ES2928757T3 - Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa - Google Patents

Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa Download PDF

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Publication number
ES2928757T3
ES2928757T3 ES16719917T ES16719917T ES2928757T3 ES 2928757 T3 ES2928757 T3 ES 2928757T3 ES 16719917 T ES16719917 T ES 16719917T ES 16719917 T ES16719917 T ES 16719917T ES 2928757 T3 ES2928757 T3 ES 2928757T3
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mmol
pyrrolo
tert
reaction
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Inventor
Atli Thorarensen
Matthew Frank Brown
Agustin Casimiro-Garcia
Ye Che
Mark Edward Flanagan
Adam Matthew Gilbert
Matthew Merrill Hayward
Jean-Baptiste Telliez
Rayomand Jal Unwalla
John I Trujillo
Sidney Xi Liang
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Pfizer Inc
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Pfizer Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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ES16719917T 2015-05-01 2016-04-19 Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa Active ES2928757T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562155824P 2015-05-01 2015-05-01
PCT/IB2016/052220 WO2016178110A1 (en) 2015-05-01 2016-04-19 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof

Publications (1)

Publication Number Publication Date
ES2928757T3 true ES2928757T3 (es) 2022-11-22

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ID=55863136

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ES16719917T Active ES2928757T3 (es) 2015-05-01 2016-04-19 Acrilamidas de pirrolo[2,3-b]pirazinilo y epóxidos de las mismas como inhibidores de la Janus Quinasa

Country Status (8)

Country Link
US (1) US10703756B2 (enExample)
EP (1) EP3288943B1 (enExample)
JP (1) JP6761815B2 (enExample)
AR (1) AR104461A1 (enExample)
CA (1) CA2984183C (enExample)
ES (1) ES2928757T3 (enExample)
TW (1) TW201706274A (enExample)
WO (1) WO2016178110A1 (enExample)

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CN110382482A (zh) * 2017-01-26 2019-10-25 亚瑞克西斯制药公司 稠合的杂-杂二环化合物及其使用方法
US11358959B2 (en) 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
US11957931B2 (en) * 2017-04-26 2024-04-16 Yale University Compositions and methods for treating vitiligo
CN110831933A (zh) 2017-05-25 2020-02-21 亚瑞克西斯制药公司 喹唑啉衍生物作为突变kras、hras或nras的调节剂
EP3652169A1 (en) * 2017-08-01 2020-05-20 Theravance Biopharma R&D IP, LLC Pyrazolo and triazolo bicyclic compounds as jak kinase inhibitors
MD3762368T2 (ro) 2018-03-08 2022-07-31 Incyte Corp Compuși diol aminopirazină ca inhibitori ai PI3K-Y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
BR112021001709A2 (pt) 2018-08-01 2021-05-04 Araxes Pharma Llc compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer
EP3833350A4 (en) * 2018-08-10 2022-05-18 Aclaris Therapeutics, Inc. Pyrrolopyrimidine itk inhibitors
JP2022518741A (ja) 2019-01-23 2022-03-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ＪＡＫキナーゼ阻害剤としてのイミダゾ［１，５－ａ］ピリジン、１，２，４－トリアゾロ［４，３－ａ］ピリジンおよびイミダゾ［１，５－ａ］ピラジン
CN112430235B (zh) * 2019-08-26 2024-04-05 东莞市东阳光仿制药研发有限公司 一种pf-06651600中间体的制备方法
KR102228668B1 (ko) * 2019-10-08 2021-03-17 (주)부흥산업사 메틸피퍼리딘 아미노피롤로 피리미딘의 제조방법
CN111407767B (zh) * 2020-03-28 2021-05-25 中山大学 一种磺胺间甲氧嘧啶衍生物在制备抗肿瘤药物中的应用
WO2023151069A1 (zh) * 2022-02-14 2023-08-17 湖南南新制药股份有限公司 吡咯并[2,3-d]六元杂芳环衍生物、其制备方法和药物用途
CN119060058A (zh) * 2024-08-21 2024-12-03 武汉九州钰民医药科技有限公司 一种甲苯磺酸利特昔替尼的合成方法

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CA2984183C (en) 2021-11-09
JP2018514560A (ja) 2018-06-07
EP3288943A1 (en) 2018-03-07
US20190002466A1 (en) 2019-01-03
CA2984183A1 (en) 2016-11-10
EP3288943B1 (en) 2022-09-28
WO2016178110A1 (en) 2016-11-10
TW201706274A (zh) 2017-02-16
JP6761815B2 (ja) 2020-09-30
US10703756B2 (en) 2020-07-07
AR104461A1 (es) 2017-07-19

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