TW202421169A - 代謝疾患相關的標靶基因ｉＲＮＡ組成物及其使用方法 - Google Patents

代謝疾患相關的標靶基因ｉＲＮＡ組成物及其使用方法

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Publication number
TW202421169A
TW202421169A TW111127223A TW111127223A TW202421169A TW 202421169 A TW202421169 A TW 202421169A TW 111127223 A TW111127223 A TW 111127223A TW 111127223 A TW111127223 A TW 111127223A TW 202421169 A TW202421169 A TW 202421169A
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Taiwan
Prior art keywords
nucleotides
dsrna agent
dsrna
strand
agent
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TW111127223A
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English (en)
Chinese (zh)
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艾梅Ｍ 迪頓
杰弗里 祖柏
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美商艾拉倫製藥股份有限公司
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Publication of TW202421169A publication Critical patent/TW202421169A/zh

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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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TW111127223A 2021-07-21 2022-07-20 代謝疾患相關的標靶基因ｉＲＮＡ組成物及其使用方法 TW202421169A (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US202163223995P 2021-07-21 2021-07-21
US63/223,995 2021-07-21
US202163278126P 2021-11-11 2021-11-11
US63/278,126 2021-11-11
US202163285143P 2021-12-02 2021-12-02
US63/285,143 2021-12-02
US202163287578P 2021-12-09 2021-12-09
US63/287,578 2021-12-09
US202263321799P 2022-03-21 2022-03-21
US63/321,799 2022-03-21
US202263323543P 2022-03-25 2022-03-25
US63/323,543 2022-03-25

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TW202421169A true TW202421169A (zh) 2024-06-01

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US (1) US20240309370A1 (https=)
EP (1) EP4373937A1 (https=)
JP (1) JP2024526890A (https=)
KR (1) KR20240036041A (https=)
CN (1) CN117716032A (https=)
AU (1) AU2022314619A1 (https=)
CA (1) CA3226887A1 (https=)
CL (1) CL2024000130A1 (https=)
CO (1) CO2024000239A2 (https=)
IL (1) IL309897A (https=)
MX (1) MX2024000981A (https=)
TW (1) TW202421169A (https=)
WO (1) WO2023003922A1 (https=)

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WO2025223537A1 (zh) * 2024-04-26 2025-10-30 信达生物制药(苏州)有限公司 一种dsRNA、其应用及制备方法
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