TW201620523A - Composition containing vitamin b6 - Google Patents

Abstract

To provide a composition containing a vitamin B6 compound in which the stability of the vitamin B6 compound to light is improved, and a method by which a vitamin B6 compound in a composition containing the vitamin B6 compound and a plant extract is stabilized against light. A composition contains at least one compound selected from the group consisting of vitamin B6 and salts thereof and further contains a plant extract, the composition having a chlorophyll content less than 0.15 ppm.

Description

Composition containing vitamin B6

The present invention relates to a composition comprising at least one compound selected from the group consisting of vitamin B6 and the salts (hereinafter collectively referred to as "vitamin B6 compound"), and a plant extract. Further, the present invention relates to a method for stabilizing a vitamin B6 compound in a composition comprising a vitamin B6 compound and a plant extract.

As vitamin B6, there are pyridoxine, pyridoxal and pyridoxamine. Vitamin B6 is a coenzyme of amino acid decarboxylase and aminotransferase in vivo. It is a component related to protein metabolism. It is widely used in medicines, hair restorers, for physical fatigue, eye fatigue, and nutritional supplements during pregnancy. Healthy food, etc.

If the vitamin B6 is exposed to light, it will decompose over time, so it must be stored in a light-shielded manner. Therefore, previous studies have various compositions that stabilize vitamin B6. For example, eye drops formulated with flavin adenine dinucleotide, pyridoxine and specific antioxidants (Patent Document 1), eye drops formulated with pyridoxine hydrochloride and berberine chloride are known ( Patent Document 2), an eye drop containing vitamin B6, oxymetazoline or a salt thereof, and a boric acid buffer (Patent Document 3).

On the other hand, in order to stably hold a preparation containing a pharmacologically active substance which is unstable to light, a light-shielding material (a brown container, an aluminum container, etc.) is used as a packaging material for containing the preparation, or a container is used for mixing or coating the ultraviolet absorbent. The light-shielding method, or a light-shielding method in which a container filled with a preparation is stored in a paper box during circulation.

However, with respect to the product obtained by the manufacturing step in which the container or the packaging material cannot be used, the active ingredient is easily decomposed by light. Also, for example, hair tonics are within 1 to several months. For the characteristics of the product to be used continuously for a long period of time, a transparent or translucent container which can confirm the amount of use or the remaining amount is used in consideration of the convenience of the user. Therefore, these products are stored in a dark place or stored in a carton, and efforts are made to maintain the photostability of the active ingredient. Further, the container coated with the ultraviolet absorber can maintain the transparency of the container to some extent, but on the other hand, it is not completely shielded from light, the light stability of the active ingredient is insufficient, or the manufacturing cost of the container is increased. problem. Moreover, such a light-shielding method by a packaging material also has a problem that the stability of light in the manufacturing step cannot be guaranteed. Moreover, after the product is unsealed, there may be cases where the user does not use the light-shielding carton, and thus the previous shading method may not be called an effective method. Further, depending on the product, it is not practical to use the preparation only under light-shielding, and the preparation is taken out from the container and used for application sites such as scalp, skin, and mucous membrane. Therefore, there is a problem that the active ingredient is exposed to light, and the active ingredient is easily decomposed at the application site.

Therefore, in order to fully utilize the excellent effect of vitamin B6 in various preparations and products, it is required to increase the stability of vitamin B6 to light without limiting the amount of vitamin B6 and the application target.

[Previous Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. Hei 8-104636

[Patent Document 2] Japanese Patent Laid-Open Publication No. 2001-48780

[Patent Document 3] Japanese Patent Laid-Open Publication No. 2006-151969

It is an object of the present invention to provide a composition comprising a vitamin B6 compound having improved stability of light to a vitamin B6 compound.

Further, it is an object of the present invention to provide a method for stabilizing a vitamin B6 compound in a composition comprising a vitamin B6 compound and a plant extract.

The present inventors have conducted various studies in order to solve the above problems, and as a result, it has been found that chlorophyll contained in a plant extract lowers the light stability of vitamin B6. Previously, chlorophyll was known as a substance involved in photosynthesis of plants, cyanobacteria, algae, etc., but it was not known that it would affect the photostability of other components such as vitamin B6 due to co-regulation of chlorophyll.

The present invention has been diligently studied based on these findings, and has found that the concentration of chlorophyll which affects the photostability of the vitamin B6 compound is 0.15 ppm or more, and is completed, and includes the following embodiments.

Item 1. A composition comprising at least one compound selected from the group consisting of vitamin B6 and a salt thereof, and a plant extract, and the chlorophyll content in the composition is less than 0.15 ppm.

The composition according to the above item 1, wherein the plant extract contains at least one compound selected from the group consisting of vitamin B6 and a salt thereof, and the compound is contained in the plant extract. Or a mixture of the plant extract and at least one compound selected from the group consisting of exogenous vitamin B6 and the salts thereof.

The composition according to the above item 1, wherein the plant extract contains no at least one compound selected from the group consisting of vitamin B6 and the salts, and the above is selected from the group consisting of vitamin B6 and the like. At least one compound selected from the group consisting of salts is additionally added to the composition.

The composition according to any one of items 1 to 3, wherein the chlorophyll is at least one chlorophyll selected from the group consisting of chlorophyll a and chlorophyll b.

The composition according to any one of the above items 1 to 4, wherein the at least one compound selected from the group consisting of vitamin B6 and the salts is pyridoxine hydrochloride.

The composition of any one of the above items 1 to 5, wherein the plant extract is an extract extracted from a plant of a green plant.

The composition according to any one of items 1 to 6, which is a hair growth agent, an eye drop, a nasal drop, an eye wash, a nasal wash or a contact lens.

Item 8. A method for photostabilizing, characterized in that it comprises light stabilization of a compound selected from the group consisting of at least one compound selected from the group consisting of vitamin B6 and salts thereof, and a composition of a plant extract. Method, and The content of chlorophyll in the composition was set to be less than 0.15 ppm.

The composition of the present invention containing a vitamin B6 compound enhances the stability of the vitamin B6 compound to light.

Further, by using the method of the present invention, the stability of the vitamin B6 compound in the composition containing the vitamin B6 compound and the plant extract can be improved.

The composition of the present invention is characterized by containing a vitamin B6 compound and a plant extract, and the chlorophyll content in the composition is less than 0.15 ppm.

(1) Composition (1-1) Vitamin B6 compound

The so-called vitamin B6 compound means vitamin B6 or a salt thereof. Here, examples of the vitamin B6 include pyridoxine, pyridoxal, and pyridoxamine. Further, examples of the salt include a hydrochloride, a sulfate, a nitrate, a hydrobromide, a phosphate, and the like, but are not particularly limited. As the vitamin B6 compound, pyridoxine hydrochloride is preferred in terms of excellent eye fatigue improvement effect. These vitamin B6 compounds may be used singly or in combination of two or more.

The vitamin B6 compound is not particularly limited in its source. For example, it may be produced by a synthetic product, or may be a natural product derived from a plant or the like. Furthermore, vitamin B6 compounds are available. Obtained commercially.

The vitamin B6 compound contained in the composition of the present invention may be an intrinsic vitamin B6 compound contained in the plant extract of the composition, or may be additionally added to the present invention separately from the plant extract. The composition (exogenous vitamin B6 compound) may further be both (inclusive + exogenous vitamin B6 compound).

The ratio of the vitamin B6 compound in the composition of the present invention is not particularly limited as long as it is a ratio at which the action of the vitamin B6 compound can be obtained. Here, as the action effect of the vitamin B6 compound, it can be mentioned that it helps the energy production from the protein and the health maintenance of the skin or mucous membrane, seborrheic dermatitis or eczema, acne, rough skin and other skin diseases, skin cell activation. Effects, improvement of dandruff or itching, improvement of erythema caused by ultraviolet rays, anti-allergic effect, improvement of physical fatigue, improvement of eye fatigue, etc. Therefore, the blending amount thereof is suitably prepared according to the use of the composition of the present invention (for example, a dermatological preparation such as a hair restorer and a cosmetic, an eye drop, a nasal drop, an eye wash, a nasal wash or a contact lens). . The usual ratio of the vitamin B6 compound is usually about 0.0001 to 1% by weight, preferably about 0.02 to 0.5% by weight, particularly preferably about 0.05 to 0.2% by weight, and in the case of a hair tonic, it is usually 0.02. ~0.5% by weight or so, preferably about 0.05 to 0.2% by weight; in the case of a cosmetic, it is usually about 0.0001 to 5% by weight, preferably about 0.05 to 0.2% by weight; in eye drops or drops In the case of a nasal medicine, it is usually about 0.005 to 0.2% by weight, preferably about 0.01 to 0.1% by weight. In the case of an eye wash or a nasal wash, it is usually about 0.0005 to 0.02% by weight. It is preferably about 0.001 to 0.01% by weight; in the case of a contact lens agent, it is usually about 0.0005 to 1% by weight, preferably about 0.001 to 0.01% by weight.

(1-2) Chlorophyll

The composition of the present invention is characterized in that the content of chlorophyll is less than 0.15 ppm.

Chlorophyll, also known as chlorophyll, is a porphyrin-based pigment contained in plants and is a chemical substance related to photosynthesis.

As the chlorophyll contained in plants, there are mainly chlorophyll a and b.

Therefore, when the amount of chlorophyll contained in the composition is in the case of a plurality of chlorophyll, it means the total amount thereof, and when it contains only one of them, it means the amount of the chlorophyll to be formulated.

The content of chlorophyll in the composition is preferably less than about 0.1 ppm, and particularly preferably less than about 0.05 ppm. Further, in the composition of the present invention, chlorophyll may be contained in a range which does not impair the effects of the present invention, and chlorophyll may be contained in an amount of about 0.001 ppm.

(1-3) Plant extract and preparation method thereof

The plant extracts to which the present invention is directed include both those which do not contain a vitamin B6 compound (a plant extract which does not contain a vitamin B6 compound), and those which contain a vitamin B6 compound (a plant extract containing a vitamin B6 compound).

In addition, the plant extract to be used in the present invention is obtained by leaching a plant body into an extraction solvent (water, ethanol, etc.) as described below, and concentrating the liquid (soft extract or dried extract). Does not refer to the chemical substance (isolated) itself extracted from the plant body.

From the viewpoint of remarkably exerting the effects of the present invention, the plant extract is preferably a plant extract extracted from a plant of a green plant. In summary, a green plant line is characterized by a system of vegetatives with typical green vegetatives by having chlorophyll (chlorophyll a and/or b) associated with photosynthesis.

Specific examples of the plant include: aloe vera, tomorrow's leaves, catechu tea, sweet tea, esculenta, hollyhock, ginkgo, ramie, Coleus scutellarioides Benth, echinacea, large flower crape, short Wild sesame, watercress, olive, persimmon, brasil palm tree, tung tree, bear sedge, golden chamomile, clematis, mulberry, white mulberry, mandarin orange, lime, motherwort, ginger, peony, medicine, large Jujube, lime, grapefruit, houttuynia, mint, marguerite, licorice, stevia, sophora, moon peach, red sandalwood, black tea, hop, lemon balm, European mistletoe, St. John's wort, a bunch of red, red Winter dandelion, wood thief, Wannian grass, alfalfa, sleeping vegetables, white birch, arnica, chamomile, thyme, mallow, wheat, bitter root, scutellaria, purple root, safflower, clove, sugar cane, polymer grass, saponaria, perilla, eucalyptus, honeysuckle , European ivy, European hawthorn, western mint, sage, tea tree, Leigonggen, sweet tea, parsley, barley, witch hazel, medicinal wall grass, guava, loofah, alfalfa, grape, beech, hail, Marjoram, horse chestnut, big leaf moon orange, bee flower, yellow vanilla hibiscus, peach, bean sprout, eucalyptus, aphid, Asian cockroach, ivy, walnut, linden, rosemary, May AI, apocynum, lettuce, fennel , papaya, geranium, wormwood, candelilla, spatholobus, celery, garlic, lobelia, and shamrock. These plants are all green plants.

Among the above plant bodies, a plant extract extracted from at least one plant selected from the group consisting of aloe vera, sweet tea, tung tree, mulberry tree, white mulberry, jujube, and houttuynia cordata is preferred.

In the plant extract, the plant extract containing the vitamin B6 compound is preferably extracted from leaves or stems of at least one plant selected from the group consisting of tomorrow leaves, polymer grass, parsley, lettuce, celery and garlic. Plant extracts.

In the case of preparing the composition of the present invention, in the case of using a plant extract containing no vitamin B6 compound, the plant extract is used in combination with the above-mentioned vitamin B6 compound. That is, in this case, the composition of the present invention contains a plant extract containing no vitamin B6 compound and a vitamin B6 compound which is exogenous. On the other hand, in the case of preparing the composition of the present invention, when a plant extract containing a vitamin B6 compound is used, the plant extract containing the vitamin B6 compound can be directly used without additionally adding the above vitamin B6 compound, and It can be used in combination with a vitamin B6 compound. That is, in this case, the composition of the present invention contains a plant extract containing a vitamin B6 compound (including an inclusive vitamin B6 compound, does not contain an exogenous vitamin B6 compound), or a plant extract containing a vitamin B6-containing compound. And exotic vitamin B6 compounds.

The ratio of the plant extract formulated in the composition of the present invention is as long as it is available The ratio of the effect of the extract of the substance is not particularly limited. Here, the effect of the plant extract varies depending on the type of the plant, and a moisturizing effect can be cited. Therefore, the blending amount thereof is suitably prepared according to the use of the composition of the present invention (for example, a dermatological preparation such as a hair restorer and a cosmetic, an eye drop, a nasal drop, an eye wash, a nasal wash or a contact lens). .

The usual ratio of the plant extract is, for example, about 0.00001 to 5% by weight, preferably 0.0001 to 1% by weight, and particularly preferably about 0.005 to 0.1% by weight, based on the weight of the dried product. In the case of a dose, it is usually about 0.00001 to 5% by weight, preferably about 0.0001 to 1% by weight. In the case of an eye drop or a nasal drop, it is usually about 0.00001 to 1% by weight. Preferably, it is about 0.0001 to 0.1% by weight; in the case of an eye wash or a nasal wash, it is usually about 0.00001 to 1% by weight, preferably about 0.0001 to 0.1% by weight; in the case of a contact lens agent, It is usually about 0.00001 to 1% by weight, preferably about 0.0001 to 0.1% by weight.

Further, in the case of using a plant extract containing a vitamin B6 compound as a plant extract, it is preferred to adjust the ratio of the vitamin B6 compound in the composition (lower limit and upper limit) to adjust the blending ratio of the above plant extract.

The raw material of the plant extract can be directly used as a whole of the plant, and a part of the plant can also be used.

In general, chlorophyll is mainly contained in the leaves or stems of the plant, and therefore, the plant extract is preferably a plant extract extracted from a whole plant body containing leaves or stems, and more preferably from the viewpoint of exerting the effects of the present invention. Leaf and/or stem extract plant extract.

Hereinafter, all or part of the plant will be collectively referred to as "plant body".

In the extraction, a plant body (all of the plants or a part such as leaves, stems, roots, etc.) can be used as a raw state (undried matter), a dryer (dried matter), or a freezer (frozen). In addition, it is also possible to pulverize the undried, dried or frozen material of the plant body into a suitable large size. Small and powdered.

Examples of the method for producing the extract of the plant include a method in which the extraction step and the separation step are combined, a method in which the separation step is further combined in the above method, and the like, but the method is not limited thereto.

The extraction step is a step of extracting a component necessary for the extract from the plant body using an extraction solvent, and the extraction method or extraction conditions are not particularly limited.

The type of the extraction solvent is not particularly limited, and examples thereof include water, an organic solvent, and a mixed solvent thereof. Examples of the water include water at all temperatures such as cold water, normal temperature water, warm water, hot water, and water vapor, and may be subjected to sterilization treatment, ion exchange treatment, osmotic pressure adjustment, or buffering. The organic solvent is preferably a hydrophilic organic solvent, and for example, a carbon number of 1 to 5 monohydric alcohol (ethanol, methanol, propanol, isopropanol, etc.) or a polyhydric alcohol having 2 to 5 carbon atoms (glycerol or different) can be used. Examples of propylene glycol, propylene glycol, and 1,3-butylene glycol, esters (such as methyl acetate), and ketones (such as acetone). These hydrophilic organic solvents may be used alone or in combination of two or more. In the present invention, in terms of safety and extraction efficiency of the active ingredient, it is preferred to use at least one selected from the group consisting of water, ethanol, 1,3-butylene glycol, and a mixture thereof. Extraction solvent.

When a mixed solution of water and 1,3-butanediol is used as the extraction solvent, the content of 1,3-butanediol in the mixed solution is preferably about 0.1 to 70% by weight, more preferably 5~. It is about 60% by weight, and more preferably about 10 to 50% by weight.

When a mixed solution of water and ethanol is used as the extraction solvent, the content of ethanol in the mixed solution is preferably from about 0.1 to 99.5% by weight, more preferably from about 5 to 95% by weight, still more preferably from 50 to 95. The weight is about 60% to about 90% by weight.

Examples of the extraction method include dip extraction, stirring extraction, reflux extraction, shaking extraction, and ultrasonic extraction. As extraction conditions, room temperature extraction, heat extraction (also referred to as warm extraction), pressure extraction, and super extraction are mentioned. Critical extraction, etc., preferably at room temperature or by heating. The extraction time is not particularly limited. Also, pH adjustment can be performed. The above extraction operation The extraction may be carried out once, and the extraction residue obtained after the extraction operation may be re-extracted to perform the extraction operation. Further, it is also possible to perform a treatment such as filtration after the extraction step.

The separation step is a solid-liquid method in which the insoluble matter of the extraction residue is separated from the extract from the extract obtained above, and examples thereof include centrifugal separation, pressure filtration, filtration (pressurization, atmospheric pressure), chromatography, and the like. A method of extracting and separating by using an adsorbent or an absorbent. The extract obtained from the extract can be used as it is, or can be further purified by differentiation or the like.

The distinguishing step is a method of purifying and concentrating the essential components from the extract obtained above. Examples of the method used in the discrimination step include chromatography using a living carbon, an anion exchange resin, a cation exchange resin, a silicone resin, a polystyrene resin adsorbing an aromatic compound, or the like as a carrier, dialysis, molecular sieve, and decompression. Methods such as concentration, freeze drying, etc., but are not limited thereto. Further, after this step, the step of recovering the supernatant by centrifugation or the like may be carried out as needed.

Further, it is also possible to perform filtration or the like as needed before and after the above steps. For the filtration, gauze or a filter, a commercially available filter, or the like can be used. Further, sterilization treatment or the like can be performed as needed.

The plant extract obtained by the above method may be used as it is in a liquid form, or may be powdered by a drying step such as spray drying, vacuum drying or freeze drying.

As described above, the composition of the present invention is characterized in that the content of chlorophyll is less than 0.15 ppm. The chlorophyll is usually derived from a plant extract, and therefore it is preferred to carry out the treatment of removing or reducing chlorophyll when preparing the plant extract. Examples of the treatment include an extraction method using various extraction solvents (water, ethanol, 1,3-butylene glycol, a mixed solution thereof, etc.), a method of distinguishing using a carrier (activated carbon or the like), and using centrifugal separation or Filter separation, filtration and separation methods.

Moreover, the content of chlorophyll contained in the plant extract can be obtained by using a spectrophotometer It is measured by an absorptiometry method, a high performance liquid chromatography method, an extraction separation method, a derivative conversion method, or the like.

(1-4) Other ingredients

The composition of the present invention may, if necessary, be included in the range which does not impair the pharmacological action and stability of the vitamin B6 compound and the plant extract, and further contains other ingredients which are generally used in the field. However, the case of repeating the ingredients contained therein is not listed here. Examples of such other components include a solvent, a hyperemia-removing component, an eye-regulating component, an anti-inflammatory component, astringent component, an antihistamine component, an antiallergic component, a vitamin, an amino acid, an antibacterial component, a bactericidal component, and a saccharide. Polysaccharides and derivatives thereof, cellulose and derivatives thereof, water-soluble polymers, local anesthetic components, steroid components, glaucoma therapeutic components, and cataract treatment components. As other preferable components in the present invention, for example, the following may be mentioned.

Solvent: As the solvent, for example, water, an alcohol, an ether, or a mixture thereof may be mentioned. The alcohol may, for example, be at least one selected from the group consisting of a polyol and a lower alcohol.

Examples of the polyhydric alcohol include 1,2-propanediol, glycerin, diglycerin, triglycerin, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, 1,3-propanediol, dipropylene glycol, and trisole. Propylene glycol, butanediol, dibutylene glycol, pentanediol, pentanetriol, hexanediol, cyclohexanetriol, pentaerythritol, trimethylolpropane, sorbitol, and mannitol. Examples of the lower alcohol include methanol, ethanol, propanol, isopropanol, butanol, isobutanol, pentanol, and isoamyl alcohol. Among them, as the alcohol, propylene glycol, glycerin, ethanol, and the like are preferable as the alcohol in terms of safety and stability of the vitamin B6 compound and the plant extract.

The total content ratio of the alcohols in the composition of the present invention depends on the type of the polyol or the lower alcohol, preferably about 40% by weight or less, more preferably about 30% by weight or less, and still more preferably about 20% by weight. The following, but there are no special restrictions.

Congestion-removing component: for example, an α-adrenergic agonist can be cited, specifically, it can be listed Epinephrine, epinephrine hydrochloride, ephedrine hydrochloride, oxymetazoline hydrochloride, tetrahydrozoline hydrochloride, tetrahydrozoline nitrate, naphazoline hydrochloride, naphazoline nitrate, phenylephrine hydrochloride, hydrochloric acid Methyl ephedrine, heavy tartaric acid and adrenaline. These may be any of d, l or dl.

The eye muscle regulator component: for example, an anticholinergic ester agent having an active center similar to acetylcholine, and specific examples thereof include a quaternary ammonium compound such as gemmin of methyl sulphate and such a quaternary ammonium compound. Pharmacologically acceptable salts and the like.

Anti-inflammatory agent component or astringent component: for example, zinc sulfate, zinc lactate, allantoin, ε-aminohexanoic acid, indomethacin, chlorinated lysozyme, silver nitrate, pranoprofen, dipotassium glycyrrhizinate, Diclofenac sodium, bromfenac sodium, berberine chloride, berberine sulfate, methyl salicylate, and the like.

Vitamins: for example, may contain at least one vitamin selected from the group consisting of vitamin A, vitamin B (other than the above vitamin B6 compound), vitamin C, vitamin D, vitamin E, and other vitamins. . Examples of the vitamin A include, for example, retinol, retinol, retinoid, carotenes, dehydroformaldehyde, lycopene, and pharmacologically acceptable salts thereof. Examples of the vitamin B can be exemplified by thiamine, dithiothiamine, thiophene, otoxuramine, seletonamide, bisisobutyl thiamine, bisphenyl sulfonamide, propyl thiamine, and benzene. Phosphine thiamine, furan thiamine, riboflavin, flavin adenine dinucleotide, hydrocobalamin, cyanocobalamin, mecobalamin, deoxyadeno cobalamin, folic acid, tetrahydrofolate, dihydrofolate, nicotinic acid Nicotinamide, nicotinol, pantothenic acid, panthenol, biotin, choline, inositol and their pharmacologically acceptable salts. Examples of the vitamin C class include ascorbic acid and derivatives thereof, erythorbic acid and derivatives thereof, and pharmacologically acceptable salts thereof. Examples of the vitamin D class include ergot calciferol, cholecalciferol, hydroxycholecalciferol, dihydroxycholecalciferol, dihydrocohol, and pharmacologically acceptable salts thereof. Examples of the vitamin E class include tocopherol and its derivatives, ubiquinone derivatives, and pharmacologically acceptable salts thereof. As other vitamins, for example, For example: carnitine, ferulic acid, γ-glutol, orotic acid, rutin, eriocitrin, hesperidin and its pharmacologically acceptable salts.

Examples of the amino acid: aminoethyl sulfonic acid (taurine), glutamic acid, creatinine, sodium glutamate, and sodium chondroitin can be mentioned. These may be any of d, l or dl.

Antibacterial agent component or fungicide component: for example, amine-based deoxycorticillin sulfate, kampomycin sulfate, stabalamycin sulfate, sisosine sulfate, streptomycin sulfate, tobramycin, and scleromycin sulfate , alkyl polyaminoethylglycine, chloramphenicol, tetracycline hydrochloride, hydroxytetracycline hydrochloride, ofloxacin, norfloxacin, levofloxacin, lomefloxacin hydrochloride, sulfacillin sodium, Cefmenoxime hydrochloride, benzylpenicillin potassium, berberine sulfate, berberine chloride, colistin sodium, erythromycin, erythromycin lactobionate, guitarmycin, spiramycin, neomycin sulfate , polymyxin sulfate, dibekacin, amikacin, amikacin sulfate, acyclovir, Iodo deoxycytidine, iodine, cyclocytidine, cytarabine, Trifluorothymidine, bromodeoxyuridine, polyvinyl alcohol iodine, iodine, amphotericin B, isoconazole, econazole, clotrimazole, mycin, streptavidin, flucytosine, miconazole Wait.

Examples of the saccharide include monosaccharides and disaccharides, and specific examples thereof include glucose, trehalose, lactose, and fructose.

Examples of the polysaccharide or a derivative thereof include sodium hyaluronate, sodium chondroitin sulfate, and the like.

Examples of the cellulose or a derivative thereof or the salt thereof include sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, and methylcellulose.

Examples of the water-soluble polymer other than the above include polyvinyl alcohol (complete or partial saponified product), polyvinylpyrrolidone, dextrin, and polyethylene glycol.

Local anesthetic components: for example, lidocaine, oxybuprocaine, dibucaine, procaine, ethyl urethane, mepivain, and the like can be mentioned.

Examples of the steroid component include hydrocortisone, prednisolone, and the like.

The glaucoma therapeutic component: for example, levobnorolol, timolol, and the like can be mentioned.

Cataract treatment component: for example, pirenoxine or the like can be cited.

The content ratio of the components in the composition is appropriately determined depending on the type of the preparation, the type of the component to be contained, and the like. For example, it is about 0.0001 to 50% by weight, preferably about 0.0001 to 25% by weight, and more preferably about 0.001 to 10% by weight, based on the total amount of the preparation.

Further, in the aqueous liquid preparation of the present invention, it is possible to contain an additive which is generally used in the field, without damaging the pharmacological action and stability of the vitamin B6 compound and the plant extract. However, the case of repeating the ingredients contained therein is not listed here. Examples of such a component include preservatives, bactericides or antibacterial agents, tackifiers, solubilizers or dissolution aids, pH adjusters, isotonic agents, perfumes, cooling agents, chelating agents, buffers, and stabilization. Agents, substrates, and the like. As a preferable additive in the present invention, for example, the following additives can be mentioned.

Preservatives, bactericides or antibacterial agents: for example, alkyldiamine ethylglycine hydrochloride, sodium benzoate, ethanol, chlorobutanol, hexadienoic acid, potassium hexadienoate, sodium dehydroacetate, methylparaben, Ethyl p-hydroxybenzoate, propyl paraben, butyl paraben, hydroxyquinoline, phenylethyl alcohol, benzyl alcohol, biguanide, rivanol and the like.

Tackifier: Examples thereof include sodium carboxymethylcellulose, dextran, polyethylene glycol, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropylmethylcellulose, methylcellulose, and polyethylene. Alcohol (complete or partially saponified), polyvinylpyrrolidone, polyethylene glycol, sodium chondroitin, and the like.

Examples of the cosolvent or the dissolution aid include a glycine type amphoteric surfactant such as an alkyldiaminoethylglycine, a sulfonate such as an alkyl ether carboxylate or a tetradecenesulfonate, and a lauryl group. Alkyl sulfate such as sodium sulfate, N-mercapto taurate such as N-cocoylmethyltaurate, POE alkyl ether such as POE (polyoxyethylene) (10) sodium lauryl ether phosphate N-decylamino acid salt such as phosphoric acid and its salt, sodium lauryl methyl propylamine, POE (3) laurel An anionic surfactant such as POE alkyl ether sulfate or α-olefin sulfonate such as sodium ether sulfate. Specifically, there are polyoxyethylene hydrogenated castor oil 60, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, polyoxyethylene (20) Yamanashi Sugar anhydride tristearate, polyoxyethylene (20) sorbitan oleate, polyoxyl (40) ester of stearic acid, sucrose stearate, decaglyceryl monostearate, lauryl Glucoside, polyethylene glycol 4000. Furthermore, the numbers in parentheses indicate the addition of moles.

Examples of the cationic surfactant include a quaternary ammonium compound and a biguanide compound. Examples of the quaternary ammonium compound include cetylpyridinium chloride hydrate, decaquinium chloride, benzethonium chloride, benzalkonium chloride, alkyldimethylammonium chloride, and alkyltrimethyl chloride. Alkyl ammonium, methyl benzethonium chloride, lauric acid, cholestylmethylmercaptomethylpyridinium or the like. Further, examples of the biguanide compound include chlorhexidine or a salt thereof, and preferably chlorhexidine gluconate or chlorhexidine hydrochloride.

Examples of the pH adjuster include hydrochloric acid, aminoethylsulfonic acid, ε-aminohexanoic acid, acetic acid, sodium hydroxide, sodium hydrogencarbonate, sodium carbonate, triethanolamine, monoethanolamine, and the like.

Isotonic agents: for example, sodium hydrogen sulfite, sodium sulfite, potassium chloride, calcium chloride, sodium chloride, magnesium chloride, potassium acetate, sodium acetate, sodium hydrogencarbonate, sodium carbonate, sodium thiosulfate, magnesium sulfate, glycerin , propylene glycol and the like.

Perfume or cooling agent: for example, terpenes (specifically, aniseed brain, eugenol, camphor, geranyl alcohol, decyl ether, borneol, menthol, limonene, borneol, etc.; these may be d Any of the body, body or dl body) (specifically, fennel oil, ice mint oil, cinnamon oil, spearmint oil, peppermint water, peppermint oil, peppermint oil, citrus oil, eucalyptus oil, Rose oil, etc.).

Examples of the chelating agent include ascorbic acid, tetrasodium ethylenediaminetetraacetate, sodium ethylenediaminetetraacetate, citric acid, and the like.

Examples of the buffer: citric acid, sodium citrate, acetic acid, potassium acetate, sodium acetate, sodium hydrogencarbonate, sodium carbonate, boric acid, borax, and the like.

Stabilizers: for example, cyclodextrin, dibutylhydroxytoluene, tromethamine, tocopherol, sodium metabisulfite, monoethanolamine, aluminum monostearate, and the like can be mentioned.

Base: for example, octyldodecanol, olive oil, sesame oil, titanium oxide, potassium bromide, soybean oil, camellia oil, corn oil, rapeseed oil, paraffin wax, castor oil, resin matrix, peanut oil, lanolin Vaseline and so on.

(1-6) osmotic pressure and pH of the composition

The composition of the present invention can be adjusted to an osmotic pressure ratio within a range acceptable to the living body as needed. The osmotic pressure ratio with respect to physiological saline is usually about 0.3 to 4, preferably about 0.5 to 2, more preferably about 0.5 to 1.4. In addition to the above pH adjusting agent, the adjustment of the osmotic pressure ratio can be carried out by appropriately using a buffering agent, an isotonic agent, a salt or the like.

The composition of the present invention is, for example, in the following liquid dosage form, and it is usually preferred if the pH is 2 to 10, and the pH is 4 to 9 in terms of the stability of the administration and the stability of the active ingredient. Preferably, if the pH is 6-8, it is further preferred. In the composition for outer skin, it is usually preferred that the pH is from 3 to 10, and the pH is from 3 to 9 in terms of low irritation to the skin, good feeling of use, and stability of the active ingredient. More preferably, the pH is preferably from 4 to 8.

In particular, in the case of an application for a mucosa such as an eye drop, a nasal drop, an eye wash, a nasal wash, or a contact lens, it is usually in terms of low irritation of the mucosa and stability of the active ingredient. If the pH is 5 to 9.5, it is preferably, and if the pH is 5.5 to 9, it is more preferable, and if the pH is 6 to 8, it is further preferable.

(1-7) Method for producing composition

The vitamin B6 compound tends to become unstable in a composition containing a large amount of water, and is easily decomposed by light. Therefore, when the composition containing the vitamin B6 compound of the present invention is a composition containing water (aqueous composition), the stability of the vitamin B6 compound to light can be effectively improved.

When the composition of the present invention contains water, the content of water in the composition is preferably It is about 5% by weight or more, more preferably about 20% by weight or more, further preferably about 50% by weight or more, and particularly preferably 70% by weight or more. Further, the upper limit is about 99.9% by weight or less, preferably about 99% by weight or less, and more preferably about 95% by weight or less.

The composition of the present invention can be handled and prepared by a known method according to the use thereof (skin preparations such as hair restorer and cosmetic, eye drop, nasal drops, eye wash, nasal wash, contact lens, etc.). Each of the above components is produced by mixing. Furthermore, the order in which the components are formulated is not particularly limited.

For example, in the case of a dermatological preparation such as a hair growth agent, a topical analgesic or a cosmetic, or an ophthalmic preparation such as an eye drop or an eye wash, the components may be first mixed, and then subjected to filtration sterilization treatment as needed. Prepared by filling the container. More specifically, when the composition is a hair growth agent, the components such as vitamin B6 compound and plant extract can be dissolved by using distilled water or purified water and additives, and adjusted to a specific osmotic pressure and pH value, and sterilized. It is manufactured by filtration sterilization in an environment and aseptically filled into a container which has been washed and sterilized.

(1-8) Use of the composition

The composition of the present invention can be used, for example, in the form of internal or external use depending on the purpose, and can be provided as a topical preparation for various uses.

As an internal form, for example, various solid preparations such as tablets, pills, capsules (soft capsules, hard capsules), powders (powders), and granules (including dry syrup), or internal liquid preparations can be prepared ( A dosage form such as a liquid preparation containing a liquid preparation, a suspension, a syrup, or a gelling agent.

The external form can be prepared, for example, as a skin preparation (a lotion, a suspension, an emulsion, an aerosol), an ointment, a cream, a gel agent, or a paste. Attachment and other dosage forms. In addition, the ophthalmic preparation is not limited to the therapeutic preparation, and may be used as a non-therapeutic preparation such as a contact lens. Specific as an ophthalmic preparation For example, eye drops (also known as eye drops, including eye drops which can also be used when wearing contact lenses), eye washes (also known as eye washes, including use when wearing contact lenses) Eyewashing agents, contact lens wearing solutions, and contact lens agents (washing liquid, preservation solution, rinse solution, disinfectant, and Multi-Purpose Solution). Further, in the present specification, the term "contact lens" means all types of contact lenses such as a hard contact lens (including an oxygen-permeable rigid contact lens) and a soft contact lens.

Since the composition of the present invention has improved stability against light due to the vitamin B6 compound, it is preferably applied to a preparation in which the stability of the former vitamin B6 compound to light is low. A preparation containing water, such as a liquid preparation, a skin preparation for a liquid preparation, an eye wash, and a contact lens, may be mentioned as a preparation which is particularly problematic for the low stability of the light of the vitamin B6 compound (aqueous composition) ()). The reason for this is that in a composition containing water, the vitamin B6 compound tends to become unstable and is easily decomposed by light.

Since the vitamin B6 compound has high stability to light, the composition of the present invention can also be used as a multi-aqueous aqueous solution, such as an eye drop, which is packaged in a form for multiple administrations and continuously used by the user. (eye drops), eye wash (eye wash), nasal wash (nasal wash), oral medication (oral pharyngeal, and sputum-containing medication), ear drops, nasal drops (nasal drops), invisible Glasses, liquid internal medicine (liquid gastrointestinal medicine, liquid cold medicine, etc.), external skin medication (hair growth agent, topical analgesic, topical itch, etc.), cosmetics (lotion, lotion, beauty lotion, etc.) )Wait.

When the composition of the present invention is used as a specific preparation, the stability of the vitamin B6 compound to light can be improved without depending on the design of the container and the packaging material. The container for packaging the composition of the present invention is not particularly limited. For example, in order to grasp the content or the remaining amount of the composition filled with an ophthalmic preparation, etc., it is preferable to include polyethylene. A container having translucency such as an olefin resin such as polypropylene or a polyester resin such as polyethylene terephthalate.

In the case of filling into a transparent or translucent container, previously, vitamin B6 combination The article is easily exposed to light, and the composition containing the plant extract and the vitamin B6 is filled into a transparent or translucent container to reduce the stability of the vitamin B6 compound to light, which is very difficult. However, since the composition of the present invention enhances the stability of the vitamin B6 to light, even if a transparent or translucent container is used as the container for packaging the composition, the effect of the composition of the present invention can be exerted, and the combination can be achieved. The material is kept steadily. As the transparent or translucent container, the transmittance in the visible light region is usually 10% or more, preferably 30% or more, more preferably 50% or more, further preferably 70% or more, and particularly preferably 80% or more. Further, the upper limit of the transmittance is 99% or less, but the upper limit is not particularly required.

(2) Photo-stabilization method of vitamin B6 compound

The light stabilizing method of the present invention is characterized in that it is a photostabilizing method of the above compound in a composition containing a vitamin B6 compound and a plant extract, and the content of the chlorophyll in the composition is set to less than 0.15 ppm. .

The content of the vitamin B6 compound and the plant extract contained in the composition may be the content described in the item of the above composition.

The light stabilizing method of the present invention can improve the vitamin B6 compound in the composition by the composition containing the vitamin B6 compound and the plant extract, so that the content of the chlorophyll in the composition is less than 0.15 ppm. stability. The content of chlorophyll in the composition is preferably less than about 0.1 ppm, and particularly preferably less than about 0.05 ppm.

Descriptions of other ingredients, additives, and the like in the composition are as described in the items of the above composition.

[Examples]

Hereinafter, the present invention will be more specifically described by way of examples. However, the invention is not limited by the examples.

(1) Preparation of the composition

Preparation of plant extracts using aloe vera (aloe vera: Aloe vera) as a plant Things.

The ethanol extract of aloe vera is pulverized by finely chopping raw aloe vera, and about 10 times the amount of ethanol aqueous solution (80% by weight of ethanol, 80% EtOH) is added to the total amount of the dried product. It is extracted at 70-90 ° C for 2 to 3 hours to obtain (Aloe EtOH extract). Thereafter, activated carbon was added to remove chlorophyll, thereby obtaining an activated carbon treatment extract of aloe (aloe EtOH extract (after activated carbon treatment)). Further, the 1,3-butanediol extract of aloe vera is dried by finely chopping raw aloe vera, and about 30 times by weight of 1,3-butanediol is added to the total amount of the dried product. The aqueous solution was extracted at room temperature for 5-7 days to obtain (aloe BG (butylene glycol) extract).

The content of the solid component of the aloe extract is as follows.

80% EtOH extract of aloe vera (Aloe EtOH extract in the table): 2.5% by weight (dry weight)

Aloe 1,3-butanediol extract (Aloe BG extract in the table): 1% by weight (dry weight)

80% EtOH extraction of aloe vera and extract after activated carbon treatment (aloe extract from the table (after activated carbon treatment)): 1% by weight (dry weight)

Using the above aloe extract, the components shown in Table 1 were dissolved in purified water, and the total amount was set to 100 g to prepare a test liquid of the composition.

Among the aloe extracts (Aloe EtOH extract, Aloe BG extract and Aloe EtOH extract (after activated carbon treatment)) prepared above, it was confirmed that aloe and aloe were contained as a component of aloe. Accordingly, the aloe extracts are suitable plant extracts containing the active ingredients of aloe vera.

In order to adjust the pH of the test solution, citric acid and sodium citrate were used. The pH of the test solution was set to pH 5.5.

Pyridoxine hydrochloride (vitamin B6) is added separately from aloe extract (plant extract).

The content of chlorophyll (Chlorophyll) in the test solution was determined by the spectrophotometry using a spectrophotometer according to the following procedure. 4 g of the sample was taken, 0.1 g of basic calcium carbonate was added, and 5 mL of water and 40 mL of acetone were added, and the mixture was placed in an ultrasonic cleaner and centrifuged. This step was repeated 2 times. 50 mL of diethyl ether and 40 mL of water were added to the supernatant, and the mixture was allowed to stand, and the aqueous layer was removed, and this operation was repeated 3 times. Further, it was subjected to dehydration filtration using anhydrous sodium sulfate, and made up to 100 mL with diethyl ether. This was measured using a spectrophotometer (manufactured by Hitachi, Ltd., model U-2000) at measurement wavelengths of 660 nm and 642.5 nm, and was evaluated according to the following formula.

Total chlorophyll (mg / 100g) = (7.12E 660 + 16.8E 642.5) × V × 100/1000

Chlorophyll a (mg / 100g) = ( 9.93E 660 -0.777E 642.5) × V × 100/1000

Chlorophyll b (mg/100g) = total chlorophyll (mg/100g) - chlorophyll b (mg/100g)

The so-called E _660, E _642.5, refers to 660nm, the absorbance at 642.5nm, W refers to the amount of collected sample (g), V refers ether constant volume (mL).

In the table, EtOH represents ethanol and BG represents 1,3-butanediol.

(2) Light stability evaluation of vitamin B6 in the composition Test method for light stability

Each test solution was filled with 100 mL or 200 mL to a clear glass bottle (capacity: 200 mL), and these were used as test samples. As a fluorescent lamp tester, a growth chamber (Sanyo Electric, MLR-351) was used, and the test sample was irradiated with 10,000 lux/hr of light at 15 ° C for 54 hours, and exposed to light of 540,000 lux. This light exposure amount is set based on the "Osaka Prefecture LED Lighting Equipment Development Promotion Planning Policy" (Osaka Prefecture), based on the average exposure of the general family for about 6 months.

The concentration of pyridoxine hydrochloride in the test sample before and after light irradiation was measured by high performance liquid chromatography. From the pyridoxine hydrochloride concentration of the sample to be measured, the residual ratio (%) of pyridoxine hydrochloride after light irradiation was calculated according to the following formula.

Residual rate (%) = 100 × pyridoxine hydrochloride concentration after light irradiation (% by weight) /pyridinium hydrochloride concentration before light irradiation (% by weight)

(3) Test results

The test results of the photostability are shown in Tables 1 and 2.

Examples 1 to 3 containing pyridoxine hydrochloride (vitamin B6 compound) and aloe extract (plant extract) and chlorophyll a (chlorophyll) content of less than 0.15 ppm after photostability test, residual pyridoxine hydrochloride The rate is higher. Specifically, in Examples 1 to 3, pyridinium hydrochloride The residual rate of sterol is 90% or more.

In Comparative Examples 1 to 3 in which the content of chlorophyll a was 0.15 ppm or more, the residual ratio of pyridoxine hydrochloride was lowered to 85% or less.

That is, it was found that the stability of pyridoxine hydrochloride to light can be improved by adjusting the concentration of chlorophyll a in the composition containing the aloe extract to less than 0.15 ppm.

Further, in aloe vera, chlorophyll a and b are usually contained, but the content of chlorophyll b is less than the content of chlorophyll a, and in any of the examples and comparative examples, it is less than 0.05 ppm.

Algae and cyanobacteria also contain chlorophyll (chlorophyll). As the chlorophyll contained in the algae, there are chlorophyll b (a part of green algae), chlorophyll c (hay algae and algae), chlorophyll d (red algae), and chlorophyll e (unequalile algae). As a chlorophyll contained in cyanobacteria, there is chlorophyll c.

Here, algae and cyanobacteria were used instead of the above-mentioned plant body (aloe), and a test liquid of a composition such as an extract was prepared in the same manner as the above aloe. The composition contains pyridoxine hydrochloride (vitamin B6 compound), an extract of algae and cyanobacteria, and the like, and the content of chlorophyll is less than 0.15 ppm. Then, the test liquids were also evaluated for the photostability of the vitamin B6 in the composition in the same manner as the above plant.

As a result, it was found that the composition of the extract or the like prepared from algae and cyanobacteria had a high residual ratio of pyridoxine hydrochloride after the photostability test.

From these circumstances, it has been found that, in the same manner as the plant extract, the composition containing the extract or the like prepared from the algae and the cyanobacteria can be improved by adjusting the concentration of the chlorophyll in the composition to less than 0.15 ppm. The stability of pyridoxine hydrochloride to light.

(3) Formulation example Hair tonic

A hair restorer (Formulation Examples 1 to 9) having a chlorophyll content of the composition shown in Table 3 of less than 0.15 ppm was prepared. Any of the hair growth agents are excellent in the stability of pyridoxine hydrochloride, pyridoxal hydrochloride, and pyridoxamine dihydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Eye drops

The eye drops of the composition shown in Table 4 having a chlorophyll content of less than 0.15 ppm (Formulation Examples 10 to 18) were prepared. Any eye drop is excellent in the stability of pyridoxine hydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Nasal drops

Nasal drops having a composition of the chlorophyll of the composition shown in Table 5 of less than 0.15 ppm (Formulation Example 19) were prepared. The nasal drops are also excellent in the stability of pyridoxine hydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Eye wash

An eye wash (formulation example 20) having a chlorophyll content of the composition shown in Table 6 of less than 0.15 ppm was prepared. The eye wash is also excellent in the stability of pyridoxine hydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Nasal wash

Nasal drops having a composition of the chlorophyll of the composition shown in Table 7 of less than 0.15 ppm (Formulation Example 21) were prepared. The nasal wash is also excellent in the stability of pyridoxine hydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Contact lens agent

A contact lens agent (Formulation Example 22) having a chlorophyll content of the composition shown in Table 8 of less than 0.15 ppm was prepared. The contact lens agent is also excellent in the stability of pyridoxine hydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Cream

A cream having a composition of the chlorophyll of the composition shown in Table 9 of less than 0.15 ppm was prepared (Formulation Example 23). The cream is also excellent in the stability of pyridoxine hydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Lotion

A lotion having a composition of the chlorophyll of the composition shown in Table 10 of less than 0.15 ppm was prepared (Formulation Example 24). The lotion is also excellent in the stability of pyridoxine hydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Beauty liquid

A cosmetic liquid having a composition of the composition shown in Table 11 and having a chlorophyll content of less than 0.15 ppm was prepared (Formulation Example 25). The cosmetic liquid is also excellent in the stability of pyridoxine hydrochloride.

In the table, the unit of the content of each compounding component is % by weight.

Drink

A drink having a composition of the composition shown in Table 12 having a chlorophyll content of less than 0.15 ppm was prepared (Formulation Example 26). The drink is also excellent in the stability of pyridoxine hydrochloride.

Claims (16)

A composition comprising at least one compound selected from the group consisting of vitamin B6 and the salts thereof, and a plant extract, and the chlorophyll content of the composition is less than 0.15 ppm. The composition of claim 1, wherein the plant extract contains at least one compound selected from the group consisting of vitamin B6 and a salt thereof, and the compound is contained in the plant extract, or A mixture of the plant extract and at least one compound selected from the group consisting of exogenous vitamin B6 and salts thereof. The composition of claim 1, wherein the plant extract is free of at least one compound selected from the group consisting of vitamin B6 and a salt thereof, and the above is selected from the group consisting of vitamin B6 and the salts thereof. At least one compound of the group is additionally added to the composition. The composition of claim 1, wherein the chlorophyll is selected from the group consisting of chlorophyll a and chlorophyll b. The composition of claim 2, wherein the chlorophyll is selected from the group consisting of chlorophyll a and chlorophyll b. The composition of claim 3, wherein the chlorophyll is selected from the group consisting of chlorophyll a and chlorophyll b. The composition of claim 1, wherein the at least one compound selected from the group consisting of vitamin B6 and the salts is pyridoxine hydrochloride. The composition of claim 2, wherein the at least one compound selected from the group consisting of vitamin B6 and the salts is pyridoxine hydrochloride. The composition of claim 3, wherein the at least one compound selected from the group consisting of vitamin B6 and the salts is pyridoxine hydrochloride. The composition of claim 4, wherein the at least one compound selected from the group consisting of vitamin B6 and the salts is pyridoxine hydrochloride. The composition of claim 5, wherein the at least one compound selected from the group consisting of vitamin B6 and the salts is pyridoxine hydrochloride. The composition of claim 6, wherein the at least one compound selected from the group consisting of vitamin B6 and the salts is pyridoxine hydrochloride. The composition of any one of claims 1 to 12, wherein the plant extract is an extract extracted from a plant of a green plant. The composition according to any one of claims 1 to 12, which is a hair growth agent, an eye drop, a nasal drop, an eye wash, a nasal wash or a contact lens. The composition of claim 13, which is a hair growth agent, eye drops, nasal drops, eye wash, nasal wash or contact lens. A method for stabilizing light, which comprises a method for stabilizing a compound selected from the group consisting of at least one compound selected from the group consisting of vitamin B6 and salts thereof, and a compound of the plant extract, and The content of chlorophyll in the composition was set to be less than 0.15 ppm.