TW210335B - - Google Patents
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- TW210335B TW210335B TW079109927A TW79109927A TW210335B TW 210335 B TW210335 B TW 210335B TW 079109927 A TW079109927 A TW 079109927A TW 79109927 A TW79109927 A TW 79109927A TW 210335 B TW210335 B TW 210335B
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- Taiwan
- Prior art keywords
- alkyl
- general formula
- group
- amino
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- 150000001875 compounds Chemical class 0.000 claims abstract description 48
- -1 triazolyl thioamides Chemical class 0.000 claims abstract description 35
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 239000002253 acid Substances 0.000 claims abstract description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 22
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
- 238000011049 filling Methods 0.000 claims description 12
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 12
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- 230000000694 effects Effects 0.000 claims description 7
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract description 4
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- 150000002367 halogens Chemical group 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- OHCXVBBPKJAIBJ-UHFFFAOYSA-N hydroxysulfonothioyl hydrogen carbonate Chemical compound OC(=O)OS(O)(=O)=S OHCXVBBPKJAIBJ-UHFFFAOYSA-N 0.000 description 1
- 125000002636 imidazolinyl group Chemical group 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- KSOKAHYVTMZFBJ-UHFFFAOYSA-N iron;methane Chemical compound C.[Fe].[Fe].[Fe] KSOKAHYVTMZFBJ-UHFFFAOYSA-N 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 1
- 239000001751 lycopene Substances 0.000 description 1
- 229960004999 lycopene Drugs 0.000 description 1
- 235000012661 lycopene Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 125000005394 methallyl group Chemical group 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- NJTGANWAUPEOAX-UHFFFAOYSA-N molport-023-220-454 Chemical compound OCC(O)CO.OCC(O)CO NJTGANWAUPEOAX-UHFFFAOYSA-N 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- KFIGICHILYTCJF-UHFFFAOYSA-N n'-methylethane-1,2-diamine Chemical compound CNCCN KFIGICHILYTCJF-UHFFFAOYSA-N 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
- 125000002755 pyrazolinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- GIKWXTHTIQCTIH-UHFFFAOYSA-L radium bromide Chemical compound [Br-].[Br-].[Ra+2] GIKWXTHTIQCTIH-UHFFFAOYSA-L 0.000 description 1
- 229940075451 radium bromide Drugs 0.000 description 1
- 229910001624 radium bromide Inorganic materials 0.000 description 1
- 229910052704 radon Inorganic materials 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000013643 reference control Substances 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 235000019600 saltiness Nutrition 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 235000018984 snakeroot Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 208000018198 spasticity Diseases 0.000 description 1
- IAHFWCOBPZCAEA-UHFFFAOYSA-N succinonitrile Chemical compound N#CCCC#N IAHFWCOBPZCAEA-UHFFFAOYSA-N 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 229960002415 trichloroethylene Drugs 0.000 description 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229940045860 white wax Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU896163A HU206096B (en) | 1989-11-24 | 1989-11-24 | Process for producing triazolylcarboxylic acid thioamide derivatives and pharmaceutical compositions comprising same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW210335B true TW210335B (oth) | 1993-08-01 |
Family
ID=10971287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW079109927A TW210335B (oth) | 1989-11-24 | 1991-03-23 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5175163A (oth) |
| EP (1) | EP0434982B1 (oth) |
| JP (1) | JPH03209371A (oth) |
| KR (1) | KR910009674A (oth) |
| CN (1) | CN1052116A (oth) |
| AT (1) | ATE119888T1 (oth) |
| BG (1) | BG60318B2 (oth) |
| CA (1) | CA2030775A1 (oth) |
| CZ (1) | CZ280559B6 (oth) |
| DE (1) | DE59008718D1 (oth) |
| DK (1) | DK0434982T3 (oth) |
| ES (1) | ES2029778T3 (oth) |
| FI (1) | FI905800A7 (oth) |
| GR (1) | GR910300109T1 (oth) |
| HU (1) | HU206096B (oth) |
| IL (1) | IL96452A0 (oth) |
| IN (1) | IN171500B (oth) |
| PH (1) | PH27376A (oth) |
| PL (1) | PL166887B1 (oth) |
| RU (1) | RU2045521C1 (oth) |
| TW (1) | TW210335B (oth) |
| ZA (1) | ZA909409B (oth) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0710654A4 (en) * | 1993-07-23 | 1996-08-28 | Green Cross Corp | TRIAZOLE DERIVATIVE AND ITS PHARMACEUTICAL USE |
| ATE328874T1 (de) * | 2000-12-22 | 2006-06-15 | Ortho Mcneil Pharm Inc | Substituieten triazoldiamin derivaten und ihre verwendung als kinase inhibitoren |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2352944A (en) * | 1942-07-04 | 1944-07-04 | Gen Electric | Triazole derivatives |
| GB949170A (en) * | 1960-03-15 | 1964-02-12 | France Etat | Carbamyl and thiocarbamyl substances, methods for producing same and applications thereof |
| US4421753A (en) * | 1982-01-15 | 1983-12-20 | American Cyanamid Company | 1-(5-Amino-4H-1,2,4-triazol-3-yl)-4-substituted-piperazines |
| DD205905A1 (de) * | 1982-08-17 | 1984-01-11 | Univ Rostock | Verfahren zur herstellung von substituierten 1,2,4-triazolo (2,3-a)-1,3,5-triazinen |
-
1989
- 1989-11-24 HU HU896163A patent/HU206096B/hu not_active IP Right Cessation
-
1990
- 1990-11-21 PH PH41587A patent/PH27376A/en unknown
- 1990-11-21 US US07/617,126 patent/US5175163A/en not_active Expired - Fee Related
- 1990-11-22 JP JP2315680A patent/JPH03209371A/ja active Pending
- 1990-11-22 BG BG093292A patent/BG60318B2/bg unknown
- 1990-11-23 ES ES90122351T patent/ES2029778T3/es not_active Expired - Lifetime
- 1990-11-23 DK DK90122351.1T patent/DK0434982T3/da active
- 1990-11-23 FI FI905800A patent/FI905800A7/fi not_active IP Right Cessation
- 1990-11-23 KR KR1019900019076A patent/KR910009674A/ko not_active Ceased
- 1990-11-23 CA CA002030775A patent/CA2030775A1/en not_active Abandoned
- 1990-11-23 ZA ZA909409A patent/ZA909409B/xx unknown
- 1990-11-23 IL IL96452A patent/IL96452A0/xx unknown
- 1990-11-23 RU SU904831825A patent/RU2045521C1/ru active
- 1990-11-23 DE DE59008718T patent/DE59008718D1/de not_active Expired - Fee Related
- 1990-11-23 PL PL90287909A patent/PL166887B1/pl unknown
- 1990-11-23 IN IN950/MAS/90A patent/IN171500B/en unknown
- 1990-11-23 EP EP90122351A patent/EP0434982B1/de not_active Expired - Lifetime
- 1990-11-23 AT AT90122351T patent/ATE119888T1/de active
- 1990-11-23 CZ CS905839A patent/CZ280559B6/cs unknown
- 1990-11-24 CN CN90109404A patent/CN1052116A/zh active Pending
-
1991
- 1991-03-23 TW TW079109927A patent/TW210335B/zh active
- 1991-09-09 US US07/755,219 patent/US5276030A/en not_active Expired - Fee Related
- 1991-12-10 GR GR91300109T patent/GR910300109T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ583990A3 (en) | 1995-11-15 |
| IN171500B (oth) | 1992-10-31 |
| HU896163D0 (en) | 1990-02-28 |
| US5276030A (en) | 1994-01-04 |
| ZA909409B (en) | 1991-09-25 |
| CA2030775A1 (en) | 1991-05-25 |
| IL96452A0 (en) | 1991-08-16 |
| CZ280559B6 (cs) | 1996-02-14 |
| PL287909A1 (en) | 1991-09-23 |
| PL166887B1 (pl) | 1995-06-30 |
| JPH03209371A (ja) | 1991-09-12 |
| GR910300109T1 (en) | 1991-12-10 |
| FI905800A7 (fi) | 1991-05-25 |
| HUT59112A (en) | 1992-04-28 |
| RU2045521C1 (ru) | 1995-10-10 |
| ATE119888T1 (de) | 1995-04-15 |
| EP0434982A2 (de) | 1991-07-03 |
| DE59008718D1 (de) | 1995-04-20 |
| KR910009674A (ko) | 1991-06-28 |
| ES2029778T1 (es) | 1992-10-01 |
| HU206096B (en) | 1992-08-28 |
| EP0434982B1 (de) | 1995-03-15 |
| US5175163A (en) | 1992-12-29 |
| PH27376A (en) | 1993-06-21 |
| BG60318B2 (bg) | 1994-07-25 |
| CN1052116A (zh) | 1991-06-12 |
| ES2029778T3 (es) | 1995-06-01 |
| DK0434982T3 (da) | 1995-05-22 |
| FI905800A0 (fi) | 1990-11-23 |
| EP0434982A3 (en) | 1991-12-18 |
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