TW201738372A - 類胡蘿蔔素的製造方法 - Google Patents

類胡蘿蔔素的製造方法 Download PDF

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TW201738372A
TW201738372A TW106110500A TW106110500A TW201738372A TW 201738372 A TW201738372 A TW 201738372A TW 106110500 A TW106110500 A TW 106110500A TW 106110500 A TW106110500 A TW 106110500A TW 201738372 A TW201738372 A TW 201738372A
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Taiwan
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amino acid
carotenoid
variant
enzyme
gene
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TW106110500A
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English (en)
Chinese (zh)
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永井秀忠
佐藤渉
高橋季之
佐藤温美
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捷客斯能源股份有限公司
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    • C12P23/00Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
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    • C12Y205/01086Trans,polycis-decaprenyl diphosphate synthase (2.5.1.86)
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    • C12Y202/01Transketolases and transaldolases (2.2.1)
    • C12Y202/010071-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)
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    • C12Y205/00Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01091All-trans-decaprenyl-diphosphate synthase (2.5.1.91)

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TW106110500A 2016-03-31 2017-03-29 類胡蘿蔔素的製造方法 TW201738372A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2016071303A JP6357186B2 (ja) 2016-03-31 2016-03-31 カロテノイドの製造方法

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TW201738372A true TW201738372A (zh) 2017-11-01

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US (1) US11268121B2 (enExample)
EP (1) EP3441464A4 (enExample)
JP (1) JP6357186B2 (enExample)
KR (1) KR102316650B1 (enExample)
CN (1) CN109715796B (enExample)
AU (1) AU2017245123B2 (enExample)
CA (1) CA3018942A1 (enExample)
TW (1) TW201738372A (enExample)
WO (1) WO2017171098A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6357186B2 (ja) * 2016-03-31 2018-07-11 Jxtgエネルギー株式会社 カロテノイドの製造方法
JPWO2020059745A1 (ja) * 2018-09-20 2021-09-24 Eneos株式会社 脳腫瘍またはそれに起因する症状の抑制または治療のための組成物
KR102323664B1 (ko) * 2019-04-25 2021-11-08 부경대학교 산학협력단 파라코커스 속 균주를 이용한 사료첨가제
CN110438033B (zh) * 2019-07-02 2021-04-27 浙江工业大学 一种油脂降解菌、应用及油脂降解方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK199887D0 (da) 1987-04-15 1987-04-15 Danisco Bioteknologi As Gaerstamme
JP3242531B2 (ja) 1993-07-22 2001-12-25 日石三菱株式会社 カロチノイド色素の製造方法
US5607839A (en) 1993-07-22 1997-03-04 Nippon Oil Company, Ltd. Bacteria belonging to new genus process for production of carotenoids using same
US5935808A (en) 1997-07-29 1999-08-10 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Carotenoid-producing bacterial species and process for production of carotenoids using same
JP4280627B2 (ja) * 2001-06-06 2009-06-17 ディーエスエム アイピー アセッツ ビー.ブイ. 改善されたイソプレノイド産生法
US7232665B2 (en) * 2002-12-19 2007-06-19 E. I. Du Pont De Nemours And Company Mutations affecting carotenoid production
US20040219629A1 (en) * 2002-12-19 2004-11-04 Qiong Cheng Increasing carotenoid production in bacteria via chromosomal integration
US7741070B2 (en) * 2003-12-24 2010-06-22 Massachusetts Institute Of Technology Gene targets for enhanced carotenoid production
ES2440665T3 (es) 2004-06-04 2014-01-29 Kirin Holdings Kabushiki Kaisha Método para producir astaxantina o un producto metabólico de la misma utilizando genes de carotenoide cetolasa y carotenoide hidroxilasa
CN101044243B (zh) * 2004-08-19 2011-12-28 帝斯曼知识产权资产管理有限公司 类异戊二烯的生产方法
US20060219629A1 (en) 2005-03-31 2006-10-05 Andrew Noestheden Oil and water separator
JP2006340676A (ja) 2005-06-10 2006-12-21 Asahi Kasei Corp アスタキサンチンの製造方法
JP2007097584A (ja) 2005-09-06 2007-04-19 Yamaha Motor Co Ltd アスタキサンチン含有量の高い緑藻およびその製造方法
US20070054351A1 (en) 2005-09-06 2007-03-08 Yamaha Hatsudoki Kabushiki Kaisha Green algae having a high astaxanthin content and method for producing the same
JP2007143492A (ja) 2005-11-29 2007-06-14 Tosoh Corp カロテノイド類の生産方法
JP2007244205A (ja) 2006-03-13 2007-09-27 Tosoh Corp カロテノイド類の製造方法
US7422873B2 (en) * 2006-03-31 2008-09-09 E.I. Du Pont De Nemours And Company Mutant carotenoid ketolase
JP5066385B2 (ja) 2007-04-12 2012-11-07 電源開発株式会社 アスタキサンチン産生細菌、細菌培養物およびアスタキサンチンの製造方法
KR20090062566A (ko) * 2007-12-13 2009-06-17 한국원자력연구원 카로티노이드를 고농도로 생산하는 미생물 및 이를 이용한카로티노이드 생산 방법
KR100936216B1 (ko) * 2008-01-03 2010-01-11 한국과학기술원 코엔자임 q10 생성능을 가지는 재조합 미생물 및 이를이용한 코엔자임 q10의 제조방법
NZ592213A (en) 2008-10-17 2012-10-26 Jx Nippon Oil & Energy Corp Carotenoid fermentation method using bacterium strain E-396 (FERM BP-4283) or A-581-1 (FERM BP-4671)
JP5762691B2 (ja) 2010-03-15 2015-08-12 Jx日鉱日石エネルギー株式会社 発酵によるアスタキサンチン製造方法
EP2444415A1 (en) 2010-10-20 2012-04-25 Genoplante-Valor 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis
JP2012139164A (ja) 2010-12-28 2012-07-26 Tosoh Corp 微生物を用いたカロテノイドの製造法
AR095746A1 (es) * 2012-11-21 2015-11-11 Chromatin Inc Modificación de plantas para producir farneseno y otros terpenoides
WO2015189428A1 (en) * 2014-06-13 2015-12-17 Deinove Method of producing terpenes or terpenoids
JP6357186B2 (ja) * 2016-03-31 2018-07-11 Jxtgエネルギー株式会社 カロテノイドの製造方法

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Publication number Publication date
EP3441464A1 (en) 2019-02-13
CN109715796B (zh) 2021-04-09
JP2017176099A (ja) 2017-10-05
US11268121B2 (en) 2022-03-08
WO2017171098A1 (ja) 2017-10-05
AU2017245123B2 (en) 2023-05-25
KR20180131543A (ko) 2018-12-10
CA3018942A1 (en) 2017-10-05
EP3441464A4 (en) 2020-01-08
US20200299747A1 (en) 2020-09-24
AU2017245123A1 (en) 2018-10-11
CN109715796A (zh) 2019-05-03
JP6357186B2 (ja) 2018-07-11
KR102316650B1 (ko) 2021-10-22

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