TW406130B - Methods of in vitro predicting a patient's susceptibility to increase periodontal disease severity and the kits therefor - Google Patents
Methods of in vitro predicting a patient's susceptibility to increase periodontal disease severity and the kits therefor Download PDFInfo
- Publication number
- TW406130B TW406130B TW085109393A TW85109393A TW406130B TW 406130 B TW406130 B TW 406130B TW 085109393 A TW085109393 A TW 085109393A TW 85109393 A TW85109393 A TW 85109393A TW 406130 B TW406130 B TW 406130B
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- Prior art keywords
- patient
- periodontal disease
- dual gene
- disease
- sequence
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Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/510,696 US5686246A (en) | 1995-08-03 | 1995-08-03 | Detecting genetic predisposition to periodontal disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW406130B true TW406130B (en) | 2000-09-21 |
Family
ID=24031795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW085109393A TW406130B (en) | 1995-08-03 | 1996-08-03 | Methods of in vitro predicting a patient's susceptibility to increase periodontal disease severity and the kits therefor |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5686246A (enExample) |
| EP (2) | EP0853630A4 (enExample) |
| JP (1) | JP4042811B2 (enExample) |
| KR (1) | KR19990036067A (enExample) |
| CN (1) | CN1198166A (enExample) |
| AR (1) | AR003182A1 (enExample) |
| AT (1) | ATE207927T1 (enExample) |
| AU (1) | AU719965B2 (enExample) |
| BR (1) | BR9604044A (enExample) |
| CA (1) | CA2228424C (enExample) |
| DE (1) | DE69616478T2 (enExample) |
| DK (1) | DK0769560T3 (enExample) |
| ES (1) | ES2166866T3 (enExample) |
| ID (1) | ID17246A (enExample) |
| IL (1) | IL123053A (enExample) |
| IS (1) | IS4653A (enExample) |
| MX (1) | MX9800941A (enExample) |
| MY (1) | MY132156A (enExample) |
| NO (1) | NO980439L (enExample) |
| NZ (1) | NZ315836A (enExample) |
| PT (1) | PT769560E (enExample) |
| SI (1) | SI9620098A (enExample) |
| TW (1) | TW406130B (enExample) |
| WO (1) | WO1997006180A1 (enExample) |
| ZA (1) | ZA966585B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6951721B2 (en) * | 1996-02-12 | 2005-10-04 | Gene Logic Inc. | Method for determining the haplotype of a human BRCA1 gene |
| GB9621129D0 (en) | 1996-10-10 | 1996-11-27 | Duff Gordon W | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| US6210877B1 (en) * | 1997-03-10 | 2001-04-03 | Interleukin Genetics, Inc. | Prediction of coronary artery disease |
| US6524795B1 (en) * | 1997-03-10 | 2003-02-25 | Interleukin Genetics, Inc. | Diagnostics for cardiovascular disorders |
| US7820383B2 (en) | 1997-03-10 | 2010-10-26 | Interleukin Genetics, Inc. | Method for diagnosing myocardial infarction |
| GB9723553D0 (en) * | 1997-11-07 | 1998-01-07 | Duff Gordon W | Prediction of the risk of chronic obstructive airway disease |
| GB9711040D0 (en) | 1997-05-29 | 1997-07-23 | Duff Gordon W | Prediction of inflammatory disease |
| US20050282198A1 (en) * | 1997-05-29 | 2005-12-22 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for diseases associated with an IL-1 inflammatory haplotype |
| AU9217198A (en) * | 1997-09-03 | 1999-03-22 | Oncormed | Method for predicting prognosis and treatment response for genetically based abnormalities |
| IL135957A0 (en) * | 1997-11-07 | 2001-05-20 | Interleukin Genetics Inc | Diagnostics and therapeutics for chronic obstructive airway disease |
| US6746839B1 (en) | 1998-01-12 | 2004-06-08 | Interleukin Genetics, Inc. | Diagnostics and therapeutics for an obstructive airway disease |
| US6130042A (en) * | 1998-03-05 | 2000-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for diagnosing periodontal disease |
| US20050032077A1 (en) * | 1998-03-10 | 2005-02-10 | Duff Gordon W. | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| WO1999054707A2 (en) * | 1998-04-21 | 1999-10-28 | Interleukin Genetics, Inc. | Fetal testing for prediction of low birth weight |
| US6733967B1 (en) | 1998-04-21 | 2004-05-11 | Interleukin Genetics, Inc. | Fetal testing for prediction of low birth weight |
| US6251598B1 (en) * | 1998-10-30 | 2001-06-26 | Interleukin Genetics, Inc. | Methods for diagnosing sepsis |
| US20090023147A1 (en) * | 1999-08-30 | 2009-01-22 | Kenneth Kornman | Diagnostics and therapeutics for osteoporosis |
| US6225069B1 (en) * | 2000-02-29 | 2001-05-01 | The Board Of Trustees Of The University Of Arkansas | Methods to identify genetic predisposition to alzheimer's disease |
| US20030124524A1 (en) * | 2000-06-23 | 2003-07-03 | Kenneth Kornman | Screening assays for identifying modulators of the inflammatory or immune response |
| US7054758B2 (en) * | 2001-01-30 | 2006-05-30 | Sciona Limited | Computer-assisted means for assessing lifestyle risk factors |
| DE10112348A1 (de) * | 2001-03-13 | 2002-10-02 | Antje Roetger | Nukleotidträger zur Diagnose und Therapie oraler Erkrankungen |
| US20030152947A1 (en) * | 2001-06-15 | 2003-08-14 | Crossman David C. | Methods for detecting and treating the early onset of aging-related conditions |
| EP1463745A4 (en) * | 2001-11-19 | 2007-11-07 | Interleukin Genetics Inc | FUNCTIONAL POLYMORPHISMS OF THE INTERLEUKIN-1 SITE AFFECTING TRANSCRIPTION AND SUSCEPTIBILITY TO INFLAMMATORY AND INFECTIOUS DISEASES |
| US20080311581A1 (en) * | 2001-11-19 | 2008-12-18 | David Wyllie | Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases |
| US20070264645A1 (en) * | 2002-01-25 | 2007-11-15 | Kenneth Kornman | IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| US20030148288A1 (en) * | 2002-02-01 | 2003-08-07 | Yi-Wei Tang | Colorimetric genetic test for clinically significant TNF polymorphism and methods of use thereof |
| US20040229228A1 (en) * | 2002-07-25 | 2004-11-18 | Northwestern University | Il-1 genotype in early kidney allograft rejection |
| BR0314552A (pt) * | 2002-09-30 | 2005-08-09 | Novartis Ag | Métodos para prognosticar elevações de colesterol durante terapia imunossupressora |
| EP1680513B1 (en) * | 2003-08-08 | 2010-12-01 | Interleukin Genetics, Inc. | Diagnostic for osteoporosis |
| US20070003947A1 (en) * | 2005-01-18 | 2007-01-04 | Decarlo Arthur A | Detecting genetic risk for periodontal disease |
| EP1851245B1 (en) | 2005-01-26 | 2012-10-10 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
| US8105775B2 (en) * | 2005-10-25 | 2012-01-31 | Interleukin Genetics, Inc. | IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| WO2008060627A2 (en) * | 2006-11-15 | 2008-05-22 | Interleukin Genetics, Inc. | The il-1 gene cluster, insulin resistance and coronary artery disease associated polymorphisms and haplotypes and methods of using same |
| US7925192B2 (en) * | 2007-09-04 | 2011-04-12 | Ricoh Company, Ltd. | Developing roller, developing device, process cartridge, and image forming apparatus |
| US20090170105A1 (en) * | 2007-11-08 | 2009-07-02 | Interleukin Genetics, Inc. | Diagnostics for Aging-Related Dermatologic Disorders |
| EP2304052A2 (en) * | 2008-05-02 | 2011-04-06 | Interleukin Genetics, Inc. | Detecting genetic predisposition to osteoarthritis associated conditions |
| ES2708826T3 (es) | 2008-05-02 | 2019-04-11 | Orig3N Inc | Detección de la predisposición genética a afecciones asociadas a la osteoartritis |
| SG191078A1 (en) | 2010-12-09 | 2013-07-31 | Interleukin Genetics Inc | Improved method and kit for determining severity and progression of periodontal disease |
| CA3011363A1 (en) | 2016-01-12 | 2017-07-20 | Interleukin Genetics, Inc. | Methods for predicting response to treatment |
| US10329620B2 (en) | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| KR101894018B1 (ko) * | 2017-02-09 | 2018-08-31 | 주식회사 테라젠이텍스 | 치주 질환의 위험도를 예측하기 위한 조성물, 마이크로어레이, 및 키트, 및 이를 이용한 방법 |
| CA3142662A1 (en) | 2019-06-06 | 2020-12-10 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
Family Cites Families (13)
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| US5110920A (en) * | 1982-01-22 | 1992-05-05 | Cetus Corporation | HLA typing method and DNA probes used therein |
| US4582788A (en) * | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
| DE3377363D1 (en) * | 1982-03-31 | 1988-08-18 | Ajinomoto Kk | Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells |
| US4666828A (en) * | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4801531A (en) * | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4772685A (en) * | 1985-10-02 | 1988-09-20 | Merck & Co., Inc. | Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies |
| US4992367A (en) * | 1986-05-12 | 1991-02-12 | Hoffmann-La Roche Inc. | Enhanced expression of human interleukin-2 in mammalian cells |
| US5268267A (en) * | 1987-08-21 | 1993-12-07 | The General Hospital Corporation | Method for diagnosing small cell carcinoma |
| US5158871A (en) * | 1988-02-12 | 1992-10-27 | University Of Connecticut | Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates |
| US5272057A (en) * | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5215895A (en) * | 1989-11-22 | 1993-06-01 | Genetics Institute, Inc. | Dna encoding a mammalian cytokine, interleukin-11 |
| US5328829A (en) * | 1990-07-05 | 1994-07-12 | Forsyth Dental Infirmary For Children | Method of determining sites of active periodontal disease |
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1995
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- 1996-08-02 AR ARP960103869A patent/AR003182A1/es unknown
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| US5686246A (en) | 1997-11-11 |
| JP4042811B2 (ja) | 2008-02-06 |
| DE69616478T2 (de) | 2002-08-08 |
| EP0853630A1 (en) | 1998-07-22 |
| SI9620098A (sl) | 1998-10-31 |
| WO1997006180A1 (en) | 1997-02-20 |
| DK0769560T3 (da) | 2002-02-18 |
| KR19990036067A (ko) | 1999-05-25 |
| BR9604044A (pt) | 1998-06-09 |
| JP2001517067A (ja) | 2001-10-02 |
| ES2166866T3 (es) | 2002-05-01 |
| ID17246A (id) | 1997-12-11 |
| CN1198166A (zh) | 1998-11-04 |
| NO980439L (no) | 1998-03-13 |
| AR003182A1 (es) | 1998-07-08 |
| IS4653A (is) | 1998-01-19 |
| MY132156A (en) | 2007-09-28 |
| NO980439D0 (no) | 1998-02-02 |
| ATE207927T1 (de) | 2001-11-15 |
| EP0769560A3 (en) | 1999-11-24 |
| EP0769560A2 (en) | 1997-04-23 |
| IL123053A (en) | 2000-01-31 |
| EP0769560B1 (en) | 2001-10-31 |
| MX9800941A (es) | 1998-10-31 |
| ZA966585B (en) | 1997-02-26 |
| IL123053A0 (en) | 1998-12-06 |
| PT769560E (pt) | 2002-04-29 |
| CA2228424A1 (en) | 1997-02-20 |
| AU719965B2 (en) | 2000-05-18 |
| AU6763396A (en) | 1997-03-05 |
| NZ315836A (en) | 1999-10-28 |
| CA2228424C (en) | 2005-12-27 |
| DE69616478D1 (de) | 2001-12-06 |
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