TW295588B - - Google Patents

Download PDF

Info

Publication number
TW295588B
TW295588B TW083103379A TW83103379A TW295588B TW 295588 B TW295588 B TW 295588B TW 083103379 A TW083103379 A TW 083103379A TW 83103379 A TW83103379 A TW 83103379A TW 295588 B TW295588 B TW 295588B
Authority
TW
Taiwan
Prior art keywords
compound
base
amino
please read
page
Prior art date
Application number
TW083103379A
Other languages
English (en)
Chinese (zh)
Original Assignee
Kirin Brewery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery filed Critical Kirin Brewery
Application granted granted Critical
Publication of TW295588B publication Critical patent/TW295588B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/04Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02Acyclic radicals, not substituted by cyclic structures
    • C07H15/04Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW083103379A 1993-04-15 1994-04-15 TW295588B (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8863093 1993-04-15

Publications (1)

Publication Number Publication Date
TW295588B true TW295588B (enExample) 1997-01-11

Family

ID=13948136

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083103379A TW295588B (enExample) 1993-04-15 1994-04-15

Country Status (11)

Country Link
US (1) US5780441A (enExample)
EP (1) EP0694558B1 (enExample)
JP (1) JP4020958B2 (enExample)
KR (1) KR100281265B1 (enExample)
CN (1) CN1045302C (enExample)
AT (1) ATE176237T1 (enExample)
AU (1) AU683653B2 (enExample)
CA (1) CA2160566C (enExample)
DE (1) DE69416306T2 (enExample)
TW (1) TW295588B (enExample)
WO (1) WO1994024142A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW261533B (enExample) * 1992-07-16 1995-11-01 Kirin Brewery
TW555562B (en) * 1996-12-27 2003-10-01 Kirin Brewery Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof
ES2221147T3 (es) * 1997-02-05 2004-12-16 Kirin Beer Kabushiki Kaisha Composiciones liofilizadas conteniendo glicoesfingolipidos.
CN1222293C (zh) 1997-04-10 2005-10-12 麒麟麦酒株式会社 含有α-糖基神经酰胺的NKT细胞活化剂
TW575420B (en) 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
US6610835B1 (en) * 1998-02-12 2003-08-26 Emory University Sphingolipid derivatives and their methods of use
JPH11269189A (ja) * 1998-03-19 1999-10-05 Nissin Food Prod Co Ltd 免疫調節作用を有する化合物
JP4099267B2 (ja) * 1998-08-07 2008-06-11 株式会社紀文フードケミファ 乳化剤および乳化組成物
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
AU2002327338A1 (en) * 2001-07-25 2003-02-17 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
AU2003251518B2 (en) * 2002-06-13 2009-07-02 New York University Synthetic C-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
JP2007525165A (ja) 2003-03-07 2007-09-06 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク タイプ1ライアノジン受容体に基づく方法
US7645873B2 (en) 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
US7771726B2 (en) * 2003-10-08 2010-08-10 New York University Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
AU2005235080A1 (en) * 2004-03-31 2005-11-03 New York University Novel synthetic C-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases
US8022043B2 (en) * 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
US7772380B2 (en) 2004-08-27 2010-08-10 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
CN101080487B (zh) 2004-10-07 2012-11-14 阿戈斯治疗公司 成熟树突细胞组合物及其培养方法
WO2006083671A2 (en) 2005-01-28 2006-08-10 Brigham Young University Bacterial glycolipid activation of cd1d-restricted nkt cells
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP1776963A1 (en) 2005-10-19 2007-04-25 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
US20070231344A1 (en) * 2005-10-28 2007-10-04 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
SI2056842T1 (sl) 2006-04-07 2013-02-28 The Scripps Research Institute Modificiran galaktosil-ceramid za zdravljenje kancerogenih obolenj
AU2007269299B2 (en) * 2006-06-30 2013-01-17 Brigham Young University Adjuvants and methods of use
WO2008103392A2 (en) 2007-02-21 2008-08-28 Vaccinex, Inc. Modulation of nkt cell activity with antigen-loaded cdid molecules
US8916164B2 (en) * 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (en) * 2007-11-07 2009-05-13 Wittycell Nkt cell activating gycolipids covalently bound antigens and/or drug
EP2060252A1 (en) 2007-11-19 2009-05-20 Wittycell New formulation of galactosylceramide derivatives
WO2009101475A2 (en) * 2007-12-05 2009-08-20 Wittycell S.A.S. Compositions for and methods of enhancing the immune response to antigens
CN102215864A (zh) * 2008-10-08 2011-10-12 威蒂赛尔公司 用于抗流感的疫苗组合物
KR20110137290A (ko) * 2009-01-08 2011-12-22 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 세포벽 결합 세라미드 유사 당지질을 갖는 박테리아 백신 및 이의 용도
WO2010083728A1 (en) 2009-01-23 2010-07-29 Dapeng Zhou Nanoparticle formulated glycolipid antigens for immunotherapy
EP2647384B1 (en) 2010-12-02 2018-05-23 Riken IMMUNOTHERAPY USING ALLO-NKT CELLS, CELLS FOR IMMUNOTHERAPY IN WHICH alpha CHAIN OF T-CELL RECEPTOR (TCR) GENE HAS BEEN REARRANGED TO UNIFORM V alpha-J alpha , AND BANKING OF NKT CELLS DERIVED FROM SAID CELLS
AU2013306767A1 (en) 2012-08-22 2015-03-12 Regimmune Corporation Preparation for preventing or treating type I diabetes
KR20150106872A (ko) 2012-11-05 2015-09-22 가부시키가이샤 레그이뮨 면역 관용 유도제
US10151745B2 (en) 2012-11-21 2018-12-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for determining the risk of acute graft versus host disease
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
CN106726875B (zh) * 2016-11-24 2019-05-21 晨光生物科技集团股份有限公司 一种含鞘糖脂类物质的提取物的制备方法
AU2021392472A1 (en) 2020-12-04 2023-07-06 Osaka University Cd1d-ligand-compound-containing liposome preparation having improved pharmacokinetics

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4598051A (en) * 1980-03-12 1986-07-01 The Regents Of The University Of California Liposome conjugates and diagnostic methods therewith
US4806466A (en) * 1981-10-29 1989-02-21 The Regents Of The University Of California Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes
IT1168205B (it) * 1983-07-21 1987-05-20 Wellcome Italia Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
JPS6157594A (ja) * 1984-08-30 1986-03-24 Suntory Ltd ガラクトスフインゴ脂質及びその製造法
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
ZA866023B (en) * 1985-08-13 1987-03-25 Solco Basel Ag New process for the preparation of sphingosine derivatives
JPH07116209B2 (ja) * 1986-04-11 1995-12-13 メクト株式会社 シアロシルセラミド類及びその製造方法
US4990603A (en) * 1986-07-04 1991-02-05 Mect Corporation Sialic acid derivatives and process therefor
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
US4937232A (en) * 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
US5026557A (en) * 1987-09-09 1991-06-25 The Liposome Company, Inc. Adjuvant composition
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
US5041441A (en) * 1988-04-04 1991-08-20 The Regents Of The University Of Michigan Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
DE3840044A1 (de) * 1988-11-27 1990-06-07 Behringwerke Ag Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung
US5028715A (en) * 1989-02-06 1991-07-02 Southwest Research Institute Radioprotective agents and their method of manufacture
DE69011465T2 (de) * 1989-09-29 1995-03-23 Ajinomoto Kk Verwendung von Human-ADF (=Adult T-cell leukemia-derived factor) zur Herstellung von Medikamenten.
JP3068910B2 (ja) * 1990-11-08 2000-07-24 麒麟麦酒株式会社 新規スフィンゴ糖脂質、その製造法および使用
JPH06145189A (ja) * 1991-01-23 1994-05-24 Kitasato Inst:The スフィンゴ糖脂質
JPH0559081A (ja) * 1991-08-29 1993-03-09 Kirin Brewery Co Ltd 新規スフインゴ糖脂質、その製造法および使用
TW261533B (enExample) * 1992-07-16 1995-11-01 Kirin Brewery
US5567684A (en) * 1994-09-14 1996-10-22 The Regents Of The University Of California Synthetic ganglioside derivatives

Also Published As

Publication number Publication date
KR100281265B1 (ko) 2001-02-01
DE69416306T2 (de) 1999-06-17
EP0694558A4 (en) 1996-08-21
DE69416306D1 (de) 1999-03-11
AU683653B2 (en) 1997-11-20
US5780441A (en) 1998-07-14
CA2160566A1 (en) 1994-10-27
EP0694558B1 (en) 1999-01-27
WO1994024142A1 (fr) 1994-10-27
CN1124963A (zh) 1996-06-19
AU6513094A (en) 1994-11-08
ATE176237T1 (de) 1999-02-15
EP0694558A1 (en) 1996-01-31
CA2160566C (en) 2004-07-13
CN1045302C (zh) 1999-09-29
JP4020958B2 (ja) 2007-12-12

Similar Documents

Publication Publication Date Title
TW295588B (enExample)
EP0666268B1 (en) Novel sphingoglycolipid and use thereof
JPWO1994024142A1 (ja) 新規スフィンゴ糖脂質およびその使用
Rao et al. Sialyl Lewis X mimics derived from a pharmacophore search are selectin inhibitors with anti-inflammatory activity.
Yao et al. Dissymmetric pyridyl-substituted 3, 5-bis (arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation
WO1998044928A1 (fr) ACTIVATEURS DE CELLULES NKT, CONTENANT DES α-GLYCOSYLCERAMIDES
WO2006026389A2 (en) Ceramide derivatives as modulators of immunity and autoimmunity
SA93130351B1 (ar) مشتقات إندولبيرولوكربازول
JP2018080204A (ja) α−グルコシルヘスペリジンの結晶とその用途
RU2410389C2 (ru) Противоопухолевое средство
US6770629B2 (en) Administration of a sulfopyranosylacylglycerol to treat certain cancers
TW467908B (en) Synthetic insulin mimetic substances
US20210332062A1 (en) Hetero-substituted cyclic lactone analogues and uses thereof
KR101969814B1 (ko) 글리코실 세라마이드 화합물 및 그 제조방법
Xu et al. Synthesis and crystal structures of C24-epimeric 20 (R)-ocotillol-type saponins
CN113637045A (zh) 原人参二醇衍生物及其制备方法和应用
AU2017221673A1 (en) Novel indole derivative and anti-cancer composition containing same
JP5670478B2 (ja) ハロゲン化ジデオキシ糖誘導体ならびにその調製方法および応用
KR102890254B1 (ko) 스테로이드 유도체 조절제의 염 및 결정형
JP2002533468A (ja) イノシトール含有六糖、その合成及びその使用
DE69632176T2 (de) Anti-inflammatorische Verbindungen
US20090054355A1 (en) Proliferation Inhibitor Of Helicobacter Pylori Including Alpha-N-Acetyl-Glucosaminyl Bond-Containing Monosaccharide Derivatives
JPS6019716A (ja) 抗腫瘍剤
JPH1160592A (ja) コレスタノール化合物及びこれを含有する医薬
JP3927993B2 (ja) 放射線治療増感剤