TW217383B - - Google Patents

Info

Publication number
TW217383B
TW217383B TW078106510A TW78106510A TW217383B TW 217383 B TW217383 B TW 217383B TW 078106510 A TW078106510 A TW 078106510A TW 78106510 A TW78106510 A TW 78106510A TW 217383 B TW217383 B TW 217383B
Authority
TW
Taiwan
Prior art keywords
pct
formula
date mar
compounds
sec
Prior art date
Application number
TW078106510A
Other languages
English (en)
Chinese (zh)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of TW217383B publication Critical patent/TW217383B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Amplifiers (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Artificial Filaments (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Television Receiver Circuits (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Television Systems (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Stereophonic System (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW078106510A 1988-09-12 1989-08-23 TW217383B (Direct)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12

Publications (1)

Publication Number Publication Date
TW217383B true TW217383B (Direct) 1993-12-11

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
TW078106510A TW217383B (Direct) 1988-09-12 1989-08-23

Country Status (14)

Country Link
US (1) US5541339A (Direct)
JP (1) JP3380237B2 (Direct)
KR (1) KR0137959B1 (Direct)
AT (1) ATE198335T1 (Direct)
AU (1) AU632288B2 (Direct)
CA (1) CA1340215C (Direct)
DE (1) DE68929275T2 (Direct)
DK (1) DK175458B1 (Direct)
FI (1) FI103668B (Direct)
GR (1) GR3035589T3 (Direct)
LV (1) LV12806B (Direct)
NO (1) NO303498B1 (Direct)
TW (1) TW217383B (Direct)
WO (1) WO1990002746A1 (Direct)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2076465C (en) * 1992-03-25 2002-11-26 Ravi V. J. Chari Cell binding agent conjugates of analogues and derivatives of cc-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
EP1448199A1 (en) 2001-11-09 2004-08-25 Boehringer Ingelheim Pharmaceuticals Inc. Benzimidazoles useful as protein kinase inhibitors
US7138420B2 (en) * 2002-08-08 2006-11-21 Boehringer Ingelheim Pharmaceuticals Inc. Substituted benzimidazole compounds
CA2501547A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
AU2004255566B2 (en) * 2003-07-07 2010-07-08 Merk Patent Gmbh Malonamide derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
CA2619790A1 (en) * 2005-08-17 2007-02-22 Schering Corporation Novel high affinity thiophene-based and furan-based kinase ligands
MX338185B (es) 2007-01-25 2016-04-05 Dana Farber Cancer Inst Inc Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
EP2134854B1 (en) 2007-03-15 2015-04-15 Ludwig Institute for Cancer Research Ltd. Treatment method using egfr antibodies and src inhibitors and related formulations
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CA2696360C (en) 2007-08-14 2018-11-20 Ludwig Institute For Cancer Research Monoclonal antibody targeting the egfr receptor and uses thereof
EP2344478B1 (en) 2008-11-03 2017-09-27 Syntarga B.V. Cc-1065 analogs and their conjugates
ES2594952T3 (es) 2010-04-21 2016-12-27 Syntarga B.V. Conjugados de análogos de CC-1065 y conectores bifuncionales
EP3388060A1 (en) 2012-10-22 2018-10-17 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
TR201810856T4 (tr) 2014-01-10 2018-08-27 Synthon Biopharmaceuticals Bv CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
ES2722103T3 (es) * 2014-01-27 2019-08-07 Pfizer Agentes citotóxicos bifuncionales
ES2785551T3 (es) 2014-06-30 2020-10-07 Glykos Finland Oy Derivado de sacárido de una carga útil tóxica y sus conjugados con anticuerpos
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
KR102046862B1 (ko) * 2015-03-20 2019-11-20 화이자 인코포레이티드 Cti 약물작용발생단을 함유하는 이관능성 세포독성제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
ATE112279T1 (de) * 1986-12-19 1994-10-15 Upjohn Co Cc-1065 analoge.

Also Published As

Publication number Publication date
DK41791D0 (da) 1991-03-08
US5541339A (en) 1996-07-30
GR3035589T3 (en) 2001-06-29
AU632288B2 (en) 1992-12-24
FI103668B1 (fi) 1999-08-13
ATE198335T1 (de) 2001-01-15
JP3380237B2 (ja) 2003-02-24
WO1990002746A1 (en) 1990-03-22
DK175458B1 (da) 2004-11-01
NO910958D0 (no) 1991-03-11
CA1340215C (en) 1998-12-15
AU4192289A (en) 1990-04-02
KR900701801A (ko) 1990-12-04
FI103668B (fi) 1999-08-13
DK41791A (da) 1991-03-08
JPH04500664A (ja) 1992-02-06
NO303498B1 (no) 1998-07-20
NO910958L (no) 1991-05-10
LV12806A (en) 2002-03-20
DE68929275D1 (de) 2001-02-01
KR0137959B1 (ko) 1998-05-15
DE68929275T2 (de) 2001-05-23
LV12806B (lv) 2002-05-20
FI911193A0 (fi) 1991-03-11

Similar Documents

Publication Publication Date Title
TW217383B (Direct)
TR200000197T2 (tr) Yeni bileşimler
ATE133181T1 (de) Dehydrodidemnin b
FI931708A0 (fi) Herbicida substituerade aryl-haloalkylpyrazoler
IL113462A0 (en) Substituted pyridylpyrazoles, their preparation and pesticidal compositions containing them
ZW24786A1 (en) Insecticidal pyrazolines
TR200000152T2 (tr) Yeni bileşikler.
PH24452A (en) (2,2-bis(aminomethyl 1,3,propanediol-n,n)platinum complexes
ES2153814T3 (es) Analogos de cc-1065 que tienen dos subunidades cpi.
DE58907767D1 (de) Pflegeset insbesondere für den Reisebedarf.
ATE195055T1 (de) Insektizide zusammensetzung die diatomeenerde und siliziumdioxid enthalten
MX9302735A (es) 4'-metoxiacetofenonas halogenadas como microbicidas y preservativos.
MY107258A (en) 1-methoxypyrimidinyl-n-nitrophenyl-1h-1,2,4-triazole-3- sulphonamides, processes for their preparation and their use as herbicides.
NO960271D0 (no) Tiokarbamoylforbindelser anvendt som mikrobiocider
ATE87314T1 (de) Platin-arzneimittel.
DE3660426D1 (de) Urea acryl derivatives
EP0043976A3 (en) Anti-tumor agent
EP0232784A3 (en) (gem-heterocyclodimethanamine-n,n')platinum complexes
ES2054631T3 (es) 1-(2-halogeno-alcoxi-bencenosulfonil)-3-heteroaril-ureas, 3-substituidas.
DE3571975D1 (de) Azidobenzazepines
FR2574798B1 (fr) Nouvelle adenosine substituee en n6 et medicament la contenant comme principe actif
MY105072A (en) Substituted alkenes, processes for their preparation and their use as pesticides.
DE3853677D1 (de) Silylgruppen enthaltende Aminverbindungen zur Verwendung als antimikrobische Wirkstoffe.
ATE73444T1 (de) Chemische zusammensetzungen und verwendung als brennstoff-additive.
IT8919173A0 (it) Dispositivo per la decomposizione di rifiuti vegetali ed animali, nonche' suo impiego.