CN117716032A - 代谢病症相关靶基因iRNA组合物和其使用方法 - Google Patents

代谢病症相关靶基因iRNA组合物和其使用方法 Download PDF

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Publication number
CN117716032A
CN117716032A CN202280051430.9A CN202280051430A CN117716032A CN 117716032 A CN117716032 A CN 117716032A CN 202280051430 A CN202280051430 A CN 202280051430A CN 117716032 A CN117716032 A CN 117716032A
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nucleotides
dsrna agent
dsrna
strand
antisense strand
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A·M·迪顿
J·祖贝
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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CN202280051430.9A 2021-07-21 2022-07-20 代谢病症相关靶基因iRNA组合物和其使用方法 Pending CN117716032A (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US202163223995P 2021-07-21 2021-07-21
US63/223,995 2021-07-21
US202163278126P 2021-11-11 2021-11-11
US63/278,126 2021-11-11
US202163285143P 2021-12-02 2021-12-02
US63/285,143 2021-12-02
US202163287578P 2021-12-09 2021-12-09
US63/287,578 2021-12-09
US202263321799P 2022-03-21 2022-03-21
US63/321,799 2022-03-21
US202263323543P 2022-03-25 2022-03-25
US63/323,543 2022-03-25
PCT/US2022/037658 WO2023003922A1 (en) 2021-07-21 2022-07-20 Metabolic disorder-associated target gene irna compositions and methods of use thereof

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CN117716032A true CN117716032A (zh) 2024-03-15

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US (1) US20240309370A1 (https=)
EP (1) EP4373937A1 (https=)
JP (1) JP2024526890A (https=)
KR (1) KR20240036041A (https=)
CN (1) CN117716032A (https=)
AU (1) AU2022314619A1 (https=)
CA (1) CA3226887A1 (https=)
CL (1) CL2024000130A1 (https=)
CO (1) CO2024000239A2 (https=)
IL (1) IL309897A (https=)
MX (1) MX2024000981A (https=)
TW (1) TW202421169A (https=)
WO (1) WO2023003922A1 (https=)

Cited By (6)

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Publication number Priority date Publication date Assignee Title
WO2025195381A1 (zh) * 2024-03-21 2025-09-25 成都先衍生物技术有限公司 一种靶向INHBE基因表达的siRNA及其缀合物和用途
WO2025201416A1 (zh) * 2024-03-27 2025-10-02 施能康生物医药（苏州）有限公司 靶向抑制素亚单位βE的核酸及其用途
WO2025228327A1 (zh) * 2024-04-28 2025-11-06 上海拓界生物医药科技有限公司 靶向ACVR2A的RNAi剂及其医药用途
CN120905229A (zh) * 2024-12-09 2025-11-07 成都先衍生物技术有限公司 一种靶向INHBE基因表达的siRNA及其缀合物和用途
WO2025247212A1 (zh) * 2024-05-27 2025-12-04 大睿生物医药科技(上海)有限公司 调控INHBE表达的dsRNA分子
WO2026007966A1 (zh) * 2024-07-01 2026-01-08 武汉人福创新药物研发中心有限公司 抑制INHBE基因表达的siRNA、偶联物及其应用

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EP4674965A1 (en) * 2023-03-02 2026-01-07 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting inhibin ?e, sirna conjugate, and medical use thereof
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CN121752722A (zh) * 2023-08-21 2026-03-27 苏州炫景生物科技有限公司 靶向inhbe基因的双链寡核苷酸、缀合物、组合物及其用途
IL326882A (en) 2023-08-30 2026-04-01 Arrowhead Pharmaceuticals Inc RNAi agents for inhibiting expression of inhibitory subunit beta E (INHBE), their pharmaceutical compositions and methods of use
WO2025064660A2 (en) * 2023-09-21 2025-03-27 Alnylam Pharmaceuticals, Inc. Activin a receptor type 1c (acvr1c) irna compositions and methods of use thereof
WO2025082057A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 抑制抑制素Beta E基因表达的抑制剂及其用途
WO2025137390A1 (en) * 2023-12-20 2025-06-26 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of activin receptor-like kinase 7 (alk7), compositions thereof, and methods of use
TW202525307A (zh) * 2023-12-21 2025-07-01 大陸商上海舶望製藥有限公司 抑制抑制素亞基βE（INHBE）的表達的組合物和方法
WO2025157269A1 (zh) * 2024-01-26 2025-07-31 康哲研发有限公司 双链siRNA及其缀合物的应用
WO2025185730A1 (zh) * 2024-03-08 2025-09-12 上海拓界生物医药科技有限公司 靶向INHBE的RNAi剂
WO2025193754A2 (en) * 2024-03-11 2025-09-18 Basecure Therapeutics Llc Compositions and methods for inhibition of expression of inhibin subunit beta e (inhbe) genes
WO2025223537A1 (zh) * 2024-04-26 2025-10-30 信达生物制药(苏州)有限公司 一种dsRNA、其应用及制备方法
WO2025228441A2 (en) * 2024-04-30 2025-11-06 Sanegene Bio Usa Inc. Small interfering rna targeting inhbe and uses thereof
WO2025264948A2 (en) 2024-06-21 2025-12-26 Eli Lilly And Company Inhbe rna interference agents
WO2026021537A1 (en) * 2024-07-26 2026-01-29 Qilu Pharmaceutical Co., Ltd. iRNA COMPOSITION AND METHOD OF USING SAME

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