JP2015054836A - Oral agent for hair restoration and growth, and food for hair restoration and growth - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide pharmaceuticals, foods and the like for hair restoration and growth which promote hair growth, exhibit the hair restoration and growth effects to improve hair loss and thinning effectively, and can be ingested orally by human safely, daily, and easily.SOLUTION: A hair restoration and growth agent and/or a food for hair restoration and growth contain as an active ingredient trehalose and one or more kinds selected from L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenol which are enclosed with enteric-coated material.

Description

  The present invention relates to an oral preparation or food for hair growth nourishment that effectively improves hair loss and thinning hair, promotes hair growth, and can be taken orally by humans safely and daily. It is.

  Due to increasing stress due to changes in the social environment in recent years and changes in dietary habits, the age of people suffering from thinning hair, hair loss, circular hair loss, etc. has decreased, and at the same time, not only men but also women have similar problems The number of people is increasing rapidly. Current causes of hair loss include endocrine system abnormalities, hair cycle abnormalities, autonomic dysfunction, nutritional disorders, inheritance, aging, and stress.

  Under such circumstances, various hair restorers and hair nourishing agents are actively developed, and many external hair restorers and hair nourishing agents currently in use include hormones, vitamins, amino acids, Vasodilators, anti-inflammatory agents and the like are used. However, these external hair restorers and hair nourishing agents are sufficient for hair growth and nourishment due to safety concerns such as skin irritation, and because there are limits to the amount of intake from the skin even though they are effective ingredients. The effect of was not obtained, it was never satisfactory.

  In addition, for internal hair restorers and hair nourishing agents, for the purpose of promoting hair growth by activating from the inside of the body, for ingesting nutritional supplements and blood circulation promoting substances orally for hair growth and hair growth, etc. Has been proposed. For example, a food composition containing millet, ginkgo biloba extract and isoflavone that exhibits an effect of improving thinning hair and hair loss (Patent Document 1), an enamel and ginseng that exhibit effects of preventing hair loss and promoting hair growth In addition, there is disclosed a hair-growth hair-growing food and drink containing at least one plant extract selected from hypericum, hypericum, salvia, bodaiju, lacanka, kombu, hijiki, hibamata and wakame (Patent Document 2).

  However, there are many internal hair restorers and hair nourishing agents that do not provide sufficient hair-growth / hair-restoration effects, and many that are difficult to ingest daily for safety reasons. Drugs and foods for hair growth that effectively improve human hair loss and thinning hair, promote hair growth, and can be taken orally by humans safely and daily Etc. continue to be sought in the industry.

  Trehalose, on the other hand, is a non-reducing carbohydrate in which two glucose molecules are linked by α, α-1, and 1. Its physiological functions are osteoporosis prevention, low palatability, food allergy reduction, and oral mucosa protection. Numerous physiological actions have been clarified. And it is presumed that there are many physiological actions by oral administration that have not been clarified yet, and the discovery and utilization of further physiological actions are expected.

Japanese Patent Laid-Open No. 2001-238637 JP 2001-321121 A

  The present invention promotes hair growth, exhibits a hair growth and hair restoration effect, and effectively improves hair loss and thinning hair. The purpose is to provide food.

  In order to achieve the above object, as a result of intensive studies, the present inventors, as an active ingredient, together with trehalose, L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, one or more ingredients other than trehalose selected from plant polyphenols and The present inventors have found that an oral preparation or food containing a product encapsulated with an enteric material solves the above problems, and has completed the present invention.

That is, the embodiment of the present invention is as follows.
(1) An oral hair-restoring agent containing trehalose and one or more selected from trehalose and L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenols as an enteric material. Hair promoter, hair loss / thin hair prevention and treatment agent).
(2) The agent according to (1), wherein the weight ratio of trehalose and other components is in the range of 100: 0.00001 to 100: 50 in terms of solid content.
(3) The plant polyphenol is a Chinese parsley water extract, eye water extract, rhubarb water extract, hypericum water extract, shrimp water extract, gentian water extract, coffee water extract, citrus flavonoid or its enzyme The agent according to (1) or (2), which is one or more selected from a processed product, an enju-derived rutin or an enzyme-treated product thereof.
(4) The trehalose content per unit is 50 to 400 mg, which is used to be orally administered to humans for 1 to 5 units (preferably 2 to 4 units) per day. The agent according to any one of (1) to (3).
(5) The agent according to any one of (1) to (4), which is a capsule or a tablet.

(6) A hair-growth hair-growing food comprising trehalose and one or more selected from trehalose and L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenols as an enteric material ( Food for promoting hair growth, food for preventing hair loss and thinning hair).
(7) The food according to (6), wherein the weight ratio of trehalose and other components is in the range of 100: 0.00001 to 100: 50 in terms of solid content.
(8) The plant polyphenol is a Chinese parsley water extract, eye water extract, rhubarb water extract, hypericum water extract, shrimp water extract, gentian water extract, coffee water extract, citrus flavonoid or its enzyme The food according to (6) or (7), which is one or more selected from a processed product, an enju-derived rutin or an enzyme-treated product thereof.

  According to the present invention, an oral composition comprising trehalose and one or more components other than trehalose selected from trehalose and L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenol encapsulated with an enteric material. By daily or continuous ingestion of the agent or food, hair loss and thinning hair can be effectively improved and hair growth can be promoted. And since all the active ingredients of the product of the present invention are components that have a lot of food experience, the product of the present invention using these components as an active ingredient has the advantage that it can be taken orally safely and easily by humans.

  First, in the present invention, hair growth / hair growth means that hair loss and thinning are effectively improved, hair growth is promoted, and / or the like.

  Trehalose, which is an active ingredient of the product of the present invention, is a non-reducing saccharide in which two molecules of glucose are linked by α, α-1, and 1. In the present invention, Not only synthetic products but also commercial products can be used. Commercially available products should have a certain purity (for example, 90% or more, preferably 95% or more) (for example, the trade name “Treha”, a product of Hayashibara Co., Ltd. (purity 98% or more)). Such). In the present invention, trehalose is used in a smaller amount (that is, a dose) compared to the case where trehalose is simply used for improving physical properties of foods and beverages, improving flavor, etc., and usually less than 5,000 mg per adult, preferably It is characterized in that the effect can be exhibited at 10 to 3,000 mg, more desirably about 50 to 2,000 mg.

  Next, L-ascorbic acid glucoside has a structure in which a glucose molecule is bonded to the 2-position hydroxyl group of a vitamin C (L-ascorbic acid) molecule, which is difficult to oxidize / reduce and decompose and digest in the small intestine. It is easily hydrolyzed by enzymes to form vitamin C, and is also called stable vitamin C or glycosylated vitamin C. In the present invention, it is possible to use purified products or synthetic products that have been subjected to certain purification, and commercial products (for example, 90% or more, preferably 95% or more) with a purity of a certain level or more (for example, 95% or more). It is also possible to use “ASCO Fresh” (purity of 98% or more)), a product of Hayashibara Co., Ltd. Furthermore, it is optional to use not only a free acid but also a neutralized product or a salt as long as the effects of the present invention are not impaired.

  Furthermore, 5-aminolevulinic acid is a natural amino acid contained in animals and plants that constitutes a tetrapyrrole compound such as chlorophyll and heme, and this is also subjected to certain purification in the same manner as L-ascorbic acid glucoside. It is possible to use refined products, synthetic products, and commercial products. Furthermore, it is optional to use not only a free acid but also a neutralized product or a salt as long as the effects of the present invention are not impaired.

  Royal jelly is a milky white creamy substance secreted from the pharyngeal glands of worker bees and contains many fatty acids and amino acids including 10-hydroxydecenoic acid (decenoic acid), and various vitamins and minerals. In total, more than 40 kinds of nutrients are included. A commercially available product (raw royal jelly or a dried product thereof) can also be used.

  As the plant polyphenol, any polyphenols (including water extract) contained in various plants can be used, and is not particularly limited. In particular, Chinese parsley water extract, eye water extract, Use one or more selected from rhubarb water extract, hypericum water extract, shrimp water extract, gentian water extract, coffee water extract, citrus-derived flavonoid or its enzyme-treated product, Enju-derived rutin or its enzyme-treated product Is preferred.

  In addition, Chinese parsley (English name: coriander) is a plant belonging to the genus Coriander, and in Europe its leaves are sometimes referred to as Cilantro, but in Japan, the leaves, dried grains, etc. Regardless of whether it is called a cilantro. The Chinese parsley water extract used in the present invention means a product obtained by extracting the whole plant of Chinese parsley with water or a dried product thereof. That is, the Chinese parsley water extract used in the present invention means a polyphenol-containing product or a dried product thereof substantially extracted with water among the components contained in the Chinese parsley.

  In addition, the eye (indigo) is an annual plant belonging to the genus Indetaceae, and the eye water extract used in the present invention is the whole plant of the eye or a specific part of the plant body such as leaves, stems, fruits and seeds. Means a polyphenol-containing product obtained by extraction with water or a dried product thereof.

  Rhubarb is a plant belonging to the genus Rhizoaceae, and the rhubarb water extract used in the present invention contains polyphenols obtained by extracting water (mainly rhizomes) obtained by removing leaves from rhubarb whole plants with water. Or a dried product thereof.

  Hypericum is a plant belonging to the genus Hypericum of the family Hypericumaceae, and the hypericum water extract used in the present invention is obtained by extracting a specific part of the hypericum plant or a plant such as leaves, stems, and roots with water. Means a polyphenol-containing product or a dried product thereof.

  Ebisusa is a plant belonging to the genus Coralumaceae, and the water extract used in the present invention is obtained by extracting the entire Ebisusa plant or specific parts of the plant body such as leaves, stems, and seeds with water. Means a polyphenol-containing product or a dried product thereof.

  Gentian is a plant belonging to the genus Genus of Gentianaceae, and the gentian water extract used in the present invention is obtained by extracting a whole plant of gentian or a specific part of a plant body such as leaves, stems and roots with water. Means a polyphenol-containing product or a dried product thereof.

  Coffee is a plant belonging to the genus Aceraceae, and the coffee water extract used in the present invention is obtained by extracting a whole plant of coffee or a specific part of a plant body such as seeds, fruits, leaves, etc. with water. Means a polyphenol-containing product or a dried product thereof.

  As a specific extraction method of these polyphenol-containing water extracts, for example, the extraction raw material is washed with water, drained, and then minced using a blender, and filtered through a filter using a centrifuge. To do. If necessary, the extraction raw material can be dried or roasted in advance, crushed, and then extracted with cold water or hot water to obtain a filtrate containing polyphenol. The filtrate thus obtained is usually heat-treated at 121 ° C. for 10 minutes and allowed to cool to room temperature, whereby each water extract used in the present invention can be obtained. Each water extract thus obtained usually contains about 500 to 20,000 μg / ml of polyphenol when measured according to a known foreign thiocult method. In addition, although the solid content concentration of each water extract varies depending on the temperature and time when the extraction raw material is heated, the amount of the plant polyphenol included in the present invention is the content of polyphenol contained in each water extract. Based on That is, in the present invention, in many cases, other components other than polyphenol contained in each water extract are included together with polyphenol, but the amount of vegetable polyphenol contained in the present invention is included in each water extract. Means the polyphenol content. In addition, about the dry thing of these water extracts, what is necessary is just to acquire the water extract obtained by the said method by well-known methods, such as freeze-drying, spray drying (spray drying), and reduced pressure drying.

  Moreover, when using citrus-derived flavonoids or enzyme-treated products thereof as plant polyphenols, and / or enthu-derived rutin or enzyme-treated products thereof, examples of citrus-derived flavonoids used include hesperidin contained in citrus fruits, In the present invention, this enzyme-treated product (such as glycosylated hesperidin) can also be used. And enju origin rutin means the rutin obtained from enju, In this invention, this enzyme processed material (sugar transfer rutin etc.) can also be used.

  The glycosyl hesperidin and glycosyl rutin can be prepared by various methods, but from the viewpoint of economy, a biochemical method using a glycosyltransferase is advantageous. Examples of the method include α-glucosidase, cyclomaltodextrin / glucanotransferase, and α-amylase in the presence of an α-glucosyl sugar compound such as a partial starch hydrolyzate or maltooligosaccharide, and hesperidin or enju derived rutin. Can be obtained in high yields by the action of an enzyme selected from a plurality of types including Regarding such enzyme reaction, JP-A-3-7593, JP-A-3-27293, JP-A-3-58790, JP-A-3-115292, JP-A-10-70994, Japanese Patent Application No. A method described in Japanese Patent Laid-Open No. 9-69588 can be exemplified. Commercially available products prepared by such a method include sugar-transferred hesperidin powder (trade name “Hayashibara Hesperidin S” (total hesperidin content 70% or more by weight of solids), Hayashibara Co., Ltd.) and sugar-transferred rutin powder (trade name) “ΑG rutin P” (total rutin content 40 to 44% per solid weight) or trade name “αG rutin PS” (total rutin content 80 to 84% per solid weight), both Toyo Seika Co., Ltd. ) Although depending on the method of use, in the present invention, glycated glycated hesperidin and glycated luciferin do not necessarily have to be purified to the highest purity, and their preparation methods are not required unless they significantly impede the intended purpose. The thing of the form containing the contaminant originating in may be sufficient.

  In the present invention, one or more components other than trehalose selected from trehalose and L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenols as an active ingredient are encapsulated with an enteric material (encapsulation, coating) It is necessary to be included in oral preparations or foods. Enteric materials that are poorly acidic and neutral or alkaline soluble materials (that is, materials that are difficult to dissolve in the stomach and easy to dissolve in the intestine) are suitable. For example, animal and plant-derived protein materials, insect-derived shellac materials, cellulose derivatives, methacrylic derivatives, Acid-based polymers can be used. Preferred embodiments include gelatin capsules, zein (corn-derived protein) capsules, zein, shellac, coating with hydroxypropylmethylcellulose phthalate (HPMCP) and the like. Particularly preferred enteric capsule embodiments include, for example, Examples include capsules made of pectin-containing gelatin such as Japanese Patent Publication No. 7-25663 and Japanese Patent No. 312990.

  In the present invention, trehalose as an active ingredient and one or more combinations selected from L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenol, and the encapsulation of these ingredients in an enteric material The effect of the present invention (hair growth nourishing effect by ingestion) is exhibited only when all of the above are satisfied, and the desired effect is achieved in aspects such as single use of trehalose, single use of plant polyphenol, and no inclusion in enteric materials. I can't get it.

  As a suitable blending amount (content) of the active ingredient in the product of the present invention, for example, in the case of a capsule or tablet as a form, trehalose per 10 to 400 mg, preferably 50 to 200 mg, preferably other than trehalose, in terms of solid content. A component (one or more selected from L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenol) in a ratio of trehalose of 100: 0.00001 to 100: 50 parts by weight, more preferably 100: It is preferable to mix and enclose at a ratio of 0.0001 to 100: 5 parts by weight. In other words, the weight ratio of trehalose to other components is 100: 0.00001 to 100: 50 in terms of solid content, More preferably, it is in the range of 100: 0.0001 to 100: 5. If this ratio is deviated, it becomes difficult to exert its effect. In the case of tablets, it is optional to coat with an enteric material after tableting, or to tablet pre-entericized granules.

  The production method of the product of the present invention is not limited as long as it contains the above components as an active ingredient and is encapsulated with an enteric material. For example, the active ingredient is prepared so as to be included in the predetermined range and mixed uniformly, and after encapsulating with an enteric material, it is used as it is as a product of the present invention (for example, a capsule) or encapsulated. Later added to pharmaceuticals, quasi drugs, functional foods, health foods, dietary supplements, general foods, etc. The form of the oral preparation or food to be added is not particularly limited as long as it can be taken orally by humans (preferably, hardly soluble in the stomach and easily soluble in the intestine) such as solid, gel, and paste. Absent.

  All of the active ingredients of the product of the present invention are highly safe and can be safely ingested by humans, etc., and all of the above ingredients are industrially stable and inexpensively supplied Therefore, the product of the present invention has an advantage that it is inexpensively and stably provided industrially.

  In addition, to the product of the present invention, components other than the above active ingredients, for example, alcohols, starches, proteins, amino acids other than 5-aminolevulinic acid, fibers, and carbohydrates other than trehalose, as long as the desired effects are not hindered (Glucose, maltose, etc.), sugar alcohol (sorbitol, maltitol, etc.), lipids, fatty acids including essential fatty acids, vitamins other than L-ascorbic acid glucoside, minerals (magnesium, calcium, zinc, potassium, iron , Sodium and their salts), flavorings, coloring agents, sweeteners, seasonings (including high-intensity sweeteners such as sucralose, saccharin, stevia, and aspartame), stabilizers, and other raw materials commonly used And / or 1 type (s) or 2 or more types of a raw material can be mix | blended. Also, manufacture of pharmaceuticals and quasi drugs such as additives, stabilizers, surfactants, antibacterial agents, thickeners, antioxidants, chelating agents, foaming agents, binders, bulking agents, excipients, etc. It is also possible to obtain a pharmaceutical preparation in which one or more of the pharmaceutically acceptable ingredients in are combined in an appropriate combination. Then, in consideration of the composition of the target food composition or preparation and the purpose of use, the active ingredient may be blended in the process from the raw material stage to the completion of the product.

  The product of the present invention can effectively improve hair loss and thinning and promote hair growth by daily oral ingestion by human beings. 1 to 5 capsules / day, preferably 2 to 4 capsules / day, daily at a frequency of 1 to several times / day, or at intervals of several days, preferably 1 week or more Ingest for more than a month. This dose may be increased or decreased as appropriate according to age, sex, basal metabolic rate and the like. The ingestion method is not limited as long as the effects of the invention can be exerted. Desirably, the ingestion method is preferably taken with water on an empty stomach between meals or before meals.

  Examples of the application target of the present invention include humans who want to eliminate hair loss and thinning hair and promote hair growth. Moreover, the hair-restoring food for hair growth of the present invention not only effectively improves hair loss and thinning hair, promotes hair growth, but also exhibits excellent effects in maintaining and promoting health.

  In the present invention, “oral hair restoration (oral hair growth promoter, oral hair loss / thin hair prevention and treatment agent)” means trehalose, L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, vegetable polyphenol. For the purpose of maintaining health, etc., containing not only the pharmaceutical agent that is an active ingredient, but also the above-mentioned active ingredient, and having a specific function and form such as a supplement. A composition for hair restoration that is ingested, has a defined dose (effective amount) and usage of the active ingredient, and can be ingested in units of one to several units, clearly distinguishing it from being used only as food Products (including quasi drugs) are also included. However, compositions that are merely used as food are excluded, and naturally those other than hair restoration applications are also excluded.

  Examples of the present invention will be described below, but the present invention is not limited to these examples, and various modifications can be made within the technical idea of the present invention.

  The product of the present invention, the control product and the comparative product were produced as follows.

  Glucose transfer rutin powder (trade name “αG rutin PS” (total rutin content per solid content 80 to 84%), Toyo Seika Co., Ltd.) 1 part by weight, coffee water extract 1 part by weight, and trehalose ( (Trade name “Trehha”, Hayashibara Co., Ltd.) 1,000 parts by weight are uniformly mixed with stirring, and this is added to an enteric pectin-containing gelatin capsule prepared by the method described in Japanese Patent Publication No. 7-25663. About 120 mg each was sealed to obtain a capsule which is a product of the present invention (Example 1).

  Sugar-transferred hesperidin powder (trade name “Hayashibara Hesperidin S” (total hesperidin content of 70% or more per solid weight), Hayashibara Co., Ltd.) 1 part by weight, and trehalose (trade name “Treha”, Hayashibara Co., Ltd.) 1,000 About 120 mg per capsule is encapsulated in enteric pectin-containing gelatin capsules prepared by the production method described in Japanese Patent Publication No. 7-25663 by uniformly stirring and mixing parts by weight. An agent was obtained (Example 2).

  Glucose-transferred hesperidin powder (trade name “Hayashibara Hesperidin S” (total hesperidin content 70% or more by weight of solids), Hayashibara Co., Ltd.) 5 parts by weight, sugar-transferred vitamin C powder (trade name “ASCO Fresh”, Hayashibara Co., Ltd.) ) 5 parts by weight and 10,000 parts by weight of trehalose (trade name “Treha”, Hayashibara Co., Ltd.) were uniformly stirred and mixed, and the enteric pectin prepared by the manufacturing method described in Japanese Patent Publication No. 7-25663 About 120 mg of each capsule was encapsulated in a gelatin-containing capsule to obtain a capsule of the present invention (Example 3).

  5 parts by weight of 5-aminolevulinic acid hydrochloride (Merck Co., Ltd.), 5 parts by weight of royal jelly powder (trade name “Royal Jelly powder αF”, Matsuura Pharmaceutical Co., Ltd.), and trehalose (trade name “Treha”, Hayashibara Co., Ltd.) 10 2,000 parts by weight are stirred and mixed uniformly, and this is sealed in an enteric pectin-containing gelatin capsule prepared by the manufacturing method described in Japanese Patent Publication No. 7-25663, about 120 mg each, and the product of the present invention. A capsule was obtained (Example 4).

  Chinese parsley water extract 5 parts by weight, indigo water extract 5 parts by weight, maltitol powder 2,000 parts by weight, and trehalose (trade name “Treha”, Hayashibara Co., Ltd.) 10,000 parts by weight Were stirred and mixed, and about 100 mg each was tableted, and further coated with zein to obtain tablets of the present invention (Example 5).

  1 part by weight of dry matter of Hypericum perforatum water extract, 1 part by weight of dry matter of Ebisusa water extract, 1 part by weight of dry matter of gentian water extract, 200 parts by weight of maltose powder, and trehalose (trade name “Treha”, Inc. (Hayashibara) 1,000 parts by weight of the mixture were uniformly stirred and mixed, and each tablet was tableted with about 100 mg each, and further coated with shellac to obtain a tablet according to the present invention (Example 6).

  Glucose transfer rutin powder (trade name “αG rutin PS” (total rutin content 80 to 84% per solid, Toyo Seika Co., Ltd.) 1 part by weight, coffee water extract 1 part by weight, and trehalose (trade name "Treha", Hayashibara Co., Ltd.) Stir and mix 1,000 parts by weight evenly, and encapsulate it in a pullulan capsule (Capsgel Japan Co., Ltd.) that is easily soluble in the stomach. Was obtained (Control Example 1).

  Sugar-transferred hesperidin powder (trade name “Hayashibara Hesperidin S” (total hesperidin content of 70% or more per solid content), Hayashibara Co., Ltd.) 1 part by weight, and trehalose (trade name “Treha”, Hayashibara Co., Ltd.) 1,000 parts by weight The mixture was stirred and mixed uniformly, and about 120 mg per capsule was enclosed in a pullulan capsule (Capsgel Japan Co., Ltd.) that was easily soluble in the stomach to obtain a capsule as a control product (Control Example 2).

  Glucose-transferred hesperidin powder (trade name “Hayashibara Hesperidin S” (total hesperidin content 70% or more by weight of solids), Hayashibara Co., Ltd.) 5 parts by weight, sugar-transferred vitamin C powder (trade name “ASCO Fresh”, Hayashibara Co., Ltd.) ) 5 parts by weight and 10,000 parts by weight of trehalose (trade name “Treha”, Hayashibara Co., Ltd.) are uniformly stirred and mixed, and this is one in a readily soluble pullulan capsule (Capsgel Japan Co., Ltd.). About 120 mg per capsule was encapsulated to obtain a capsule as a control product (Control Example 3).

  5-aminolevulinic acid hydrochloride (Merck Co., Ltd.) 5 parts by weight, royal jelly powder (trade name “Royal jelly powder αF” (Matsuura Pharmaceutical Co., Ltd.), and trehalose (trade name “Treha”, Hayashibara Co., Ltd.) 10,000 weights The mixture was stirred and mixed uniformly, and this was encapsulated in approximately 120 mg per capsule in an easily soluble pullulan capsule (Capsgel Japan Co., Ltd.) to obtain a capsule as a control product (Control Example 4). .

  Chinese parsley water extract 5 parts by weight, indigo water extract 5 parts by weight, maltitol powder 2,000 parts by weight, and trehalose (trade name “Treha”, Hayashibara Co., Ltd.) 10,000 parts by weight Were stirred and mixed, and about 100 mg each was tableted to obtain a control tablet (Control Example 5).

  1 part by weight of dry matter of Hypericum perforatum water extract, 1 part by weight of dry matter of Ebisusa water extract, 1 part by weight of dry matter of gentian water extract, 200 parts by weight of maltose powder, and trehalose (trade name “Treha”, Inc. (Hayashibara) 1,000 parts by weight of the mixture was stirred and mixed uniformly, and about 100 mg each was tableted to obtain a control tablet (Control Example 6).

  About 120 mg of trehalose (trade name “Treha”, Hayashibara Co., Ltd.) is enclosed in enteric pectin-containing gelatin capsules prepared by the manufacturing method described in Japanese Patent Publication No. 7-25663, and is a comparative product. A capsule was obtained (Comparative Example 1).

  About 120 mg of Trehalose (trade name “Treha”, Hayashibara Co., Ltd.) was encapsulated in an easily soluble, pullulan capsule (Capsugel Japan Co., Ltd.) in the stomach to obtain a comparative capsule. Example 2).

  Glucose transfer rutin powder (trade name “αG rutin PS” (total rutin content 80 to 84% per solid content), Toyo Seika Co., Ltd.) 1 part by weight, and 1 part by weight of dried coffee water extract are stirred and mixed uniformly. Then, about 0.2 mg of each was encapsulated in an enteric pectin-containing gelatin capsule prepared by the method described in Japanese Patent Publication No. 7-25663 to obtain a capsule as a comparative product (comparison) Example 3).

  Glucose-transferred hesperidin powder (trade name “Hayashibara Hesperidin S” (total hesperidin content of 70% or more per solid content), Hayashibara Co., Ltd.) manufactured by the manufacturing method described in Japanese Examined Patent Publication No. 7-25663 made of enteric pectin-containing gelatin About 0.1 mg per capsule was encapsulated to obtain a comparative capsule (Comparative Example 4).

  5 parts by weight of the dried Chinese parsley water extract, 5 parts by weight of the dried indigo water extract, and 2,000 parts by weight of maltitol powder are stirred and mixed uniformly. Furthermore, it was coated with zein to obtain a comparative tablet (Comparative Example 5).

  1 part by weight of dry matter of hypericum water extract, 1 part by weight of dry matter of water extract of Ebisusa, 1 part by weight of dry matter of gentian water extract and 2000 parts by weight of maltose powder are uniformly stirred and mixed. About 30 mg each was tableted, and further coated with shellac to obtain a comparative tablet (Comparative Example 6).

  The products of the present invention (Examples 1 to 6), control products (Control Examples 1 to 6) and comparative products (Comparative Examples 1 to 6) thus obtained are summarized in Table 1 below.

(Human hair growth effect confirmation test in humans)
Next, hair growth and nourishing effects were evaluated by the following methods using the above samples (capsule or tablet as the form). In other words, volunteer adults (30 to 65 years old) who suffer from hair loss and thinning hair are divided into groups of 10 persons (5 males, 5 females), and the above samples are each one before each meal, 3 / day. Ingested at a rate of 1 month.

  Then, the change in hair before and after sample intake was evaluated according to the following criteria, and the average value was obtained.

3 points: A sufficient improvement was felt in reducing hair gloss, stiffness, tension, smoothness, thickness and hair loss.
Two points: A clear improvement was observed in the reduction of hair gloss, stiffness, tension, smoothness, thickness and hair loss.
1 point: A slight improvement in hair gloss, stiffness, tension, smoothness, thickness and loss of hair loss was felt.
0 point: No improvement was felt in the reduction of hair gloss, stiffness, tension, smoothness, thickness and hair loss.

  The test results are shown in Table 2 below. From these results, Examples 1-6 using a sample (capsule or tablet) in which a predetermined component other than trehalose was encapsulated with an enteric material as an active ingredient were trehalose. In addition, a significant hair-restoring effect was confirmed as compared with Control Examples 1 to 6 using a sample (capsule or tablet) in which predetermined components other than trehalose were not encapsulated with an enteric material. Moreover, these Examples 1-6 are significant even if compared with the comparative examples 1-6 using the sample (capsule or tablet) which enclosed trehalose alone or only the components other than trehalose with an enteric material etc. The hair nourishing effect was confirmed. In other words, compared with the case of Examples 1-6, the control examples 1-6 using the capsule or tablet which did not enclose the structure of the active ingredient which concerns on this invention with the enteric material, or this invention In any of Comparative Examples 1 to 6 using a capsule or tablet in which trehalose alone, which is not a component of such an active ingredient, or only an ingredient other than trehalose was encapsulated with an enteric material or the like, no hair growth effect was confirmed.

  These results show that the composition of the present invention (combination of active ingredients and encapsulation with an enteric material) is effective for the improvement of symptom of hair loss and thinning hair for the first time. It shows that it is effective. It is also supported that daily intake of the product of the present invention provides sufficient improvement in hair gloss, stiffness, tension, smoothness, thickness and hair loss.

  As described above, the product of the present invention can improve hair loss and thinning hair effectively by daily oral ingestion, promote hair growth, and can be safely administered to humans. It is.

  The present invention is summarized as follows.

  The present invention promotes hair growth, exhibits a hair growth and hair restoration effect, and effectively improves hair loss and thinning hair. The purpose is to provide food.

  And as an active ingredient, a hair-growth nourishing agent and / or a hair-growth nourishing comprising at least one selected from trehalose and L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenols with an enteric material. The above-mentioned problem is solved by a food for hair.

Claims (8)

  An oral hair growth agent comprising trehalose and one or more selected from trehalose and L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenols as an enteric material.   The agent according to claim 1, wherein the weight ratio of trehalose and other components is in the range of 100: 0.00001 to 100: 50 in terms of solid content.   Plant polyphenol is a Chinese parsley water extract, eye water extract, rhubarb water extract, hypericum water extract, shrimp water extract, gentian water extract, coffee water extract, citrus-derived flavonoid or enzyme-treated product thereof, The agent according to claim 1 or 2, wherein the agent is one or more selected from enju-derived rutin or an enzyme-treated product thereof.   The trehalose content per unit is 50 to 400 mg, which is used to be orally administered to humans for 1 to 5 units per day. The agent described in 1.   The agent according to any one of claims 1 to 4, which is a capsule or a tablet.   A hair restoration hair-growing food containing trehalose and one or more selected from trehalose and L-ascorbic acid glucoside, 5-aminolevulinic acid, royal jelly, and vegetable polyphenols as an enteric material.   The foodstuff according to claim 6, wherein the weight ratio of trehalose and other components is in the range of 100: 0.00001 to 100: 50 in terms of solid content.   Plant polyphenol is a Chinese parsley water extract, eye water extract, rhubarb water extract, hypericum water extract, shrimp water extract, gentian water extract, coffee water extract, citrus-derived flavonoid or enzyme-treated product thereof, The food according to claim 6 or 7, wherein the food is one or more selected from Enju-derived rutin or an enzyme-treated product thereof.