CN120418263A - 环肽的纯化方法和生产方法 - Google Patents

环肽的纯化方法和生产方法

Info

Publication number
CN120418263A
CN120418263A CN202380089424.7A CN202380089424A CN120418263A CN 120418263 A CN120418263 A CN 120418263A CN 202380089424 A CN202380089424 A CN 202380089424A CN 120418263 A CN120418263 A CN 120418263A
Authority
CN
China
Prior art keywords
solvent
purification
cyclic peptide
compound
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380089424.7A
Other languages
English (en)
Chinese (zh)
Inventor
田宫实
新居启司
饭仓仁
海老原玲
猪俣祐贵
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of CN120418263A publication Critical patent/CN120418263A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN202380089424.7A 2022-12-28 2023-12-27 环肽的纯化方法和生产方法 Pending CN120418263A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022212468 2022-12-28
JP2022-212468 2022-12-28
PCT/JP2023/047127 WO2024143514A1 (ja) 2022-12-28 2023-12-27 環状ペプチドの精製法及び製造法

Publications (1)

Publication Number Publication Date
CN120418263A true CN120418263A (zh) 2025-08-01

Family

ID=91717859

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380089424.7A Pending CN120418263A (zh) 2022-12-28 2023-12-27 环肽的纯化方法和生产方法

Country Status (6)

Country Link
EP (1) EP4631955A1 (https=)
JP (1) JPWO2024143514A1 (https=)
KR (1) KR20250125378A (https=)
CN (1) CN120418263A (https=)
TW (1) TW202440607A (https=)
WO (1) WO2024143514A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202523345A (zh) 2023-09-28 2025-06-16 日商中外製藥股份有限公司 使用混合酸酐法的胜肽化合物的製造方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL156394A0 (en) * 2000-12-18 2004-01-04 Cubist Pharm Inc Methods for preparing purified lipopeptides
ES2546808T3 (es) 2006-03-24 2015-09-28 Jitsubo Co., Ltd. Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo
CN106220482B (zh) 2010-08-30 2020-01-07 味之素株式会社 含有支链的芳香族化合物
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
CN103059108A (zh) * 2013-01-16 2013-04-24 安徽帝元生物科技有限公司 一种枯草菌脂肽钠的纯化方法
CN104725257A (zh) * 2015-02-11 2015-06-24 海门市润圣纺织品有限公司 一种氨基酸及多肽物质的纯化方法
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
JP7163916B2 (ja) 2017-07-05 2022-11-01 日産化学株式会社 ベンジル化合物
WO2019117274A1 (ja) 2017-12-15 2019-06-20 中外製薬株式会社 ペプチドの製造方法、及び塩基の処理方法
WO2020111238A1 (ja) 2018-11-30 2020-06-04 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法
WO2020122182A1 (ja) 2018-12-12 2020-06-18 中外製薬株式会社 分子内水素結合可能な官能基を有するアミノ酸とそれらのアミノ酸を含むペプチド化合物、およびそれらの製造方法
CN114585916B (zh) 2019-10-15 2025-03-11 中外制药株式会社 含有用具有Fmoc骨架的保护基保护的氨基的化合物的定量法
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
EP4083051A4 (en) 2019-12-27 2024-01-17 Chugai Seiyaku Kabushiki Kaisha METHOD FOR SYNTHESIS OF A PEPTIDE COMPOUND
JP7766028B2 (ja) 2020-06-03 2025-11-07 中外製薬株式会社 高難度配列の効率的ペプチド縮合法
KR20230097018A (ko) 2020-11-05 2023-06-30 추가이 세이야쿠 가부시키가이샤 다이케토피페라진 형성에 의한 결손을 억제하는 펩타이드 합성 방법
WO2022138891A1 (ja) 2020-12-25 2022-06-30 中外製薬株式会社 Ｎ－置換－アミノ酸残基を含むペプチド化合物の製造方法
CN116547295A (zh) 2020-12-28 2023-08-04 中外制药株式会社 氨基酸向固相合成用树脂的担载方法
US12312379B2 (en) 2021-05-07 2025-05-27 Chugai Seiyaku Kabushiki Kaisha Methods for producing cyclic compounds comprising N-substituted amino acid residues
TW202342495A (zh) 2021-12-28 2023-11-01 日商中外製藥股份有限公司 N-烷基胺基酸及含有n-烷基胺基酸之胜肽的製造方法

Also Published As

Publication number Publication date
EP4631955A1 (en) 2025-10-15
WO2024143514A1 (ja) 2024-07-04
KR20250125378A (ko) 2025-08-21
TW202440607A (zh) 2024-10-16
JPWO2024143514A1 (https=) 2024-07-04

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