CA2984183C - Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof - Google Patents

Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof Download PDF

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Publication number
CA2984183C
CA2984183C CA2984183A CA2984183A CA2984183C CA 2984183 C CA2984183 C CA 2984183C CA 2984183 A CA2984183 A CA 2984183A CA 2984183 A CA2984183 A CA 2984183A CA 2984183 C CA2984183 C CA 2984183C
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Prior art keywords
pyrrolo
carboxamide
pyrazine
acryloy1
acryloylpiperidin
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CA2984183A
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English (en)
French (fr)
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CA2984183A1 (en
Inventor
Atli Thorarensen
Matthew Frank Brown
Agustin Casimiro-Garcia
Ye Che
Mark Edward Flanagan
Adam Matthew Gilbert
Matthew Merrill Hayward
Jean-Baptiste Telliez
Rayomand Jal Unwalla
John I. Trujillo
Sidney Xi Liang
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Pfizer Inc
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Pfizer Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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CA2984183A 2015-05-01 2016-04-19 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof Active CA2984183C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562155824P 2015-05-01 2015-05-01
US62/155,824 2015-05-01
PCT/IB2016/052220 WO2016178110A1 (en) 2015-05-01 2016-04-19 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof

Publications (2)

Publication Number Publication Date
CA2984183A1 CA2984183A1 (en) 2016-11-10
CA2984183C true CA2984183C (en) 2021-11-09

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ID=55863136

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CA2984183A Active CA2984183C (en) 2015-05-01 2016-04-19 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof

Country Status (8)

Country Link
US (1) US10703756B2 (enExample)
EP (1) EP3288943B1 (enExample)
JP (1) JP6761815B2 (enExample)
AR (1) AR104461A1 (enExample)
CA (1) CA2984183C (enExample)
ES (1) ES2928757T3 (enExample)
TW (1) TW201706274A (enExample)
WO (1) WO2016178110A1 (enExample)

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JP2022518741A (ja) 2019-01-23 2022-03-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ＪＡＫキナーゼ阻害剤としてのイミダゾ［１，５－ａ］ピリジン、１，２，４－トリアゾロ［４，３－ａ］ピリジンおよびイミダゾ［１，５－ａ］ピラジン
CN112430235B (zh) * 2019-08-26 2024-04-05 东莞市东阳光仿制药研发有限公司 一种pf-06651600中间体的制备方法
KR102228668B1 (ko) * 2019-10-08 2021-03-17 (주)부흥산업사 메틸피퍼리딘 아미노피롤로 피리미딘의 제조방법
CN111407767B (zh) * 2020-03-28 2021-05-25 中山大学 一种磺胺间甲氧嘧啶衍生物在制备抗肿瘤药物中的应用
WO2023151069A1 (zh) * 2022-02-14 2023-08-17 湖南南新制药股份有限公司 吡咯并[2,3-d]六元杂芳环衍生物、其制备方法和药物用途
CN119060058A (zh) * 2024-08-21 2024-12-03 武汉九州钰民医药科技有限公司 一种甲苯磺酸利特昔替尼的合成方法

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JP2018514560A (ja) 2018-06-07
EP3288943A1 (en) 2018-03-07
US20190002466A1 (en) 2019-01-03
CA2984183A1 (en) 2016-11-10
EP3288943B1 (en) 2022-09-28
WO2016178110A1 (en) 2016-11-10
TW201706274A (zh) 2017-02-16
ES2928757T3 (es) 2022-11-22
JP6761815B2 (ja) 2020-09-30
US10703756B2 (en) 2020-07-07
AR104461A1 (es) 2017-07-19

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