KR102313511B1 - Preparation for relieving hangover comprising Curcumin - Google Patents
Preparation for relieving hangover comprising Curcumin Download PDFInfo
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- KR102313511B1 KR102313511B1 KR1020140040522A KR20140040522A KR102313511B1 KR 102313511 B1 KR102313511 B1 KR 102313511B1 KR 1020140040522 A KR1020140040522 A KR 1020140040522A KR 20140040522 A KR20140040522 A KR 20140040522A KR 102313511 B1 KR102313511 B1 KR 102313511B1
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- curcumin
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- present
- hangover
- extract
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Abstract
본 발명은 유효성분으로 생체 이용률 및 생체 흡수율이 개선된 미분화된 커큐민 및 헛개나무 추출물을 함께 함유하는 숙취 해소 또는 예방용 조성물을 제공한다. 본 발명의 조성물은 커큐민과 헛개나무 추출물을 각각 사용하는 경우보다 더욱 우수한 숙취 예방 효과를 가질 수 있다. 본 발명은 상기 생체 이용률 및 생체 흡수율이 개선된 커큐민 및 헛개나무 추출물의 시너지 효과를 통해 숙취 예방 및 개선 효과가 뛰어난 조성물을 제공할 수 있다. 또한, 본 발명은 유효성분으로 테라큐민을 함유함으로써 제형 안정성이 향상된 츄잉 가능한 카라멜 또는 구미 제형의 제제를 제공한다.The present invention provides a composition for relieving or preventing a hangover containing micronized curcumin and Heotgae tree extract with improved bioavailability and bioabsorption as an active ingredient. The composition of the present invention may have a better hangover prevention effect than when curcumin and Heotgae tree extract are used respectively. The present invention can provide a composition excellent in the prevention and improvement of hangover effect through the synergistic effect of curcumin and Heotgae tree extract having improved bioavailability and bioabsorption rate. In addition, the present invention provides a preparation of chewable caramel or gummi formulations with improved formulation stability by containing theracumin as an active ingredient.
Description
본 발명은 숙취 해소 및/또는 숙취 예방을 위한 조성물에 관한 것으로, 더욱 구체적으로는 각 성분들이 갖는 효과 이상의 시너지 효과를 통해 향상된 숙취 해소 및/또는 예방 효과를 가질 수 있는 조성물에 관한 것이다.The present invention relates to a composition for relieving a hangover and/or preventing a hangover, and more particularly, to a composition that can have an improved hangover relief and/or prevention effect through a synergistic effect beyond the effect of each component.
본 발명은 또한 커큐민을 유효성분으로 함유하는 특정 제형에 관한 것이다.The present invention also relates to specific formulations containing curcumin as an active ingredient.
일반적으로 체내로 들어온 에탄올은 세포질 내의 알콜탈수소효소(alcohol dehydrogenase, ADH) 와 알데하이드탈수소효소(aldehyde dehydrogenase, ALDH)의 작용에 의해 아세테이트로 되어 순환계를 통해 간세포 밖으로 배설된다. 이 중 특히 에탄올의 최초 대사산물인 아세트알데히드는 에탄올에 비해 월등히 반응성이 높고 독성이 강하여 숙취 및 알콜성 부작용의 주원인 물질로 알려져 있다. In general, ethanol entering the body is converted to acetate by the action of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cytoplasm and is excreted out of hepatocytes through the circulation. Among them, acetaldehyde, which is the first metabolite of ethanol, is known to be the main cause of hangover and alcoholic side effects because it is significantly more reactive and toxic than ethanol.
또한, 상기 아세트알데히드 탈수소효소에는 아세트알데히드가 저농도이더라도 산화를 개시하는 II형과 아세트알데히드가 고농도로 되지 않으면 작용을 하지 않는 I형이 있으나, 동양인은 일반적으로 II형 아세트알데히드효소가 결핍 또는 부족하기 때문에 아세트알데히드의 산화가 느리고, 따라서 산화되지 못한 아세트알데히드 및/또는 에틸알콜의 독작용에 의하여 정상적인 신진대사가 방해 받아 다양한 숙취현상을 느끼게 되는 것이다. 이러한 음주후의 숙취현상을 해소하기 위하여 다양한 약효 성분들을 이용한 드링크류가 다수 개발되어 왔다.In addition, the acetaldehyde dehydrogenase includes type II, which initiates oxidation even at low concentrations of acetaldehyde, and type I, which does not act unless acetaldehyde is at a high concentration, but Asians generally lack or lack type II acetaldehyde. For this reason, the oxidation of acetaldehyde is slow, and thus, normal metabolism is disturbed by the poisoning of acetaldehyde and/or ethyl alcohol that has not been oxidized, and various hangover phenomena are felt. In order to solve the hangover phenomenon after drinking, a number of drinks using various medicinal ingredients have been developed.
이와 같이, 숙취를 제거하고, 혈중 알콜농도를 감소시킬 수 있는 제제의 연구가 그 동안 활발히 이루어져 왔으나 뚜렷한 성과가 있는 제제는 없었다.As such, studies on agents capable of removing hangovers and reducing blood alcohol concentration have been actively conducted, but no agents with clear results have been found.
한편 유효성분이 현탁 또는 분산된 구미(gummy) 제형의 경우 제조 과정에서, 특히 냉각, 건조 등의 과정에서 유효성분이 침전하여 함량, 성상 등의 불균일성을 종종 야기하는 문제점이 있다.On the other hand, in the case of a gummy formulation in which the active ingredient is suspended or dispersed, there is a problem that the active ingredient is precipitated during the manufacturing process, particularly in the process of cooling and drying, and often causes non-uniformity in content and properties.
이에 본 발명자들은 음주로 인한 숙취해소 전반에 대해 우수한 약효를 가지면서 종래에 복합적으로 이용된 바 없는 새로운 조성의 숙취해소용 조성물을 개발하고자 하였다. Accordingly, the present inventors tried to develop a composition for relieving a hangover of a new composition that has not been used in combination in the past while having an excellent medicinal effect on the overall hangover relieving caused by drinking.
본 발명이 해결하고자 하는 과제는 혈액 내 아세트알데히드의 농도를 감소시키고, 두통, 메스꺼움, 구토, 현기증, 근육통 등과 같은 숙취 증상을 효과적으로 개선할 수 있는 조성물을 제공하는 것이다.An object of the present invention is to provide a composition that can reduce the concentration of acetaldehyde in the blood and effectively improve hangover symptoms such as headache, nausea, vomiting, dizziness, muscle pain, and the like.
또한, 본 발명은 제형적 안정성이 개선된 구미(gummy) 제형의 커큐민 제제를 제공하고자 한다.In addition, the present invention is to provide a curcumin formulation in a gummy formulation with improved formulation stability.
상기 과제를 해결하기 위하여, 본 발명은 유효성분으로 생체 이용률 및 생체 흡수율이 개선된 커큐민(Curcumin) 및 헛개나무 추출물을 함께 포함하는 숙취 해소 또는 예방용 조성물을 제공한다. In order to solve the above problems, the present invention provides a composition for relieving or preventing a hangover comprising curcumin and Heotgae tree extract with improved bioavailability and bioabsorption as an active ingredient.
본 발명은 생체 흡수율과 생체 이용률을 증가시킨 특정 커큐민과 헛개나무 추출물을 동시에 사용한 결과, 각각 이용하는 경우보다 더욱 우수한 숙취 해소 효과를 나타냄을 확인하고, 상기 커큐민과 상기 헛개나무 추출물의 시너지 효과를 통해 기존 숙취 해소 음료에 비해 현저히 향상된 효과를 갖는 숙취 해소용 조성물을 제공할 수 있음에 기초한다.The present invention confirmed that, as a result of using a specific curcumin with increased bioabsorption and bioavailability at the same time, it showed a more excellent hangover relieving effect than when using each of them, and through the synergistic effect of the curcumin and the extract It is based on being able to provide a composition for relieving a hangover having a significantly improved effect compared to a hangover relieving drink.
커큐민은 강황의 주성분으로, 숙취 해소, 간 기능 개선, 근육 피로도 개선, 피부 수분도 증가 등 항산화에 효과적인 반면 낮은 용해도와 흡수율로 인해 상용화가 어려웠다. 커큐민의 입도 (D50, D50은 입도 누적분포에서 최대값의 50%에 해당하는 값임)는 평균 약 20 ㎛ 정도로 용해도가 0.0001mg/ml에 불과하여 거의 용해되지 않는다.Curcumin, the main component of turmeric, is effective as an antioxidant, such as relieving hangover, improving liver function, improving muscle fatigue, and increasing skin moisture, but it has been difficult to commercialize due to its low solubility and absorption rate. The particle size of curcumin (D 50 , D 50 is a value corresponding to 50% of the maximum value in the cumulative particle size distribution) is about 20 μm on average, and the solubility is only 0.0001 mg/ml, so it is hardly dissolved.
이러한 커큐민의 단점을 극복하고 활용성을 높이기 위하여 생체 이용률과 생체 흡수율을 향상시키기 위한 연구를 실시하였다. 그 결과 커큐민의 입자 사이즈를 나노 입자(nano particle) 단위로 제작할 경우 생체 내 흡수를 증가시킬 수 있음을 확인하였다. 즉, 평균 입도가 약 100 내지 900 nm인 커큐민의 경우 용해도가 크게 향상되고 체내 흡수율이 증가될 수 있어 체내 이용률이 개선될 수 있음을 확인하였다. 특히 그 중에서 테라큐민은 상기 커큐민의 용해도와 체내 흡수율을 개선시켜 활용성을 증가시킨 것으로, 개선된 고용해도, 고흡수율을 활용해 숙취해소, 간 기능 개선, 피부 건조개선, 근육 피로 개선 등 다양한 분야에 이용된다. In order to overcome these shortcomings of curcumin and increase its usability, a study was conducted to improve the bioavailability and bioabsorption rate. As a result, it was confirmed that when the particle size of curcumin was manufactured in nano-particle units, absorption in the body could be increased. That is, it was confirmed that, in the case of curcumin having an average particle size of about 100 to 900 nm, solubility in the body is greatly improved and absorption in the body can be increased, so that the utilization rate in the body can be improved. In particular, theracumin has increased usability by improving the solubility and absorption rate of curcumin in the body, and it utilizes the improved high solubility and high absorption rate to relieve hangovers, improve liver function, improve skin dryness, and improve muscle fatigue. is used for
헛개나무(Hovenia dulcis Thunb)는 갈매나무과(Rhamnaceae)의 낙엽활엽교목으로 우리나라를 비롯하여 일본, 중국 등에서도 분포하고 있다. 헛개나무는 잎, 가지, 열매 등을 모두 약으로 사용하는데, 예로부터 주독 해독, 정혈, 이뇨, 갈증해소, 해독작용 등에 효과가 있는 것으로 알려져 왔으며, 최근 많은 연구결과를 통해 헛개나무 추출물이 숙취 해소 및 간기능 보호 효능이 우수한 것으로 증명되었다. 헛개나무의 주요 기능성 성분으로는 플라보노이드(flavonoid) 계열의 hovenitin Ⅰ, Ⅱ, Ⅲ, (+)-ampelopsin, laricetrin, myrcetin, (+)-gallocatechin 등이 보고되어 있고, 사포닌(saponin)과 글리코사이드(glycoside) 계열의 hovenidulcioside, hovenodulinol, hodulsin, hoduloside 등이 알려져 있다. 특히 이러한 유효성분들은 간을 보호해주고 알코올 중독과 숙취를 해소하는 것으로 알려져 있다. Hovenia dulcis Thunb is a deciduous broad-leaved arboreous tree of the Rhamnaceae family, distributed in Korea, Japan, and China. All of the leaves, branches, and fruits are used as medicines, and it has been known since ancient times to be effective in detoxification, blood purification, diuresis, thirst quenching, and detoxification. And it has been proven that the liver function protective effect is excellent. As the main functional ingredients of H. serrata, flavonoids hovenitin Ⅰ, Ⅱ, Ⅲ, (+)-ampelopsin, laricetrin, myrcetin, (+)-gallocatechin, etc. have been reported, and saponin and glycoside ( glycoside), hovenidulcioside, hovenodulinol, hodulsin, hoduloside, and the like are known. In particular, these active ingredients are known to protect the liver and relieve alcoholism and hangover.
그러나 아직까지 상기 커큐민, 특히 용해도를 개선한 커큐민과 헛개나무를 동시에 사용하여 숙취 해소 효과를 얻었다는 사실은 확인된 바 없다.However, it has not yet been confirmed that the above curcumin, particularly curcumin, which has improved solubility, and Heotgae tree were used at the same time to obtain the effect of relieving a hangover.
본 발명의 발명자들은 상기 체내 흡수율과 이용률이 개선된 커큐민과 함께 헛개나무(헛개나무 추출물)을 동시에 사용하여 숙취 해소 및 예방 효과에 시너지 효과를 갖는다는 사실을 확인하고 본 발명을 완성하였다.The inventors of the present invention have completed the present invention by confirming the fact that they have a synergistic effect in relieving and preventing hangovers by simultaneously using Heotgae tree (huotgae tree extract) together with curcumin, which has improved absorption and utilization rates in the body.
본 발명의 커큐민은 전기영동광산란법(Electrophoretic Light Scattering, 레이저 도플러법) (예를 들어, ELS-8000 이용)으로 측정한 평균 입도(D50)가 100 내지 900 nm이며, 바람직하게는 100 내지 400 nm, 더욱 바람직하게는 150 내지 300 nm일 수 있다. 상기 입도 범위에서 커큐민의 용해도가 우수하며, 체내 흡수율도 높일 수 있다. 이와 같은 미분화된 커큐민으로, 예를 들어, 본 발명의 목적상 테라큐민TM이 사용될 수 있다. 상기 테라큐민은 평균 입도가 약 0.19~0.3 ㎛이다. Curcumin of the present invention has an average particle size (D 50 ) measured by an electrophoretic light scattering (laser Doppler method) (eg, using ELS-8000) of 100 to 900 nm, preferably 100 to 400 nm, more preferably 150 to 300 nm. In the above particle size range, the solubility of curcumin is excellent, and the absorption rate in the body can be increased. As such micronized curcumin, for example, theracumin TM can be used for the purposes of the present invention. The theracumin has an average particle size of about 0.19 to 0.3 μm.
이에 본 발명의 발명자들은 상기 커큐민, 특히 미분화된, 특정 입도를 가지는 커큐민(예를 들어, 테라큐민TM)과 헛개나무 추출물, 특히 헛개나무의 열매 추출물을 함께 사용함으로써, 다양한 숙취 증상에 대해 개선된 효과를 갖는다는 사실을 확인하고 커큐민과 헛개나무 (열매) 추출물을 함께 이용한 숙취 해소 또는 예방용 조성물에 관한 본 발명을 완성하게 되었다. 더욱이, 커큐민 및 헛개나무 추출물을 각각 사용할 때 보다 커큐민 및 헛개나무 추출물을 함께 사용할 때 나타나는 시너지 효과에 의해 음주 후 나타나는 부작용들에 대한 개선 효과가 더욱 우수하다는 사실을 실험을 통하여 입증하였으며, 본 발명에 따른 조성물의 숙취 해소 효과가 탁월함을 발견하게 되었다. Therefore, the inventors of the present invention have improved the symptoms of various hangovers by using the above curcumin, particularly micronized, curcumin having a specific particle size (eg, theracumin TM ) and a genus oleifera extract, particularly an extract of a sycamore tree. After confirming the fact that it has an effect, the present invention regarding a composition for relieving or preventing a hangover using curcumin and Heotgae tree (fruit) extract was completed. Moreover, it has been proven through experiments that the improvement effect on side effects after drinking is more excellent than when using curcumin and cypress extract, respectively, due to the synergistic effect that occurs when curcumin and cypress extract are used together. It was found that the hangover relieving effect of the following composition was excellent.
본 명세서에 사용된 "숙취 해소"라 함은 음주 후에 나타나는 다양한 증상이 완화, 개선 또는 치유되는 현상을 의미한다. 구체적으로, 혈액 내 아세트알데히드의 농도를 감소시키고, 두통, 메스꺼움, 구토, 현기증, 근육통 등과 같은 증상이 개선되는 것을 의미한다. As used herein, "hangover relief" refers to a phenomenon in which various symptoms appearing after drinking are alleviated, improved, or cured. Specifically, it means reducing the concentration of acetaldehyde in the blood and improving symptoms such as headache, nausea, vomiting, dizziness, and muscle pain.
본 발명은 상기 커큐민의 획득 방법에 특별히 한정되지 않으며, 당 업계에 공지된 방법으로 화학적으로 합성하거나, 시판되는 물질을 사용할 수 있다.The present invention is not particularly limited to the method for obtaining curcumin, and may be chemically synthesized by a method known in the art or a commercially available material may be used.
본 발명의 헛개나무 추출물은 본 발명이 속한 분야에서 통상적인 방법으로 추출해낸 추출물을 의미하며, 추출 후 분획, 분리, 여과 등의 방법으로 추가적으로 정제될 수 있다. Heotgae tree extract of the present invention means an extract extracted by a conventional method in the field to which the present invention belongs, and may be further purified by methods such as fractionation, separation, filtration after extraction.
예를 들어, 본 발명에 따른 상기 헛개나무 추출물은 헛개나무, 바람직하게는 헛개나무 열매의 용매 추출물 또는 이의 건조물일 수 있다. 헛개나무 추출 시 추출 용매는 천연물 추출에 사용되는 용매이면 제한 없이 사용할 수 있으며, 예를 들어, 정제수; 메탄올, 에탄올, 프로필알코올, 부틸알코올 등의 탄소수 1 내지 4의 저급 알코올; 글리세린, 부틸렌글라이콜, 프로필렌글라이콜 등의 다가 알코올; 메틸아세테이트, 에틸아세테이트, 아세톤, 벤젠, 헥산, 디에틸에테르, 디클로로메탄 등의 탄화수소계 용매; 또는 이들은 혼합 용매를 이용할 수 있으나, 정제수, 메탄올, 에탄올, 프로필알코올, 부틸알코올과 같은 탄소수 1 내지 4의 저급 알코올, 또는 이들의 혼합 용매를 사용하는 것이 바람직하고, 정제수, 에탄올 또는 이들의 혼합용매를 사용하는 것이 더욱 바람직하며, 정제수와 에탄올의 혼합용매를 사용하는 것이 본 발명의 목적상 더욱 바람직하다. For example, the Heotgae tree extract according to the present invention may be a Heotgae tree, preferably a solvent extract of the Heotgae tree fruit, or a dried product thereof. In the case of extracting the spruce, the extraction solvent may be used without limitation as long as it is a solvent used for extracting natural products, for example, purified water; lower alcohols having 1 to 4 carbon atoms, such as methanol, ethanol, propyl alcohol, and butyl alcohol; polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Alternatively, a mixed solvent may be used, but it is preferable to use a lower alcohol having 1 to 4 carbon atoms, such as purified water, methanol, ethanol, propyl alcohol, or butyl alcohol, or a mixed solvent thereof, purified water, ethanol, or a mixed solvent thereof It is more preferable to use, and it is more preferable for the purpose of the present invention to use a mixed solvent of purified water and ethanol.
상기 추출 용매의 양은 헛개나무 (열매) 중량대비 10 내지 100배가 이용될 수 있고, 바람직하게는 20 내지 80배가 이용될 수 있으며, 더욱 바람직하게는 30 내지 50배가 이용될 수 있으나, 이에 한정되는 것은 아니다.The amount of the extraction solvent may be used 10 to 100 times relative to the weight of Heotgae tree (fruit), preferably 20 to 80 times, more preferably 30 to 50 times, but limited thereto no.
상기 헛개나무 추출물을 추출하는 방법은 교반 추출, 냉침 추출, 열수 추출, 침지 추출, 초임계 추출, 아임계 추출, 고온 추출, 고압 추출, 환류 냉각 추출 또는 초음파 추출 등의 당업계의 통상적인 추출방법을 사용할 수 있으며, 가온하여 환류 추출 또는 상온에서 추출하는 것이 바람직하다. 추출 시 온도는 10 내지 30℃인 것이 바람직하고, 상기 추출 시간은 1일 내지 20일인 것이 바람직하며, 1 내지 5일인 것이 더욱 바람직하나 이에 한정되지 않는다.The method of extracting the Heotgae tree extract is a conventional extraction method in the art such as stirring extraction, cold extraction, hot water extraction, immersion extraction, supercritical extraction, subcritical extraction, high temperature extraction, high pressure extraction, reflux cooling extraction or ultrasonic extraction. may be used, and extraction under reflux by heating or extraction at room temperature is preferred. The extraction temperature is preferably 10 to 30 ℃, the extraction time is preferably 1 to 20 days, more preferably 1 to 5 days, but is not limited thereto.
더욱 구체적으로, 헛개나무, 바람직하게는 헛개나무 열매를 음건하여 분쇄한 후, 추출용매를 헛개나무 분쇄물의 1 내지 20배 부피량만큼 가하여 추출하고 나서, 선택적으로 (감압)농축, 건조 또는 정제 과정을 거쳐 제조할 수 있다. 보다 구체적으로, 전술한 방법과 같이 추출용매를 가하여 유효성분물질을 추출하되 (a) 냉각 콘덴서가 장치되어 용매가 증발되는 것을 방지한 상태에서 50 내지 100℃의 온도 조건에서 1 내지 20시간 가열하여 추출하거나, (b) 5 내지 37℃의 온도 조건에서 1 내지 15일간 침적시켜 유효성분을 추출할 수 있다. More specifically, after drying and pulverizing the fruit of the sagebrush tree, preferably, the fruit of the sycamore tree, the extraction solvent is added by 1 to 20 times the volume of the pulverized sycamore tree, and then, optionally (reduced pressure) concentration, drying or refining process It can be manufactured through More specifically, the active ingredient is extracted by adding an extraction solvent as described above, but (a) heating at a temperature of 50 to 100° C. for 1 to 20 hours in a state where a cooling condenser is installed to prevent evaporation of the solvent. The active ingredient may be extracted by extraction or (b) immersion for 1 to 15 days at a temperature of 5 to 37°C.
또한, 본 발명에 따른 또 다른 실시예에 따르면, 상기 숙취 해소를 위한 헛개나무 추출물은 헛개나무 추출물의 분획물일 수 있다.In addition, according to another embodiment according to the present invention, the Heotgae tree extract for relieving the hangover may be a fraction of the Heotgae tree extract.
본 발명의 헛개나무 분획물은 상기 헛개나무 추출물(바람직하게는 탄소수 1-4의 저급 알코올 추출물)을 헥산, 클로로포름, 부탄올 및 에틸 아세테이트와 같은 물보다 극성이 낮은 용매로 분획하여 얻을 수 있으며, 바람직하게는 헥산 또는 클로로포름을 이용할 수 있으나, 이에 한정되지 않는다.The Heotgae tree fraction of the present invention can be obtained by fractionating the Heotgae tree extract (preferably a lower alcohol extract having 1-4 carbon atoms) with a solvent having a lower polarity than water, such as hexane, chloroform, butanol and ethyl acetate, preferably may use hexane or chloroform, but is not limited thereto.
상기 분획물은 건조시키기 전의 액상 상태의 헛개나무 추출물을 이용하거나 건조된 헛개나무 추출물을 물, 에탄올 또는 이들의 혼합용매 등 적당한 용매에 현탁 또는 용해시킨 후, 헥산, 클로로포름, 부탄올 또는 에틸 아세테이트와 같은 물보다 극성이 낮은 용매를 순차적으로 첨가하여 각각의 층을 분리한 다음 각 층을 감압 농축 및/또는 건조시켜 수득할 수 있다.The fractions are prepared by using the extract of hullifera in a liquid state before drying, or after suspending or dissolving the extract of fenugreek in a suitable solvent such as water, ethanol, or a mixed solvent thereof, in water such as hexane, chloroform, butanol or ethyl acetate. It can be obtained by sequentially adding a solvent having a lower polarity to separate each layer, and then concentrating and/or drying each layer under reduced pressure.
이때, 상기 감압 농축은 진공회전증발기를 이용하는 것이 바람직하나 이에 한정하지 않는다. In this case, the vacuum concentration is preferably performed using a vacuum rotary evaporator, but is not limited thereto.
또한, 본 발명에 따른 “건조”는 감압 건조, 진공 건조, 비등 건조, 분무 건조, 상온 건조 또는 동결 건조일 수 있으나, 동결 건조를 하는 것이 더욱 바람직하다. 다만 본 발명은 이러한 건조 방법에 한정되지 않는다.In addition, "drying" according to the present invention may be reduced pressure drying, vacuum drying, boiling drying, spray drying, room temperature drying or freeze drying, but freeze drying is more preferable. However, the present invention is not limited to this drying method.
상기 미분화된 커큐민 및 헛개나무 추출물은 1:2 내지 1:9의 비율로 본 발명에 따른 숙취 해소 조성물에 포함될 수 있다. 본 발명의 발명자들은 상기 커큐민과 헛개나무 추출물을 혼합한 경우, 커큐민과 헛개나무 추출물을 각각 이용하는 경우보다 더욱 우수한 숙취 해소 효과가 있음을 확인하였다. 더욱이, 상기 함량 범위에서 상기 성분들의 혼합에 의한 시너지 효과가 가장 뛰어났음을 확인하였을 뿐만 아니라, 상기 함량 범위에서 비용 대비 가장 효과적으로 본 발명의 목적을 달성할 수 있다. The undifferentiated curcumin and Heotgae tree extract may be included in the hangover relief composition according to the present invention in a ratio of 1:2 to 1:9. The inventors of the present invention confirmed that, when the curcumin and Heotgae tree extract were mixed, there was a more excellent hangover relieving effect than when curcumin and Heotgae tree extract were used, respectively. Moreover, in the content range, it was confirmed that the synergistic effect by mixing the components was the most excellent, and the object of the present invention can be achieved most effectively compared to the cost in the content range.
본 발명의 조성물은 상기 커큐민 및 헛개나무 추출물 이외에 본 발명의 목적을 저해하지 않는 범위 내에서 추가로 비오페린, 비타민B1 질산염, 비타민B6 염산염, 비타민 C, 글루콘산 마그네슘, 무수구연산, 펙틴, 젤란검, 벌꿀, 황금 추출물 및 과일 농축액으로 이루어진 군에서 선택된 어느 하나 이상을 더 포함할 수 있다. The composition of the present invention may further contain bioperin, vitamin B1 nitrate, vitamin B6 hydrochloride, vitamin C, magnesium gluconate, citric acid anhydride, pectin, and gellan gum within the range that does not impair the purpose of the present invention, in addition to the curcumin and the extract of the genus oleracea. , may further include any one or more selected from the group consisting of honey, golden extract and fruit concentrate.
상기 커큐민 및 헛개나무 추출물 이외에 포함되는 상기 성분들은 특별히 함량이 한정되지 않으며, 상기 커큐민 및 헛개나무 추출물이 본 발명의 목적을 달성하는데 방해가 되지 않는 한도 내에서 적절한 양이 조성물에 포함되어 사용될 수 있다.The content of the components other than the curcumin and the cypress extract is not particularly limited, and an appropriate amount may be included in the composition as long as the curcumin and the wormwood extract do not interfere with achieving the object of the present invention. .
본 발명의 조성물은 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상술한 천연 탄수화물은 포도당, 과당과 같은 모노사카라이드, 말토스, 슈크로스와 같은 디사카라이드, 및 덱스트린, 사이클로덱스트린과 같은 폴리사카라이드, 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 감미제로서는 타우마틴, 스테비아 추출물과 같은 천연 감미제나, 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다.The composition of the present invention may contain various flavoring agents or natural carbohydrates as additional ingredients. The above-mentioned natural carbohydrates are monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol. As the sweetener, natural sweeteners such as taumatine and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like can be used.
상기 성분들 외에 본 발명의 조성물은 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제 등을 함유할 수 있다. In addition to the above components, the composition of the present invention may contain various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, etc. have.
본 발명의 일 실시예에 따른 커큐민과 헛개나무 추출물을 동시에 함유하는 조성물은 다양한 형태로 제조되어 섭취될 수 있으며, 통상적인 약제학적 제형 즉 액제, 현탁제, 캡슐제, 정제, 껌, 환제, 과립제의 제형으로 제조할 수 있고 특히 바람직하게는 음료, 드링크제 등과 같은 액상의 제형을 가질 수 있다. The composition containing both curcumin and the extract of Heotgae tree according to an embodiment of the present invention can be prepared and ingested in various forms, and conventional pharmaceutical formulations such as liquids, suspensions, capsules, tablets, gums, pills, granules It may be prepared in the form of a liquid formulation, particularly preferably a beverage, such as a drink.
본 발명의 일 실시예에 따른 조성물은 음주 전 또는 음주 후 섭취할 수 있으며, 바람직하게는 음주 30분 전 섭취할 수 있다. 이를 통해 미분화된 커큐민과 헛개나무 추출물의 시너지 효과에 의한 숙취 해소 또는 예방 효과를 얻을 수 있다.The composition according to an embodiment of the present invention may be consumed before or after drinking, preferably 30 minutes before drinking. Through this, it is possible to obtain the effect of relieving or preventing a hangover by the synergistic effect of undifferentiated curcumin and Heotgae tree extract.
본 발명의 또 다른 실시예들에 따른 조성물은 테라큐민을 함유하며, 제형 안정성이 향상된 츄잉 가능한(chewable) 제형 또는 구미(gummy) 제형을 가질 수 있다. The composition according to still other embodiments of the present invention may have a chewable formulation or a gummy formulation containing teracumin and improved formulation stability.
상기 츄잉 가능한 제형 또는 구미 제형은 사탕, 캬라멜, 젤리 등의 형태로 씹을 수 있으며, 끈적끈적한 점성을 갖는 제형이면 모두 해당될 수 있으며, 특별히 상기 사탕, 젤리, 캬라멜 등에 한정되는 것은 아니다. The chewable formulation or the gummi formulation can be chewed in the form of candy, caramel, jelly, etc., and may be any formulation having a sticky viscosity, and is not particularly limited to the candy, jelly, caramel, and the like.
상기 츄어블 또는 구미 제형에는 젤라틴, 옥수수 시럽, 슈크로즈 시럽, 글루코스 시럽 및 기타 천연 및 인공 감미제가 본 발명의 목적을 저해하지 않는 범위 내에서 적절히 첨가될 수 있다. 첨가될 수 있는 성분들은 츄잉 가능한 제품 또는 구미 제형의 제품에 포함될 수 있는 것이라면 특별히 제한되지 않고 모두 포함될 수 있다.Gelatin, corn syrup, sucrose syrup, glucose syrup, and other natural and artificial sweeteners may be appropriately added to the chewable or gummie formulation within a range that does not impair the purpose of the present invention. The ingredients that can be added are not particularly limited as long as they can be included in the chewable product or the product of the gummi formulation, and all may be included.
일반적으로 구미 제형의 조성물은 섭취가 용이하고, 부피를 적게 차지하고, 휴대가 용이하다는 장점을 갖는다. 이에 본 발명의 발명자들은 숙취 해소를 위한 조성물, 특히 본 발명의 커큐민을 포함하는 숙취 해소용 조성물의 제형으로 구미 제형에 대해 연구해왔다. In general, the composition of the Gumi formulation has the advantages of being easy to ingest, occupying a small volume, and being easy to carry. Accordingly, the inventors of the present invention have been studying the Gumi formulation as a composition for relieving a hangover, in particular, a formulation of a composition for relieving a hangover containing curcumin of the present invention.
그러나, 분말 형태의 입자들은 용매 분산성이 좋지 않으며, 게다가 유효성분으로 사용되는 커큐민 성분의 배합 및 건조 과정에서 침전이 일어나는 등의 문제가 발생할 수 있어 분말 형태의 입자 대신 주재(主材)를 농축물 또는 추출물의 형태로 이용하는 것이 일반적이다. However, powder-type particles have poor solvent dispersibility, and in addition, problems such as precipitation may occur during mixing and drying of the curcumin component used as an active ingredient. It is generally used in the form of water or extract.
특히, 일반적인 커큐민의 경우 재료의 배합 후 건조 과정에서 입자 크기에 따른 층을 형성하거나, 침전이 일어날 수 있어 커큐민이 제제 내에 균일하게 분포되지 않아, 구미 제제의 제형적 안정성이 좋지 못한 단점이 있었다. In particular, in the case of general curcumin, a layer according to the particle size may be formed or precipitation may occur during the drying process after mixing the materials, so that curcumin is not uniformly distributed in the formulation, resulting in poor formulation stability of the Gumi formulation.
본 발명의 일 실시예에 따른 테라큐민을 함유하는 조성물은 제형 안정성이 우수하다. 본 명세서에서 사용된 제형 안정성이 우수하다는 의미는 제품 내에 테라큐민 입자가 골고루 분산되어 있고, 분말의 침전이 육안으로 관찰되지 않는 상태를 의미한다. The composition containing theracumin according to an embodiment of the present invention has excellent formulation stability. As used herein, the excellent formulation stability means that the theracumin particles are evenly dispersed in the product, and the precipitation of the powder is not observed with the naked eye.
본 발명의 발명자들은 유효성분인 커큐민이 제제 내에 고루 분포될 수 있고, 제형 안정성을 증가시킬 수 있는 방법에 대해 연구를 거듭한 결과, 통상적인 커큐민 대신에 특정 입자 사이즈, 특히 미분화된 입자 사이즈를 갖는 커큐민인, 본 발명의 테라큐민을 유효성분으로 함유함으로써 제형적 안정성이 개선된 커큐민 함유 구미 또는 츄어블 카라멜 제제를 개발할 수 있게 되었다. The inventors of the present invention have repeatedly studied how the active ingredient curcumin can be evenly distributed in the formulation and increase formulation stability. As a result, it has a specific particle size, especially a micronized particle size, instead of conventional curcumin. It has become possible to develop curcumin-containing gummi or chewable caramel formulations with improved formulation stability by containing curcumin, the theracumin of the present invention, as an active ingredient.
상기 커큐민은 전기영동광산란법(Electrophoretic Light Scattering, 레이저 도플러법) (예를 들어, ELS-8000 이용)으로 측정한 평균 입도(D50)가 100 내지 900 nm이며, 바람직하게는 100 내지 400 nm, 더욱 바람직하게는 150 내지 300 nm일 수 있다. 상기 입도 범위에서 커큐민의 용해도가 우수하며, 상기 입도 범위의 커큐민은 배합 후 건조하는 과정에서 입자 분산도가 우수하여 제형 안정성이 크게 향상될 수 있다. 입자 크기에 따른 분리. 이와 같은 미분화된 커큐민으로, 예를 들어, 본 발명의 목적상 테라큐민TM이 사용될 수 있다. 상기 테라큐민은 평균 입도가 약 0.19~0.3 ㎛이다. The curcumin has an average particle size (D 50 ) measured by an electrophoretic light scattering (laser Doppler method) (eg, using ELS-8000) of 100 to 900 nm, preferably 100 to 400 nm, More preferably, it may be 150 to 300 nm. The solubility of curcumin in the above particle size range is excellent, and curcumin in the above particle size range has excellent particle dispersion during drying after mixing, so that formulation stability can be greatly improved. Separation according to particle size. As such micronized curcumin, for example, theracumin TM can be used for the purposes of the present invention. The theracumin has an average particle size of about 0.19 to 0.3 μm.
본 발명의 또 다른 실시예에 따르면, 바람직하게, 커큐민을 포함하는 구미 또는 츄어블 카라멜 제형의 제제는 숙취 해소의 목적을 향상시키기 위하여 헛개나무 추출물을 더 포함할 수 있다. According to another embodiment of the present invention, preferably, the formulation of the gummi or chewable caramel formulation containing curcumin may further include a Heotgae tree extract to improve the purpose of relieving a hangover.
본 발명의 미분화된 커큐민 및 헛개나무 추출물을 동시에 함유하는 조성물은 각각 사용하는 경우보다 더욱 우수한 숙취 해소 효과를 나타낼 수 있다. The composition containing the micronized curcumin and the Heotgae tree extract of the present invention at the same time can exhibit a more excellent hangover relieving effect than when each is used.
미분화된 커큐민 및 헛개나무 추출물을 동시에 사용할 때 나타나는 시너지 효과에 의해 음주 후 나타나는 여러 증상들을 개선할 수 있으며 더 나아가 알코올 섭취로 인한 간질환을 예방할 수 있다. Due to the synergistic effect that appears when undifferentiated curcumin and mulberry extract are used at the same time, various symptoms appearing after drinking can be improved, and furthermore, liver disease caused by alcohol intake can be prevented.
또한, 본 발명의 조성물은 복용하기 간편한 드링크제로 활용할 수 있어, 음주 전후 편리하게 이용할 수 있다.In addition, the composition of the present invention can be used as a drink that is easy to take, and can be conveniently used before and after drinking.
또한 본 발명은 제형적 안정성이 개선된, 커큐민을 유효성분으로 함유하는 츄잉 가능한 제형 또는 구미 제형의 제제를 제공한다. 커큐민의 입도를 나노 사이즈로 획기적으로 감소시켜 구미 제형의 조성물을 제조하는 과정에서 발생할 수 있는 제형 불안정성을 개선하여, 휴대가 편리하고 섭취가 용이한 제형으로 생산할 수 있다.In addition, the present invention provides a formulation of a chewable formulation or a gummy formulation containing curcumin as an active ingredient, with improved formulation stability. By remarkably reducing the particle size of curcumin to a nano size, formulation instability that may occur in the process of preparing the composition of the Gumi formulation can be improved, so that it can be produced in a formulation that is convenient to carry and easy to consume.
도 1은 비교예 1 내지 4 및 실시예 1의 조성물을 섭취한 그룹의 혈액 내 아세트알데히드 농도를 측정하여 나타낸 그래프이다.
도 2는 테라큐민, 인도산 커큐민, 및 국내 유통 커큐민을 포함하는 젤리에 있어서, 입자들의 분산도를 나타낸 그림이다. ①은 테라큐민 파우더, ②는 인도산 커큐민 파우더 ③은 인도산 커큐민 액 ④는 국내 유통되는 커큐민 파우더가 포함된 젤리를 나타낸다.1 is a graph showing the measurement of the concentration of acetaldehyde in the blood of a group that ingested the compositions of Comparative Examples 1 to 4 and Example 1.
2 is a diagram showing the degree of dispersion of particles in a jelly containing theracumin, curcumin from India, and domestic distribution curcumin. ① indicates terracumin powder, ② indicates Indian curcumin powder, ③ indicates Indian curcumin liquid, and ④ indicates jelly containing curcumin powder distributed in Korea.
이하, 본 발명의 이해를 돕기 위하여 실시예 등을 들어 상세하게 설명하기로 한다. 그러나, 본 발명에 따른 실시예들은 여러 가지 다른 형태로 변형될 수 있으며, 본 발명의 범위가 하기 실시예들에 한정되는 것으로 해석되어서는 안 된다. 본 발명의 실시예들은 당업계에서 평균적인 지식을 가진 자에게 본 발명을 보다 완전하게 설명하기 위해 제공되는 것이다.
Hereinafter, examples and the like will be described in detail to help the understanding of the present invention. However, the embodiments according to the present invention may be modified in various other forms, and the scope of the present invention should not be construed as being limited to the following examples. The embodiments of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art.
실시예 1. 테라큐민 및 헛개나무 추출물을 함유하는 드링크제 제조Example 1. Preparation of drink formulations containing theracumin and Heotgae tree extract
80℃ 이상의 열수 1리터에 하기 표 1의 성분 중 젤란검 및 펙틴을 먼저 완전 용해하고 향을 제외한 원료를 순차적으로 투입하여 혼합한 후, 정제수(열수)를 가해 전체 부피 4 리터로 제조한 후 통상의 방법에 따라 가온멸균하여 100mL씩 충진하여 드링크제를 제조하였다. 하기 성분들의 함량은 중량%로 나타냈다.
Gellan gum and pectin among the ingredients in Table 1 below are first completely dissolved in 1 liter of hot water at 80° C. or higher, and then the raw materials except for the fragrance are sequentially added and mixed, and purified water (hot water) is added to prepare a total volume of 4 liters. A drink was prepared by heating and sterilizing according to the method of 100mL each. The contents of the following components are expressed in weight %.
비교예 1-4. 테라큐민 함유 드링크제 제조Comparative Example 1-4. Manufacture of drinks containing teracumin
하기 표 2는 테라큐민의 함량을 달리하여 제조한 테라큐민(Theracurmin) 300mg (비교예 2) 및 500mg (비교예 3)과, 테라큐민을 포함하지 않는 대조군 (비교예 1)의 성분 및 함량을 나타낸 표이다. 단위는 중량%이다.Table 2 below shows the components and contents of Theracurmin 300mg (Comparative Example 2) and 500mg (Comparative Example 3), and the control group (Comparative Example 1) not containing Theracumin, prepared by varying the Theracumin content. table shown. The unit is % by weight.
대조군Comparative Example 1
control
Theracurmin 300mgComparative Example 2
Theracurmin 300mg
Theracurmin 500mgComparative Example 3
Theracurmin 500mg
상기 비교예 1 내지 3은 80℃ 이상의 열수에 상기 표 2의 함량에 따라 각 성분을 혼합한 후, 정제수(열수)를 가하여 4 리터 부피로 제조한 후 통상의 방법에 따라 가온멸균하여 병에 100mL씩 충진하여 드링크제를 제조하였다.
In Comparative Examples 1 to 3, each component was mixed with hot water at 80° C. or higher according to the contents of Table 2, purified water (hot water) was added to prepare a volume of 4 liters, followed by heating and sterilization according to a conventional method to 100 mL in a bottle A drink was prepared by filling each.
실험예 1. 아세트알데히드 농도 측정Experimental Example 1. Measurement of acetaldehyde concentration
19세 이상, 체중 50Kg의 남성 30명을 선발하여 무작위로 6명씩 다섯 그룹으로 나누고, 식사를 하지 않고 실험을 실시하였다.Thirty males aged 19 years or older and weighing 50 kg were randomly divided into 5 groups of 6 each, and the experiment was conducted without eating.
알코올 섭취량은 알코올 0.5g/Kg으로 정하고 실험 대상자 30명에게 6시부터 1.5시간 동안 15분 간격으로 정해진 알코올을 섭취시켰다. 음주 완료 후 각자에게 배정된 비교예 1 내지 4 및 실시예 1을 음주 30분 전에 100 mL씩 섭취시켰다. 음주 후 30분부터 12시간 동안 일정 간격으로 팔 정맥에서 채혈하여 성분 분석을 위한 전처리를 한 후 체내 아세트알데히드 농도를 측정하였고, 그 결과를 도 1에 나타냈다. Alcohol intake was set at 0.5 g/Kg of alcohol, and 30 subjects were given alcohol at 15-minute intervals from 6 o'clock to 1.5 hours. After completion of drinking, each of Comparative Examples 1 to 4 and Example 1 were ingested by 100 mL each 30 minutes before drinking. After drinking, blood was collected from the veins of the arm at regular intervals for 12 hours from 30 minutes after drinking, and the concentration of acetaldehyde in the body was measured after pretreatment for component analysis, and the results are shown in FIG. 1 .
도 1에 나타난 바에 따르면, 테라큐민이 포함되지 않은 비교예 1의 조성물을 섭취한 사람의 경우 음주 후 4 시간까지 여전히 높은 아세트알데히드 농도를 나타냈다. 테라큐민 성분이 함유된 비교예 2 및 3의 조성물을 섭취한 군은 상대적으로 아세트알데히드 농도가 비교예 1에 비해서는 낮은 것으로 나타났다. 그러나 비교예 2 및 3의 조성물을 섭취한 군의 경우에도 여전히 음주 후 2시간이 경과한 시점에도 혈액내 아세트알데히드 농도가 500ppb 이상인 것으로 나타났다. 또한, 숙취 해소 효과가 있는 것으로 알려져 있는 헛개 추출물(비교예 4)을 섭취한 군은 아세트알데히드 농도가 아주 약간 감소한 것으로 나타났다. As shown in FIG. 1 , in the case of a person who consumed the composition of Comparative Example 1 that did not contain theracumin, the acetaldehyde concentration was still high until 4 hours after drinking. It was found that the acetaldehyde concentration of the group taking the compositions of Comparative Examples 2 and 3 containing the theracumin component was relatively lower than that of Comparative Example 1. However, even in the case of the group taking the compositions of Comparative Examples 2 and 3, it was found that the concentration of acetaldehyde in the blood was 500 ppb or more even when 2 hours had elapsed after drinking. In addition, it was found that the acetaldehyde concentration was very slightly decreased in the group ingested with the extract (Comparative Example 4), which is known to have a hangover relieving effect.
이에 반해, 테라큐민 및 헛개나무 추출물을 동시에 함유하는 조성물을 섭취한 군의 경우에는 섭취 후 음주를 시작한 시점부터 아세트알데히드 농도가 다른 군에 비해 가장 낮은 것으로 나타났으며, 음주 후 30분이 경과한 시점부터 아세트알데히드 농도가 약 500ppb 정도에 불과한 것으로 나타났다. On the other hand, in the case of the group that consumed the composition containing theracumin and Hengae extract at the same time, the acetaldehyde concentration was the lowest from the time of starting drinking after ingestion compared to the other groups, and 30 minutes after drinking It was found that the acetaldehyde concentration was only about 500 ppb.
이는 테라큐민과 헛개나무 추출물을 동시에 사용함으로써 이들간의 상호 시너지 작용에 의해 체내 아세트알데히드 축적 농도가 크게 감소된 것으로 생각되며, 더욱이 실시예 1의 경우 비교예 4에서 사용한 헛개나무 추출물의 절반에 해당하는 40 g 정도만 사용하였음에도 현저히 향상된 알코올 분해 효과를 보였다. It is thought that the accumulation of acetaldehyde in the body is greatly reduced by the mutual synergistic action between theracumin and the extract of H. serrata cumin, and moreover, in the case of Example 1, it corresponds to half of the extract from H. Although only about 40 g was used, the alcohol decomposition effect was significantly improved.
결론적으로 음주 후 30분이 경과한 시점에서 측정한 아세트알데히드 농도를 비교한 결과, 비교예 2의 테라큐민에 의해 감소된 아세트알데히드 농도가 약 1500ppb이고, 비교예 4의 헛개나무 추출물에 의해 감소된 아세트알데히드 농도가 약 500ppb였다. 그러나 실시예 1의 경우 테라큐민의 농도는 비교예 2와 동일하나, 헛개나무 추출물의 양을 그 절반만 사용하였음에도 2000ppb 정도가 감소된 것으로 나타났다. 따라서, 테라큐민과 헛개나무 추출물을 각각 사용하는 경우보다 이들을 동시에 사용함으로써 예상하지 못한 시너지 효과에 의해 알코올 분해가 촉진되어 체내 아세트알데히드 농도가 감소된 것으로 생각되었다.
In conclusion, as a result of comparing the acetaldehyde concentration measured at the time point 30 minutes after drinking, the acetaldehyde concentration reduced by theracumin of Comparative Example 2 was about 1500 ppb, and the acetaldehyde concentration reduced by the Heotgae tree extract of Comparative Example 4 was compared. The aldehyde concentration was about 500 ppb. However, in the case of Example 1, the concentration of theracumin is the same as that of Comparative Example 2, but it was found that about 2000 ppb was reduced even though only half of the amount of the Heotgae tree extract was used. Therefore, it was thought that alcohol decomposition was promoted by an unexpected synergistic effect by using them at the same time rather than when theracumin and the extracts of Heotgae tree were used, respectively, and the concentration of acetaldehyde in the body was reduced.
실험예 2. 숙취증상 해소 관능 평가Experimental Example 2. Sensory evaluation of hangover symptom relief
실험예 1과 동일한 실험자들을 대상으로 숙취증상 해소 효과를 평가하기 위하여 가장 일반적인 숙취 증상을 적시하고 음주자의 반응이 아주 심한 경우 5점, 심한 경우 4점, 약간 심한 경우 3점, 보통인 경우 2점, 없는 경우 1점으로 한 설문지를 음주 후 4시간, 8시간, 12시간 후 3회에 걸쳐 작성하도록 하여 비교 검토하여 이를 표 3에 나타냈다. 설문은 비교예 2 내지 4 및 실시예 1의 조성물을 섭취한 그룹에 대해서만 실시하였다. In order to evaluate the effect of relieving hangover symptoms for the same experimenters as in Experimental Example 1, the most common hangover symptoms were indicated, and the reaction of the drinker was very severe, 5 points, severe 4 points, slightly severe 3 points, moderate 2 points In the absence of , the questionnaire with 1 point was completed 3 times after 4 hours, 8 hours, and 12 hours after drinking, and compared and reviewed, and the results are shown in Table 3. The questionnaire was conducted only for the group that consumed the compositions of Comparative Examples 2 to 4 and Example 1.
상기 표 3에 나타난 바에 따르면, 음주 4시간이 경과한 시점에 실시예의 경우 대부분이 2 점대의 점수를 받아 상대적으로 숙취 증상이 많이 약한 것으로 나타났으나, 비교예 2 내지 4에서는 음주 4시간이 경과된 시점에는 3점대 후반 및 4점대의 높은 점수를 받았다. As shown in Table 3, when 4 hours of drinking had elapsed, most of the Examples received a score of 2 points, indicating that hangover symptoms were relatively weak, but in Comparative Examples 2 to 4, 4 hours of drinking had elapsed. At the time of completion, it received high scores in the late 3s and 4s.
또한 음주 12 시간이 경과한 시점에서도 실시예를 제외하고는 대부분이 여전히 숙취 증상이 남아있는 것으로 나타났다. In addition, it was found that most of the hangover symptoms still remained even after 12 hours of drinking, except in Examples.
이를 통해 본 발명의 테라큐민 및 헛개나무 추출물을 함께 함유하는 조성물은 각각 사용한 경우보다 훨씬 더 우수한 숙취 해소 효과를 갖는다는 점을 확인할 수 있었다.
Through this, it was confirmed that the composition containing theracumin and the extract of Heotgae tree of the present invention had a much better hangover relieving effect than when each was used.
실험예Experimental example 3. 제형 안정성 비교 3. Comparison of formulation stability
테라큐민(테라밸류 사), 인도산 커큐민 파우더, 인도산 커큐민 액, 및 국내 유통 커큐민(푸른잎 b&f)을 각각 준비하였다. 일반적인 젤리를 제조하는 과정을 통하여 각각 테라큐민, 인도산 커큐민 및 국내 유통 커큐민을 함유하는 젤리를 제조하였다. Theracumin (Teravalue Co.), Indian curcumin powder, Indian curcumin liquid, and domestically distributed curcumin (Greenleaf b&f) were prepared, respectively. Jelly containing theracumin, curcumin from India, and curcumin distributed in Korea was prepared through the process of manufacturing general jelly, respectively.
아래 표 4는 한천 혼합용액에 상기 네 가지 종류의 커큐민을 가한 후 냉각한 상태에서 젤리상의 혼합물의 상태를 나타낸 표이다. Table 4 below is a table showing the state of the jelly-like mixture in a cooled state after adding the four types of curcumin to the agar mixture.
상기 표 4에 나타난 바에 따르면, 테라큐민이 함유된 젤리상은 냉각 후 테라큐민의 분산도가 매우 우수하여, 침전이 거의 발생하지 않았으나, 인도산 커큐민과 국내 유통 커큐민을 이용한 경우 하단에 입자들의 침전이 관찰되었다. As shown in Table 4, the jelly phase containing theracumin had a very good dispersibility of theracumin after cooling, so that almost no precipitation occurred. became
도 2를 참조하면, 테라큐민을 함유한 경우 전체적으로 균일한 색을 나타내고, 입자가 고루 분포한 것으로 나타났다. Referring to FIG. 2 , it was found that when theracumin was contained, the overall color was uniform and the particles were evenly distributed.
따라서, 본 발명의 테라큐민이 다른 커큐민들에 비해서 구미 제형으로 제조하기에 적합한 것을 알 수 있다.Therefore, it can be seen that the theracumin of the present invention is suitable for preparing a gummy formulation compared to other curcumin.
Claims (10)
상기 커큐민과 헛개나무 추출물은 1:2 내지 1:9 (커큐민:헛개나무 추출물)의 중량 비율로 포함되는 숙취 해소 또는 예방용 조성물.It is characterized in that it contains curcumin and Heotgae tree extract having an average particle size of 100 to 900 nm as active ingredients,
The curcumin and Heotgae tree extract are 1:2 to 1:9 (curcumin: Heotgae tree extract) in a weight ratio of a composition for relieving or preventing a hangover.
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| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| X091 | Application refused [patent] | ||
| AMND | Amendment | ||
| X701 | Decision to grant (after re-examination) | ||
| GRNT | Written decision to grant |