RU2143212C1 - Biologically-active additive - Google Patents

Abstract

FIELD: food-stuff production industry. SUBSTANCE: biologically-active additive particularly relates to production of dietetic and prophylactic substances and also to perfumery, cosmetic and pharmaceutical branches of industry. Biologically-active additive contains in function of micro and macro elements, such ingredients as adaptogen and/or detoxicant, also such components as concentrate of conifer needles where derivatives of chlorophyll amounts to 230-2000 mg%, carotenoids 10-180 mg%, vitamin E 20-80 mg%, phytosterin 0.5-4.0 mg%, sodium salts of fatty and resin acids 30-90%. Biologically-active additive can additionally contain vegetation and/or animal-origin raw material, binding substances and/or technological components for tablet- and capsule-making. Combination of aforesaid components allows for producing biologically-active additive from natural raw material. Additive is optimally balanced as to life indispensable components and can reveal its characteristics both as adaptogens and detoxicants, and its general characteristics due to their interchangeable action. It allows for substantial widening of its application in food-stuff, perfumery and cosmetic branches of industry. It can be used in curing various diseases of cardiovascular and digestive systems, endocrine and nervous systems. It also allows for widening range of producing biologically-active additives possessing radio-protective, sedative and immune-corrective action. EFFECT: higher efficiency. 12 cl, 4 ex

Description

 The invention relates to the food industry, namely to dietary and prophylactic additives from plant materials, perfumes, cosmetics and pharmaceuticals.

 It is known that needles and its young shoots contain a large number of biologically active substances, vitamins and minerals. Isolation of therapeutic and prophylactic products from needles, this multicomponent system, proceeds in two directions: obtaining complex preparations from needles or isolation of individual biologically active compounds (V.I. Yagodin. Fundamentals of chemistry and technology of processing green wood. - L .: Publishing House Leningrad State University, 1981, 223 pp.).

 It is known that in folk medicine they use needles in the form of water infusions in the treatment of colds, as well as a restorative and anti-scurvy agent rich in vitamins (Tomchuk R.I., Tomchuk G.V. Woody greens and its use. - M .: Forest industry, 1966, 194 p.). Treatment-and-prophylactic water extracts are currently obtained from coniferous woody plants that increase the body's resistance to various diseases (RF Application N 93006909/14, A 61 K 35/78, 04.02.93. BI N7, 1995. M. Zholondz. Cancer, Myths, Theory, and Prevention (St. Petersburg: Komplekt, 1998, p. 208). In addition, aqueous extracts are introduced into tonic drinks.

 However, the fat-soluble components of pine and spruce needles, which in the form of coniferous chlorophyll-carotene paste (HKHP) are widely used in veterinary medicine, cosmetics and medicine, are no less useful. It is known that CCPP is used in veterinary medicine as a bioactive feed additive, in particular in poultry farming and animal husbandry, where, under the influence of paste, the deficiency of vitamins in feeds and, above all, vitamin A is compensated, the reproductive function of animals and resistance to various diseases are enhanced (Khinich V.I. chlorophyll-carotene paste as a stimulator of A-vitamin metabolism of laying hens at the beginning of egg laying / In the book: Use of biologically active substances of wood. - Riga: Zinatne, 1973, p. 135). In cosmetics, KHPK is used as a bactericidal and hemostatic agent in toothpastes, creams, and shampoos (Voitsekhovskaya V.L., Wolfenzon I.I. Cosmetics today. - M.: Chemistry, 1988, p. 167).

 It is known that CCPP is used in medicine as an external agent for the treatment of burns, sluggish wounds and ulcers, as well as for the treatment of colpitis, vulvovaginitis. erosion of the cervix in the form of solutions for douching (Mashkovsky M.D. Medicines. - M .: Medicine, 1972, part 2, p. 6). However, KHPK, which includes the needles lipid complex, rich in chlorophyll, b-carotene and other carotenoids, vitamins A, E, b-sitoterin, minerals, was used only as an external agent and was not widely used in medicine. In the next edition of the popular reference book of Mashkovsky M. D. "Medicines" it is not mentioned. In addition, when using CKD, burning and irritation on the skin can be observed (see ibid., Mashkovsky M. D. Medicines. - M .: Medicine, 1972. Part 2. P. 6).

 The lipid complex of pine and spruce needles is such a valuable product that on its basis and on the basis of KHPK substances were created that are used in cosmetics and medicine. Thus, substances were obtained where the needles lipid complex was completely preserved and additional trace elements, such as sodium, copper and / or zinc, were introduced (Pat. RF N 2074704, A 61 K 7/00, 7/48, 12.29.92. BI N 7, 1997 and Pat. RF N 2040266, A 61 K 35/78, 12/29/92, BI N 21, 1995). These substances with sodium and other elements mentioned above are called "Coniferous Natural Complex" (KHN).

 Known means for the prevention of cancer based on the lipid complex of pine and spruce needles - KHN (Pat. RF N 2082423, A 61 K 35/78, 45/05, 04/12/94, BI N 18, 1997), which contains such components of the needles as chlorophyll derivatives, as well as physiologically acceptable substances and excipients. The composition of the active principle of CNS includes sodium salts of chlorophyllins (and / or other metal derivatives of chlorophyllins), carotenoids, including b-carotene, sodium and / or copper, and / or zinc salts of fatty and resin acids, vitamin E, K, plant sterols. including b-sitosterol, phytoncide essential oils, waxy products, B vitamins, prenols and water. The use of this natural complex gives a significantly greater therapeutic effect than the individual components isolated from it, which is typical for many plant complexes, such as extracts of valerian, motherwort, etc.

 This product is available in the form of a therapeutic and nutritional tablet supplement under the trade name "Feocarpine". Means "Feokarpin" has a pronounced oncological prophylactic effect on tumors of the breast and colon, inhibits the development and multiplicity of tumor formation.

 The closest technical solution will be a dietary supplement containing micro and macro elements, adaptogens and / or detoxicants (RU, 2075950, C1, 03/27/97).

 However, this additive does not have a sufficiently pronounced therapeutic and prophylactic effect, because poorly balanced for vital components.

 The technical result of the claimed invention is to obtain dietary supplements from natural raw materials, which are optimally balanced in terms of vital components and can exhibit properties of both adaptogens and detoxicants, and general properties due to their interchangeable action, which can significantly expand its scope (in food and perfumery cosmetic industry) and the possibility of use for various diseases of the cardiovascular and gastrointestinal systems, endocrine and nervous systems, and e expands the arsenal BAA having radioprotective, immunnokorregiruyuschim and sedative action.

 This is achieved through the use of needles concentrate as micro- and macroelements, where the content of chlorophyll prizvodnyh is - 230-2000 mg%, carotenoids - 10-180 mg%, vitamin E - 20-80 mg%, vitamin K - 1.0- 2.0 mg%, phytosterols - 0.5-4.0%, polyprenols - 0.4-1.2%, sodium salts of fatty and resin acids - 30-90%, and sodium chlorophyllins can be used as derivatives of chlorophyll and / or copper and / or zinc.

 Supplements can also optionally contain tannins and / or glycosides, and / or saponins, and / or amino acids, and / or polysaccharides, and as sources use plant materials and / or animal raw materials, and medicinal plants can be used as plant materials, and / or grain and / or vegetable raw materials or extracts from them, and as an animal, antlers of maral, and / or deer, and / or deer, and / or extracts of animal organs, and / or fish, and / or hydrobionts. This dietary supplement can be used in the production of bakery products in an amount up to 10 wt.%, In the manufacture of confectionery products - up to 5 wt.%, In the production of oil and fat products up to 6 wt.%, In the production of meat and dairy products - up to 4.0 wt.% , in the production of soft drinks - up to 5 wt.%, in the production of perfumes and cosmetics - up to 5 wt.%, in the production of pharmaceutical products - up to 100 wt.%. And in the production of tablet, capsule and plate forms, binders are additionally introduced, in addition to the technological components for tabletting and encapsulation.

 New unknown properties of the needles concentrate were revealed during tests at the Oncology Research Institute named after prof. N.N. Petrova of the Ministry of Health of the Russian Federation.

 As a result of tests, it was found that dietary supplement is low toxic: when administered to mice and rats at a dose of 6000 mg / kg of body weight, it does not cause death of animals v. In animal experiments on a model of benzene leukopenia, the hemostatic effect of dietary supplements was established, which was manifested in the stimulation of leukopoiesis in rats exposed to benzene. Such an action of dietary supplements can be explained by the content in its composition of such a compound as sodium chlorophyllin, which is able to stimulate both hematopoiesis and leukopoiesis, as well as the combined effect of the whole complex of biologically active substances of dietary supplements. This is due to the synergistic effect of sodium chlorophyllin and / or other derivatives of porphyrins in combination with carotenoids, tocopherol, prenols and other dietary supplements isolated from needles in the ratios created by nature and therefore very useful for the human and animal body. In experiments performed on animals, a positive effect of dietary supplements on lipid metabolism and a slowdown in the development of experimental atherosclerosis was found.

 The adaptogenic effect of the needles concentrate was studied in rats exposed to the toxic and carcinogenic agent N-methyl-N-nitrosourea (MNM). Adaptogenic action is currently understood to mean the ability to increase physical and mental performance and resistance to various adverse effects (K. Yaremenko Adaptogens as a means of preventive medicine. Tomsk: Publishing House of Tomsk University, 1990, 96 pp.). Supplements increased the survival of animals exposed to CMA, and increased the resistance of rats to the harmful effects of CMA. The mechanisms of the adaptogenic action of dietary supplements can be explained, apparently, both due to the activation of the body's defenses under the action of this vitamin-mineral natural complex from needles, and due to its detoxifying effect.

 As our studies have shown, depending on the dosage and method of use, our concentrate may exhibit the interchangeable effect of adaptogenic and detoxicant properties, i.e. increased immunity can be achieved by manifesting the sum of the properties of the concentrate. The identification of new properties of the needles concentrate allows us to significantly expand not only the area of use, but also the scope, because at present, it can be used in the treatment and prevention of atherosclerosis, in disorders and diseases of the immune, cardiovascular, gastrointestinal systems, as well as as a radioprotector and immunocorrector.

 Supplements are optimally balanced for vital elements, and depending on the disease, an adjustment for these elements can be made. Supplements can be made in the form of tablets, capsules, plates, ointments and pastes.

 Example No. 1.

 Coniferous needles concentrate with medicinal plants with licorice root and ginseng were used as dietary supplements. The resulting dietary supplement was used as an adaptogenic agent to increase the overall resistance of the body. However, after 1 week of constant use, a weak detoxifying effect began to be observed, which intensified by the end of the month.

 Example No. 2.

 The dietary supplement of example 1 was introduced in the production of a soft drink in an amount of 2%. The resulting drink had a pleasant smell of needles, and also found its application as a prophylactic, tonic, adaptogenic agent.

 Example No. 3.

 The needles concentrate was mixed with vegetable raw materials (wheat bran, oats) and used in the production of bakery products in an amount of 0.5% as a general strengthening agent for patients who underwent surgery in the rehabilitation period.

 Example No. 4.

 The needles concentrate was mixed with a set of dried medicinal herbs and these compounds were used as a herbal tea in patients with chronic protracted forms of bronchitis and other pulmonary diseases.

Claims (13)

 1. A biologically active food supplement containing micro and macro elements, an adaptogen and / or detoxicant, characterized in that, as micro and macro elements, an adaptogen and / or detoxicant, it contains a needles concentrate, where chlorophyll derivatives are 230 - 2000 mg%, carotenoids - 10 - 180 mg%, vitamin E - 20 - 80 mg%, vitamin K - 1.0 - 2.0 mg%, phytosterol - 0.5 - 4.0%, polyprenols - 0.4 - 1.2 %, sodium salts of fatty and resin acids 30 - 90%.  2. The dietary supplement according to claim 1, characterized in that, as chlorophyll derivatives, it contains sodium chlorophyllin and / or copper chlorophyllin, and / or zinc chlorophyllin.  3. Supplements according to claim 1, characterized in that it additionally contains vitamins and / or tannins, and / or glycosides, and / or saponins, and / or amino acids, and / or polysaccharides.  4. Supplements under item 3, characterized in that as sources of vitamins and / or tannins, and / or glycosides, and / or saponins, and / or amino acids, and / or polysaccharides contains plant and / or animal raw materials.  5. Supplements according to claim 4, characterized in that the plant material contains medicinal plants and / or grain and / or vegetable raw materials or their extracts.  6. Supplements according to claim 4, characterized in that the animal feed contains antlers of deer and / or deer, and / or deer, and / or extracts of animal organs, and / or fish, and / or hydrobionts.  7. Supplements according to any one of claims 1 to 6, characterized in that in the production of bakery products the amount of concentrate is up to 10 wt.%.  8. Supplements according to any one of claims 1 to 6, characterized in that in the manufacture of confectionery products, the amount of concentrate is up to 5 wt.%.  9. Supplements according to any one of claims 1 to 6, characterized in that in the production of oil and fat products, the amount of concentrate is up to 6 wt.%.  10. Supplements according to any one of claims 1 to 6, characterized in that in the production of meat and dairy products, the amount of concentrate is up to 4 wt.%.  11. Supplements according to any one of claims 1 to 6, characterized in that in the production of soft drinks the amount of concentrate is up to 5 wt.%.  12. Supplements according to any one of claims 1 to 6, characterized in that in the manufacture of perfumes and cosmetics, the amount of concentrate is up to 5 wt.%.  13. Supplements according to any one of paragraphs.1 to 3, characterized in that in the production of tablets, capsules, lamellar, pasty and ointment forms further comprises binders and / or technological components.