TW201920242A - Glp-2融合多肽及用於治療及預防胃腸病症之用途 - Google Patents

Glp-2融合多肽及用於治療及預防胃腸病症之用途 Download PDF

Info

Publication number
TW201920242A
TW201920242A TW107129366A TW107129366A TW201920242A TW 201920242 A TW201920242 A TW 201920242A TW 107129366 A TW107129366 A TW 107129366A TW 107129366 A TW107129366 A TW 107129366A TW 201920242 A TW201920242 A TW 201920242A
Authority
TW
Taiwan
Prior art keywords
glp
seq
peptide
amino acid
acid sequence
Prior art date
Application number
TW107129366A
Other languages
English (en)
Chinese (zh)
Inventor
科拉克 潘
安琪拉 諾頓
羅格 貝蒂娜 史塔克
孫可豐
Original Assignee
美商沙爾 Nps製藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商沙爾 Nps製藥有限公司 filed Critical 美商沙爾 Nps製藥有限公司
Publication of TW201920242A publication Critical patent/TW201920242A/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW107129366A 2017-08-22 2018-08-22 Glp-2融合多肽及用於治療及預防胃腸病症之用途 TW201920242A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762548601P 2017-08-22 2017-08-22
US62/548,601 2017-08-22
US201862621144P 2018-01-24 2018-01-24
US62/621,144 2018-01-24
US201862659394P 2018-04-18 2018-04-18
US62/659,394 2018-04-18

Publications (1)

Publication Number Publication Date
TW201920242A true TW201920242A (zh) 2019-06-01

Family

ID=65440156

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107129366A TW201920242A (zh) 2017-08-22 2018-08-22 Glp-2融合多肽及用於治療及預防胃腸病症之用途

Country Status (9)

Country Link
US (2) US20200199192A1 (enExample)
EP (1) EP3672621A4 (enExample)
JP (1) JP7249492B2 (enExample)
CN (1) CN111182916A (enExample)
AU (1) AU2018321841A1 (enExample)
BR (1) BR112020003736A2 (enExample)
CA (1) CA3071966A1 (enExample)
TW (1) TW201920242A (enExample)
WO (1) WO2019040399A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210355187A1 (en) * 2018-10-24 2021-11-18 Shire-Nps Pharmaceuticals, Inc. Glp-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ,インク. Gpr119アゴニスト
PH12022552277A1 (en) 2020-02-28 2024-03-04 Kallyope Inc Gpr40 agonists
EP4126004A1 (en) 2020-03-30 2023-02-08 Zealand Pharma A/S Agonist combination
CA3178994A1 (en) 2020-05-19 2021-11-25 Iyassu Sebhat Ampk activators
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ,インク. Ampkアクチベーター
WO2021263040A1 (en) * 2020-06-26 2021-12-30 Shire-Nps Pharmaceuticals, Inc. Stable peptibody formulations
CA3245162A1 (en) * 2022-03-03 2023-09-07 Univ Pennsylvania Viral vectors encoding fusion proteins, GLP-2 receptor agonists, and their uses in the treatment of short bowel syndrome
WO2024123812A1 (en) * 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases
WO2025106930A1 (en) * 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Circular polyribonucleotides encoding glucagon-like peptide 2 (glp-2) and uses thereof
WO2025162422A1 (zh) * 2024-01-31 2025-08-07 杭州先为达生物科技股份有限公司 胰高血糖素样肽2衍生物及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US5149636A (en) 1982-03-15 1992-09-22 Trustees Of Columbia University In The City Of New York Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4956288A (en) 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
US5643252A (en) 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
US20090175795A1 (en) * 2005-07-29 2009-07-09 Amprotein Corporation Chimeric therapeutic agents
WO2007067828A2 (en) * 2005-10-24 2007-06-14 Centocor, Inc. Glp-2 mimetibodies, polypeptides, compositions, methods and uses
JP5290177B2 (ja) 2006-08-31 2013-09-18 セントカー・インコーポレーテツド Glp−2ミメティボディ、ポリペプチド、組成物、方法および用途
US8580922B2 (en) 2011-03-04 2013-11-12 Shire Human Genetic Therapies, Inc. Peptide linkers for polypeptide compositions and methods for using same
PT2755675T (pt) * 2011-09-12 2018-10-11 Amunix Operating Inc Composições de péptido semelhante a glucagão-2 e métodos para produzir e utilizar as mesmas
KR101895047B1 (ko) 2011-12-30 2018-09-06 한미사이언스 주식회사 면역글로불린 단편을 이용한 위치 특이적 글루카곤 유사 펩타이드-2 약물 결합체
CN106029087A (zh) * 2013-12-20 2016-10-12 印第安纳大学研究及科技有限公司 脂质化肠降血糖素受体配体人免疫球蛋白fc区融合多肽
KR101825048B1 (ko) * 2014-12-31 2018-02-05 주식회사 제넥신 GLP 및 면역글로불린 하이브리드 Fc 융합 폴리펩타이드 및 이의 용도
CN107987170B (zh) * 2016-10-27 2018-12-18 浙江道尔生物科技有限公司 一种用于治疗肠道疾病的融合蛋白
KR102825098B1 (ko) * 2017-11-06 2025-06-26 다케다 야쿠힌 고교 가부시키가이샤 수술전, 수술동안 또는 수술후 투여용 glp-2 유사체 및 펩티바디

Also Published As

Publication number Publication date
CA3071966A1 (en) 2019-02-28
JP7249492B2 (ja) 2023-03-31
EP3672621A1 (en) 2020-07-01
EP3672621A4 (en) 2021-11-24
US20230031280A1 (en) 2023-02-02
JP2020531030A (ja) 2020-11-05
US20200199192A1 (en) 2020-06-25
AU2018321841A1 (en) 2020-02-20
WO2019040399A1 (en) 2019-02-28
BR112020003736A2 (pt) 2020-09-08
CN111182916A (zh) 2020-05-19

Similar Documents

Publication Publication Date Title
TW201920242A (zh) Glp-2融合多肽及用於治療及預防胃腸病症之用途
CN103649127B (zh) 用于代谢病症和疾病治疗的组合物、应用和方法
TWI436776B (zh) Fgf21突變體及其用途
ES2932861T3 (es) Composiciones de IL-22 Fc y procedimientos de uso
CN114129709A (zh) 包含肽变异体的药物组合物及其使用方法
JP2021517584A (ja) 増殖分化因子15アゴニスト化合物およびその使用方法
AU2017358289A1 (en) Pharmaceutical composition for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis comprising fusion proteins
CN112839952A (zh) 包含基于pd-1的嵌合蛋白的组合疗法
KR20190124247A (ko) Csf1r-기반 키메라 단백질
AU2016332062A1 (en) Treatment of bile acid disorders
US20180028612A1 (en) Compositions and methods of using a soluble TNF-alpha receptor modified for increased half-life
TW202440627A (zh) Tnfr2結合多肽及使用方法
CN112912384A (zh) 组合疗法
EP4301771A2 (en) Mutant pd-1 extracellular domains
WO2023092324A1 (zh) 多特异性配体结合分子及其应用
TW202029979A (zh) Glp-2融合多肽及用於治療及預防胃腸病症之用途
HK40029773A (en) Glp-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions
CN108601819B (zh) 用死亡受体激动剂改善系统性硬化症
HK1258208B (en) Ameliorating systemic sclerosis with death receptor agonists