JP2008156306A - Material derived from boysenberry fruit, and supplement, drug or food produced by using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a material composed mainly of a material derived from boysenberry fruit having high cancer inhibiting activity and to provide a supplement, a drug or a food produced by using the material. <P>SOLUTION: The invention provides a material derived from boysenberry fruit, especially a concentrated liquid of boysenberry fruit, a powder of boysenberry fruit, a polyphenol extracted from boysenberry fruit or ellagic acid or a carbohydrate extracted from boysenberry fruit, and a supplement, a drug or a food containing the above material as a main component. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a material derived from Boysenberry fruit and a supplement, drug or food using the material.

  Patent Document 1 describes prevention of red spots (sunburn), skin darkening, spots, and freckles caused by skin pigmentation when a moisturizer, whitening agent or skin cosmetic containing Boysenberry juice or a processed product thereof as an active ingredient. It is effective for improvement. This is because it has been discovered that “ellagic acid”, a kind of flavonoid, has an effect of suppressing the production of melanin pigment.

It is also known that the ellagic acid acts as a cleaner that “kneads” carcinogens and deprives them of the activity of these chemicals.
Japanese Patent Laid-Open No. 2002-322077

  The present applicant has found that a material containing a substance derived from Boysenberry fruit as a main component has a high carcinogenic inhibitory effect, and has led to the present invention.

  In view of the above, an object of the present invention is to provide a material mainly composed of a substance derived from Boysenberry fruit having a high carcinogenesis-inhibiting action, and a supplement, drug or food using the same.

  Therefore, this invention is providing the material which has the substance derived from Boysenberry fruit as a main component.

  Further, the material is a concentrated solution of Boysenberry fruit, and is preferably Boysenberry fruit powder. In addition, it is desirable that the substance is polyphenol extracted from Boysenberry fruit, ellagic acid extracted from Boysenberry fruit, and also a carbohydrate extracted from Boysenberry fruit. Furthermore, it is desirable that the carbohydrate is any of a monosaccharide, a disaccharide, and a polysaccharide.

  Furthermore, it is desirable that the present invention is a supplement, drug or food containing the above-mentioned material as a main component.

  Polyphenol or ellagic acid presumed to have a carcinogenesis-inhibiting effect by ingesting the material according to the invention described above in the form of supplements, drugs or foods, and other active ingredients contained in Boysenberry fruit together with it. However, since it is efficiently ingested by the human body, it is possible to make the carcinogenesis-inhibiting action effective.

  Boysenberry is a plant belonging to the family Rosaceae and can be cultivated in general, so it is easily available. The Boysenberry fruit and Boysenberry fruit are rich in anthocyanins, ellagic acid, and antioxidant vitamins, which are functional polyphenols that are effective in preventing lifestyle-related diseases, aging, and carcinogenesis. Specifically, in 100 g of Boysenberry juice, 0.53 g of quercetin, 0.50 mg of quercetin glycoside (quercetin-3-glucoside equivalent), 0.17 mg of caffeic acid, 19 mg of ellagic acid, anthocyanins as antioxidant components 13 mg (cyanidin-3-glucoside equivalent) and vitamin C28 mb are contained.

  The above Boysenberry fruit is squeezed to produce Boysenberry juice, which is further concentrated to a predetermined concentration by heating or evacuation, and the resulting concentrate is used as it is or with predetermined nutrients and / or additives. By adding it, it is used as a supplement, as a drug, or as a raw material for food.

  Boysenberry fruit juice is produced by squeezing the Boysenberry fruit described above, and this is heated to dry or vacuum dried to form a powder, and the powder is used as a supplement by adding the nutrients and / or additives as they are or as a predetermined component. It is used as a medicine or as a raw material for food.

  In addition, Boysenberry fruit itself is heated to dry or vacuum dried to form a powder, and this powder is used as a supplement, as a medicine, or as a raw material of food by adding predetermined nutrients and / or additives. It is also possible.

  A predetermined polyphenol is extracted from the Boysenberry concentrated fruit juice obtained in Example 1 described above, and the extracted polyphenol is used as a supplement, as a medicine, or as a supplement by adding predetermined nutrients and / or additives. It is used as a raw material and additive for food.

  A predetermined ellagic acid is extracted from the Boysenberry concentrated fruit juice obtained in Example 1 described above, and the extracted ellagic acid is used as a supplement by adding the extracted ellagic acid as it is or with predetermined nutrients and / or additives. Or as a food ingredient and additive.

  A predetermined sugar is extracted from the Boysenberry concentrated fruit juice obtained in Example 1 described above, and the extracted sugar is used as a supplement as it is or as a supplement by adding predetermined nutrients and / or additives. Or as a food ingredient and additive. The carbohydrate is a monosaccharide, disaccharide or polysaccharide.

  Moreover, about the substance derived from the said Boysenberry fruit, the effect was demonstrated by the following experiments.

[Method]
Polyphenol and ascorbic acid in Boysenberry juice were quantified by HPLC. In addition, after 7 weeks old male ICR mice were allowed to freely ingest this juice for 1 week, iron nitrilotriacetic acid (Fe-NTA) was administered intraperitoneally to induce oxidative nephropathy. In the control group, water was administered for one week, and physiological saline was administered intraperitoneally. The mice were killed 1 hour after the administration of Fe-NTA, and the amount of TBARS in the kidney was measured as an index of lipid peroxidation, and the amount of blood urea nitrogen and the amount of creatinine were measured as indexes of kidney damage.

[Results and discussion]
In the water intake group, the amount of TBARS per kidney protein increased 1.5-fold by Fe-NTA treatment (p <0.05: physiological saline, 0.8 ± 0.2 nmols / mg; Fe-NTA). 1.2 ± 0.3 nmols / mg). On the other hand, in the group that freely ingested Boysenberry, the increase was suppressed by 72% (p <0.05: 17.3 ± 3.0 mg / dl). Thus, intake of Boysenberry juice inhibited renal oxidative stress and kidney damage by Fe-NTA.

Claims (9)

  A material mainly composed of Boysenberry fruits.   The material according to claim 1, wherein the substance is a concentrated solution of Boysenberry fruit.   The material according to claim 1, wherein the substance is a powder of Boysenberry fruit.   The material according to claim 1, wherein the substance is polyphenol extracted from Boysenberry fruit.   The material according to claim 1, wherein the substance is ellagic acid extracted from Boysenberry fruit.   The material according to claim 1, wherein the substance is a carbohydrate extracted from Boysenberry fruit.   The supplement which has as a main component the material as described in any one of Claims 1-6.   The chemical | medical agent which has as a main component the material as described in any one of Claims 1-6.   The foodstuff which has as a main component the material as described in any one of Claims 1-6.