KR20250125378A - 고리형 펩타이드의 정제 방법 및 제조 방법 - Google Patents

고리형 펩타이드의 정제 방법 및 제조 방법

Info

Publication number
KR20250125378A
KR20250125378A KR1020257022924A KR20257022924A KR20250125378A KR 20250125378 A KR20250125378 A KR 20250125378A KR 1020257022924 A KR1020257022924 A KR 1020257022924A KR 20257022924 A KR20257022924 A KR 20257022924A KR 20250125378 A KR20250125378 A KR 20250125378A
Authority
KR
South Korea
Prior art keywords
purification
solvent
cyclic peptide
solution
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257022924A
Other languages
English (en)
Korean (ko)
Inventor
미노루 다미야
게이지 니이
히토시 이쿠라
아키라 에비하라
유키 이노마타
Original Assignee
추가이 세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 추가이 세이야쿠 가부시키가이샤 filed Critical 추가이 세이야쿠 가부시키가이샤
Publication of KR20250125378A publication Critical patent/KR20250125378A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/32—Extraction; Separation; Purification by precipitation as complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1020257022924A 2022-12-28 2023-12-27 고리형 펩타이드의 정제 방법 및 제조 방법 Pending KR20250125378A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022212468 2022-12-28
JPJP-P-2022-212468 2022-12-28
PCT/JP2023/047127 WO2024143514A1 (ja) 2022-12-28 2023-12-27 環状ペプチドの精製法及び製造法

Publications (1)

Publication Number Publication Date
KR20250125378A true KR20250125378A (ko) 2025-08-21

Family

ID=91717859

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020257022924A Pending KR20250125378A (ko) 2022-12-28 2023-12-27 고리형 펩타이드의 정제 방법 및 제조 방법

Country Status (6)

Country Link
EP (1) EP4631955A1 (https=)
JP (1) JPWO2024143514A1 (https=)
KR (1) KR20250125378A (https=)
CN (1) CN120418263A (https=)
TW (1) TW202440607A (https=)
WO (1) WO2024143514A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202523345A (zh) 2023-09-28 2025-06-16 日商中外製藥股份有限公司 使用混合酸酐法的胜肽化合物的製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022234864A1 (ja) 2021-05-07 2022-11-10 中外製薬株式会社 Ｎ－置換アミノ酸残基を含む環状化合物の製造方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL156394A0 (en) * 2000-12-18 2004-01-04 Cubist Pharm Inc Methods for preparing purified lipopeptides
ES2546808T3 (es) 2006-03-24 2015-09-28 Jitsubo Co., Ltd. Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo
CN106220482B (zh) 2010-08-30 2020-01-07 味之素株式会社 含有支链的芳香族化合物
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
CN103059108A (zh) * 2013-01-16 2013-04-24 安徽帝元生物科技有限公司 一种枯草菌脂肽钠的纯化方法
CN104725257A (zh) * 2015-02-11 2015-06-24 海门市润圣纺织品有限公司 一种氨基酸及多肽物质的纯化方法
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
JP7163916B2 (ja) 2017-07-05 2022-11-01 日産化学株式会社 ベンジル化合物
WO2019117274A1 (ja) 2017-12-15 2019-06-20 中外製薬株式会社 ペプチドの製造方法、及び塩基の処理方法
WO2020111238A1 (ja) 2018-11-30 2020-06-04 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法
WO2020122182A1 (ja) 2018-12-12 2020-06-18 中外製薬株式会社 分子内水素結合可能な官能基を有するアミノ酸とそれらのアミノ酸を含むペプチド化合物、およびそれらの製造方法
CN114585916B (zh) 2019-10-15 2025-03-11 中外制药株式会社 含有用具有Fmoc骨架的保护基保护的氨基的化合物的定量法
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
EP4083051A4 (en) 2019-12-27 2024-01-17 Chugai Seiyaku Kabushiki Kaisha METHOD FOR SYNTHESIS OF A PEPTIDE COMPOUND
JP7766028B2 (ja) 2020-06-03 2025-11-07 中外製薬株式会社 高難度配列の効率的ペプチド縮合法
KR20230097018A (ko) 2020-11-05 2023-06-30 추가이 세이야쿠 가부시키가이샤 다이케토피페라진 형성에 의한 결손을 억제하는 펩타이드 합성 방법
WO2022138891A1 (ja) 2020-12-25 2022-06-30 中外製薬株式会社 Ｎ－置換－アミノ酸残基を含むペプチド化合物の製造方法
CN116547295A (zh) 2020-12-28 2023-08-04 中外制药株式会社 氨基酸向固相合成用树脂的担载方法
TW202342495A (zh) 2021-12-28 2023-11-01 日商中外製藥股份有限公司 N-烷基胺基酸及含有n-烷基胺基酸之胜肽的製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022234864A1 (ja) 2021-05-07 2022-11-10 中外製薬株式会社 Ｎ－置換アミノ酸残基を含む環状化合物の製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
K. Nomura et al., "Broadly Applicable and Comprehensive Synthetic Method for N-Alkyl-Rich Drug-like Cyclic Peptides", J. Med. Chem., 2022, 65, 19, 13401-13412

Also Published As

Publication number Publication date
EP4631955A1 (en) 2025-10-15
WO2024143514A1 (ja) 2024-07-04
TW202440607A (zh) 2024-10-16
CN120418263A (zh) 2025-08-01
JPWO2024143514A1 (https=) 2024-07-04

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