JP5746454B2 - Luxury goods - Google Patents

Description

The present invention relates to a luxury product containing composite hydrotalcite particles, and more specifically, digestive mucosal protection containing composite hydrotalcite particles in which a trace amount of zinc is dissolved in hydrotalcite, ie, ulcer The present invention relates to drinks, chewing gum, candy, chewable type and other luxury items effective for prevention and ulcer treatment.

Gastric ulcer treatment agents have been studied for a long time, and a wide variety of products have been developed. Most of these agents for treating gastric ulcer are organic (Patent Document 1), and there are concerns about their safety to the human body.
Synthetic hydrotalcite, which is an antacid, is an inorganic substance for treating gastric ulcer (Patent Document 2) (Patent Document 3). Synthetic hydrotalcite is an ideal medicinal antacid and is said to be effective as an ulcer treatment. The hydrotalcite particles are typically represented by the chemical formula Mg ₆ Al ₂ (OH) ₁₆ CO ₃ · 4H ₂ O, and the production method thereof is described in the US Patent Specification (Patent Document 4). . However, when conventional hydrotalcite particles are used as an ulcer treatment agent, long-term administration is necessary, and long-term administration may damage the mucous membrane of the stomach inner wall. In order to solve this problem, the present inventors have developed composite hydrotalcite particles in which a small amount of a specific amount of zinc (Zn) is contained as a solid solution in the hydrotalcite particles. It has been found that it has an excellent ulcer treatment action without damaging the mucosa of the inner wall and has already been proposed.
JP-A-6-49035 Japanese Patent Publication No.46-2280 Japanese Patent Publication No. 50-30039 U.S. Pat.No. 3,539,306

The present inventors have said that the composite hydrotalcite particles have an excellent ulcer treatment action without damaging the esophagus and stomach lining, and are excellent in preventing mucosal damage of the esophagus, stomach and the like induced by alcohol. Because of its unique characteristics, it is easy to ingest everyday products that contain complex hydrotalcite particles. It is excellent in protecting the digestive mucous membrane and treating ulcers, and it tends to be deficient in the human body. The present invention has been found out that it can be replenished.

According to the present invention, a luxury product containing composite hydrotalcite particles represented by the following formula (1) is provided.
(Mg _a Zn _b ) _1-X Alx (OH) ₂ (A ^n- ) x / n ・ mH ₂ O (1)
In the formula, A ^n-is CO ₃ ^2-, SO ₄ ^2- or Cl ^-, n represents the 1 or 2 shows x, a, b and m are each a value that satisfies the following condition.
0 <x ≦ 0.5, a = 1−b, 0 <b <1, 0 ≦ m <4

Next, the effect of the composite hydrotalcite particles used in the present invention will be described.
The effects on gastric ulcer are as follows.
1. Healing effect test for acetic acid ulcer Using composite hydrotalcite particles [Mg _0.735 Zn _0.015 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O] using male rats (SPF) Examined. The hydrotalcite particles used for comparison are the grade name “Alkamak” manufactured by Kyowa Chemical Industry Co., Ltd., which is considered to be excellent in conventional antacid and gastric ulcer treatment. This alkamak is represented by the chemical formula Mg ₆ Al ₂ (OH) ₁₆ CO ₃ · 4H ₂ O.

(Test method)
Sample Number of rats Target group (medium) 6 animals Hybrid hydrotalcite particles 6 animals Alkamak 6 animals

A laparotomy is performed under anesthesia with sodium pentobarbital (40 mg / Kg, ip), and 30 μL of 20% acetic acid is injected into the submucosal tissue at the boundary between the stomach and pyloric vestibule from the serosa side to create an acetic acid ulcer. 3 days after the ulcer model is created, the test substance is orally administered once a day for 10 days. The day after the final administration, the stomach was excised under anesthesia with pentobarbital sodium (40 mg / Kg, ip), the long diameter x short diameter (mm) of the ulcer was measured, and the product (mm ² ) was taken as the damage factor. The results are as follows.

Sample Dose Number of rats
(mg / Kg, po) (mm ² ) (%)
Reference example (subject group) ^*) -6 16.6 ± 1.3-
Composite hydrotalcite particles 100 6 10.3 ± 2.1 38
Alkamak 100 6 17.0 ± 2.3 -2

^*) : 0.5% methylcellulose (5mL / Kg)

This result shows that the composite hydrotalcite particles of the present invention are effective.

2. Ethanol-induced gastric mucosa injury test Using male rats (SPF) with composite hydrotalcite particles [Mg _0.735 Zn _0.015 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O] and ethanol-induced gastric mucosa Damage test was performed. The hydrotalcite particles used for comparison are the grade name “Alkamak” manufactured by Kyowa Chemical Industry Co., Ltd., which is considered to be excellent in conventional antacid and gastric ulcer treatment.

(Test method)
Sample Number of rats Target group (medium) 6 animals Hybrid hydrotalcite particles 6 animals Alkamak 6 animals

(Administration)
Route of administration: Oral administration Volume of administration: 5 mL / Kg
Administration method: Use a disposable syringe and a sonde for oral administration.
Administration period: Administer 60 minutes before creation of a gastric mucosa injury model.

After fasting for about 24 hours, 1 mL of ethanol (99.5%) / rat is orally administered. One hour after ethanol administration, the blood is removed by letting blood out under anesthesia with pentobarbital sodium (40 mg / Kg, ip). Inject 10 mL of 1% formalin solution into the removed stomach and immerse in the same solution for 10 minutes or longer. The stomach is dissected along the Great Bay and the length of the damage that has occurred is measured under a stereomicroscope. The damage per animal is taken as the damage factor. The results are shown below.

Sample Dose Number of rats Injury factor range Inhibition rate
(mg / Kg, po) (mm ² ) (%)
Reference example (subject group) ^*) -6 116.3 ± 20.1-
Composite hydrotalcite particles 100 6 58.4 ± 13.1 50
Alkamak 100 6 95.2 ± 14.0 18

^*) : 0.5% methylcellulose (5mL / Kg)

This result shows that the composite hydrotalcite particles of the present invention are effective. That is, it is a composite hydrotalcite particle that is a gastric ulcer therapeutic agent that is fast-acting and has no side effects compared to conventional gastric ulcer therapeutic agents.
Based on the above results, the present invention makes it possible to ingest composite hydrotalcite particles as a favorite product in terms of ease of ingestion.

The luxury product of the present invention also has a supplement of zinc, which is one of the essential minerals necessary for the human body. In the case of a gastric ulcer caused by excessive stress, the zinc (Zn) concentration in the blood decreases due to the stress. This is because the metallothionein protein produced in the liver due to stress increases, but since zinc is used in large quantities at that time, zinc in the blood (Zn) collects in the liver, which lowers the blood concentration of zinc. Can not supply enough to the stomach. Therefore, the blood concentration of zinc that suppresses the occurrence of ulcers becomes low, and ulcers occur. By taking the composite hydrotalcite particles of the present invention, not only the wound healing effect of the gastric wall mucosa, the composite hydrotalcite particles are decomposed by gastric acid in the stomach, zinc (Zn) is absorbed into the blood, the liver and It seems that the zinc (Zn) concentration in the blood and the supply of zinc (Zn) to the stomach also help the healing of stomach ulcers.

Zinc, one of the essential minerals, tends to be deficient recently.
Zinc deficiency not only lowers taste and immunity, but especially in the case of pregnant women, zinc in the body is transferred to the fetus, so that zinc deficiency tends to occur and immunity is reduced. Zinc deficiency has also been reported to cause depression. It has also been found that if a baby is born with a zinc deficiency, the baby's depressed brain waves are not observed and the proteins that make up the brain cells are not synthesized, which adversely affects learning and memory. Zinc deficiency anemia has also been reported. There are reports that about 48% of anemic women had zinc anemia.

These can be provided by composite hydrotalcite particles in which a trace amount of zinc, which tends to be deficient in the human body, is dissolved in hydrotalcite particles. That is, the present inventor provides composite hydrotalcite particles that are relatively inexpensive and non-toxic or relatively low in toxicity as easy-to-use preference items such as drinks, chewing gums, and candy. For example, by taking the drink of the present invention before sports or during sports, or by taking the luxury product of the present invention before harsh work, the chewing gum of the present invention is easily prevented before drinking. It has a merit that it is extremely effective in preventing the occurrence of ulcers caused by drinking alcohol (alcohol), and it is a favorite product that can be supplemented with zinc (Zn).

The composite hydrotalcite particles of the present invention are almost non-toxic, and the LD ₅₀ is 15,000 mg / Kg or more (oral rat).

The shape of the composite hydrotalcite particles of the present invention is not particularly limited, but it is advantageous that the average secondary particle diameter measured by the laser diffraction scattering method is 0.2 to 25 μm, preferably 0.4 to 10 μm. The specific surface area of the BET method is 5 to 100 m ² / g, preferably 10 to 50 m ² / g.

The method for producing composite hydrotalcite particles of the present invention may be performed by adding a predetermined amount of zinc salt in the conventional method for producing hydrotalcite particles. For example, an aqueous solution containing a salt of Mg, Zn and Al (nitrate, chloride, and sulfate) in a ratio of the metal element constituting the target hydrotalcite particle and an aqueous sodium carbonate solution (Na ₂ CO ₃ /Al=0.35- 0.75) and an aqueous solution of sodium hydroxide, and coprecipitate the aqueous solution of sodium hydroxide with the pH of the reaction solution maintained at 10 to 10.5. The reaction is carried out at room temperature to 100 ° C. Alternatively, the reaction product can be washed as it is, and the suspension (aqueous system) can be hydrothermally reacted at a temperature of 70 to 200 ° C. for 0.5 to 24 hours.

A luxury product containing the composite hydrotalcite particles of the present invention may contain nutrients such as sugars, minerals, vitamins, amino acids, food additives, vegetable juice, fruit juice, fragrance, fats and oils, food raw materials, etc. as necessary. It can be used alone or in combination of two or more as required.

As saccharides used in the present invention, known saccharides can be widely used. For example, monosaccharides such as glucose, fructose and lactose, disaccharides such as sugar, granulated sugar, maltose, trehalose, sucrose and lactose. Isomerized sugar such as glucose fructose liquid sugar, fructose glucose liquid sugar, sugar mixed glucose fructose liquid sugar, sugar mixed fructose glucose liquid sugar, etc., oligosaccharides such as starch syrup, malt syrup, reduced syrup, maltodextrin and other oligosaccharides, lactoligosaccharide etc. Examples include sugars, reduced starch syrup, maltitol, reduced palatinose, reduced lactose, reduced starch saccharified product, sugar alcohols such as sorbitol, xylitol, maltitol, erythritol, and palatinit. These may be used alone or in combination of two or more. Used.

As nutrients used in the luxury product of the present invention, known ones can be widely used. Examples of minerals (electrolytes and trace elements) include potassium chloride, calcium pantothenate sodium chloride, sodium acetate, Magnesium sulfate, magnesium chloride, calcium chloride, calcium gluconate, calcium lactate, Schiff calcium, dipotassium phosphate, monosodium phosphate, calcium glycerophosphate, eggshell calcium, cow bone meal, milk calcium, iron citrate, ferrous pyrophosphate , Ferric pyrophosphate, sodium iron citrate succinate, manganese sulfate, copper sulfate, zinc sulfate, sodium iodide, potassium sorbate, zinc, manganese, copper, iodine, cobalt, pyrophosphate, zinc yeast, selenium yeast, Chrome yeast, iodine yeast, copper fermentation , Manganese yeast, molybdenum yeast, iron yeast, ferric, and the like, as the vitamins, various vitamins water-soluble and fat-soluble, such as vitamin A (retinols), vitamin B _{1 (thiamine),} vitamin B ₂ (riboflavin), vitamin B ₆ (pyridoxine), vitamin B ₁₂ (cyanocobalamin), vitamin C, vitamin D (such as cholecalciferol), vitamin E (tocopherol), vitamin K, niacin, bisbenchamine, nicotinamide, Calcium pantothenate, folic acid, biotin, choline bitartrate, etc., and vitamin-like substances include polyunsaturated fatty acids, ubiquinone, lipoic acid, orotic acid, pangamic acid, carnitine, choline, inositol, p-aminobenzoic acid , Bioflavonoids, vitamin U, etc. As amino acids, for example, alanine, arginine, aspartic acid, asparagine, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, etc. Other examples include dietary fibers such as glucomannan, various celluloses, chitin, and chitosan. Examples of proteins include hydrolyzed gelatin, milk protein, casein, collagen, keratin, fibroin, and brion. It is used alone or in combination of two or more.

As the food additive used in the luxury product of the present invention, known ones can be widely used. For example, aspartame, acesulfame potassium, licorice extract, sucralose, thaumatin, xylitol, saccharin, saccharin sodium, stevia, D -Sweeteners such as sorbitol, Anato dye, Turmeric dye, Caramel, Imocarotene, Dinariella carotene, Carrot carotene, Gardenia blue pigment, Gardenia red pigment, Gardenia yellow pigment, Cochineal pigment, Food tar pigment, Copper chlorophyll, Copper chlorophyllin sodium , Colorants such as safflower pigment, safflower red pigment, safflower yellow pigment, benzoic acid, sodium benzoate, shirako protein extract, sorbic acid, potassium sorbate, propionic acid, calcium propionate, polylysine, Preservatives such as konoki extract, kawara mugwort extract, hinoki thiol extract, pectin degradation product, honoki extract, forsythia extract, gellan gum, agar, carrageenan, farsellan, sodium alginate, locust bean gum, xanthan gum, guar gum, pectin Casein and sodium caseinate, tamarind seed gum, quince seed gum, karaya gum, chitin, chitosan, gum arabic, tragacanth gum, gutty gum, arabinogalactan, alginate propylene glycol ester, quince, tara gum, almond gum, aeromonas gum, azotobacter vinelandie gum, Amassed gum, welan gum, psyllium seed gum, curdlan, dextran, gelatin, carboxymethylcellulose sodium Oxidation of cellulose derivatives such as mud, gelling agents such as water-soluble soybean polysaccharide (thickening polysaccharide, thickening stabilizer), L-ascorbic acid, erythorbic acid, catechin, dibutylhydroxytoluene, tocopherol, butylhydroxyanisole, etc. Inhibitors, color formers such as sodium nitrite, potassium nitrate, and sodium nitrate, bleaching agents such as sodium chlorite and sodium sulfite, antifungal and antibacterial agents such as imazalyl, orthophenylphenol, and thiabendazole, glycerin fatty acid ester, saponin , Emulsifiers such as sucrose fatty acid ester and lecithin, swelling agents such as sodium hydrogen carbonate, glucono delta lactone and potassium aluminum sulfate (alum), acidulants such as citric acid, citrate, malic acid, L-tartaric acid and lactic acid , Caffeine, naringin, wormwood extract Bitterings such as foods, brighteners such as shellac, paraffin wax and beeswax, excipients such as lactose, starch and corn starch, binders such as starch paste and gum arabic glue, gum bases such as vinyl acetate resin, gelton and chicle, Other food additives such as seasonings, citrus, binders, antifoaming agents, extraction solvents, coagulants, shelf life improvers, propylene glycol, mold release agents, filter aids, pH adjusters, softeners, etc. These may be used alone or in combination of two or more as required.

Furthermore, as fruit juice or vegetable juice used in luxury products, known ones can be widely used, for example, apple, green apple, orange, mandarin, lime, mandarin, apricot, papaya, acerola, melon, pear, Lychee, grapefruit, peach, strawberry, muscat, grape, pineapple, lemon, pear, lychee, blueberry, mango, banana, and other concentrated juices. Vegetable juices include tomatoes, carrots, kale, cabbage, broccoli. , Vegetable juices such as lettuce and celery. These may be used alone or in combination of two or more.

As the fragrance used in the present invention, known fragrances can be widely used. For example, orange, grapefruit, apple, lemon, lime, tangerine, yuzu, mandarin orange, jujube, grape, strawberry, pineapple, banana, peach , Melon, watermelon, plum, cherry, pair, apricot, currant, ume, perilla, cassis mango, mangosteen, guava, raspberry, blueberry and other fruit flavors, yogurt, green tea, tea, cocoa, chocolate, coffee, almond, Examples include flavors such as maple, vanilla, whiskey, brandy, rum, wine, liqueur, cocktail, mint and herb, and can be used alone or in combination of two or more as required.

As fats and oils used in the present invention, publicly known ones can be widely used. For example, milk fats such as butter and fresh cream, vegetable fats and oils, fractionated fats and oils, hardened fats and oils, transesterified fats and oils, etc. One kind or two or more kinds can be used in combination. Examples of vegetable oils include margarine, rice oil, soybean oil, rapeseed oil, cottonseed oil, corn oil, sunflower oil, sesame oil, nut oil, olive oil, safflower oil, palm oil, palm kernel oil and coconut oil, and other milk. , Skim milk powder, whole milk powder, yogurt and other milk components can be mentioned, and these can be used alone or in combination of two or more.

As the food raw material used in the present invention, various substances used as raw materials for food can be widely used.

In addition to the above, in the present invention, Spruce, licorice, Kyodo, Shazenshi, Shazensou, Senega, Asenyaku, Fennel, Caronin, Keihi, Syougaku, Sakuhaku, Soyo, Chikutsuninjin, Chimpi, Maoh, Nantenjitsu, Onji, Sexan, Tokon Herbal medicines such as potato, bacon, gogon, gomin, saishin, zion, musk, shajin, carrot, bakmondo, hanger, spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, mayonnaise, katsura, thyme, tea tree, Shiso, echinacea, strawberry tea, rahan fruit, peppery, karin, ginseng, turf, kumquat, radish, mugwort, saponin, loquat, plantain, fennel, ginger, ginkgo, saffron, jujube and their chips, powder Juice, herbs extracts, etc. and, menthol, cineol, anethole, include components of these herbs carboxylic like, and used in combination of these singly or two or more.

In addition, the ingredients used for the chewing gum in the present invention include a gum base, a softener, an emulsifier, a resin, a filler, a fragrance, a saccharide, etc., and any of the ingredients can be widely used.For example, as a gum base, Natural resins such as chicle, ester gum which is glycerin ester of rosin, synthetic rubber such as vinyl acetate, polyisobutylene or polybutene, emulsifier, stearic acid-based monoglyceride of saturated fatty acid, sorbitan fatty acid ester, etc. , Tallow, hydrogenated tallow, hydrogenated vegetable oil, partially hydrogenated vegetable oil, cocoa butter, glycerol monostearate, glycerol triacetate, lecithin, monoglyceride, diglyceride, triglyceride, acetylated monoglyceride, fatty acid, syrup, etc. , Nurin, poly dextrin, calcium carbonate, magnesium carbonate, magnesium silicate, grinding limestone, aluminum silicate, talc, clay, alumina, titanium dioxide, and minerals such as calcium phosphates. As the sugar and the fragrance, those described above can be used.

EXAMPLES Hereinafter, although this invention is demonstrated in detail based on an Example, the scope of the present invention is not limited to these Examples.
In the examples, (a) Zn, (b) average secondary particle diameter, and (c) BET specific surface area of the composite hydrotalcite particles mean values measured by the measurement methods described below.
(A) Analysis of Zn It measured by the atomic absorption method.
(B) Average secondary particle size
Measure using a MICROTRACK particle size distribution analyzer X-100 type (Nikkiso Co., Ltd.).
After adding 700 mg of sample powder to 70 mL of water and treating with ultrasound (NISSEI, MODEL US-300, current 300 μA) for 3 minutes, take 2 to 4 mL of the dispersion, and add 250 mL of deaerated water. In addition to the sample chamber of the contained particle size distribution meter, the analyzer is operated and the suspension is circulated for 8 minutes, and then the particle size distribution is measured. The measurement is performed twice in total, and the arithmetic average value of the 50% cumulative secondary particle diameter obtained for each measurement is calculated to obtain the average secondary particle diameter of the sample.
(C) BET specific surface area Measured by an adsorption method of liquid nitrogen.

Table 1 shows the measured values of Zn content, average secondary particle diameter, and BET specific surface area of the composite hydrotalcite particles used in the following examples.

Composition: Mg _0.665 Zn _0.0016 Al _0.333 (OH) ₂ (CO ₃ ) _0.167・ 0.5H ₂ O
A suspension for effect evaluation was prepared using the composite hydrotalcite particles.

Composite hydrotalcite particles 600mg
Total remaining amount of water 30ml

Using the suspension prepared in the above formulation, 5 panelists who always feel uncomfortable in their stomachs after drinking have their stomach taken before drinking, and the stomach condition (suspension of the next day after drinking) (Effective for stomach). As a result, as shown in Table 2, by taking the suspension containing composite hydrotalcite particles of the present invention before drinking, adverse effects on the stomach due to alcohol could be prevented.

Composition: Mg _0.6578 Zn _0.0088 Al _0.333 (OH) ₂ (CO ₃ ) _0.167・ 0.5H ₂ O
A drink was prepared with the following composition using the composite hydrotalcite particles.

Composite hydrotalcite particles 0.3%
Vitamin _{(A, B 1, B 2} , B 6, B 12, D, E) <1%
Fruit juice (apple, grape) 50%
Selenium yeast 0.001%
Calcium pantothenate 0.03%
Erythritol 7.0%
Citric acid 0.3%
Total remaining water 100%

The drink obtained by the above blending can be drunk as it is, and may be packaged once. As the packaging, generally known containers for beverages can be used, and examples thereof include polyester, stretched nylon, polyester terephthalate, polypropylene, aluminum, steel, paper, glass and the like, and one or more of these laminates. Furthermore, a film laminated with aluminum foil, a can, a glass bottle, a pouch type, or the like can be used. Particularly preferred is a pouch type with a cap.

Composition: Mg _0.7485 Zn _0.0015 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O
A drink was prepared with the following composition using the composite hydrotalcite particles.

Composite hydrotalcite particles 12%
Xylitol 5%
Citric acid 0.5%
Magnesium stearate 0.1%
Water 82.4%
Total 100%

The drink obtained by the above blending is a concentrated drink, and can be drunk with a known beverage such as water, milk, fruit juice, etc. by weighing the required amount.

Composition: Mg _0.7414 Zn _0.0086 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O
Using this composite hydrotalcite particle, a jelly-like drink was prepared with the following composition.

Composite hydrotalcite particles 0.5%
Glucomannan 0.15%
Carrageenan 0.03%
Fructose glucose 18.0%
Granulated sugar 0.20%
Citric acid 0.15%
Sodium citrate 0.20%
Grape flavor 0.30%
Total remaining water 100%

The drink obtained by the above formulation is jelly-like and may be packaged once. If the capacity is packaged in a stick shape of about 10 g, it is particularly convenient to carry.

Composition: Mg _0.7985 Zn _0.0015 Al _0.20 (OH) ₂ (CO ₃ ) _0.0994 (SO ₄ ) _0.0006・ 0.6H ₂ O
Using this composite hydrotalcite particle, a jelly-like drink was prepared with the following composition.

Composite hydrotalcite particles 0.5%
10% sugar
Oligosaccharide 5.0%
Citric acid 0.5%
Pectin 0.2%
Agar 0.3%
Vitamins _{(A, B 1, B 2} , B 6, B 12, C, D, E, folic acid) <1%
Nonfat dry milk 0.5%
Selenium yeast 0.01%
Apple flavor <1%
Total remaining water 100%

You may package the jelly-like drink obtained by the said mixing | blending one by one. The total volume is preferably 30 to 120 ml.

Composition: Mg _0.7914 Zn _0.0086 Al _0.20 (OH) ₂ (CO ₃ ) _0.0994 (SO ₄ ) _0.0006・ 0.6H ₂ O
Using this composite hydrotalcite particle, a jelly-like drink was prepared with the following composition.

Composite hydrotalcite particles 0.5%
Xylitol 15.0%
Sucralose 5.0%
Gellan gum 0.7%
Xanthan gum 0.4%
Vitamins _{(A, B 1, C,} D) <0.5%
Selenium yeast 0.1%
Calcium lactate 0.5%
Magnesium stearate 0.5%
Fruit juice (grapefruit) 10.0%
Total remaining water 100%

In this example, the jelly layer (a) containing the composite hydrotalcite particles is adjusted separately from the jelly layer (b) not containing, and the a layer is filled so as to be wrapped by the b layer when packaging. In this case, a pouch-type package with a mouth plug is preferable so that the layer a does not spread so much in the oral cavity and is easy to drink. The adjustment method is as follows.
The composite hydrotalcite particles are emulsified with a small amount of high-temperature water that does not cause the solution to gel (layer a). The other ingredients are mixed at a high temperature with the remaining amount of water (b) 10% of that is added to layer a and emulsified uniformly. Each of a and b was cooled to obtain a jelly-like target product.

Composition Mg _0.74 Zn _0.01 Al _0.25 (OH) ₂ (CO ₃ ) _0.125・ 0.5H ₂ O
The drink of fermented milk was prepared with the following composition using the composite hydrotalcite particles.

Composite hydrotalcite particles 0.5%
Milk 15.0%
Fresh cream 6.0%
Nonfat dry milk 10.5%
Sugar 20.0%
Gelatin 0.40%
Agar 0.14%
Sodium citrate 0.11%
Lactic acid bacteria Fragrance 0.05%
Total remaining water 100%

The fermented milk drink obtained by the above blending can be consumed as it is, and may be packaged once.

Composition: Mg _0.743 Zn _0.007 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O
Using the composite hydrotalcite particles, a chewing gum was prepared with the following composition.

Composite hydrotalcite particles 1.0%
Xylitol 40.0%
Palatinit 20.0%
Chitosan oligosaccharide 5.0%
ASPAM Tame 0.1%
Menthol 2.0%
Softener 0.9%
Gum base 100% total remaining

The adjustment method can be generally performed by a known method.
The gum base used in this example was 10.0% by mass of chicle, 5.0% by mass of gelton, 10.0% by mass of solver, 3.0% by mass of natural rubber, 15.0% by mass of vinyl acetate resin, and polyisobutylene 10 0.0 wt%, ester gum 15.0 wt%, microwax 20.0 wt%, fatty acid monoglyceride 2.0 wt%, filler 10.0 wt% (total 100.0 wt%) Both known ingredients and blending amounts can be widely used.

Composition: Mg _0.747 Zn _0.003 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O
Using the composite hydrotalcite particles, a chewing gum was prepared with the following composition.

Composite hydrotalcite particles 0.2%
Xylitol 40.0%
Maltitol 15.0%
Aspartame 0.5%
l-Menthol 0.5%
Fragrance 2.0%
Partially pregelatinized starch 10.0%
Maltodextrin 5.0%
Calcium gluconate 1.0%
Calcium sulfate 0.5%
Sodium chloride 0.1%
Gum base Total remaining 100.0%

The adjustment method can be generally performed by a known method.
The gum base used in this experimental example was 15.0% by mass of vinyl acetate resin, 15.0% by mass of SBR, 20.0% by mass of ester gum, 30.0% by mass of microwax, 10.0% by mass of fatty acid monoglyceride, and filler. Although it is a 10.0 mass% (total 100.0 mass%) mixture, a well-known thing can be widely utilized for a blending component and a compounding quantity.

Composition: Mg _0.747 Zn _0.003 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O
Using the composite hydrotalcite particles, soft candy was prepared with the following composition.

Composite hydrotalcite particles 0.5%
Sugar 26.0%
Minamata 40.0%
Crystalline cellulose 1.2%
Concentrated yogurt 8.0%
Rapeseed oil 7.0%
Sucrose fatty acid ester 0.5%
Gelatin 2.4%
Citric acid 0.7%
Yogurt flavor 0.4%
Total remaining water 100%

The adjustment method can be generally performed by a known method.

Composition: Mg _0.662 Zn _0.004 Al _0.333 (OH) ₂ (CO ₃ ) _0.167・ 0.5H ₂ O
Using the composite hydrotalcite particles, soft candy was prepared with the following composition.

Composite hydrotalcite particles 0.5%
Maltitol 50.2%
Reduced starch sugar compound 19.7%
Sorbitan fatty acid ester 0.3%
Whole milk powder 9.1%
Milk protein 1.4%
Sucrose fatty acid ester 0.5%
Vegetable oil 5.6%
Peach flavor 0.1%
Total remaining water 100%

The adjustment method can be generally performed by a known method.

Composition: Mg _0.660 Zn _0.006 Al _0.333 (OH) ₂ (CO ₃ ) _0.167・ 0.5H ₂ O
Hard candy was prepared using the composite hydrotalcite particles.

Composite hydrotalcite particles 2.0%
Honey 50%
Minamata 30%
Herbal extract 0.3%
Vitamin C 0.1%
Menthol 0.1%
Safflower pigment 0.01%
Water balance 100%

The adjustment method can be generally performed by a known method.

Composition: Mg _0.735 Zn _0.015 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O
Hard candy was prepared using the composite hydrotalcite particles.

Composite hydrotalcite particles 0.5%
Sugar 55.0%
Minamata 38.0%
Plum extract 0.5%
Perilla extract 0.5%
Perfume 0.02%
Water balance 100%

The adjustment method can be generally performed by a known method.

Composition: Mg _0.65 Zn _0.1 Al _0.25 (OH) ₂ (CO ₃ ) _0.125 · 0.5H ₂ O
Using the composite hydrotalcite particles, chewable (ramune confectionery) was prepared with the following composition.

Composite hydrotalcite particles 0.7%
Glucose 35.0%
Corn starch 47.0%
Citric acid 4.7%
Grape juice 6.0%
Water balance 100%

The adjustment method can be generally performed by a known method.

Composition: Mg _0.658 Zn _0.017 Al _0.333 (OH) ₂ (SO ₄ ) _0.175 · 0.398H ₂ O
Using the composite hydrotalcite particles, a chewable tablet was prepared with the following composition.

Composite hydrotalcite particles 300mg
Reduced palatinose 300mg
Xylitol 400mg
Aspartame 3mg
Menthol 1mg
Peppermint oil 1mg
Vitamins (A, B ₁ , B ₂ , B ₆ , B ₁₂ , C, D, V, folic acid) 0.5 mg
Mixed herb extract 1mg
Total 1006.5mg

The adjustment method can be generally performed by a known method.

Claims (10)

A gastric ulcer treatment agent composed of composite hydrotalcite particles represented by the following formula (1) is added to a luxury product , and an agent that is a zinc supplement is added, so that the composite hydrotalcite concentration is 0.05 wt%. A gastric ulcer treatment agent characterized by containing zinc (Zn) in an amount of 0.00006 wt% or more, and an agent-containing luxury product that is a zinc supplement .
Record

_{(Mg a Zn b) 1-} x Al x (OH) 2 (An -) x / n · mH 2 O (1)
In the formula, An ⁻ represents CO ₃ ²⁻ or Cl ⁻ , n represents 1 or 2, and x, a, b, and m each represent a value that satisfies the following conditions.
0.2 ≦ x ≦ 0.4, a = 1-b, 0.6 ≦ a ≦ 0.9, 0.0005 ≦ b ≦ 0.1, 0 ≦ m <4 In the formula (1), An ^- is CO ₃ ^2- , The agent for containing gastric ulcer according to claim 1, which is a zinc supplement. The agent- containing luxury item which is a gastric ulcer therapeutic agent according to claim 1 or 2 and which is a zinc supplement. The agent- containing luxury article, which is a gastric ulcer therapeutic agent according to claim 1 or 2 , and is a zinc supplement. 3. The agent- containing favorite product which is a gastric ulcer therapeutic agent according to claim 1 or 2 and which is a zinc supplement. 3. The gastric ulcer therapeutic agent according to claim 1 or 2, wherein the luxury product is a chewable type luxury product, and the agent- containing luxury product which is a zinc supplement. The gastric ulcer according to claim 1 or 2 , wherein the luxury product is a drink, and is a gastric ulcer therapeutic agent comprising 0.1 to 25 g of the composite hydrotalcite particles in 200 ml of water and an agent which is a zinc supplement. An agent- containing luxury product that is a therapeutic agent and a zinc supplement. The gastric ulcer therapeutic agent according to claim 1 or 2 , wherein the favorite product is chewing gum, the gastric ulcer therapeutic agent comprising the composite hydrotalcite particles, and containing 0.1 to 10 wt% of an agent that is a zinc supplement. And the additive- containing luxury goods which are zinc supplements. The gastric ulcer therapeutic agent according to claim 1 or 2 , wherein the favorite product is a candy, the gastric ulcer therapeutic agent comprising the composite hydrotalcite particles, and containing 0.5 to 10 wt% of an agent that is a zinc supplement. In addition, an additive- containing luxury product that is a zinc supplement. Gastric ulcer treatment according to claim 1 or 2 , wherein the luxury product is a chewable-type luxury product, and is a gastric ulcer treatment agent composed of the composite hydrotalcite particles, and contains 0.2 to 30 wt% of an agent that is a zinc supplement. An agent- containing luxury product that is a zinc supplement.