WO2008075649A1

WO2008075649A1 - Food or drink, quasi drug and medicinal composition for promoting hair growth and method of promoting hair growth

Info

Publication number: WO2008075649A1
Application number: PCT/JP2007/074236
Authority: WO
Inventors: Osamu Masaki
Original assignee: Mmt Co., Ltd.
Priority date: 2006-12-20
Filing date: 2007-12-17
Publication date: 2008-06-26

Abstract

In an embodiment, it is intended to provide a food or a drink for promoting hair growth and a medicinal composition for promoting hair growth which contain an extract of a plant belonging to the family Compositae or a component thereof, more specifically, a food or a drink for promoting hair growth and a medicinal composition for promoting hair growth which contain an extract of Chrysanthemum parthenium or parthenolide. In another embodiment, it is intended to provide a food or a drink for promoting hair growth and a medicinal composition for promoting hair growth which contain an extract of Chrysanthemum parthenium or parthenolide together with a member of the vitamin B family. In a still another embodiment, it is intended to provide a method of promoting hair growth, etc. by using an extract of a plant belonging to the family Compositae or a component thereof, in particular, an extract of Chrysanthemum parthenium or parthenolide. In a still another embodiment, it is intended to provide a method of promoting hair growth, etc. by using an extract of a plant belonging to the family Compositae or a component thereof, in particular, an extract of Chrysanthemum parthenium or parthenolide together with a member of the vitamin B family.

Description

Specification

Food and drink for promoting hair growth, quasi-drug, pharmaceutical composition and method for promoting hair growth

[0001] The present invention relates to a food for promoting hair growth, a quasi-drug for promoting hair growth, and a pharmaceutical composition for promoting hair growth, which contain an extract of a asteraceae plant or a component thereof, and more specifically, a feverfew extract. The present invention provides a hair growth-promoting food, a quasi-drug for hair growth promotion, and a pharmaceutical composition for hair growth promotion, comprising a product or a sesquiterpene ratatatone, specifically, baltenolide. Furthermore, the present invention includes feverfew extract or sesquiterpene ratatones, specifically parthenolides and B-group vitamin-containing foods and drinks, quasi-drugs for promoting hair growth and pharmaceutical compositions for promoting hair growth. I will provide a. The present invention also provides a method for promoting hair growth using an extract of Asteraceae plants or components thereof, particularly feverfew extract or sesquiterpene ratatatone, specifically, parthenolide. In a further aspect, the present invention also provides a method for promoting hair growth using extracts of Asteraceae plants or components thereof, particularly feverfew extract or sesquiterpene ratatones, in particular, barthenolide and group B vitamins. Background art

[0002] Many people suffer from alopecia. For example, hair loss due to accidents, alopecia areata due to stress, hair loss due to aging, young hugging, etc., there are various symptoms of alopecia. Various drugs, quasi-drugs, or cosmetics have been developed for the purpose of suppressing hair loss or for hair growth, hair growth or hair growth.

[0003] As hair growth promoting components used in pharmaceuticals, blood circulation promoters and vasodilators such as vitamin E derivatives, minoxidil, and pepper extract are known. However, the doses of these substances are limited from the viewpoint of safety and side effects, so that sufficient action and effects are often not obtained.

[0004] Recently, with an emphasis on safety, many pharmaceuticals, quasi-drugs, and cosmetics for promoting hair growth containing extracts and ingredients derived from natural products have been developed. These include components such as assembly extract, carrot extract, cordyceps extract, and Citrus unshiu (see Patent Document 1). These quasi-drugs and cosmetics have unknown effects, safety There are many things that are questioned, and are generally expensive.

[0005] In view of the above circumstances, foods and drinks, quasi-drugs and pharmaceuticals for promoting hair growth for promoting hair growth that are highly safe, inexpensive, reliable, strong and effective. It can be said that the necessity for the composition is high.

Patent Document 1: JP 2000-290146 A

Disclosure of the invention

Problems to be solved by the invention

[0006] It is a problem to be solved by the present invention to provide a food and drink, a quasi-drug, and a pharmaceutical composition for promoting hair growth for enhancing hair growth with a surely high safety effect. .

Means for solving the problem

[0007] As a result of intensive research aimed at solving the above-mentioned problems, the present inventors have found that an extract of a asteraceae plant, particularly a feverfew extract and a sesquiterpene ratataton, which is a component thereof, and more specifically, baltenolide is haired. It has been found that it has a promoting effect. Furthermore, the present inventors have shown that hair growth occurs when Group B vitamins are used in combination with an extract of the Asteraceae plant, in particular feverfew extract and its component sesquiterpene rataton, in particular, barthenolide. It was found that the promotion effect becomes even more pronounced. Based on these findings, the present inventors have completed the present invention.

[0008] That is, the present invention provides:

(1) Food and drink for promoting hair growth, comprising an extract of Asteraceae plants;

(2) The food and drink according to (1), wherein the Asteraceae plant is feverfew;

(3) Food and drink for promoting hair growth, containing valenolide;

(4) The food / drink according to (1) to (3)! /, Which is a supplement;

(5) The food / drink according to any one of (1) to (4), further combined with a group B vitamin;

(6) Food and drink according to (5), wherein the group B vitamins are vitamin B2 and vitamin B6;

(7) a quasi-drug for promoting hair growth, comprising an extract of a asteraceae plant;

(8) The quasi drug according to (7), wherein the Asteraceae plant is feverfew;

(9) A quasi-drug containing valthenolide for promoting hair growth;

(10) In the form of lotion or ointment (7) to (9)! n.

(11) The quasi drug according to any one of (7) to (; 10), further combined with a group B vitamin;

(12) The quasi drug according to (11), wherein the group B vitamins are vitamin B2 and vitamin B6;

(13) A pharmaceutical composition for promoting hair growth, comprising an extract of a asteraceae plant;

(14) The pharmaceutical composition for promoting hair growth according to (13), wherein the Asteraceae plant is feverfew;

(15) A pharmaceutical composition for promoting hair growth, comprising valenolide;

(16) The pharmaceutical composition according to any one of (13) to (; 15) which is orally administered;

(17) The pharmaceutical composition according to any one of (13) to (15), which is in the form of a lotion or ointment;

(18) The pharmaceutical composition according to any one of (13) to (; 17), further combined with a group B vitamin;

(19) The pharmaceutical composition according to (18), wherein the group B vitamins are vitamin B2 and vitamin B6;

(20) Animal feed or veterinary pharmaceutical composition for promoting hair growth, comprising an extract of Asteraceae plants;

(21) The animal feed or veterinary pharmaceutical composition according to (20), wherein the Asteraceae plant is feverfew;

(22) Animal feed or veterinary pharmaceutical composition for promoting hair growth, comprising baltenolide;

(23) The animal feed or veterinary pharmaceutical composition according to any one of (20) to (22), further combined with a group B vitamin;

(24) Animal feed or veterinary pharmaceutical composition according to (23), wherein the group B vitamins are vitamin B2 and vitamin B6;

(25) A method for promoting hair growth, comprising administering or feeding a Compositae plant extract;

(26) The method for promoting hair growth according to (25), wherein the Asteraceae plant is feverfew;

(27) A method for promoting hair growth, comprising administering or feeding baltenolide;

(28) The method according to any one of (25) to (27), further comprising administering or eating in combination with a vitamin B vitamin; (29) The method according to (28), wherein the group B vitamins are vitamin B2 and vitamin B6;

(30) Use of an Asteraceae plant extract for the manufacture of foods and drinks, supplements, quasi drugs or pharmaceutical compositions for promoting hair growth;

(31) The use according to (30), wherein the Asteraceae plant is feverfew;

(32) Use of parthenolide for the production of food and drink, supplements, quasi drugs or pharmaceutical compositions to promote hair growth;

(33) The use according to (30) to (32), characterized in that a B group vitamin is used in combination;

(34) The use according to (33), wherein the group B vitamins are vitamin B2 and vitamin B6.

The invention's effect

[0009] According to the present invention, a food and drink, a quasi-drug, and a pharmaceutical composition for promoting hair growth for promoting hair growth, which are reliable and have excellent safety effects, can be obtained. Furthermore, according to the present invention, there is provided a method for promoting hair growth that is reliable and excellent in the effect of increasing safety.

Brief Description of Drawings

[0010] FIG. 1 is a photograph showing hair regeneration over time in mice administered orally with barthenolide.

[Fig. 2] Fig. 2 is a photograph showing hair regeneration over time in mice orally administered with feverfew extract.

FIG. 3 is a photograph showing hair regeneration over time in mice orally administered with 0.5% aqueous solution of methylcellulose (control).

FIG. 4 is a graph showing the change over time in the ratio of the area of regenerated hair to the shaved area of mice orally administered with barthenolide, feverfew and control.

FIG. 5 is a photograph showing hair regeneration over time in mice coated with valthenolide.

[Fig. 6] Fig. 6 is a photograph showing hair regeneration over time in mice coated with feverfew extract.

[FIG. 7] FIG. 7 is a photograph showing hair regeneration over time in mice coated with 0.5% aqueous solution of methylcellulose (control). FIG. 8 is a graph showing the change over time in the ratio of the regenerated hair area to the shaved area of mice to which parthenolide, feverfew and control were applied.

[Fig. 9-1] Fig. 91 is a photograph showing hair regeneration in volunteers taking orally administered feverfew extract. The monitor number is a number assigned to each volunteer. The pictures show the 0th, 1st, 2nd and 3rd months from the left.

[Fig. 9-2] Fig. 9 2 is a photograph showing hair regeneration in volunteers who took (oral administration) feverfew extract. The monitor number is a number assigned to each volunteer. The pictures show the 0th, 1st, 2nd and 3rd months from the left.

[Fig. 10-1] Fig. 10-1 is a photograph showing hair regeneration in volunteers who took feverfew extract and vitamins B2 and B6 (oral administration). The monitor number is a number assigned to each volunteer. The pictures show the 0th, 1st, 2nd and 3rd months from the left.

[Fig. 10-2] Fig. 10-2 is a photograph showing hair regeneration in volunteers who took feverfew extract and vitamins B2 and B6 (oral administration). The monitor number is a number assigned to each volunteer. The pictures show the 0th, 1st, 2nd and 3rd months from the left.

[FIG. 11-1] FIG. 11 1 is a photograph showing hair regeneration in a volunteer who applied feverfew extract to the scalp. The monitor number is a number assigned to each volunteer. The pictures show the 0th, 1st, 2nd and 3rd months from the left.

[Fig. 11-2] Fig. 11 2 is a photograph showing hair regeneration in volunteers with feverfew extract applied to the scalp. The monitor number is a number assigned to each volunteer. The pictures show the 0th, 1st, 2nd and 3rd months from the left.

BEST MODE FOR CARRYING OUT THE INVENTION

In one embodiment, the present invention relates to a food and drink for promoting hair growth, which contains an extract of a asteraceae plant. The plant extract used in the food and drink of the present invention is not particularly limited as long as it is a plant extract containing sesquiterpene ratatones. Examples of plants rich in sesquiterpene ratatones include asteraceae plants, such as plants belonging to the genus Artemisia and dandelions. Sesquiterpene ratatones are asteraceae plants It is abundant in things, especially baltenolide. So far, it has been reported that extracts of asteraceae plants such as mugwort and feverfew and their component baltenolide have various physiological effects such as anti-inflammatory effects. However, it has been reported so far that Asteraceae plants, in particular feverfew extract and sesquiterpene ratatones, in particular parthenolide, show hair growth-promoting action!

[0012] In the present specification, the term "promoting hair growth" refers to a condition such as alopecia, hair loss, and other conditions that require hair growth, hair growth, hair restoration, hair growth or hair regeneration, or hair loss prevention. It means hair growth action, hair growth action, hair nourishing action, hair thickening action, hair loss prevention action, etc.

[0013] The asteraceae plant used in the food and drink of the present invention is preferably sesquiterpene ratatones, particularly those having a high parthenolide content and plants. Examples of such plants include plants belonging to the genus Artemisia, particularly preferably Tanacetum parthenium (also referred to as fever fu). Therefore, particularly preferred Asteraceae extracts used in the present invention are feverfew extracts. Feverfew plants, especially leaves, usually contain about 0.2 to 0.9% of barthenolide. Surprisingly, in the present invention, an extract of Asteraceae plants, especially feverfew extract and its component sesquiterpene lactone, specifically when applying orally ingesting valthenolide to the affected area. Particularly excellent hair growth promoting action was confirmed.

[0014] An extract of the Asteraceae plant can be obtained by a known method. The extraction part may be any part as long as it is an above-ground part of the plant, but a preferable extraction part is a leaf. The extract may be obtained by immersing the plant in a solvent as it is, but the extraction efficiency is higher when the contents are extracted after crushing. The plant may be raw or dried. For drying, a known drying method such as warm air drying or air drying can be used. Various types of plant crushing means can be used. For example, hand fir, homogenizer such as Potter-Elvegem homogenizer, blender such as Waring blender, crusher such as dyno mill, french press, mortar and pestle, rabies, freezing and crushing with liquid nitrogen, ultrasonic treatment, etc. Plants can be crushed by the above means. Suspend the plant crushed material in an appropriate medium and extract the contents. If desired, stirring may be performed during extraction. Suspension 'Extraction media can be water, ether, methanol, ethanol, or a mixture of ethanol and water. Examples include compounds. The suspension medium is preferably less toxic or non-toxic. From this point of view, water, ethanol, or a mixture of ethanol and water is particularly preferred as a suspension 'extraction medium. Extraction conditions such as temperature, pressure, and time during suspension extraction can be selected according to the type and amount of plants. In addition, the above-ground parts of plants, for example, leaves and stems, are directly dried by a known drying method such as hot air drying or air drying, and pulverized to obtain a food or drink or pharmaceutical composition of the present invention. May be used for things.

[0015] If necessary, the obtained extract can be decanted, filtered, or centrifuged to remove solids and particulate matter. The obtained extract may be concentrated by a known method such as evaporation. Further, the obtained extract may be further purified by a known method, for example, various chromatography or precipitation methods.

[0016] The plant extract used in the food and drink of the present invention can be obtained as described above. The power nashigiku extract is also commercially available, and this may be used. These extracts can be made into various forms according to usage forms, purposes, etc., and can be prepared into liquids, semi-solids, powders (for example, freeze-dried powders, etc.).

[0017] An Asteraceae plant extract, particularly a feverfew extract, can be blended with various foods to obtain the foods and drinks of the present invention. These asteraceae plant extracts are of low toxicity or non-toxic because they are derived from natural products, and can be incorporated into any food or drink. For example, the extract may be blended in juices or herbal seasonings. The food and drink of the present invention can be a health food, a functional nutritional food, or a food for specified health use (so-called “tokuho”).

[0018] In particular, supplements are mentioned as a preferred form of the food and drink of the present invention. The supplement may be in any shape that can be taken orally, such as tablets, capsules, granules, and powders (e.g., freeze-dried powder). Etc.), suspension, drink, elixir, drop, wearable form, jelly form and the like. These supplements can be manufactured in accordance with the processes used in the food and pharmaceutical fields. For example, manufacturing tablet-shaped supplements In the case of pharmacology, it is possible to use general processes such as mixing, drying, and tableting used in the pharmaceutical field. For example, in the case of a capsule form, a general process such as mixing and encapsulating can be used. Soft capsules and hard capsules can also be appropriately selected according to the purpose. In order to produce liquid supplements, water, ethanol, etc. have low toxicity, and the extract can be dissolved / suspended in a medium. In order to produce powder and granule supplements, it is also possible to use conventional processes such as mixing, drying, grinding and sieving. When a carrier or excipient is used in the production of supplements, the type and amount can be selected according to the practice in the pharmaceutical field. Examples of solid carriers or excipients include talc, carboxymethylcellulose, sucrose, and wheat flour. Examples of the liquid carrier include water, ethanol, and edible fats and oils.

[0019] The food and drink or supplement of the present invention may contain sesquiterpene ratatones, preferably parthenolide, instead of or in addition to the above-mentioned Asteraceae plant extract. It may be a baltenolide crude product or a purified product. Valtenolide may be purified or isolated from the above extract, for example. Valthenolide may be a chemically synthesized product.

[0020] The food or drink of the present invention requires all kinds of alopecia such as young hugging and alopecia areata, hair loss, other hair growth promotion, hair growth, hair restoration, hair growth or hair regeneration, or prevention of hair loss It is effective against the state. Moreover, the food and drink and the supplement of the present invention are effective regardless of gender.

[0021] The above-described effects of the food or drink or supplement of the present invention become more prominent by combining the B-group vitamin with the food or drink or sublimate of the present invention. The food and drink containing the asteraceae plant extract of the present invention and supplements may be mixed with Group B vitamins or may be consumed separately. There are eight types of B group vitamins: vitamin Bl, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenic acid, folic acid and biotin. In this specification, reference to group B vitamins includes vitamin Bl, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenic acid, folic acid and biotin, and their derivatives. In the present invention, one or more of these group B vitamins can be used. In the present invention! /, Preferred, B group vitamins are vitamin B2 and It is vitamin B6, and it is more preferable to use them in combination.

[0022] The amount of the Asteraceae plant extract (in the case of baltenolide content 0 · 9% (w / w)) ingested per day in the food or drink of the present invention is the amount of sesquite contained in the extract. Depends on the amount of rupenlatatones, especially valenolide. In the case of feverfew extract, for adults (weight 70 kg), it is common to take about 0.05 g to 50 g per day, and it is appropriate to take about 0.15 g to 15 g. 0 It is more appropriate to take about 5g to 3.Og. In addition, when using barthenolide in the food or drink or supplement of the present invention, the intake of baltenolide is generally about 0.45 mg to 450 mg per day for an adult (70 kg body weight). It is appropriate to take about 35 mg to 135 mg, and more preferably about 4.5 to 27 mg. The amount of these intakes can be increased or decreased depending on conditions such as a site where the desired hair growth promoting effect is desired. You can also take these intakes once or multiple times a day.

[0023] The amount of group B vitamins consumed per day contained in the food or drink of the present invention is about 4 mg to 10 mg, preferably 5 mg for each of the above eight vitamins if it is an adult (weight 70 kg). It is about ~ 8mg. For example, an adult (70 kg body weight) may take 6 mg of vitamin B2 and 6 mg of vitamin B6 per day with asteraceae extracts and parthenolide. As described above, the B and group vitamins may be ingested separately from the food and drink or the supplement of the present invention, and the intake amount of the B group vitamins is also the same as described above. These intakes can be increased or decreased depending on conditions such as a site where the desired hair growth promoting effect is desired. These intakes can be taken once or multiple times a day.

[0024] In the food and drink and the supplement of the present invention, asteraceae plant extracts, barthenolide, and one or more other active ingredients may be mixed in addition to the B group vitamin! / ! / ヽFor example, vitamin E and its derivatives, γ-oryzanol, / 3-strength rotin, soybean saponin, Nattokinase, flavonoids, gingerol, gallic sulfide, capsaicin, scordin, rutin, α-linolenic acid, keihi, carpronium chloride, tocopherol acetate Blood circulation promoting substances such as vitamin ビタミン, vitamin C, vitamin D, calcium, royal jelly, Inositol, Coenzyme A, Coenzyme Q10, Zinc, Sulfur, Selenium, Collagen, Gelatin, Methionine, EPA, Chondroitinic acid, Nettle, Olives, Seaweed extract, Venetian, Rosemary, Horsetail, Sorghum, Dietary fiber, Korea Carrots, catechins and the like may be contained in the food and drink or supplement of the present invention. Orally, the intake of these active ingredients and the intake of the food and drink of the present invention may be used in combination. Human power who has already undergone treatment for conditions requiring hair loss, hair loss, other hair growth promotion, hair growth, hair growth, hair growth or hair regeneration, or prevention of hair loss Taking the food and drink or supplement of the present invention Therefore, it is possible to promote the therapeutic effect.

[0025] In another aspect, the present invention provides a quasi-drug for promoting hair growth, comprising an extract of a asteraceae plant. The extract of Asteraceae used in the quasi-drug of the present invention is as described above. As a form of quasi-drug, a cosmetic form is common. Specifically, it can be in the form of lotion, cream, liniment, ointment, spray, bam, shampoo, tonic, genore, wax, treatment, knock, hair foam and the like. Apply force and quasi-drugs to areas where hair growth is desired, such as the scalp. The quasi-drug of the present invention includes components that promote the penetration of an active ingredient such as an extract of asteraceae or valthenolide, such as ethanol, glycerin, chitofilmer, propylene glycol, glycyrrhizic acid, and the like. Fragrances and coloring agents.

[0026] The quasi drug of the present invention may contain sesquiterpene ratatatone, preferably parthenolide, instead of or in addition to the above-mentioned asteraceae plant extract. It may be a crude product of baltenolide or a refined product. Valtenolide may be purified or isolated from the above extract, for example. Valthenolide may be a chemically synthesized product.

[0027] The quasi-drug of the present invention requires all types of alopecia such as young hugging and alopecia areata, hair loss, other hair growth promotion, hair growth, hair restoration, hair growth or hair regeneration, or prevention of hair loss It is effective against the state. The quasi-drug of the present invention can be applied to any part of the skin. The quasi-drug of the present invention is effective regardless of gender.

[0028] The above-mentioned effects of the quasi drug of the present invention are obtained by combining the quasi drug of the present invention with a group B vitamin. It becomes even more prominent by making it. A quasi-drug containing the asteraceae plant extract of the present invention may be mixed with a group B vitamin or may be used separately. In the present invention, one or more of group B vitamins can be used. Preferred group B vitamins are vitamin B2 and vitamin B6, and it is more preferable to use them in combination.

[0029] When an extract of Asteraceae is used in the quasi-drug of the present invention (when the content of valthenolide is 0.9% (w / w)), the application amount of the Asteraceae extract per day is: It depends on the amount of sesquiterpene ratatones, especially valenolide, contained in the extract. In the case of feverfew extract, it is common to apply about 0.05 to 50g per day for adults (weight 70kg), and it is appropriate to apply about 0.15 to 15g. It is more appropriate to apply about 0.5 g to 3. Og. In addition, when baltenolide is used in the quasi-drug of the present invention, the applied amount of baltenolide is generally about 0.45 mg to 450 mg per day for an adult (70 kg body weight). It is appropriate to apply about 35 mg to about 135 mg, and more suitably about 4.5 mg to 27 mg. These application amounts can be increased or decreased depending on conditions such as the desired hair growth promoting effect and application site. In addition, these doses can be applied to the necessary site once or multiple times a day.

[0030] The amount of vitamin B per day contained in the quasi-drug of the present invention is an adult (70 kg body weight) for each of the above eight vitamins: 4 mg to about! O mg, preferably about 5 mg to It is about 8mg. For example, 6 mg vitamin B2 and 6 mg vitamin B6 per day for adults (70 kg body weight) may be used with asteraceae plant extracts and parthenolides. As described above, the B group vitamin may be used separately from the quasi-drug of the present invention, and the dose of the B group vitamin is also the same as described above. These doses can be increased or decreased depending on conditions such as the desired hair growth promoting effect and the site where the effect is desired. These doses can be used once a day or divided into multiple doses.

[0031] In the quasi-drug of the present invention, one or more other active ingredients are mixed with the power of the asteraceae plant extract, baltenolide and group B vitamins! / Yo! / For example, assembly extract, carrot extract, vitamin A, EPA, inositol, coenzyme A, coenzyme Q10, zinc, sulfur, selenium, collagen, gelatin, methionine, chondroitin Hair growth-promoting substances such as sulfuric acid, plant sterols, nettles, white birch, horsetail, saw palmetto, safflower, cucumber, lavender, rosemary, nucleic acid, egg yolk oil, royal jelly, glyceride pentadecanoate, minoxidil, or vitamin E and its derivatives , Capsicum extract, γ-Oryzanol, β-strength rotin, soybean saponin, Nattokinase, flavonoids, gingerol, gallic sulfide, capsaicin, scordine, rutin, α-linolenic acid, keihi, carpronium chloride, tocopherol acetate Substances, bactericides, humectants, etc. may be included in the quasi drug of the present invention. Furthermore, the application of these active ingredients and the application of the quasi drug of the present invention may be used in combination. A quasi-drug of the present invention may be used by a person who has already undergone treatment for alopecia, hair removal, other hair growth promotion, hair growth, hair growth, hair growth or hair regeneration, or a condition that requires hair loss prevention. By applying, it is possible to promote the therapeutic effect.

[0032] Furthermore, the quasi-drug of the present invention may be in a form that can be taken from the mouth, such as a drink form.

[0033] In another embodiment, the present invention provides a pharmaceutical composition for promoting hair growth, comprising an extract of a asteraceae plant. The extract of Asteraceae used in the pharmaceutical composition of the present invention is as described above. The pharmaceutical composition of the present invention can be processed into various dosage forms. As described above, asteraceae extracts, particularly feverfew extracts or valenolides, have hair growth promoting effects not only when applied to the skin but also when administered orally. When the pharmaceutical composition of the present invention is applied to the skin, it can be applied to any site.

[0034] The pharmaceutical composition of the present invention to be orally administered can be produced by a known means' method. It is possible to use known carriers and excipients used in the pharmaceutical composition of the present invention. The dosage form of the pharmaceutical composition of the present invention to be administered orally includes tablets, capsules, granules, powders (eg freeze-dried powder), suspensions, drinks, elixirs, drops, sublingual tablets, chewable forms, jelly It may be a shape such as a shape. For example, when manufacturing tablets, it is possible to use general processes such as mixing, drying, and tableting used in the pharmaceutical field. In addition, for example, when producing a capsule, a general process such as mixing and encapsulation can be used. Soft capsules and hard capsules It can be appropriately selected according to the purpose. In order to produce an oral liquid dosage form, the extract of asteraceae or barthenolide must be dissolved and / or suspended in a low-toxic or non-toxic medium such as water, glycerol, ethanol or edible oil. Power S can be. To produce powder and granule oral dosage forms, it is still possible to use conventional processes such as mixing, drying, grinding and sieving. For the production of oral pharmaceutical compositions, carriers and excipients are usually used. These types and amounts can be selected in accordance with pharmaceutical practice. Examples of solid carriers or excipients include talc, carboxymethylcellulose, sucrose, flour, and starch. Examples of the liquid carrier include water, glycerol, ethanol, edible oil and fat, and syrup. These oral pharmaceutical compositions may contain conventional ingredients such as fragrances and coloring agents.

[0035] The pharmaceutical composition of the present invention may be applied to the skin by application, spraying, etc., for example, lotion, cream, ointment, liniment, spray, balm, shampoo, tonic, jewel, It can be a dosage form such as wax, treatment, knock, hair foam. A force and dermal application form can be produced by known means. The lotion can be produced by dissolving or suspending an Asteraceae extract or valthenolide in an aqueous carrier such as water or ethanol. The spray can be obtained by filling a known spraying device with a liquid obtained by dissolving or suspending an Asteraceae extract or valthenolide. Creams and ointments can be produced using vaseline, paraffin, lanolin, mouth, other fats and oils as a base material. Other skin application dosage forms are also known and can be produced by known methods. These skin-applied pharmaceutical compositions may contain conventional ingredients such as fragrances and coloring agents. Furthermore, these dermatological pharmaceutical compositions include substances that promote the penetration of active substances such as asteraceae plant extracts or valthenolides or group B vitamins into the skin, such as ethanol, glycerin, chitofilmer, etc. May be included. Furthermore, the pharmaceutical composition of the present invention can be administered by injection or infusion. Methods for producing injectable preparations and infusion preparations are known. For example, the ability to obtain these simultaneous IJs by dissolving the active ingredient in an injectable carrier such as physiological saline or distilled water. it can.

[0036] The pharmaceutical composition of the present invention may be used in place of or in addition to the above Asteraceae plant extract. In addition, sesquiterpene ratatones, preferably parthenolide, may be added. The barthenolide may be a crude product or a purified product, but highly purified parthenolide is particularly preferred. Valtenolide may be purified or isolated from the above extract, for example. Parthenolide may be a chemically synthesized product.

[0037] The pharmaceutical composition of the present invention is effective for all types of alopecia, hair loss, other hair growth promotion, hair growth, hair restoration, hair growth or hair regeneration, or a condition requiring hair loss prevention. . The pharmaceutical composition of the present invention is effective regardless of gender.

[0038] The above-described effect of the pharmaceutical composition of the present invention becomes more remarkable by combining a vitamin B with the pharmaceutical composition of the present invention. A pharmaceutical composition containing the asteraceae plant extract of the present invention may be used as a mixture of group B vitamins or may be used separately. In the present invention, one or more of group B vitamins can be used. Preferred group B vitamins are vitamin B2 and vitamin B6, and it is more preferable to use them in combination.

[0039] When an extract of a asteraceae plant (in the case of valtenolide content of 0.9% (w / w)) is used in the pharmaceutical composition of the present invention, the dosage of the asteraceae plant extract per day is determined by extraction. Dependent on the amount of sesquiterpene ratatones, especially valthenolide, contained in the product. The amount of feverfew extract to be administered as the pharmaceutical composition of the present invention is generally about 0.05 to 50 g per day for an adult (body weight 70 kg) and about 0.05 to 50 g for oral administration. Yes, it is appropriate to administer about 0.15 g to 15 g, and it is more appropriate to administer about 0.5 g to 3. Og. The amount of feverfew extract (in the case of valtenolide content 0.9% (w / w)) administered as the pharmaceutical composition of the present invention is 1 day for adults (body weight 70 kg), and for skin application. In general, about 0.05 to 50 g is applied, about 0.15 to about 15 g is appropriate, and about 0.5 to about 3 Og is more appropriate. In addition, when valtenolide is used in the pharmaceutical composition of the present invention, in the case of oral administration, the dose of parthenolide is about 0.45 mg to 450 mg per day for an adult (body weight 70 kg). 1. It is appropriate to administer about 35 mg to 135 mg, and more suitably about 4.5 mg to 27 mg. When parthenolide is used in the pharmaceutical composition of the present invention, in the case of skin application, the amount of valtenolide applied is an adult ( In the case of body weight 70 kg), it is common to apply about 0 · 45 mg to 450 mg per day, 1. 35 mg to; force of applying about 135 mg S is appropriate, and about 4.5 mg to 27 mg is applied It is more appropriate to do this. These doses or applied doses can be increased or decreased depending on conditions such as the intended hair growth promoting effect and application site. These doses can be administered or applied once a day or divided into multiple doses.

[0040] If the amount of vitamin B per day contained in the pharmaceutical composition of the present invention is an adult (body weight 70 kg), about 4 mg to each of the above 8 vitamins;! Omg, preferably 5 mg to 8 mg Degree. For example, 6 mg vitamin B2 and 6 mg vitamin B6 per day for adults (70 kg body weight) may be used with asteraceae plant extracts and parthenolides. As described above, the group B vitamin may be used separately from the pharmaceutical composition of the present invention, and the dose of the group B vitamin is the same as described above. These doses can be increased or decreased depending on conditions such as the desired hair growth promoting effect and the site where the effect is desired. These doses can be used once a day or divided into multiple doses.

[0041] In the pharmaceutical composition of the present invention, one or more other active ingredients may be mixed with the asteraceae plant extract, valthenolide, and the power of group B vitamins! / ! / In the case of an orally administered pharmaceutical composition, for example, vitamin E and its derivatives, γ—oryzanol, / 3 striking rotin, soy saponin, Nattokinase, flavonoid, gingerol, sulfide, capsaicin, scordin, noretin , Α-linolenic acid, keihi, carpronium chloride, tocopherol acetate, or other blood circulation promoters, or assembly extract, carrot extract, vitamin Α, inositol, coenzyme Α, coenzyme Q10, zinc, sulfur, selenium, collagen, gelatin, methionine , Chondroitin sulfate, plant sterol, nettle genus, white birch, horsetail, saw palmetto, safflower, yucca, lavender, rosemary, nucleic acid, egg yolk oil, royal jelly, vitamin C, vitamin D, calcium, EPA, olive, etc. Also Good. In the case of a skin-applied pharmaceutical composition, for example, hair growth promoting substances such as assembly extract, carrot extract, carpronium chloride, glyceride pentadecanoate, minoxidil, or vitamin E and its derivatives, pepper extract, assembly extract, sage extract, It may contain a blood circulation promoting substance such as Al Niki force extract or Hamamelis extract, or a bactericidal agent or moisturizing agent. Furthermore, the administration or application of these active ingredients and the book You may use together application of the pharmaceutical composition of invention. The pharmaceutical composition of the present invention is applied to a person who has already undergone treatment for alopecia, hair loss, other hair growth promotion, hair growth, hair nourishment, hair growth or hair regeneration, or a condition requiring hair loss prevention. Therefore, the therapeutic effect can be promoted.

[0042] The present invention provides, in a further aspect, a method for promoting hair growth, characterized by administering or ingesting an Asteraceae extract, preferably feverfew extract, or a sesquiterpene rataton, preferably baltenolide. To do. In this method, for example, feverfew extract or valenolide may be applied as a quasi-drug that may be consumed as a food or drink or a supplement, or may be administered or applied as a pharmaceutical composition. The dosage of the Asteraceae extract, preferably feverfew extract, or barthenolide in the method is as described above. The typical administration method of the Asteraceae plant extract, preferably feverfew extract or baltenolide in the method is oral administration and application to the skin, but is not limited to these administration methods. The method for promoting hair growth of the present invention is effective for both men and women, and is also effective for animals other than humans. The hair growth promoting method of the present invention may be used in combination with other hair growth promoting methods.

[0043] The hair growth-promoting effect of the above-described method of the present invention can be further enhanced by administering or ingesting a group B vitamin in combination. In the above method, Asteraceae plant extracts and Group B vitamins may be used simultaneously or separately. The amounts used of the Asteraceae plant extract and Group B vitamins in the above method are as described for the foods, beverages, quasi drugs and pharmaceutical compositions of the present invention. In the above method, an active ingredient other than Asteraceae plant extract and Group B vitamins may be used in combination.

[0044] In yet another embodiment, the present invention provides an extract of Asteraceae plant, preferably feverfew extract for the production of food and drink, sublimation, quasi-drug or pharmaceutical composition for promoting hair growth. Or the use of sesquiterpene ratatones, preferably parthenolides. The amount of Asteraceae extract, preferably feverfew extract, or parthenolide in the use is as described above.

[0045] In the above use, the hair growth promoting effect of the obtained food, beverage, sublimation, quasi drug or pharmaceutical composition can be further enhanced by using a group B vitamin together. Up The amount of Group B vitamins used in the above description is clear from the above explanation. For such use, V, and other active ingredients may be used in combination!

[0046] Further, the asteraceae plant extract of the present invention, preferably feverfew extract, or sesquiterpene ratataton, preferably a food and drink, quasi-drug and pharmaceutical composition containing barthenolide, and the above method and use are: Can be applied not only to humans but also to animals other than humans. For example, it can be used for pets such as dogs and cats, for livestock, and for veterinary use. Therefore, the present invention provides, in a further aspect, an animal (non-human) feed or a veterinary pharmaceutical composition for promoting hair growth, comprising an extract of Asteraceae; the above feed wherein the Asteraceae is feverfew Or a veterinary pharmaceutical composition; and an animal (non-human) feed or veterinary pharmaceutical composition for promoting hair growth, comprising parthenolide.

[0047] The hair growth promoting effect can be further enhanced by combining the above-mentioned animal (non-human) feed or veterinary pharmaceutical composition with Group B vitamins. Group B vitamins may be mixed with the above animal (non-human) feed or veterinary pharmaceutical composition, or may be provided separately. The amount of Asteraceae extracts and Group B vitamins given to animals is the ability of veterinarians to determine appropriately. The ability to be able to calculate S The above-mentioned dose for an adult with a body weight of 70 kg can be calculated from the weight of the target animal. Yo! /

[0048] Hereinafter, the present invention will be described in more detail and specifically with reference to examples. However, the examples should not be construed as limiting the present invention.

Example 1

[0049] Oral administration test

In this study, we investigated the hair growth-promoting effect of valthenolide and feverfew extract when orally administered to mice.

[0050] 1. Experimental method

C3H / He Sic mice, 7 weeks old and weighing 20-30 gos, were acclimated and used for testing at 8 weeks of age. The test groups were a barthenolide administration group, a feverfew extract administration group, and a control group, and 6 mice were used for each test group. 8-week-old mice were lightly anesthetized with ether, and the back was shaved with an electric clipper (THRIVE 6000AD, Natsume Seisakusho), and then an electric sieve. One (5494, BRAUN) was used to remove hair so as not to damage the skin surface. From the next day after depilation, oral administration of bartenolide, feverfew extract and control was performed. Parthenolide (Sigma (purity 90% or more), lot number: 066K13 85) was suspended in 0.5% methylcellulose (400cP, Wako Pure Chemicals) aqueous solution to 40mg / 10ml in the mice of the valtenolide administration group. 10 ml / kg body weight was orally administered once a day with an oral sonde (for mice, manufactured by Fuchigami Instrument Store) and syringe (ImL capacity, manufactured by Terumo). Mice in feverfew extract administration group, feverfew extract (HAND FINE CHEMICALS Co., batch number 609M907- 235, Roh Noretenoraido content of about ^{_{0. 8 0/0 (w /}} w)) to 0.5 ⁰ / ₀ Suspend to 888 mg / 10 ml in an aqueous solution of methinorescenellose (400 cP, manufactured by Wako Pure Chemical Industries, Ltd.). (Manufactured by Terumo). In the control group of mice, 0.5% methylcellulose (400 cP, manufactured by Wako Pure Chemical Industries, Ltd.) aqueous solution, 10 ml per kg of body weight once a day, oral sonde (for mice, manufactured by Fuchigami Instrument Store) and syringe (ImL capacity) (Manufactured by Terumo). The administration period was 19 days, during which time mice were freely given solid feed MF (Oriental Yeast Co., Ltd.) and filtered tap water. In order to measure the area of regenerated hair, after immobilizing the mouse under light ether anesthesia, a digital camera (COOLPIX885, Nikon) was used to take pictures of all cases every 2 days from the administration of the test substance, and image analysis software (Image Tool ver. 3.00, UTHSCSA) was used to determine the shaved area and regenerated hair area, and the ratio (%) of the regenerated hair area to the shaved area was calculated. The ratio (%) of the regenerated hair area to the shaved area is an average of 6 animals per group.

[0051] 2.Result

The results are shown in Fig. 1 and Fig. 4. Hair regeneration over control was observed in all mice in the group treated with bartenolide and the feverfew extract group. In these groups, the increase pattern of the regenerated hair area was similar, and remarkable hair regeneration was observed from the 15th day of administration. On day 19 of administration, most of the hair regenerated. After administration for 19 days, side effects such as redness, swelling, weight loss, abnormal liver function or abnormal behavior were observed. Example 2

[0052] Skin application test In this study, we investigated the hair growth-promoting action of valthenolide and feverfew extract when applied to mouse skin.

[0053] 1. Experimental method

C3H / He Sic mice, 7 weeks old and weighing 20-30 gos, were acclimated and used for testing at 8 weeks of age. The test groups were a barthenolide application group, a feverfew extract application group, and a control group, and 6 mice were used for each test group. 8-week-old mice were lightly anesthetized with ether, the back was shaved with an electric clipper (THRIVE 6000AD, Natsume Seisakusho), and then the hair was removed with an electric shiver (5494, BRAUN) so as not to damage the skin surface. From the next day after depilation, Barthenolide, feverfew extract and control were applied directly to the shaved skin. Parthenolide (Sigma (purity: 90% or more), lot number: 066K1385) was suspended in a 30% ethanol aqueous solution at a concentration of 4 mg / ml for the mice in the group applied with paltenolide, and a syringe (lml capacity, Terumo) 0.1 ml per animal was applied once a day using For mice in the feverfew extract-administered group, feverfew extract (manufactured by HAND FINE CHEMICALS, notch number 609M907-235, parthenolide content approximately 8 · 8% (w / w)) in 1200% The suspension was suspended in a volume of 1 ml, and 0.1 ml per mouse was applied once a day using a syringe (lml capacity, Terumo). In the control group of mice, 30% ethanol aqueous solution was applied once a day using a syringe (lml volume, Terumo) per mouse. The coating period was 17 days, during which time the mice were given chow MF (Oriental Yeast Co., Ltd.) and filtered tap water freely. To measure the area of regenerated hair, after immobilizing the mouse under ether light anesthesia, a digital camera (COOLPIX885, Nikon) was used to take pictures of all cases every 2 days from the administration of the test substance, and image analysis software (Image Using Too 1 ver. 3.00, UTHSCSA), the shaved area and the regenerated hair area were determined, and the ratio (%) of the regenerated hair area to the shaved area was calculated. The ratio (%) of the regenerated hair area to the shaved area is an average of 6 animals per group.

[0054] 2.Result

The results are shown in Figs. Hair regeneration over control was seen in all mice in the vartenolide and feverfew extract application groups. In these groups, an increase in the regenerated hair area in the feverfew extract application group was observed on the 11th day. The effect appeared earlier than the ride application group (the effect appeared from the 15th day). This result is thought to be due to the fact that about 2.7 times as much parthenolide was administered to the feverfew extract-administered group in terms of valtenolide. In all groups, most of the hair regenerated on the 17th day after application, and almost completely regenerated in the feverfew extract application group. After administration for 17 days, no side effects such as redness, swelling, warmth, rash, weight loss, abnormal liver function, or abnormal behavior were observed.

Example 3

Regeneration of human head hair by oral administration of feverfew extract

Feverfew extract powder (manufactured by HAND FINE CHEMICALS, batch number 609 M907-235, norenotenolide content about 0.8% (w / w)) wrapped in oblate, 3 times a day for 3 months 2 g per dose was given to 10 volunteers (27-64 years old, average age 4 5. 8 years old, 10 males) after each meal. Volunteers gave their scores for the following items.

About hair loss

1: Increased

0: No change is seen! /, Or if there is a change! /,

+ 1: Slightly decreased

+ 2: Clearly decreased

+ 3: Decreased dramatically

Glossy hair! / Te (Is the hair shiny?)

1: Reduced gloss

0: unchanged

+ 1: Slightly improved

+ 2: Clearly improved

+ 3: Dramatic improvement

Change in hair color

1: Gray hair increased

0: unchanged +1: Slightly black

+ 2: Obviously black

+ 3: Dramatically blackened

Did you get any tension in your hair?

1: Hariness has decreased

0: unchanged

+1: slightly improved

+ 2: Clearly improved

+ 3: Dramatic improvement

Changes in hair thickness

1: Hair is thin

0: unchanged

+1: Slightly thicker

+ 2: Obviously thick

+ 3: Dramatically thicker

Hair growth · Change in the amount of hair

1: Hair decreased

0: unchanged

+1: Slightly increased

+ 2: obviously increased

+ 3 Increased dramatically

[0056] The state of hair regeneration was photographed over time with a digital camera. Those that missed the technical problem and time of photography were judged to be unassessable (3 in this group). As shown in FIG. 9, hair regeneration or hair growth promotion over time was confirmed in the subject's head. In this study, no discomfort, swelling, weight loss, abnormal liver function, or other side effects were observed after taking feverfew extract.

Example 4

[0057] Regeneration of human head hair by oral administration of feverfew extract containing group B vitamins A feverfew extract powder containing vitamin B2 and vitamin B6 (manufactured by HAND FINE CHEMICALS, notch number 609M907-235, parthenolide content of about 8 · 8% (w / w)) wrapped in an oblate for 3 months, Two volunteers (23 to 64 years old, average age 44.8 years, 9 males, 1 female) were taken 3 times a day after each meal. One dose (2g feverfew extract powder) was supplemented with 2mg vitamin B2 and 2mg vitamin B6. In the same way as in Example 3, the volunteers gave themselves a rating. The state of hair regeneration was photographed over time with a digital camera. Three people were judged not to be evaluated in this group. As shown in Fig. 10, hair regeneration over time or hair growth promotion was confirmed in the subject's head. In this case, the effect of promoting hair regeneration or hair growth was more remarkable than that of Example 3 (feverfew extract alone). In this study, discomfort, swelling, weight loss, abnormal liver function, and other side effects caused by taking Group B vitamin-containing feverfew extract were not confirmed.

Example 5

[0058] Effects of applying feverfew extract

A lotion was prepared according to Example 7 using feverfew extract powder (manufactured by HAND FINE CHEMICALS, batch number 609 M907-235, parthenolide content about 0.8% (w / w)) and 10 volunteers (42 Age-63 years old, average age 44.9 years old, 10 males) applied 10ml to the scalp 3 times a day for 3 months. Then, as in Examples 3 and 4, photographs were taken and scores were given for each item. Two people were judged not to be evaluated in this group. Figure 11 shows the photo results. Even when feverfew extract was applied, hair regeneration over time or hair growth promoting effects were observed. In this test, discomfort such as itching caused by the application of feverfew extract was swollen and other side effects were not confirmed.

[0059] The scores of volunteers in Examples 3 to 5 are summarized in Tables 1 to 3 (in the table, "extract" means feverfew extract, and "vitamin" means vitamin B2 and vitamin B6). Table 1 shows the first month of administration (oral administration) or application, Table 2 shows the second month, and Table 3 shows the third month. The most remarkable hair regeneration or hair growth promoting effect was observed in the group taking orally administered feverfew extract containing group B vitamins, especially in the second and third months. Most people rated it as improved and clearly improved. The next most effective was the group that took feverfew extract (oral administration), and a certain effect was obtained even in the group to which feverfew extract was applied.

[table 1]

[Table 3] Dramatic improvement Clear improvement Little 3k¾ No change Scene 5 Hair loss 2 6 2 0 0 Hair gloss 3 5 1 1 0 Extract Hair color change 3 6 1 0 0

+ Vitamin Harshness 3 7 0 0 0 Thickness 3 4 2 1 0 Change in amount of growth 2 6 2 0 0 Hair loss 2 5 3 0 0 Hair gloss 2 4 3 1 0 Extract Hair Change in color 2 5 2 1 0 only Hair sharpness 2 5 3 0 0 Thickness of hair 1 3 6 0 0 Change in amount of hair growth 1 3 6 0 0 Hair loss 0 3 6 1 0 Hair gloss 0 2 6 2 0 Application Amber color change 0 1 5 4 0 Persimmon sharpness 1 2 6 1 0 Persimmon thickness 0 2 7 1 0 Growth condition ■ Amount change 0 2 8 0 0 Example 6

[0060] Example of lotion preparation (1)

Nonotenolide 250mg

(Manufactured by Sigma (purity 90% or more), lot number: 066K1385)

30% ethanol aqueous solution 62.5 ml

The parthenolide was ground with a mortar and pestle, and a 30% aqueous ethanol solution was gradually added to the ground parthenolide to obtain a uniform solution. A conventional fragrance may be added thereto.

Example 7

[0061] Lotion preparation example ( ² )

Feverfew extract powder 84g

(HAND FINE CHEMICALS, notch number 609M907—235)

30% ethanol aqueous solution 70ml

The feverfew extract powder was ground with a mortar and pestle, and a 30% aqueous ethanol solution was gradually added to the fried feverfew extract powder to obtain a homogeneous solution. A conventional fragrance or the like may be added thereto.

Example 8

[0062] Ointment preparation example (1) Nonotenolide 250mg

(Manufactured by Sigma (purity 90% or more), lot number: 066K1385)

Vaseline 250mg

The parthenolide was ground with a mortar and pestle, and petrolatum was added little by little to the ground parthenolide to obtain a uniform ointment. You can add conventional fragrances to this. Example 9

[0063] Ointment preparation example (2)

Feverfew extract powder 10g

(HAND FINE CHEMICALS, notch number 609M907—235)

Vaseline 10g

The feverfew extract powder was ground with a mortar and pestle, and petrolatum was added little by little to the fried feverfew extract powder to obtain a uniform ointment. A conventional fragrance or the like may be added thereto.

Industrial applicability

[0064] The present invention can be used in the fields of pharmaceuticals, quasi-drugs, foods and drinks, foods for specified health use (so-called "tokuho") and supplements, particularly in the field of health foods.

Claims

The scope of the claims

[I] A food and drink for promoting hair growth, which contains an extract of an Asteraceae plant.

[2] The food and drink according to claim 1, wherein the Asteraceae plant is feverfew.

[3] A food and drink for promoting hair growth, containing barthenolide.

[4] The food or drink according to any one of claims 1 to 3, which is a supplement.

[5] The food or drink according to any one of claims 1 to 4, further combined with a group B vitamin.

6. The food or drink according to claim 5, wherein the group B vitamins are vitamin B2 and vitamin B6.

[7] A quasi-drug for promoting hair growth, comprising an extract of an Asteraceae plant.

[8] The quasi drug according to claim 7, wherein the Asteraceae plant is feverfew.

[9] A quasi-drug containing valenolide to promote hair growth.

[10] The quasi drug according to any one of claims 7 to 9, which is in the form of a lotion or an ointment.

Yes

[I I] The quasi-drug according to any one of claims 7 to 10, further combined with a group B vitamin

P

P o

12. The quasi drug according to claim 11, wherein the group B vitamins are vitamin B2 and vitamin B6.

[13] A pharmaceutical composition for promoting hair growth, comprising an extract of an Asteraceae plant.

14. The pharmaceutical composition for promoting hair growth according to claim 13, wherein the Asteraceae plant is feverfew.

[15] A pharmaceutical composition for promoting hair growth, comprising barthenolide.

16. The pharmaceutical composition according to any one of claims 13 to 15, which is orally administered.

[17] The pharmaceutical composition according to any one of claims 13 to 15, which is in the form of a lotion or an ointment.

[18] The pharmaceutical composition according to any one of claims 13 to 17, further combined with a group B vitamin.

19. The pharmaceutical composition according to claim 18, wherein the group B vitamins are vitamin B2 and vitamin B6.

[20] An animal feed or a veterinary pharmaceutical composition for promoting hair growth, comprising an extract of an Asteraceae plant.

21. The animal feed or veterinary pharmaceutical composition according to claim 20, wherein the Asteraceae plant is feverfew. [22] An animal feed or a veterinary pharmaceutical composition for promoting hair growth, containing barthenolide.

[23] The animal feed or veterinary pharmaceutical composition according to any one of claims 20 to 22, further combined with a group B vitamin.

[24] The animal feed or veterinary pharmaceutical composition according to claim 23, wherein the group B vitamins are vitamin B2 and vitamin B6.

[25] A method for promoting hair growth, comprising administering or feeding a compositae plant extract.

26. The method for promoting hair growth according to claim 25, wherein the Asteraceae plant is feverfew.

[27] A method for promoting hair growth, comprising administering or eating barthenolide.

[28] Furthermore, the B group vitamin is administered or eaten in combination.

28. The method according to any one of -27.

29. The method according to claim 28, wherein the group B vitamins are vitamin B2 and vitamin B6.

[30] Use of an Asteraceae plant extract for the production of foods, drinks, supplements, quasi drugs or pharmaceutical compositions to promote hair growth.

31. The use according to claim 30, wherein the Asteraceae plant is feverfew.

[32] Use of parthenolide for the production of food and drink, supplements, quasi drugs or pharmaceutical compositions to promote hair growth.

[33] The use according to any one of claims 30 to 32, wherein a vitamin B group is used in combination.

Yes

[34] The use according to claim 33, wherein the group B vitamins are vitamin B2 and vitamin B6.