TW329425B - Immunoconjugates useful for treating gastro-intestinal tumors, processes for their preparation and pharmaceutical compositions containing them - Google Patents

Immunoconjugates useful for treating gastro-intestinal tumors, processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
TW329425B
TW329425B TW081107395A TW81107395A TW329425B TW 329425 B TW329425 B TW 329425B TW 081107395 A TW081107395 A TW 081107395A TW 81107395 A TW81107395 A TW 81107395A TW 329425 B TW329425 B TW 329425B
Authority
TW
Taiwan
Prior art keywords
processes
preparation
pharmaceutical compositions
compositions containing
intestinal tumors
Prior art date
Application number
TW081107395A
Other languages
English (en)
Inventor
Firman Wright Andrew
Charles Blakey David
Edward Fitton John
Lindholm Leif
Holmgren Jan
Lind Peter
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of TW329425B publication Critical patent/TW329425B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44Antibodies bound to carriers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046Stomach, Intestines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6863Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Semiconductor Lasers (AREA)
  • Bipolar Transistors (AREA)
  • Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW081107395A 1991-07-03 1992-09-19 Immunoconjugates useful for treating gastro-intestinal tumors, processes for their preparation and pharmaceutical compositions containing them TW329425B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919114399A GB9114399D0 (en) 1991-07-03 1991-07-03 Conjugates
GB929212880A GB9212880D0 (en) 1991-07-03 1992-06-17 Conjugates

Publications (1)

Publication Number Publication Date
TW329425B true TW329425B (en) 1998-04-11

Family

ID=10697775

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081107395A TW329425B (en) 1991-07-03 1992-09-19 Immunoconjugates useful for treating gastro-intestinal tumors, processes for their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
EP (1) EP0528527B1 (zh)
JP (1) JP3735379B2 (zh)
KR (1) KR100252147B1 (zh)
AT (1) ATE164768T1 (zh)
AU (1) AU665546B2 (zh)
CA (1) CA2073113C (zh)
CZ (1) CZ209792A3 (zh)
DE (1) DE69225035T2 (zh)
DK (1) DK0528527T3 (zh)
ES (1) ES2113923T3 (zh)
FI (1) FI106928B (zh)
GB (2) GB9114399D0 (zh)
GR (1) GR3026575T3 (zh)
HU (1) HU215243B (zh)
IE (1) IE922190A1 (zh)
IL (1) IL102399A (zh)
MY (1) MY110513A (zh)
NO (1) NO308539B1 (zh)
NZ (1) NZ243437A (zh)
PT (1) PT100660B (zh)
SK (1) SK209792A3 (zh)
TW (1) TW329425B (zh)
ZA (1) ZA924973B (zh)
ZW (1) ZW10192A1 (zh)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5686121A (en) * 1979-12-14 1981-07-13 Teijin Ltd Antitumor proten complex and its preparation
EP0335476A3 (en) 1984-02-08 1989-12-13 Cetus Corporation Recombinant methods for the production of ricin a, ricin b, ricin or diphtheria toxin (dt)a or ab' fragment, suitable hosts and vectors therefor, and conjugates comprising ricin toxin a chain or diphtheria toxin
US5165923A (en) * 1989-11-20 1992-11-24 Imperial Cancer Research Technology Methods and compositions for the treatment of hodgkin's disease
CA2087164C (en) * 1990-07-20 2002-11-26 Terje Kalland Target specific antibody-superantigen conjugates and their preparation

Also Published As

Publication number Publication date
CA2073113A1 (en) 1993-01-04
AU1943092A (en) 1993-01-07
ZA924973B (en) 1993-04-28
DK0528527T3 (da) 1999-01-18
KR930001928A (ko) 1993-02-22
JP3735379B2 (ja) 2006-01-18
NO922383D0 (no) 1992-06-17
IL102399A0 (en) 1993-01-14
GB9114399D0 (en) 1991-08-21
IE922190A1 (en) 1993-01-13
SK209792A3 (en) 1994-06-08
MY110513A (en) 1998-07-31
DE69225035T2 (de) 1998-08-13
AU665546B2 (en) 1996-01-11
FI923085A (fi) 1993-01-04
EP0528527A2 (en) 1993-02-24
GB9212880D0 (en) 1992-07-29
HU215243B (hu) 1998-11-30
NO922383L (no) 1993-01-04
FI923085A0 (fi) 1992-07-03
ATE164768T1 (de) 1998-04-15
KR100252147B1 (ko) 2000-09-01
EP0528527B1 (en) 1998-04-08
NZ243437A (en) 1994-10-26
GR3026575T3 (en) 1998-07-31
EP0528527A3 (en) 1993-03-17
IL102399A (en) 2003-05-29
HU9202219D0 (en) 1992-10-28
HUT67048A (en) 1995-01-30
ES2113923T3 (es) 1998-05-16
CA2073113C (en) 2004-09-14
NO308539B1 (no) 2000-09-25
FI106928B (fi) 2001-05-15
CZ209792A3 (en) 1993-01-13
PT100660B (pt) 1999-06-30
JPH05320065A (ja) 1993-12-03
PT100660A (pt) 1993-10-29
ZW10192A1 (en) 1993-03-31
DE69225035D1 (de) 1998-05-14

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Legal Events

Date Code Title Description
MK4A Expiration of patent term of an invention patent