GB354184A - An improved process for the production of hormone preparations - Google Patents

An improved process for the production of hormone preparations

Info

Publication number
GB354184A
GB354184A GB13197/30A GB1319730A GB354184A GB 354184 A GB354184 A GB 354184A GB 13197/30 A GB13197/30 A GB 13197/30A GB 1319730 A GB1319730 A GB 1319730A GB 354184 A GB354184 A GB 354184A
Authority
GB
United Kingdom
Prior art keywords
acid
substances
solution
hormones
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB13197/30A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
"PHARMAGANS" PHARMACEUTISCHES INSTITUT LUDWIG WILHELM GANS AG
Original Assignee
"PHARMAGANS" PHARMACEUTISCHES INSTITUT LUDWIG WILHELM GANS AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by "PHARMAGANS" PHARMACEUTISCHES INSTITUT LUDWIG WILHELM GANS AG filed Critical "PHARMAGANS" PHARMACEUTISCHES INSTITUT LUDWIG WILHELM GANS AG
Publication of GB354184A publication Critical patent/GB354184A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Abstract

Hormone preparations, to be administered by injection or by the mouth, are prepared by causing hormones, or salt-like compounds thereof, or substances containing these, to react with desoxycholic acid, cholic acid, or other bile acid or salt or ester thereof, preferably in presence of an aqueous or other solvent. Substances promoting solution, other medicinal substances, stabilizing agents, and flavourings may also be added. Hormones specified are adrenalin, thyroxin, insulin, sexual hormones, and endocrine gland preparations; solvents are water, salt solutions, alcohol, acetic ether, acetone, glacial acetic acid or mixtures thereof; solution-promoting substances are lipoids, fats, oils, oleic acid and stearic acid or mixtures thereof; medicinal ingredients are lipoids, phosphatides and vitamines; stabilizing ingredients are benzoic acid, alcohol and chloroform; flavourings are sugar, vanillin and almond oil. In carrying out the reaction the bile acid may be dissolved in a solvent and the hormone added, or a solution of a hormone together with a solution of a bile acid may be introduced into oleic acid or ground nut oil, or the ingredients may be brought into reaction in the colloidal state, for instance by means of a colloid mill. A number of specific examples are given. The Specification as open to inspection under Sect. 91 (3) (a) refers also to the treatment of the hormones of the anterior and posterior lobes of the hypophysis, to the use of compounds and derivatives of bile acids and of the solution-promoting substances, and to the use of one of the reactionary substances in heat-liquefied condition. This subject-matter does not appear in the Specification as accepted.
GB13197/30A 1929-04-30 1930-04-29 An improved process for the production of hormone preparations Expired GB354184A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE354184X 1929-04-30

Publications (1)

Publication Number Publication Date
GB354184A true GB354184A (en) 1931-07-29

Family

ID=6286925

Family Applications (1)

Application Number Title Priority Date Filing Date
GB13197/30A Expired GB354184A (en) 1929-04-30 1930-04-29 An improved process for the production of hormone preparations

Country Status (1)

Country Link
GB (1) GB354184A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7651995B2 (en) 2003-04-15 2010-01-26 Axcess Limited Absorption enhancers such as e.g. BHT, BHA or propyl gallate
US8314058B2 (en) 2003-04-15 2012-11-20 Axcess Limited Uptake of macromolecules

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7651995B2 (en) 2003-04-15 2010-01-26 Axcess Limited Absorption enhancers such as e.g. BHT, BHA or propyl gallate
US8314058B2 (en) 2003-04-15 2012-11-20 Axcess Limited Uptake of macromolecules

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