TW221434B - - Google Patents

Info

Publication number
TW221434B
TW221434B TW080106516A TW80106516A TW221434B TW 221434 B TW221434 B TW 221434B TW 080106516 A TW080106516 A TW 080106516A TW 80106516 A TW80106516 A TW 80106516A TW 221434 B TW221434 B TW 221434B
Authority
TW
Taiwan
Prior art keywords
lower alkyl
substituted
hydroxy
phenyl
hydrogen
Prior art date
Application number
TW080106516A
Other languages
English (en)
Chinese (zh)
Original Assignee
Ctsuka Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ctsuka Seiyaku Kk filed Critical Ctsuka Seiyaku Kk
Application granted granted Critical
Publication of TW221434B publication Critical patent/TW221434B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW080106516A 1991-04-22 1991-08-16 TW221434B (cg-RX-API-DMAC7.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9070791 1991-04-22

Publications (1)

Publication Number Publication Date
TW221434B true TW221434B (cg-RX-API-DMAC7.html) 1994-03-01

Family

ID=14006001

Family Applications (1)

Application Number Title Priority Date Filing Date
TW080106516A TW221434B (cg-RX-API-DMAC7.html) 1991-04-22 1991-08-16

Country Status (12)

Country Link
US (1) US5688949A (cg-RX-API-DMAC7.html)
EP (1) EP0591528B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0570353A (cg-RX-API-DMAC7.html)
KR (1) KR100191774B1 (cg-RX-API-DMAC7.html)
AT (1) ATE174917T1 (cg-RX-API-DMAC7.html)
AU (1) AU651986B2 (cg-RX-API-DMAC7.html)
CA (1) CA2107479C (cg-RX-API-DMAC7.html)
DE (1) DE69130683T2 (cg-RX-API-DMAC7.html)
DK (1) DK0591528T3 (cg-RX-API-DMAC7.html)
ES (1) ES2126573T3 (cg-RX-API-DMAC7.html)
TW (1) TW221434B (cg-RX-API-DMAC7.html)
WO (1) WO1992018504A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106232119A (zh) * 2013-12-11 2016-12-14 河谷控股Ip有限责任公司 A型流感rna‑依赖性rna聚合酶的小分子抑制剂

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
CA2169719C (en) * 1994-06-21 2002-04-16 Yasuo Shoji Pyrazolo[1,5-a]pyrimidine derivative
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US6664261B2 (en) * 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
JP3870298B2 (ja) * 1996-06-06 2007-01-17 株式会社大塚製薬工場 アミド誘導体
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
EA004403B1 (ru) * 1996-07-24 2004-04-29 Дюпон Фармасьютикалз Компани Производные пиразолотриазинов, фармацевтические композиции, содержащие их, способы лечения
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
DK0915880T3 (da) * 1996-07-24 2008-02-11 Bristol Myers Squibb Pharma Co Azolotriaziner og pyrimidiner
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US20020061897A1 (en) * 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
BR0208241A (pt) 2001-03-27 2004-04-13 Neurogen Corp Composto, composições farmacêutica métodos para o tratamento de ansiedade, depressão, um distúrbio do sono, distúrbio de déficit de atenção, ou demência de alzheimer, para aumentar a potência de um efeito terapêutico de um agente do cns, para determinar a presença ou ausência de receptor de gabaa em uma amostra, e para alterar a atividade de transdução de sinal de receptor de gabaa, e, uso de um composto
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
DE60319820T2 (de) * 2002-06-04 2009-03-26 Schering Corp. Pyrazoloä1,5-aüpyrimidin-verbindungen als antivirale agentien
US7196078B2 (en) * 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
ES2283868T3 (es) 2002-09-04 2007-11-01 Schering Corporation Compuestos pirazol(1,5-a) pirimidina como inhibidores de quinasa dependiente de ciclina.
CN1310918C (zh) 2002-09-04 2007-04-18 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶
US7205308B2 (en) 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
CA2497450C (en) * 2002-09-04 2011-05-31 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
TW200412966A (en) * 2002-09-04 2004-08-01 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
TWI344468B (en) 2002-09-04 2011-07-01 Schering Corp Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
BRPI0407834A (pt) 2003-02-28 2006-02-14 Teijin Pharma Ltd composto, processo para a manufatura do mesmo, composição, processo para a manufatura da mesma, método de tratamento ou prevenção de um distúrbio mediado por proteìna quinase em um indivìduo, uso de um composto, ensaio para determinar a atividade dos compostos, e, método de inibição da atividade ou função de uma proteìna quinase
WO2004087707A1 (en) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
PE20051089A1 (es) * 2004-01-22 2006-01-25 Novartis Ag Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina
CA2789097C (en) 2005-04-28 2017-02-21 Proteus Digital Health, Inc. Pharma-informatics system
WO2007032936A2 (en) * 2005-09-09 2007-03-22 Schering Corporation Azafused cyclin dependent kinase inhibitors
TWI333953B (en) * 2005-10-06 2010-12-01 Schering Corp Pyrazolopyrimidines as protein kinase inhibitors
TW200745123A (en) 2005-10-06 2007-12-16 Schering Corp Pyrazolopyrimidines as protein kinase inhibitors
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
AU2007325350B2 (en) 2006-11-29 2012-09-20 Abbvie Inc. Inhibitors of diacylglycerol O-acylotransferase type 1 enzyme
AR069803A1 (es) * 2007-12-19 2010-02-17 Genentech Inc 5- anilinoimiazopiridinas y metodos de uso
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
CA2781780C (en) * 2009-12-23 2015-02-17 Katholieke Universiteit Leuven Novel antiviral compounds
WO2012047570A1 (en) * 2010-09-28 2012-04-12 Schering Corporation Fused tricyclic inhibitors of mammalian target of rapamycin
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
MX2013005478A (es) 2010-11-15 2013-08-29 Univ Leuven Kath Compuestos heterociclicos condensados antivirales.
US8633198B1 (en) 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
EP3096762B1 (en) 2014-01-22 2023-06-28 Curovir Ab Pyrazolo[1,5-a]pyrimidines as antiviral compounds
GB201410817D0 (en) 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents
US10738056B2 (en) * 2017-09-15 2020-08-11 Aduro Biotech Inc. Pyrazolopyrimidinone compounds and uses thereof
DE102018201598A1 (de) * 2018-02-02 2019-08-08 Beiersdorf Ag Stabile Wundheilsalbe
EP4232451A4 (en) 2020-10-23 2024-11-06 Ildong Pharmaceutical Co., Ltd. CFTR MODULATOR COMPOUNDS, COMPOSITIONS AND USES THEREOF

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
US4026893A (en) * 1975-11-07 1977-05-31 Squibb & Sons Inc Pyrazolo{8 1,5-a{9 pyrido{8 3,2-e{9 pyrimidine-7-carboxylic acid derivatives
DE3338292A1 (de) * 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
JPS60100381A (ja) * 1983-11-04 1985-06-04 Yuasa Battery Co Ltd 密閉形鉛蓄電池
JPS60100581A (ja) * 1983-11-07 1985-06-04 S D S Baiotetsuku:Kk ピラゾロ〔１，５−ａ〕ピリミジン誘導体，それらを含有する農園芸用殺菌剤及びそれらの製造方法
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106232119A (zh) * 2013-12-11 2016-12-14 河谷控股Ip有限责任公司 A型流感rna‑依赖性rna聚合酶的小分子抑制剂

Also Published As

Publication number Publication date
JPH0570353A (ja) 1993-03-23
AU8295891A (en) 1992-11-17
DE69130683D1 (de) 1999-02-04
WO1992018504A1 (en) 1992-10-29
ATE174917T1 (de) 1999-01-15
KR100191774B1 (ko) 1999-06-15
DE69130683T2 (de) 1999-05-06
US5688949A (en) 1997-11-18
CA2107479C (en) 1997-12-16
EP0591528B1 (en) 1998-12-23
CA2107479A1 (en) 1992-10-23
EP0591528A4 (en) 1995-02-15
ES2126573T3 (es) 1999-04-01
AU651986B2 (en) 1994-08-11
DK0591528T3 (da) 1999-08-23
EP0591528A1 (en) 1994-04-13

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