TW201706274A - 吡咯［２，３－ｄ］嘧啶基、吡咯［２，３－ｂ］吡基和吡咯［２，３－ｂ］吡啶基丙烯醯胺及其環氧化物 - Google Patents

Info

Publication number

TW201706274A

TW201706274A TW105113139A TW105113139A TW201706274A TW 201706274 A TW201706274 A TW 201706274A TW 105113139 A TW105113139 A TW 105113139A TW 105113139 A TW105113139 A TW 105113139A TW 201706274 A TW201706274 A TW 201706274A

Authority

TW

Taiwan

Prior art keywords

pyrrole

pyridyl

propenyl

carbamamine

amino

Prior art date

2015-05-01

Links

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• 150000002118 epoxides Chemical class 0.000 title claims abstract description 11
• NMHJLFCSJVRQPZ-UHFFFAOYSA-N N-(1H-pyrrolo[2,3-b]pyridin-2-yl)prop-2-enamide Chemical class C(C=C)(=O)NC1=CC=2C(=NC=CC=2)N1 NMHJLFCSJVRQPZ-UHFFFAOYSA-N 0.000 title abstract 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 117
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• 125000004076 pyridyl group Chemical group 0.000 claims description 645
• 125000000217 alkyl group Chemical group 0.000 claims description 456
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 295
• 125000003118 aryl group Chemical group 0.000 claims description 174
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 142
• 125000006017 1-propenyl group Chemical group 0.000 claims description 140
• 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 133
• 125000001072 heteroaryl group Chemical group 0.000 claims description 128
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 120
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• 150000002431 hydrogen Chemical class 0.000 claims description 61
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 56
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• GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims description 51
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 50
• RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims description 47
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