TW455590B - Monophosphate salt of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine, pharmaceutical composition and preparation process thereof - Google Patents
Monophosphate salt of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine, pharmaceutical composition and preparation process thereof Download PDFInfo
- Publication number
- TW455590B TW455590B TW087120433A TW87120433A TW455590B TW 455590 B TW455590 B TW 455590B TW 087120433 A TW087120433 A TW 087120433A TW 87120433 A TW87120433 A TW 87120433A TW 455590 B TW455590 B TW 455590B
- Authority
- TW
- Taiwan
- Prior art keywords
- item
- scope
- ethyl
- phosphoric acid
- patent application
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (1)
- 公告 案號 455590 87120433_々£?年公丨嚼'應 申請專利範圍 丨補尤 y 十 ΪΜ 1 一種異丙基甲基-[2-(3_正-丙氧基苯氧基)乙基]胺 之單碟酸鹽。 一種製備異丙基-甲基-[2-(3 -正-丙氧基苯氧基)乙 g之單磷酸鹽之方法,其包括以下步驟: i)添加磷酸至異丙基-曱基-[2-(3 -正-丙氧基苯氧基) 乙基]胺之有機溶劑系統溶液内; i i )使該溶液結晶化; 丙氧基 步驟i ) 步驟i ) 該醇系 步驟i ) 步驟i ) 完全添 〇 添加 間。 異丙基- iii)離析因此獲得之異丙基-曱基-[2-(3 -正-苯氧基)乙基]胺之單磷酸鹽。 3. 根據令請專利範圍第2項之方法,其特徵在於 中所使用之有機溶劑系統為醋酸乙酯。 4. 根據申請專利範圍第2項之方法,其特徵在於 中所添加之磷酸係以磷酸之醇系、容液型式添加。 溶液 6. 中使用0.9-1.0當量之磷酸。 7.根據申請專利範圍第2項之方法,其特徵在於 中使用0.95當量之鱗酸。 8 .根據申請專利範圍第2項之方法,其特徵在於 加後,所形成溶液中之磷酸濃度在5 - 1 0重量%之間 9.根據申請專利範圍第2項之方法,其特徵在於 後,所形成溶液中之磷酸濃度應該在9 - 1 1重量%之 1 0 · —種用於治療疼痛之醫藥組合物,其含有該 5. 根據申請專利範圍第4項之方法,其特徵在於 是曱醇系溶液。 根據申請專利範圍第2項之方法,其特徵在於O:\55\55855.ptc 第1頁 2001. 07. 12. 009O:\55\55855.ptc 第2頁 2001.07. 12.010 公告 案號 455590 87120433_々£?年公丨嚼'應 申請專利範圍 丨補尤 y 十 ΪΜ 1 一種異丙基甲基-[2-(3_正-丙氧基苯氧基)乙基]胺 之單碟酸鹽。 一種製備異丙基-甲基-[2-(3 -正-丙氧基苯氧基)乙 g之單磷酸鹽之方法,其包括以下步驟: i)添加磷酸至異丙基-曱基-[2-(3 -正-丙氧基苯氧基) 乙基]胺之有機溶劑系統溶液内; i i )使該溶液結晶化; 丙氧基 步驟i ) 步驟i ) 該醇系 步驟i ) 步驟i ) 完全添 〇 添加 間。 異丙基- iii)離析因此獲得之異丙基-曱基-[2-(3 -正-苯氧基)乙基]胺之單磷酸鹽。 3. 根據令請專利範圍第2項之方法,其特徵在於 中所使用之有機溶劑系統為醋酸乙酯。 4. 根據申請專利範圍第2項之方法,其特徵在於 中所添加之磷酸係以磷酸之醇系、容液型式添加。 溶液 6. 中使用0.9-1.0當量之磷酸。 7.根據申請專利範圍第2項之方法,其特徵在於 中使用0.95當量之鱗酸。 8 .根據申請專利範圍第2項之方法,其特徵在於 加後,所形成溶液中之磷酸濃度在5 - 1 0重量%之間 9.根據申請專利範圍第2項之方法,其特徵在於 後,所形成溶液中之磷酸濃度應該在9 - 1 1重量%之 1 0 · —種用於治療疼痛之醫藥組合物,其含有該 5. 根據申請專利範圍第4項之方法,其特徵在於 是曱醇系溶液。 根據申請專利範圍第2項之方法,其特徵在於O:\55\55855.ptc 第1頁 2001. 07. 12. 009
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704835A SE9704835D0 (sv) | 1997-12-22 | 1997-12-22 | New compound |
Publications (1)
Publication Number | Publication Date |
---|---|
TW455590B true TW455590B (en) | 2001-09-21 |
Family
ID=20409538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW087120433A TW455590B (en) | 1997-12-22 | 1998-12-09 | Monophosphate salt of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine, pharmaceutical composition and preparation process thereof |
Country Status (22)
Country | Link |
---|---|
US (1) | US6235792B1 (zh) |
EP (1) | EP1047663A1 (zh) |
JP (1) | JP2001526254A (zh) |
KR (1) | KR20010033407A (zh) |
CN (1) | CN1280559A (zh) |
AR (1) | AR017199A1 (zh) |
AU (1) | AU1989299A (zh) |
BR (1) | BR9814381A (zh) |
CA (1) | CA2314989A1 (zh) |
EE (1) | EE200000384A (zh) |
HU (1) | HUP0004428A3 (zh) |
ID (1) | ID26940A (zh) |
IL (1) | IL136829A0 (zh) |
IS (1) | IS5544A (zh) |
NO (1) | NO20003216L (zh) |
PL (1) | PL341525A1 (zh) |
SE (1) | SE9704835D0 (zh) |
SK (1) | SK8062000A3 (zh) |
TR (1) | TR200002012T2 (zh) |
TW (1) | TW455590B (zh) |
WO (1) | WO1999032431A1 (zh) |
ZA (1) | ZA9811237B (zh) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH380746A (de) | 1958-11-06 | 1964-08-15 | Ciba Geigy | Verfahren zur Herstellung neuer sekundärer Amine |
AR004691A1 (es) | 1995-10-27 | 1999-03-10 | Astrazeneca Ab | Nuevos derivados de [3-alcoxi-fenoxi-)-etil]-dialquilamina, una composicion farmaceutica que los comprende, su uso como anestesicos locales y unprocedimiento para su preparacion |
-
1997
- 1997-12-22 SE SE9704835A patent/SE9704835D0/xx unknown
-
1998
- 1998-12-08 ZA ZA9811237A patent/ZA9811237B/xx unknown
- 1998-12-09 AR ARP980106241A patent/AR017199A1/es not_active Application Discontinuation
- 1998-12-09 TW TW087120433A patent/TW455590B/zh not_active IP Right Cessation
- 1998-12-15 CN CN98811771A patent/CN1280559A/zh active Pending
- 1998-12-15 EP EP98964600A patent/EP1047663A1/en not_active Ceased
- 1998-12-15 SK SK806-2000A patent/SK8062000A3/sk unknown
- 1998-12-15 TR TR2000/02012T patent/TR200002012T2/xx unknown
- 1998-12-15 KR KR1020007006882A patent/KR20010033407A/ko not_active Application Discontinuation
- 1998-12-15 AU AU19892/99A patent/AU1989299A/en not_active Abandoned
- 1998-12-15 IL IL13682998A patent/IL136829A0/xx unknown
- 1998-12-15 ID IDW20001132A patent/ID26940A/id unknown
- 1998-12-15 JP JP2000525368A patent/JP2001526254A/ja active Pending
- 1998-12-15 PL PL98341525A patent/PL341525A1/xx unknown
- 1998-12-15 US US09/254,420 patent/US6235792B1/en not_active Expired - Fee Related
- 1998-12-15 HU HU0004428A patent/HUP0004428A3/hu unknown
- 1998-12-15 BR BR9814381-6A patent/BR9814381A/pt not_active IP Right Cessation
- 1998-12-15 EE EEP200000384A patent/EE200000384A/xx unknown
- 1998-12-15 WO PCT/SE1998/002316 patent/WO1999032431A1/en not_active Application Discontinuation
- 1998-12-15 CA CA002314989A patent/CA2314989A1/en not_active Abandoned
-
2000
- 2000-06-21 IS IS5544A patent/IS5544A/is unknown
- 2000-06-21 NO NO20003216A patent/NO20003216L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL341525A1 (en) | 2001-04-23 |
US6235792B1 (en) | 2001-05-22 |
IL136829A0 (en) | 2001-06-14 |
SK8062000A3 (en) | 2001-02-12 |
CA2314989A1 (en) | 1999-07-01 |
CN1280559A (zh) | 2001-01-17 |
SE9704835D0 (sv) | 1997-12-22 |
WO1999032431A1 (en) | 1999-07-01 |
ZA9811237B (en) | 1999-07-19 |
HUP0004428A2 (hu) | 2002-03-28 |
BR9814381A (pt) | 2000-10-10 |
AR017199A1 (es) | 2001-08-22 |
EE200000384A (et) | 2001-12-17 |
ID26940A (id) | 2001-02-22 |
HUP0004428A3 (en) | 2002-04-29 |
AU1989299A (en) | 1999-07-12 |
IS5544A (is) | 2000-06-21 |
EP1047663A1 (en) | 2000-11-02 |
KR20010033407A (ko) | 2001-04-25 |
NO20003216D0 (no) | 2000-06-21 |
TR200002012T2 (tr) | 2000-10-23 |
JP2001526254A (ja) | 2001-12-18 |
NO20003216L (no) | 2000-06-21 |
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GD4A | Issue of patent certificate for granted invention patent | ||
MM4A | Annulment or lapse of patent due to non-payment of fees |