TW270115B - - Google Patents

Info

Publication number
TW270115B
TW270115B TW082103682A TW82103682A TW270115B TW 270115 B TW270115 B TW 270115B TW 082103682 A TW082103682 A TW 082103682A TW 82103682 A TW82103682 A TW 82103682A TW 270115 B TW270115 B TW 270115B
Authority
TW
Taiwan
Prior art keywords
pyridazo
pyrazolo
pyridazine
diazepine
enkephalinase
Prior art date
Application number
TW082103682A
Other languages
English (en)
Chinese (zh)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of TW270115B publication Critical patent/TW270115B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
TW082103682A 1992-05-15 1993-05-11 TW270115B (cg-RX-API-DMAC7.html)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88496392A 1992-05-15 1992-05-15
US4000393A 1993-04-09 1993-04-09

Publications (1)

Publication Number Publication Date
TW270115B true TW270115B (cg-RX-API-DMAC7.html) 1996-02-11

Family

ID=26716641

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082103682A TW270115B (cg-RX-API-DMAC7.html) 1992-05-15 1993-05-11

Country Status (19)

Country Link
US (1) US5366973A (cg-RX-API-DMAC7.html)
EP (1) EP0640086B1 (cg-RX-API-DMAC7.html)
JP (1) JP3360079B2 (cg-RX-API-DMAC7.html)
KR (1) KR100281450B1 (cg-RX-API-DMAC7.html)
AT (1) ATE182892T1 (cg-RX-API-DMAC7.html)
AU (1) AU669364B2 (cg-RX-API-DMAC7.html)
CA (1) CA2133963C (cg-RX-API-DMAC7.html)
DE (1) DE69325904T2 (cg-RX-API-DMAC7.html)
DK (1) DK0640086T3 (cg-RX-API-DMAC7.html)
ES (1) ES2138622T3 (cg-RX-API-DMAC7.html)
FI (1) FI108230B (cg-RX-API-DMAC7.html)
GR (1) GR3031287T3 (cg-RX-API-DMAC7.html)
HU (1) HU223663B1 (cg-RX-API-DMAC7.html)
IL (1) IL105680A (cg-RX-API-DMAC7.html)
MX (1) MX9302824A (cg-RX-API-DMAC7.html)
NO (1) NO302573B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ251930A (cg-RX-API-DMAC7.html)
TW (1) TW270115B (cg-RX-API-DMAC7.html)
WO (1) WO1993023403A1 (cg-RX-API-DMAC7.html)

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US6984645B2 (en) * 2001-11-16 2006-01-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
CN1642550A (zh) 2002-02-14 2005-07-20 美瑞德生物工程公司 β－折叠模拟物和组合物及其有关方法
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US7273881B2 (en) 2004-01-16 2007-09-25 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
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US20070015839A1 (en) * 2005-07-14 2007-01-18 Franco Folli Daily Dosage Regimen for Treating Diabetes, Obesity, Metabolic Syndrome and Polycystic Ovary Syndrome
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
JP5412273B2 (ja) 2006-03-21 2014-02-12 アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー ペプチド−ぺプチダーゼ阻害剤及びその使用
US20070238770A1 (en) * 2006-04-05 2007-10-11 Bristol-Myers Squibb Company Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
EP2636680A3 (en) 2006-05-26 2013-12-11 Amylin Pharmaceuticals, LLC Composition and methods for treatment of congestive heart failure
US7795291B2 (en) 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
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Also Published As

Publication number Publication date
FI108230B (fi) 2001-12-14
IL105680A0 (en) 1993-09-22
WO1993023403A1 (en) 1993-11-25
NO944335L (no) 1995-01-13
AU4033293A (en) 1993-12-13
ATE182892T1 (de) 1999-08-15
KR100281450B1 (ko) 2001-02-01
HU223663B1 (hu) 2004-11-29
DE69325904T2 (de) 1999-12-09
DK0640086T3 (da) 1999-12-06
JP3360079B2 (ja) 2002-12-24
EP0640086B1 (en) 1999-08-04
CA2133963A1 (en) 1993-11-25
DE69325904D1 (de) 1999-09-09
CA2133963C (en) 1998-07-07
HUT71099A (en) 1995-11-28
EP0640086A1 (en) 1995-03-01
ES2138622T3 (es) 2000-01-16
FI945363L (fi) 1994-11-14
GR3031287T3 (en) 1999-12-31
IL105680A (en) 1998-01-04
FI945363A0 (fi) 1994-11-14
NO302573B1 (no) 1998-03-23
MX9302824A (es) 1994-05-31
AU669364B2 (en) 1996-06-06
KR950701634A (ko) 1995-04-28
US5366973A (en) 1994-11-22
JPH07506832A (ja) 1995-07-27
NZ251930A (en) 1996-02-27
NO944335D0 (no) 1994-11-14

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