KR20210147707A - Composition for relieving and preventing hangover comprising Oenanthe javanica extracts - Google Patents

Abstract

The present invention relates to a method for producing an Oenanthe javanica extract containing a high content of isorhamnetin and to a composition for relieving and preventing a hangover comprising the produced Oenanthe javanica extract. In the production method, 75% ethanol and 20 times water thereof are used as a solvent and extracted at 55 to 65℃ for 22 to 26 hours after hot air drying an edible part of Oenanthe javanica, and isorhamnetin can be extracted in an optimal yield and high content. In addition, the Oenanthe javanica extract according to the production method contains a high content of isorhamnetin compared to the Oenanthe javanica extract according to other methods, thereby having very excellent hangover relieving and preventive effects.

Description

Composition for relieving and preventing hangover comprising Oenanthe javanica extracts

The present invention relates to a composition for relieving and preventing a hangover comprising a water parsley extract, wherein the water parsley extract has a high isoramnetine content, and has an effect of not only relieving a hangover but also preventing a hangover when drinking.

Alcohol is one of the favorite foods that have been widely used along with human history since ancient times, and is widely used for festivals, religious ceremonies, medicinal purposes, and stress relief. However, excessive drinking causes symptoms such as nausea, vomiting, dizziness, thirst, lethargy, headache, and muscle pain due to alcoholic hangover, which not only causes social and economic damage due to decreased work efficiency, but also causes liver, stomach, pancreas, and gastrointestinal system , brain, nervous system, etc., adversely affects the organs of the whole body, mentally devastated and, in severe cases, even develops into a state of panic, causing various social problems (Sung-Man Park and Jo Jung-Kwan, 1993; Swift R and Davidson D, 1998).

For this reason, foods using bean sprouts and bald eagles have been used to relieve hangovers after drinking. Recently, many functional drinks or foods for hangover and liver protection before and after drinking have been in the spotlight. Among them, hangover relief drinks is the largest consumption. Specifically, office workers in their 30s and 50s, the main drinking age group, prefer relatively high alcohol drinks such as soju or whiskey. Demand is gradually increasing. However, since products currently on the market have a problem of causing side effects such as bloating, vomiting, or abdominal pain, they are derived from natural products and have fewer side effects and are effective in effectively removing overall hangover symptoms. Development of a functional beverage or pharmaceutical composition This is in progress.

Water parsley ( Oenanthe javanica ) is a representative food that purifies the blood and has been valued since ancient times and served in the royal court. It has a unique flavor and taste due to its rich essential oil component, but also contains vitamins A and C, calcium, iron, and other minerals. It is an abundant representative alkaline food. According to 「Donguibogam」 or 「Bonchosupyu」, there is a record that "water parsley clears the head, smoothes the large intestine and small intestine, promotes metabolism, lowers high fever, is effective for rheumatism, and is effective for various ailments". , blood pressure lowering effect has been recognized, so it is one of the favorite foods for high blood pressure patients, and it is also known to have the effect of relieving constipation and neutralizing or removing various toxic substances in the body.

Korean Patent Registration No. 10-1280421 (2013.07.01. Announcement) Korean Patent Registration No. 10-1402322 (2014.06.02. Announcement) Korean Patent Registration No. 10-2039912 (2019.12.05. Announcement)

One object of the present invention is to provide a method for preparing a water parsley extract containing isoramnetine in a high content.

Another object of the present invention is to provide a composition for relieving and/or preventing a hangover comprising the prepared water parsley extract.

In one aspect, the present invention provides a method for producing a water parsley extract comprising isoramnetine in a high content.

Specifically, the present invention provides isoramnetine in a high content, comprising the steps of drying and pulverizing the edible part of water parsley, and preparing an extract using 75% ethanol and 20 times its water as a solvent for the pulverized water parsley. It provides a method for producing a water parsley extract comprising

The water parsley ( Oenanthe javanica ) is a leafy vegetable belonging to the buttercup family. Although the water parsley is produced throughout the country, it is preferable that the water parsley is produced in the Noan area of Naju.

The water parsley is known to contain a large amount of isoramnetin, a kind of flavonoid, but the conventional hot water extract of water parsley has a disadvantage in that the extraction yield of isoramnetin is low. However, according to the method described above, it is possible to prepare a water parsley extract containing isoramnetine in a high content.

Here, the high content is contained in an amount of 0.7 to 0.72% by weight, preferably 0.7 to 0.71% by weight, and more preferably 0.705 to 0.71% by weight, based on the total weight of the water parsley extract.

In addition, the high content means that it is present in an amount of 70 to 72 times, preferably 70 to 71 times, more preferably 70.5 to 71 times compared to the content of isoramnetin contained in the water parsley hot water extract.

Hereinafter, a method for producing a water parsley extract containing isoramnetin in a high content according to the present invention will be described in detail.

First, it is a step of drying and pulverizing the decorative part of water parsley.

The water parsley is the same as described above, and the decorative part of the water parsley refers to the leaves and stems except for the root of the water parsley.

The drying is to maintain the water content of water parsley at 20% or less, preferably 1 to 15%, more preferably 1 to 10%, and a conventional drying method, for example, hot air drying, freeze drying, natural drying, Methods such as cold air drying and vacuum drying can be used.

The pulverization is a process of crushing dried water parsley into a size that is easy to extract, and the size (width, length, and thickness) is 1 mm or less, preferably 0.5 mm or less, more preferably 0.1 using a conventional grinder. This is the process of slicing down to mm.

Next, using the pulverized water parsley with 75% ethanol and 20 times its water as a solvent, an extract is prepared.

As a specific example, when the pulverized water parsley prepared in the above step was extracted using 75% ethanol and 20 times the volume of the ethanol as a solvent, the content of isoramnetine was the best.

In addition, when extracting using the solvent, 55 to 65 ℃, preferably 58 to 62 ℃, more preferably at 60 ℃ 22 to 26 hours, preferably 23 to 25 hours, most preferably for 24 hours In the case of extraction, the content of isoramnetine was the best compared to other temperature and time conditions.

The water parsley extract prepared by the above method has an isoramnetin content of 0.7 to 0.72 wt%, preferably 0.7 to 0.71 wt%, more preferably 0.705 to 0.71 wt%, based on the total weight of the parsley extract. contains

In addition, the water parsley extract prepared by the above method exhibits an isoramnetine content that is 70 to 72 times, preferably 70 to 71 times, more preferably 70.5 to 71 times higher than that of the water parsley hot water extract.

In another aspect, the present invention provides a composition for relieving and preventing a hangover comprising a water parsley extract.

In the present invention, the water parsley extract is an extract prepared by the above-described method. The water parsley extract prepared by the above method not only can be prepared in a short time, but also contains high isoramnetine compared to other extraction methods, and has an excellent effect in relieving and preventing hangover.

The water parsley extract contains a high content of isoramnetin in an amount of 0.7 to 0.72 wt%, preferably 0.7 to 0.71 wt%, more preferably 0.705 to 0.71 wt%, based on the total weight of the parsley extract.

In the present invention, the composition for relieving and preventing hangover contains water parsley extract in an amount of 1 to 20% by weight, preferably 5 to 20% by weight, more preferably 5 to 18% by weight, even more preferably, based on the total weight of the composition. Preferably, it contains 5 to 15% by weight. When the content of water parsley extract is less than 1% by weight, the desired hangover relief and prevention effect cannot be obtained, and when it exceeds 20% by weight, the increase in hangover relief and prevention effect according to the increase in the content is insignificant.

As a specific example, when 10 male and female experimental groups who drank the composition according to the present invention drank, a water drinking group (control group), a commercially available product drinking group (comparative group 1), and hot water extract of water parsley (comparative group 2) The taste and flavor when drinking were superior, and the effect of relieving hangover was also very good.

Therefore, the composition of the present invention is very excellent in relieving hangover and preventing effect.

As a specific embodiment, the composition for relieving and preventing hangovers of the present invention may further include pear juice in addition to the water parsley extract.

The pear juice may be prepared by a conventional method, but specifically, it may be prepared by washing the pear thoroughly, removing the stem, cutting it to an appropriate size, and then juicing it with a juicer.

The pear juice is preferably added in an amount equal to the content of water parsley extract.

As a specific example, when 10 male and female experimental groups who drank the composition in which pear juice was added to the composition according to the present invention drank, the taste and flavor were superior to that of the composition containing only water parsley extract, and the taste and aroma were superior to those of the composition containing water parsley extract. The resolving effect was also found to be more excellent.

The composition of the present invention may be a pharmaceutical composition, food composition, food or health functional food depending on the intended use.

As a specific aspect, the present invention provides a water parsley extract containing a high content of isoramnetin, or a pharmaceutical composition for relieving and preventing hangovers comprising the water parsley extract and pear juice as active ingredients

The pharmaceutical composition of the present invention is formulated in various forms such as oral formulations such as powders, granules, tablets, capsules, suspensions, emulsions, syrups and aerosols, and injections of sterile injection solutions according to conventional methods for each purpose of use. and can be administered orally, or administered through various routes including intravenous, intraperitoneal, subcutaneous, rectal, topical administration, and the like.

Examples of pharmaceutically acceptable carriers, excipients or diluents that may be included in such pharmaceutical compositions include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium Phosphate, calcium silicate, cellulose, methyl cellulose, amorphous cellulose, crystalline cellulose, carboxymethyl cellulose, carboxymethyl cellulose calcium, carboxymethyl cellulose sodium, sodium starch glycolate, cyclodextrin, low-substituted hydroxypropyl cellulose, hydroxyethyl cellulose , hydroxypropyl cellulose, xanthan gum, gourd gum, agar, citric acid, sodium citrate, sodium alginate, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, sucrose fatty acid ester , shell calcium, magnesium stearate, talc and mineral oil.

The pharmaceutical composition of the present invention is an additional auxiliary agent, vitamin B group, vitamin C, vitamin E, beta-carotene, Ca, Mg, Zn, lecithin, alanine, taurine, maltol, fructose, oligosaccharide, reishi, glutate, chitosan, aspartic acid, Cordyceps , and may further include milk thistle.

The pharmaceutical composition of the present invention may further include a filler, an anti-agglomeration agent, a lubricant, a wetting agent, a flavoring agent, an emulsifier, a preservative, and the like. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, etc., and such solid preparations include at least one excipient in the composition, for example, starch, lactose, calcium carbonate, sucrose, lactose, gelatin. It is formulated by mixing, etc. In addition to simple excipients, lubricants such as magnesium stearate and talc may be used. Liquid formulations for oral use may include suspensions, solutions, emulsions, syrups, etc., and various excipients, such as wetting agents, sweeteners, fragrances, preservatives, etc., in addition to water and liquid paraffin, which are commonly used simple diluents, may be included. can

When the composition of the present invention is a pharmaceutical composition, it is administered in a pharmaceutically effective amount. In the present invention, "pharmaceutically effective amount" means an amount sufficient to treat a disease with a reasonable benefit/risk ratio applicable to medical treatment, and the effective dose level is determined by the type, severity, activity of the drug, and the type of disease in the patient; Sensitivity to the drug, time of administration, route of administration and excretion rate, duration of treatment, factors including concomitant drugs and other factors well known in the medical field. The composition of the present invention may be administered as an individual therapeutic agent or in combination with other therapeutic agents, may be administered sequentially or simultaneously with conventional therapeutic agents, and may be administered singly or multiple times. In consideration of all of the above factors, it is important to administer an amount that can obtain the maximum effect with a minimum amount without side effects, which can be easily determined by those skilled in the art. Specifically, the effective amount of the active ingredient in the composition of the present invention may vary depending on the age, sex, and weight of the patient, 10 to 20,000 mg, preferably 100 to 5,000 mg may be administered. However, the dosage is not intended to limit the scope of the present invention in any way, as it may increase or decrease depending on the route of administration, disease severity, sex, weight, age, etc.

As another specific aspect, the present invention provides a water parsley extract containing a high content of isoramnetin, or a food for relieving and preventing hangovers comprising the water parsley extract and pear juice as active ingredients

The water parsley extract or water parsley extract and pear juice of the present invention may be added to food as it is, or used together with other foods or food ingredients, and may be appropriately used according to a conventional method.

Foods to which the extract can be added include, for example, various foods, beverages, gum, tea, candy, vitamin complexes, health functional foods, powders, granules, tablets, capsules, jellies, or beverages, and there are special no limits.

Preferably, it may be added to food or beverages for the purpose of relieving a hangover. At this time, the amount of the water parsley extract or water parsley extract and pear juice in the food or beverage may be added in an amount of 0.01 to 15% by weight of the total food weight, and the beverage composition is 0.01 to 20 g, preferably 0.1 to 5 g, based on 100 mL can be added in a proportion of The food of the present invention is not particularly limited in other ingredients except for containing the extract as an essential ingredient in the indicated ratio, and may contain various flavoring agents or natural carbohydrates as additives, like conventional beverages. The above natural carbohydrates include saccharides such as glucose, fructose, maltose, sucrose, dextrin, and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol. As the flavoring agent, natural flavoring agents (taumartin, stevia extract (eg, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) may be used. Also, the food of the present invention In addition to various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic and natural flavoring agents, coloring and thickening agents, pectic acid and its salts, alginic acid, citric acid, sodium citrate and salts thereof, organic acids, protective It may contain a sexual colloid thickener, pH adjuster, stabilizer, preservative, glycerin, alcohol, carbonation agent used in carbonated drinks, etc. These additives are 0.01 per 1 part by weight of the water parsley extract of the present invention or the mixture of water parsley extract and pear juice to about 50 parts by weight.

The method for producing a water parsley extract according to the present invention can extract isoramnetin in a high content with an optimal yield, and the water parsley extract containing it has a remarkably superior effect in relieving and preventing a hangover compared to a common water parsley extract, It can be usefully used as a pharmaceutical composition for hangover relief and prevention, and as a food or functional food.

Hereinafter, examples and the like will be described in detail to help the understanding of the present invention. However, the embodiments according to the present invention may be modified in various other forms, and the scope of the present invention should not be construed as being limited to the following examples. The embodiments of the present invention are provided to more completely explain the present invention to those of ordinary skill in the art.

Material preparation and experimental methods

Purchase water parsley from Naju Noan at Naju Market, dry it with hot air at 60°C for 4 days, and then pulverize it with a grinder (SHINIL, SMX-9400MD) for 1 minute to make powder (hereinafter referred to as 'hot air dried powder for Noan water parsley') The following experiments were performed.

Isorhamnetin was selected as an indicator component of water parsley extract, and its content was measured by the following method. First, take 10 mg of isoramnetine, put it in a 100 ml volumetric flask, dissolve it completely using 5% sulfuric acid solution (H2O/MeOH/H2SO4 = 45/50/5(v/v)), fill it up to the mark, and then dilute it in half. with different concentrations (1.56, 3.125, 6.25, 12.5 , 25 ug / ml) was prepared by taking the hot-air dried material prepared presbyopia buttercup 0.3g 5% sulfuric acid solution _{(H 2 O / MeOH / H} 2 SO 4 = 45/50 /5 (v/v)) was added and dissolved, and then reacted at 90° C. for 30 minutes and cooled. Then, the same amount of ethyl acetate was added and extracted three times. The recovered supernatant was dried and dissolved in 1 mL of MeOH, followed by 0.45. Filtration was performed with a μM syringe filter, and HPLC analysis was performed using this as a test solution.

Table 1 below is isoramnetine HPLC analysis conditions.

Parameter Condition Detector UV DAD detector (360 nm) Column Shiseido Capcell pak UG120 C18 (5 μm, 250 mm x 4.6 mm) Column temperature 30 ℃ Injection vol. 10 μL flow rate 0.8 mL/min
B: 100% Acetonitrile
C: 100% Distilled Water mobile phase min B (%) C (%) 0 10 90 5 10 90 6 20 80 25 25 75 40 100 0 60 10 90

Example 1: Measurement of isoramnetine content according to extraction solvent

The content of isoramnetin according to the extraction solvent (water or ethanol) of the prepared Noanminara hot air dried powder was measured. Specifically, after immersing the dried water parsley hot air dried product by 100% water and ethanol concentration (25%, 50%, 75%, and 100%) at room temperature for 24 hours, an extract was prepared and its isoramnetine content was measured by the above method. was measured, and the results are shown in Table 2 below, and the isoramnetine content was the highest at 75% ethanol concentration.

Sample Solvent concentration (%) Extraction yield (%) Isoramnetine content (mg/g) presbyopia buttercup
hot air dried powder 0 33.6 0.010 25 23.7 0.016 50 24.7 0.023 75 18 0.026 100 6.17 0.023

Example 2: Measurement of isoramnetine content according to the amount of water

In addition to Example 1, isoramnetine content was measured for each amount of water in 75% ethanol. Specifically, the prepared Noan parsley hot air dried powder was hydrolyzed at an amount of 10 times, 20 times, 30 times, and 40 times the content of 75% ethanol, and then immersed at room temperature for 24 hours to prepare an extract, and its isoramnetine content was measured. The results are shown in Table 3 below, and the content of isoramnetine was the highest when it was hydrolyzed 20 times.

Sample Solvent concentration (%) number of singers Extraction yield (%) Isoramnetine content (mg/g) presbyopia buttercup
hot air dried powder 75 10 12.8 0.082 20 19 0.261 30 20.8 0.140 40 22.3 0.098

Example 3: Measurement of isoramnetine content according to extraction time

In addition to Examples 1 and 2, the content of isoramnetine for each extraction time was measured. Specifically, the prepared Noan parsley hot air dried powder was immersed in 75% ethanol and a solvent obtained by hydrolysis of 20 times the ethanol content at room temperature for 6 hours, 12 hours, 24 hours, and 48 hours to prepare an extract, and its extract The netin content was measured. The results are shown in Table 4 below, and the isoramnetine content was the highest when extracted for 24 hours.

Sample Solvent concentration (%) number of singers hour Extraction yield (%) Isoramnetine content (mg/g) presbyopia buttercup
hot air dried powder 75 20 6 21.2 0.090 12 18.9 0.220 24 19.73 0.325 48 20 0.313

Example 4: Measurement of isoramnetine content according to extraction temperature

In addition to Examples 1 to 3, the content of isoramnetine for each extraction temperature was measured. Specifically, the prepared Noan parsley hot air dried powder was immersed in 75% ethanol and a solvent obtained by adding 20 times the ethanol content at 0 ° C., room temperature, 40 ° C., 60 ° C., and 80 ° C. for 24 hours to prepare an extract and its isoramnetine content was measured. The results are shown in Table 5 below, and the isoramnetine content was the highest when extracted at 60°C.

Sample Solvent concentration (%) number of singers hour Temperature Extraction yield (%) Isoramnetine content (mg/g) presbyopia buttercup
hot air dried powder 75 20 24 0 15 0.604 RT 24.7 0.690 40 28 0.560 60 29 0.707 80 20.4 0.535

Preparation Example 1:

The Noan water parsley extract extracted by the optimal method according to Examples 1 to 4, that is, the Noan water parsley hot-air dried powder was immersed in 75% ethanol and a solvent obtained by adding 20 times the ethanol content at 60° C. for 24 hours. Freeze-dried. 1 g of the freeze-dried product was diluted in 10 ml of water to prepare a hangover relieving drink for presbyopia.

Preparation Example 2:

1 g of pear juice juiced with a juicer was mixed with the Noan water parsley hangover relieving drink prepared in Preparation Example 1 after cleaning the pears produced in Naju, removing the stem, and cutting them to an appropriate size.

Preparation Example 3:

In the same manner as in Preparation Example 1, an extract extracted using only the same amount of 100% water as a solvent instead of 75% ethanol and 20-fold hydrolysis solvent was used.

Example 5: Confirmation of hangover relieving efficacy

The experimental group consisted of 10 people (7 males, 3 females, 20-30 years old), and the following control groups, comparison groups, and experimental groups 1 and 2 were drank for each week. 1st week is water (control group), 2nd week is the conventional hangover relieving drink (Hutgae Condition, CJ) (Comparative group 1), 3rd week is the hangover relieving drink of Preparation Example 1 (experimental group 1), 4th week is the above manufacturing The hangover relieving drink of Example 2 (experimental group 2), and the 5th week, drink the hangover relieving drink of Preparation Example 3 (comparative group 2), and after 30 minutes, take 19% Bohae Chamisul Soju 50ml each 5 minutes a total of 5 times made to drink. After drinking, rinse your mouth with purified water, and then measure the alcohol concentration during breathing with a breath alcohol concentration meter (ALCOFIND DA-5000, DA Tech) after 0 minutes, 60 minutes and 120 minutes. In addition, sensory evaluation was performed on the overall taste and aroma at the time of ingestion of the beverage. The control group was set as 100 and relative evaluation was performed. The results are shown in Tables 6 and 7 below.

gender age key weight sensuality Breathing Alcohol Concentration (%) 0 minutes 60 minutes 120 minutes control male 25 183 78 100 0.07 0.04 0.03 male 21 178 75 100 0.08 0.04 0.04 male 21 176 80 100 0.09 0.06 0.05 male 25 172 72 100 0.12 0.09 0.08 male 24 175 69 100 0.10 0.08 0.05 male 26 171 90 100 0.08 0.05 0.02 male 26 181 91 100 0.09 0.06 0.02 female 22 155 46 100 0.12 0.09 0.06 female 24 161 52 100 0.10 0.06 0.03 female 23 162 50 100 0.12 0.10 0.08 Sum 1000 0.97 0.67 0.46 Experimental group 1 male 25 183 78 93 0.06 0.04 0.02 male 21 178 75 95 0.07 0.04 0.02 male 21 176 80 94 0.08 0.06 0.04 male 25 172 72 84 0.10 0.08 0.07 male 24 175 69 80 0.08 0.07 0.05 male 26 171 90 88 0.08 0.05 0.02 male 26 181 91 85 0.07 0.06 0.02 female 22 155 46 80 0.10 0.08 0.06 female 24 161 52 88 0.09 0.06 0.03 female 23 162 50 90 0.08 0.05 0.04 Sum 877 0.81 0.59 0.37 experimental group
2 male 25 183 78 99 0.06 0.03 0.01 male 21 178 75 105 0.07 0.04 0.01 male 21 176 80 103 0.08 0.05 0.03 male 25 172 72 98 0.10 0.06 0.04 male 24 175 69 98 0.08 0.06 0.04 male 26 171 90 96 0.08 0.07 0.05 male 26 181 91 92 0.07 0.03 0.01 female 22 155 46 110 0.10 0.05 0.03 female 24 161 52 105 0.09 0.06 0.02 female 23 162 50 95 0.08 0.04 0.02 Sum 1001 0.81 0.49 0.26

control group
One male 25 183 78 89 0.05 0.04 0.03 male 21 178 75 92 0.07 0.06 0.05 male 21 176 80 90 0.08 0.06 0.05 male 25 172 72 75 0.12 0.10 0.07 male 24 175 69 74 0.10 0.07 0.04 male 26 171 90 85 0.07 0.04 0.03 male 26 181 91 77 0.08 0.06 0.04 female 22 155 46 70 0.11 0.08 0.05 female 24 161 52 81 0.12 0.01 0.08 female 23 162 50 77 0.10 0.09 0.07 Sum 810 0.9 0.61 0.51 control group
2 male 25 183 78 91 0.07 0.05 0.03 male 21 178 75 90 0.07 0.04 0.03 male 21 176 80 90 0.09 0.07 0.05 male 25 172 72 80 0.11 0.09 0.08 male 24 175 69 81 0.10 0.07 0.04 male 26 171 90 85 0.08 0.05 0.04 male 26 181 91 85 0.07 0.06 0.03 female 22 155 46 78 0.10 0.08 0.06 female 24 161 52 86 0.10 0.08 0.07 female 23 162 50 85 0.09 0.08 0.06 Sum 851 0.88 0.67 0.49

As can be seen in Tables 6 and 7, the sensory evaluation and hangover relieving results are shown in the order of Test Group 2 > Test Group 1 > Comparative Example 2 > Comparative Example 1, and It was confirmed that the addition of pear juice to the drink has excellent sensory properties and is helpful in relieving hangovers.

Claims (5)

After drying the edible part of the water parsley by hot air, it is extracted with 75% ethanol and 20 times its water as a solvent at 55 to 65 ° C. for 22 to 26 hours. How to.
The water parsley extract according to claim 1, wherein the parsley extract containing isoramnetine in a high content contains 0.7 to 0.72 wt% of isoramnetine based on the total weight of the parsley extract, It contains isoramnetine in a high content A method for producing a water parsley extract.
The method according to claim 1, wherein the water parsley extract containing isoramnetin in a high content contains isoramnetine in an amount 70 to 72 times higher than the content of isoramnetin contained in the water parsley hot water extract. A method for producing a water parsley extract containing isoramnetin in a high content.
A food composition for relieving or preventing a hangover comprising the water parsley extract prepared by the method of any one of claims 1 to 3 as an active ingredient.
The food composition for relieving or preventing a hangover according to claim 4, further comprising pear juice in addition to the water parsley extract.