JP6761815B2 - ピロロ［２，３−ｄ］ピリミジニル、ピロロ［２，３−ｂ］ピラジニル、ピロロ［２，３−ｂ］ピリジニルアクリルアミド、およびそのエポキシド - Google Patents

ピロロ［２，３−ｄ］ピリミジニル、ピロロ［２，３−ｂ］ピラジニル、ピロロ［２，３−ｂ］ピリジニルアクリルアミド、およびそのエポキシド Download PDF

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JP6761815B2
JP6761815B2 JP2017556831A JP2017556831A JP6761815B2 JP 6761815 B2 JP6761815 B2 JP 6761815B2 JP 2017556831 A JP2017556831 A JP 2017556831A JP 2017556831 A JP2017556831 A JP 2017556831A JP 6761815 B2 JP6761815 B2 JP 6761815B2
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linear
amino
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straight
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JP2018514560A5 (enExample
JP2018514560A (ja
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ソラレンセン アトリ
ソラレンセン アトリ
フランク ブラウン マシュー
フランク ブラウン マシュー
カジミーロ−ガルシア アウグスティン
カジミーロ−ガルシア アウグスティン
チェ イエ
チェ イエ
マーク　エドワード　フラナガン
エドワード フラナガン マーク
マシュー ギルバート アダム
マシュー ギルバート アダム
メリル ヘイワード マシュー
メリル ヘイワード マシュー
テリェツ ジャン−バプティスト
テリェツ ジャン−バプティスト
ジャル アンワラ レヨムンド
ジャル アンワラ レヨムンド
アイ．トルヒーリョ ジョン
アイ．トルヒーリョ ジョン
シー リャン シドニー
シー リャン シドニー
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ファイザー・インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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JP2017556831A 2015-05-01 2016-04-19 ピロロ［２，３−ｄ］ピリミジニル、ピロロ［２，３−ｂ］ピラジニル、ピロロ［２，３−ｂ］ピリジニルアクリルアミド、およびそのエポキシド Expired - Fee Related JP6761815B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562155824P 2015-05-01 2015-05-01
US62/155,824 2015-05-01
PCT/IB2016/052220 WO2016178110A1 (en) 2015-05-01 2016-04-19 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof

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JP2018514560A JP2018514560A (ja) 2018-06-07
JP2018514560A5 JP2018514560A5 (enExample) 2019-05-23
JP6761815B2 true JP6761815B2 (ja) 2020-09-30

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US (1) US10703756B2 (enExample)
EP (1) EP3288943B1 (enExample)
JP (1) JP6761815B2 (enExample)
AR (1) AR104461A1 (enExample)
CA (1) CA2984183C (enExample)
ES (1) ES2928757T3 (enExample)
TW (1) TW201706274A (enExample)
WO (1) WO2016178110A1 (enExample)

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WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
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CR20200464A (es) 2018-03-08 2021-04-14 Incyte Corp Compuestos diólicos de aminopirazina como inhibidores de pi3k-y
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
BR112021001709A2 (pt) 2018-08-01 2021-05-04 Araxes Pharma Llc compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer
JP7591500B2 (ja) * 2018-08-10 2024-11-28 アクラリス セラピューティクス，インコーポレイテッド ピロロピリミジンｉｔｋ阻害剤
CN113498352A (zh) * 2019-01-23 2021-10-12 施万生物制药研发Ip有限责任公司 作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪
CN112430235B (zh) * 2019-08-26 2024-04-05 东莞市东阳光仿制药研发有限公司 一种pf-06651600中间体的制备方法
KR102228668B1 (ko) * 2019-10-08 2021-03-17 (주)부흥산업사 메틸피퍼리딘 아미노피롤로 피리미딘의 제조방법
CN111407767B (zh) * 2020-03-28 2021-05-25 中山大学 一种磺胺间甲氧嘧啶衍生物在制备抗肿瘤药物中的应用
WO2023151069A1 (zh) * 2022-02-14 2023-08-17 湖南南新制药股份有限公司 吡咯并[2,3-d]六元杂芳环衍生物、其制备方法和药物用途
CN119060058A (zh) * 2024-08-21 2024-12-03 武汉九州钰民医药科技有限公司 一种甲苯磺酸利特昔替尼的合成方法

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CA2984183A1 (en) 2016-11-10
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TW201706274A (zh) 2017-02-16
WO2016178110A1 (en) 2016-11-10
EP3288943B1 (en) 2022-09-28
US20190002466A1 (en) 2019-01-03
US10703756B2 (en) 2020-07-07
EP3288943A1 (en) 2018-03-07
JP2018514560A (ja) 2018-06-07

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