1、IL-2、IL-3、IL-4、IL-5、IL-6、IL-7、IL-8、IL-9、IL=10、IL-11、IL-12を含むインターロイキン;インターフェロン-γ、インターフェロン-1a、インターフェロン-αを含むインターフェロン;TNF-α;TNF-β;TGF-β;コレラ毒素AおよびBフラグメント;大腸菌(E.coli)内毒素AおよびBフラグメント;セクレチン;ヒストンデアセチラーゼ、スーパーオキシドジスムターゼ、カタラーゼ、アデノシンデアミナーゼ、チミジンキナーゼ、シトシンデアミナーゼ、プロテアーゼ、リパーゼ、カルボヒドラーゼ、ヌクレオチダーゼ、ポリメラーゼ、キナーゼ、およびホスファターゼなどの酵素;運搬または結合タンパク質で特にビタミン、金属イオン、アミノ酸、または脂質もしくはリポタンパク質と結合またはそれらを運搬するもの、例えばコレステロールエステル転送タンパク質、リン脂質転送タンパク質、HDL結合タンパク質など;コラーゲン、エラスチン、またはフィブロネクチンなどの結合組織タンパク質;アクチン、ミオシン、ジストロフィン、またはミニ・ジストロフィンなどの筋肉タンパク質;神経、肝臓、心臓、または脂肪細胞のタンパク質;細胞傷害性タンパク質;チトクローム;細胞の複製、増殖、または分化を起こさせるタンパク質;細胞内シグナル伝達タンパク質または細胞外シグナル伝達タンパク質(例えばホルモン)などのシグナル伝達分子;BDNF、CNTF、NGF、IGF、GMF、aFGF、bFGF、VEGF、NT3、T3、およびHARPなどの栄養因子;アポリポタンパク質;抗体分子;可溶性の形態の受容体、例えばT細胞受容体およびサイトカイン、インターフェロン、またはケモカインの受容体;抗原性のエピトープおよびフラグメントを含んでいるタンパク質またはペプチド;ならびに上記のもののいずれかの誘導体、コンジュゲート、および配列変異体。これらのタンパク質およびその他のタンパク質はヒト、植物、動物、細菌もしくは真菌のソース由来のものとすることができ、また天然のソースから抽出されたもの、発酵によって組換え体として調製されたもの、または化学的に合成されたものとすることができる。
Caco-2細胞(ヒト結腸癌由来の細胞系統)をコンフルエントな単層として有孔膜(孔径0.4μm、表面積0.33cm2)の表面上に増殖させて2つの水性コンパートメントに分け、上部のコンパートメントには培地を200μL満たし、下部のコンパートメントには600μLの培地を入れる。その単層を横切る電気抵抗を、単層の両側の上部コンパートメントと下部コンパートメントの培地中に挿入した電極と接続させた上皮電圧計(epithelial voltometer)を用いて測定する。この経上皮電気抵抗(TEER)は、上部コンパートメントへの芳香族アルコール添加の前と15分後に測定する(代表的な結果を下記の表に示す)。各化合物について4回反復測定するが、それらの濃度については下記の表に示している。TEERの低下は、細胞単層を横切る物質(大きな液相を含む)の流れの増加を示しているものと考えられる。
150mgのタウロコール酸ナトリウムを75mgの没食子酸プロピルとガラスバイアル瓶中で混合し、825μLの蒸留水を添加する。長時間振盪しても室温では溶解できないが、超音波浴中で短時間超音波処理して加温すると無色透明な溶液が得られる。8.4mgのウシインスリンをその溶液に撹拌しつつ添加した後、そのインスリン懸濁液をボルテックスしつつ10μLの氷酢酸を添加する。澄明な溶液でpHが3.15のものが急速に得られる。そのバイアル瓶の内容物を振盪しつつ急速凍結し、一晩凍結乾燥させる。翌日、乾燥固形物が得られる。その固形物の10mgを2mLのバイアル瓶に量り取り、50μLの蒸留水を添加する。澄明な溶液が急速に形成される。
実施例2に記載の条件と同一条件で行い、タウロコール酸塩の替わりにタウロデオキシコール酸塩を用いる。最終の溶液の乾燥前のpHは3.36である。前述の実施例と同様に、乾燥固形物に蒸留水を添加すると急速に澄明な溶液となる。
2.3mgのサケカルシトニンを蒸留水中に溶解し、その溶液全体をタウロコール酸ナトリウムおよび没食子酸プロピルの混合物中に添加することを除いては、実施例2に記載の条件と同一条件で行う。前述の実施例と同様に、蒸留水を添加すると急速に澄明な溶液となる。
タウロコール酸塩の替わりにタウロデオキシコール酸塩を用いることを除いては、実施例4に記載の条件と同一条件で行う。
カルシトニンの替わりに0.5mgの副甲状腺ホルモンを用いることを除いては、実施例4に記載の条件と同一条件で行う。
タウロコール酸塩の替わりにタウロデオキシコール酸塩を用いることを除いては、実施例6に記載の条件と同一条件で行う。
胆汁酸塩/PG混合物をタンパク質を添加することなく乾燥し、副甲状腺ホルモンを乾燥粉末として添加して凍結乾燥後に乾燥残査とすることを除いては、実施例7に記載の条件と同一条件で行う。
副甲状腺ホルモンの替わりに20mgのヒト成長ホルモンを用いることを除いては、実施例8に記載の条件と同一条件で行う。
75mgの没食子酸プロピルを200μLのプロピレングリコール中にボルテックスして溶解する。得られた溶液200μLを、1mgの固形のカルシトニンを入れたバイアル瓶に移す。そのバイアル瓶を短時間ボルテックスして固形物を分散させた後、37℃で1時間振盪して澄明な溶液を得る。
100mgの没食子酸プロピルを200μLのベンジルアルコール中でボルテックスし、室温で数分後に澄明な溶液を得る。得られた溶液200μLを1mgの固形のカルシトニンを入れたバイアル瓶に移す。そのバイアル瓶を短時間ボルテックスして固形物を分散させる。
100mgの没食子酸プロピルを200μLのトランスクトール中でボルテックスし、室温で1分後に澄明な溶液を得る。得られた溶液200μLを1mgの固形のカルシトニンを入れたバイアル瓶に移す。そのバイアル瓶を37℃で1時間、短時間ボルテックスして固形物を分散させ、澄明な溶液を得る。得られた溶液200μLを、1mgの固形のカルシトニンを入れたバイアル瓶に移す。そのバイアル瓶を短時間ボルテックスして固形物を分散させた後、37℃で1時間振盪して澄明な溶液を得る。その溶液100μLを別の新しいバイアル瓶に移し、そのバイアル瓶に100μLの蒸留水を添加する。全てのコンポーネントは溶液中に単一相の澄明な液体として含まれる。
100mgのブチル化ヒドロキシトルエンを200μLのトランスクトール中でボルテックスし、室温で数分後に澄明な溶液を得る。得られた溶液200μLを1mgの固形のカルシトニンを入れたバイアル瓶に移す。そのバイアル瓶を短時間ボルテックスして固形物を分散させ、37℃で1時間振盪して澄明な溶液を得る。その溶液100μLを別の新しいバイアル瓶に移し、そのバイアル瓶に100μLの蒸留水を添加して、37℃で澄明な乳白色の溶液を得る。
Claims (29)
- (a)活性巨大分子成分、および
(b)ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ならびにそれらの類似体および誘導体から選択された芳香族アルコール吸収促進剤であって、その芳香族アルコール吸収促進剤が該活性巨大分子成分の量と比較して重量比でそれより多量または等量存在しているもの、
の混合物を含む医薬組成物。 - (a)活性巨大分子成分、および
(b)没食子酸プロピル、ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ならびにそれらの類似体および誘導体から選択された芳香族アルコール吸収促進剤であって、その芳香族アルコール吸収促進剤が該活性巨大分子成分の量と比較して重量比でそれより多量または等量存在しているもの、および
(c)水性溶媒中で該芳香族アルコール吸収促進剤の溶解性を増大させることのできる可溶化助剤、
の混合物を含んでいる医薬組成物。 - 混合物が、重量比で5%未満の水を含んでいる、請求項1または2に記載の組成物。
- 組成物が、pH 3から7で透過性となる腸溶性コーティングを施されている、請求項1〜3のいずれか1項に記載の組成物。
- 混合物が、重量比で少なくとも1%の芳香族アルコール吸収促進剤を含んでいる、請求項1〜4のいずれか1項に記載の組成物。
- 芳香族アルコール吸収促進剤の活性巨大分子成分に対する重量比が少なくとも5:1である、請求項1〜5のいずれか1項に記載の組成物。
- 混合物が溶液または微粒子分散液の形態である、請求項1〜6のいずれか1項に記載の組成物。
- 混合物が固体の形態である、請求項1〜7のいずれか1項に記載の組成物。
- 活性巨大分子成分が、ポリペプチドもしくはタンパク質、ポリヌクレオチド、多糖、またはそれらの混合物である、請求項1〜8のいずれか1項に記載の組成物。
- 芳香族アルコール吸収促進剤が、BHT、BHA、ならびにそれらの類似体および誘導体から選択されたものであり、芳香環に結合したメチル基またはメトキシ基、および/またはヒドロキシル基に対してオルトの位置の水素が、何れかの位置で特にハロゲン原子によって置換されているかまたは置換されていない、直鎖状または分枝したC1-12アルキル、C1-12アルキルオキシ、C1-12アルキルチオ、またはC2-12アルケニルで置換されたヒドロキシトルエンまたはヒドロキシアニソールの類似体および誘導体を含む、請求項1〜9のいずれか1項に記載の組成物。
- 芳香族アルコール吸収促進剤が、没食子酸エステルを含む没食子酸プロピルまたはそれの類似体もしくは誘導体であり、エステルは直鎖状または分枝したC1-12アルキル、C1-12アルキルオキシ、C1-12アルキルチオ、またはC2-12アルケニルエステルであり、それらの化合物はハロゲン、直鎖状または分枝したC1-12アルキル、C1-12アルキルオキシ、C1-12アルキルチオ、またはC2-12アルケニルエステルで置換されているか、または置換されていない、請求項2〜9のいずれか1項に記載の組成物。
- 可溶化助剤が、胆汁酸またはその塩、ベンジルアルコール、フェニルエタノール、フェノキシエタノール、トランスクトール、およびイソプロパノールから選択されたものである、請求項2〜11のいずれか1項に記載の組成物。
- 活性巨大分子成分が、インスリン、カルシトニン、成長ホルモン、副甲状腺ホルモン、またはエリスロポエチン、ならびにそれらの誘導体および類似体で、合成したものまたは天然のソース由来のもののいずれかであり、ヒトまたは動物のいずれかに由来する構造と一致するものである、請求項1〜12のいずれか1項に記載の組成物。
- 活性巨大分子成分が、インスリン、カルシトニン、副甲状腺ホルモン、またはそれらの誘導体もしくは類似体で、合成したものまたは天然のソース由来のもののいずれかであり、ヒトまたは動物のいずれかに由来する構造と一致するものである、請求項1〜13のいずれか1項に記載の組成物。
- 活性巨大分子成分が、インスリン、またはそれの誘導体もしくは類似体で、合成したものまたは天然のソース由来のもののいずれかであり、ヒトまたは動物のいずれかに由来する構造と一致するものであり、さらにインスリン増感剤を含んでいる、請求項14に記載の組成物。
- ヒトまたは動物の体の治療的または診断的処置に使用するための、請求項1〜15のいずれか1項に記載の組成物。
- ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ならびにそれらの類似体および誘導体から選択された芳香族アルコールの、腸管壁を横切る巨大分子の吸収のための促進剤としての、医薬組成物中での使用。
- ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ならびにそれらの類似体および誘導体から選択された芳香族アルコールの、活性巨大分子成分を含有する医薬品の製造における、該活性巨大分子成分のヒトまたは動物体内への吸収を促進するための使用。
- 没食子酸プロピル、ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ならびにそれらの類似体および誘導体から選択された芳香族アルコールの、水性溶媒中での該芳香族アルコール吸収促進剤の溶解性を増大させることのできる可溶化助剤と共に用いる、腸管壁を横切る巨大分子の吸収の促進剤としての、医薬組成物中での使用。
- 没食子酸プロピル、ブチル化ヒドロキシトルエン、ブチル化ヒドロキシアニソール、ならびにそれらの類似体および誘導体から選択された芳香族アルコールの、水性溶媒中での該芳香族アルコール吸収促進剤の溶解性を増大させることのできる可溶化助剤と共に用いる、活性巨大分子成分のヒトまたは動物体内への吸収を促進するための、該活性巨大分子成分を含有する医薬品の製造における使用。
- 組成物が、重量比で5%未満の水分を含んでいる、請求項17〜20のいずれか1項に記載の使用。
- 可溶化助剤が、コンジュゲートされた胆汁酸またはその塩、ベンジルアルコール、フェニルエタノール、フェノキシエタノール、トランスクトール、およびイソプロパノールから選択されたものである、請求項19または20に記載の使用。
- 医薬品が、溶液の形態で、微粒子分散液として、または固体として提供される、請求項18または20に記載の使用。
- 活性巨大分子成分/吸収されることとなる巨大分子が、ポリペプチドもしくはタンパク質、ポリヌクレオチド、多糖、またはそれらの混合物である、請求項17〜23のいずれか1項に記載の使用。
- 吸収されることとなる巨大分子/吸収されることとなる活性巨大分子成分が、インスリン、カルシトニン、成長ホルモン、副甲状腺ホルモン、およびエリスロポエチン、ならびにそれらの誘導体および類似体であって、合成したものまたは天然のソース由来のもののいずれかであり、ヒトまたは動物のいずれかに由来する構造と一致するものである、請求項24に記載の使用。
- 吸収されることとなる巨大分子/吸収されることとなる活性巨大分子成分が、インスリン、カルシトニン、副甲状腺ホルモン、またはそれらの誘導体もしくは類似体であって、合成したものまたは天然のソース由来のもののいずれかであり、ヒトまたは動物のいずれかに由来する構造と一致するものである、請求項25に記載の使用。
- 巨大分子成分が、インスリンまたはそれの誘導体もしくは類似体であって、合成したものまたは天然のソース由来のもののいずれかであり、ヒトまたは動物のいずれかに由来する構造と一致するものであり、インスリン増感剤も存在している、請求項26に記載の使用。
- 活性巨大分子成分の患者体内での吸収を促進させる方法であって、該患者に請求項1〜16のいずれか1項の組成物を投与することを含む方法。
- 請求項1〜16のいずれか1項に記載の組成物の投与によって、治療可能な状態または疾患に罹患している患者を治療する方法。
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JP2006523663A (ja) * | 2003-04-15 | 2006-10-19 | アクセス リミテッド | 高分子の取り込み |
JP2013543880A (ja) * | 2010-11-25 | 2013-12-09 | シグモイド・ファーマ・リミテッド | 胃腸管疾患を治療するためのヒドララジン含有免疫調節組成物 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006523663A (ja) * | 2003-04-15 | 2006-10-19 | アクセス リミテッド | 高分子の取り込み |
JP2013543880A (ja) * | 2010-11-25 | 2013-12-09 | シグモイド・ファーマ・リミテッド | 胃腸管疾患を治療するためのヒドララジン含有免疫調節組成物 |
JP2016153419A (ja) * | 2010-11-25 | 2016-08-25 | シグモイド・ファーマ・リミテッドSigmoid Pharma Limited | 胃腸管疾患を治療するためのヒドララジン含有免疫調節組成物 |
JP2019529525A (ja) * | 2016-08-05 | 2019-10-17 | トーラス・ディベロップメント・カンパニー・エルエルシー | 室温で安定な経口カルシトニン製剤 |
JP7300793B2 (ja) | 2016-08-05 | 2023-06-30 | パーク・セラピューティクス,インコーポレーテッド | 室温で安定な経口カルシトニン製剤 |
WO2020161771A1 (ja) * | 2019-02-04 | 2020-08-13 | マルホ株式会社 | 皮膚用組成物 |
WO2020162402A1 (ja) * | 2019-02-04 | 2020-08-13 | マルホ株式会社 | 皮膚用組成物 |
Also Published As
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AU2004229216B2 (en) | 2010-04-01 |
CN1805733A (zh) | 2006-07-19 |
GB0308732D0 (en) | 2003-05-21 |
BRPI0409440A (pt) | 2006-04-18 |
RU2005135433A (ru) | 2006-06-10 |
WO2004091584A1 (en) | 2004-10-28 |
EP1620073A1 (en) | 2006-02-01 |
ZA200508343B (en) | 2007-12-27 |
US20100056425A1 (en) | 2010-03-04 |
CA2522098C (en) | 2013-11-12 |
CA2522098A1 (en) | 2004-10-28 |
RU2341281C2 (ru) | 2008-12-20 |
US7651995B2 (en) | 2010-01-26 |
NZ543171A (en) | 2009-03-31 |
JP5016919B2 (ja) | 2012-09-05 |
AU2004229216A1 (en) | 2004-10-28 |
US20150093419A1 (en) | 2015-04-02 |
KR101135822B1 (ko) | 2012-04-16 |
KR20060023114A (ko) | 2006-03-13 |
US20060223740A1 (en) | 2006-10-05 |
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