TW202440607A - 環狀胜肽的純化方法及製造方法 - Google Patents
環狀胜肽的純化方法及製造方法 Download PDFInfo
- Publication number
- TW202440607A TW202440607A TW112151299A TW112151299A TW202440607A TW 202440607 A TW202440607 A TW 202440607A TW 112151299 A TW112151299 A TW 112151299A TW 112151299 A TW112151299 A TW 112151299A TW 202440607 A TW202440607 A TW 202440607A
- Authority
- TW
- Taiwan
- Prior art keywords
- solvent
- purification
- cyclic peptide
- solution
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/32—Extraction; Separation; Purification by precipitation as complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022212468 | 2022-12-28 | ||
| JP2022-212468 | 2022-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202440607A true TW202440607A (zh) | 2024-10-16 |
Family
ID=91717859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW112151299A TW202440607A (zh) | 2022-12-28 | 2023-12-28 | 環狀胜肽的純化方法及製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4631955A1 (https=) |
| JP (1) | JPWO2024143514A1 (https=) |
| KR (1) | KR20250125378A (https=) |
| CN (1) | CN120418263A (https=) |
| TW (1) | TW202440607A (https=) |
| WO (1) | WO2024143514A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202523345A (zh) | 2023-09-28 | 2025-06-16 | 日商中外製藥股份有限公司 | 使用混合酸酐法的胜肽化合物的製造方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL156394A0 (en) * | 2000-12-18 | 2004-01-04 | Cubist Pharm Inc | Methods for preparing purified lipopeptides |
| ES2546808T3 (es) | 2006-03-24 | 2015-09-28 | Jitsubo Co., Ltd. | Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo |
| CN106220482B (zh) | 2010-08-30 | 2020-01-07 | 味之素株式会社 | 含有支链的芳香族化合物 |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| CN103059108A (zh) * | 2013-01-16 | 2013-04-24 | 安徽帝元生物科技有限公司 | 一种枯草菌脂肽钠的纯化方法 |
| CN104725257A (zh) * | 2015-02-11 | 2015-06-24 | 海门市润圣纺织品有限公司 | 一种氨基酸及多肽物质的纯化方法 |
| CN110869544B (zh) | 2017-06-09 | 2024-03-08 | 中外制药株式会社 | 膜透过性高的环状肽化合物及包含其的文库 |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| JP7163916B2 (ja) | 2017-07-05 | 2022-11-01 | 日産化学株式会社 | ベンジル化合物 |
| WO2019117274A1 (ja) | 2017-12-15 | 2019-06-20 | 中外製薬株式会社 | ペプチドの製造方法、及び塩基の処理方法 |
| WO2020111238A1 (ja) | 2018-11-30 | 2020-06-04 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
| WO2020122182A1 (ja) | 2018-12-12 | 2020-06-18 | 中外製薬株式会社 | 分子内水素結合可能な官能基を有するアミノ酸とそれらのアミノ酸を含むペプチド化合物、およびそれらの製造方法 |
| CN114585916B (zh) | 2019-10-15 | 2025-03-11 | 中外制药株式会社 | 含有用具有Fmoc骨架的保护基保护的氨基的化合物的定量法 |
| BR112022007535A2 (pt) | 2019-11-07 | 2022-07-12 | Chugai Pharmaceutical Co Ltd | Composto peptídico cíclico tendo ação inibitória de kras |
| EP4056580A4 (en) | 2019-11-07 | 2023-12-06 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID |
| EP4083051A4 (en) | 2019-12-27 | 2024-01-17 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR SYNTHESIS OF A PEPTIDE COMPOUND |
| JP7766028B2 (ja) | 2020-06-03 | 2025-11-07 | 中外製薬株式会社 | 高難度配列の効率的ペプチド縮合法 |
| KR20230097018A (ko) | 2020-11-05 | 2023-06-30 | 추가이 세이야쿠 가부시키가이샤 | 다이케토피페라진 형성에 의한 결손을 억제하는 펩타이드 합성 방법 |
| WO2022138891A1 (ja) | 2020-12-25 | 2022-06-30 | 中外製薬株式会社 | Ｎ－置換－アミノ酸残基を含むペプチド化合物の製造方法 |
| CN116547295A (zh) | 2020-12-28 | 2023-08-04 | 中外制药株式会社 | 氨基酸向固相合成用树脂的担载方法 |
| US12312379B2 (en) | 2021-05-07 | 2025-05-27 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing cyclic compounds comprising N-substituted amino acid residues |
| TW202342495A (zh) | 2021-12-28 | 2023-11-01 | 日商中外製藥股份有限公司 | N-烷基胺基酸及含有n-烷基胺基酸之胜肽的製造方法 |
-
2023
- 2023-12-27 WO PCT/JP2023/047127 patent/WO2024143514A1/ja not_active Ceased
- 2023-12-27 KR KR1020257022924A patent/KR20250125378A/ko active Pending
- 2023-12-27 EP EP23912291.4A patent/EP4631955A1/en active Pending
- 2023-12-27 JP JP2024567964A patent/JPWO2024143514A1/ja active Pending
- 2023-12-27 CN CN202380089424.7A patent/CN120418263A/zh active Pending
- 2023-12-28 TW TW112151299A patent/TW202440607A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4631955A1 (en) | 2025-10-15 |
| WO2024143514A1 (ja) | 2024-07-04 |
| KR20250125378A (ko) | 2025-08-21 |
| CN120418263A (zh) | 2025-08-01 |
| JPWO2024143514A1 (https=) | 2024-07-04 |
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