JP2012065607A - Supplement - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a supplement aiming at immunity power improvement for maintaining bodily essential health.SOLUTION: The supplement to be administered orally includes at least a component to improve immunity power. The immunity power improving component has as the raw material, a natural living body grown under a pesticide-free or reduced-pesticide condition. The raw material includes fish and shellfish, and mushroom besides food selected from "food having high possibility of preventing cancer" released by American National Cancer Research Institute. The raw material of the immunity power improving component may include garlic, cabbage, ginger, carrot, celery, soybean, fish and shellfish such as short-necked clam and oyster, mushroom such as Shiitake, and laver.

Description

  The present invention relates to supplements taken by oral administration.

  Conventional supplements mainly replenish deficient components. Also, the provided components were mainly synthesized artificially.

However, ingestion of only a specific component is effective for poor physical condition and the like, which is apparently caused by the lack of the component, but does not directly lead to the maintenance of the fundamental health of the body.
In addition, artificially synthesized components are limited to only those components, while natural foods may contain related useful components, unknown useful components, and the like.

  Regarding food ingredients and active ingredients that contribute to general health maintenance of the body, there are proposals based on the food pyramid including Non-Patent Document 1, and the chain theory of life mentioned in Non-Patent Documents 2-3.

  On the other hand, immunity is a factor related to the maintenance of the fundamental health of the body. The conventional technologies for supplements related to improving immunity include Patent Documents 1 to 6 and the like, but none of them mainly contributes to the maintenance of the fundamental health of the body with an emphasis on improving immunity.

JP2007-254338 “Physiologically active substance, immunomodulating activator, allergy suppressing activator, anticancer activator, active oxygen scavenger activator, food, beverage, supplement and pharmaceutical product using the same” JP2008-273919 “Prevention / Repair Agent for Tissue / Cell Damage” JP 2008-273379 “Phytonutrient nutrition supplement” JP2009-209057 "Immunoactive agent and method for producing the same, human food, animal / livestock feed, plant immunoactive agent and cosmetic raw materials containing the immunoactive agent" JP 2009-240327 “Fermented plant material for immune stimulation and metastasis inhibition” JP 2010-116391 “Physiologically active substance, allergy suppressing active agent containing the same, immune regulator, food and drink, supplement and pharmaceutical product” Japanese Patent Application No. 2010-103545 “Supplement Proposal Method, and System, Program, and Storage Medium for Implementing the Method”

US National Cancer Institute, published in 1990, an article on “Food that is Highly Potential to Prevent Cancer”, Internet URL http://www.aicr.org/site/PageServer?pagename=homepage, Search Date = September 2010 16th Quick understanding of nutrition for health, Roger Williams, Chuo Koronsha, 1983 Nutrition Against Disease: EnvironmentalPrevention, Roger John Williams, BantamBooks 1973

  Therefore, an object of the present invention is to provide a supplement mainly aimed at improving immunity as a fundamental health maintenance of the body.

In order to achieve the above object, the supplement of the present invention is an orally administered supplement containing at least a component for improving immunity, and the component for improving immunity grows under conditions of no pesticide or reduced pesticide. In addition to those selected from the “National Cancer Institute” “Non-patent Document 1”, the raw material is fish and shellfish. Including mushrooms, characterized by improved nutritional balance.
As seafood, crayfish and oysters are particularly preferable, and as mushrooms, shiitake is particularly preferable.

  Here, as a raw material of an immunity improving component, it is preferable to contain garlic, cabbage, ginger, carrot, celery, soybean, seafood, mushrooms, and laver.

  Brown rice, tea, wheat, onion, tomato, eggplant, green pepper, broccoli, cauliflower, brussels sprouts, orange, grapefruit, kale may be further included as a raw material for the immunity enhancing component.

  In addition, as an immunity improvement component, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, niacin, folic acid, pantothenic acid, biotin, inositol, quercetin, potassium, magnesium, It is preferable to contain calcium, iron, zinc, copper, selenium, chromium, molybdenum, manganese, and iodine.

  According to the present invention, non-patent documents 1 to 3 are taken into consideration, and further, the supplement having ingredients and raw materials mainly for improving immunity contributes to the fundamental health maintenance of the body.

Table showing examples of supplements according to the invention

  The inventor proposes a method for proposing a supplement suitable for each user in Patent Document 7. As an extension of Patent Document 7, the present invention has led to the development of a supplement that focuses on improving immunity for the purpose of maintaining fundamental health common to each person.

  Embodiments of the present invention will be described below with reference to the drawings. Embodiments can be appropriately changed in design by using conventionally known techniques such as the above-mentioned patent documents, and conventionally known techniques can be appropriately applied to supplement manufacturing methods and apparatuses.

FIG. 1 is a table showing examples of supplements according to the present invention.
The supplement according to the present invention contains at least a component that improves immunity, and the immunity enhancing component is made from a natural material grown under the conditions of no pesticide or reduced pesticide, preferably no pesticide.
In the illustrated raw material, garlic, cabbage, ginger, carrot, celery, and soybean belonging to the first stage of the pyramid are common to foods belonging to the first stage of the conventionally known food pyramid (Non-patent Document 1). It is also a food to do.

On the other hand, in the present invention, seafood, mushrooms, seafood and mushrooms are included as foods belonging to the additional food item.
As seafood, crayfish and oysters are particularly preferable, and as mushrooms, shiitake is particularly preferable.
This is in particular for improving immunity by supplementing with vitamin B12 and vitamin D.

More specifically, it is preferable to use garlic, cabbage, ginger, carrot, celery, soybeans, clams, oysters and other seafood, shiitake mushrooms, and seaweed. All of these are preferably used, but some of them can be omitted.
In addition, laver is used especially for supplementing iodine.

In the raw materials shown in the figure, brown rice, tea, wheat, onion, tomato, eggplant, green pepper, broccoli, cauliflower, brussels sprouts, orange, grapefruit, and kale belonging to the second stage of the pyramid are the first stage of the conventionally known food pyramid. It is also a common food with the food belonging to the item.
It is preferable to use all of these ingredients, but some of them can be omitted.

  In the present invention, as useful foods for the purpose of improving immunity, mesimacob, yamabushi mochi, chaga, fucoidan, propolis, ganoderma, agaricus, cordyceps, quercetin, chlorella, DHA, turmeric and the like are appropriately contained. Also good. It is preferable to use all of these ingredients, but some of them can be omitted.

Ingredients that improve immunity include vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, niacin, folic acid, pantothenic acid, biotin, inositol, quercetin, potassium, magnesium, Since calcium, iron, zinc, copper, selenium, chromium, molybdenum, manganese, and iodine are preferable, it is preferable to select the above-mentioned foodstuff and the amount thereof so as to contain a certain amount of these components.
Also regarding this component, it is preferable to contain all of them, but some of them can be omitted.

  In addition to improving immunity, supplements for anti-aging, beauty, diet, health, etc. are also possible.

  For anti-aging purposes, multivitamin, multimineral, vitamin B, vitamin C, vitamin E, alpha lipoic acid, nucleic acid, L-carcinine, SOD, polyphenol, astaxanthin, coenzyme Q10, blueberry extract, ginkgo biloba extract, It is preferable to add or increase β-carotene and zinc.

  For beauty purposes, multivitamin, multimineral, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin E, vitamin P, niacin, biotin, collagen, elastin, polyphenol, pantothenic acid , Hyaluronic acid, acetylglucosamine, inositol, coenzyme Q10, α-carotene, β-carotene, soy saponin, royal jelly, twintose, folic acid, rose petal extract, pomegranate seed extract, black cohosh extract, soy isoflavone, kuzu isoflavone squalene, brewer's yeast, It is preferable to add or increase the Fenugreek extract, calcium, magnesium, copper, iron, zinc and manganese.

  For diet purposes, multivitamin, multimineral, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, coenzyme Q10, dietary fiber, seaweed, pepper, capsaicin, gymnema, peptide, lecithin, Arginine, lysine, chitosan, alpha lipoic acid, conjugated linoleic acid, L-cartinine, L-ortinine, L-ortinic acid salt, citrus arantium, chitoglucan, garcinia extract, crope extract, mulberry leaf extract, kidney bean extract, mellilot extract, It is preferable to add or increase barley extract, Tochu extract, Coleus forskori extract, calcium, magnesium, potassium and iron.

  For health purposes, multivitamin, multimineral, vitamin B, vitamin C, vitamin E, coenzyme Q10, beta carotene, dietary fiber, seaweed, protein, lecithin, EPA, DHA, alpha lipoic acid, citric acid, It is preferable to add or increase nucleic acid, L-carcinin, SOD, polyphenol, collagen, glucosamine, chondroitin, enexia, lactic acid bacteria, garlic, ginkgo biloba extract, chamomile, and zinc.

  In addition to the above-mentioned components, conventionally known supplement additives may be added as components to be included in the supplement. Examples include various vitamins, amino acids, peptides, proteins, minerals, dietary fiber, fatty acids, carbohydrates, nucleic acids, organic acids, fungi, extracts from animals and plants, lipids, and the like.

  Examples of vitamins include beta-carotene, vitamin D, vitamin E, vitamin E derivatives, fat-soluble vitamins such as vitamin K, coenzyme Q10, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, pantothenic acid And water-soluble vitamins such as folic acid. Moreover, multivitamin is mentioned as what contains two or more of these integrally.

  In addition, it is preferable to mix | blend as a multivitamin based on the chain theory of life mentioned in nonpatent literature 2-3 etc., for example, beta-carotene, vitamin C, vitamin B1, vitamin B2, pantothenic acid, vitamin E, Examples include combinations of niacin, vitamin B6, vitamin B12, folic acid, vitamin K, biotin, quercetin, and inositol.

  Examples of amino acids include glycine, alanine, valine, leucine, isoleucine, serine, threonine, cysteine, tyrosine, methionine, asparagine, aspartic acid, glutamic acid, glutamine, arginine, lysine, histidine, phenylalanine, tryptophan, proline, homoserine, ornithine. Citrulline, carnitine, β-alanine and the like.

  Examples of peptides include peptide amides and esters, soybean peptides, β-casein, α-lactalbumin, β-lactoglobulin, casein, lactoferrin, whey protein, and the like.

  Examples of the protein include animal proteins such as milk protein, collagen and elastin, and vegetable proteins such as silk protein and soybean protein.

  Examples of the mineral include calcium, phosphorus, iodine, selenium, magnesium, zinc, iron, and potassium. Moreover, multimineral is mentioned as what contains two or more of these integrally.

  In addition, it is preferable to mix | blend as a multimineral based on the chain theory of life mentioned in nonpatent literature 2-3 etc., for example, magnesium, calcium, zinc, copper, manganese, iron, chromium, selenium, molybdenum, vanadium. And potassium combinations.

  Examples of dietary fiber include plant cell walls such as cellulose, lignin and hemicellulose, soluble saccharides, indigestible substances derived from animal foods, and the like.

  Examples of the fatty acid include various saturated fatty acids, unsaturated fatty acids such as linoleic acid, γ-linolenic acid, DHA, and EPA.

  Examples of the saccharide include monosaccharides such as glucose and fructose, fructooligosaccharides, soybean oligosaccharides, dairy oligosaccharides, raffinose, galactooligosaccharides, xylooligosaccharide oligosaccharides, and the like.

  Examples of the nucleic acid include DNA and RNA.

  Examples of the organic acid include citric acid and malic acid.

  Examples of fungi include lactic acid bacteria and bifidobacteria.

  Examples of extracts from animals and plants include polyphenols, anthocyanins, isoflavones, catechins, curcumins, flavonoids, sesaminols, soybean saponins, ellagic acid, ginkgolides, allicin, glutathione, cystatins, chlorophylls, carotenoids, α-carotene, lutein, lycopene, Examples include fucoxanthin, tannic acid, theaflavin, and chlorella.

  Examples of the lipid include monoacylglycerol, diacylglycerol, triacylglycerol, squalene, wax, cholesterol, glycerophospholipid, sphingophospholipid, fatty acid ester, plant sterol and the like.

Supplements refer to quasi-drugs, foods, dietary supplements, health foods, etc. other than those that require a doctor's prescription. Tablets, powders, capsules, drinks, etc. The form may be sufficient and the excipient | filler normally used in a formulation may be included suitably.
Moreover, you may give modifications, such as sustained release, stabilization, easy disintegration, difficulty disintegration, enteric-solubility, and easy absorption.

Examples of components that can be blended typically include carrier components and additives.
Examples of the carrier component or additive in the solid agent include an excipient, a disintegrant, a binder, a lubricant, an antioxidant, a coating agent, a coloring agent, a corrigent, a surfactant, a plasticizer, a sweetener, In addition to flavoring agents, examples include disintegration aids, foaming agents, adsorbents, preservatives, wetting agents, and antistatic agents. Examples of the carrier component or additive in the liquid preparation include, for example, a solvent, a pH adjusting agent, a cooling agent, a suspending agent, an antifoaming agent, a thickening agent, a solubilizing agent, the surfactant, an antioxidant, In addition to colorants, sweeteners, flavoring agents, antiseptic / antibacterial agents, chelating agents, solubilizers or solubilizers, stabilizers, fluidizers, emulsifiers, thickeners, buffering agents, isotonic agents, A dispersing agent etc. can be illustrated.
Although the component which can be mix | blended arbitrarily is illustrated below, it is not limited to these components.
Moreover, it is preferable to refrain from adding them as much as possible or to reduce the content even if they are added.

  Examples of excipients include sugar alcohols such as D-sorbitol, mannitol, and xylitol, sugars such as glucose, sucrose, lactose, and fructose, crystalline cellulose, carmellose sodium, croscarmellose sodium, calcium hydrogen phosphate, wheat starch, rice Examples include starch, corn starch, potato starch, dextrin, β-cyclodextrin, light silicic anhydride, titanium oxide, magnesium aluminate metasilicate, talc, and kaolin.

  Examples of the disintegrant include low-substituted hydroxypropylcellulose, carboxymethylcellulose calcium, croscarmellose sodium, hydroxypropyl starch, and partially pregelatinized starch.

  Binders include cellulose derivatives such as methylcellulose, ethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, acrylic polymer, gelatin, gum arabic, pullulan, pregelatinized starch, agar, tragacanth, sodium alginate And propylene glycol alginate.

  Examples of the lubricant include stearic acid, magnesium stearate, calcium stearate, polyoxyl stearate, cetanol, talc, hydrogenated oil, sucrose fatty acid ester, dimethylpolysiloxane, beeswax, and white beeswax.

  Examples of the antioxidant include dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHA), tocopherol, and citric acid.

  Coating agents include hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, carboxymethylethylcellulose, cellulose acetate phthalate, polyvinyl acetal diethylaminoacetate, aminoalkyl methacrylate copolymer, hydroxy Examples thereof include propylmethylcellulose acetate succinate, methacrylic acid copolymer, polyvinyl acetate diethylaminoacetate, shellac and the like.

  Coloring agents include food red No. 2, food red No. 3, food red No. 102, food yellow No. 4, food yellow No. 5, food blue No. 1, food yellow No. 4, metal lake, copper chlorofin sodium, riboflavin, turmeric Examples include extract and carotene solution.

  Examples of the corrigent include aspartame, ascorbic acid, stevia, menthol, licorice crude extract, and simple syrup.

  Surfactants include polyoxyethylene hydrogenated castor oil, glyceryl monostearate, sorbitan monostearate, sorbitan monolaurate, polyoxyethylene polyoxypropylene, polysorbates, sodium lauryl sulfate, macrogol, sucrose fatty acid esters, etc. Is mentioned.

  Examples of the plasticizer include triethyl citrate, polyethylene glycol, triacetin, cetanol and the like.

  Sweetening agents include natural or synthetic sweetening agents such as sucrose, mannitol, aspartame.

  Examples of flavoring agents include camphor, borneol, cinnamaldehyde, and the like.

  Examples of the solvent include water, ethanol, isopropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, behenyl alcohol, 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

  Examples of the pH adjuster include citric acid, malic acid, sodium hydrogen phosphate, and dipotassium phosphate.

Suspending agents include kaolin, carmellose sodium, xanthan gum, methylcellulose, tragacanth and the like.

  Examples of the antifoaming agent include dimethylpolysiloxane and silicon antifoaming agent.

  Examples of thickeners include xanthan gum, tragacanth, methylcellulose, and dextrin.

  Examples of the solubilizer include ethanol, sucrose fatty acid ester, macrogol and the like.

The method for producing the supplement of the present invention is not particularly limited, and can be produced by appropriately applying conventionally known methods.
For example, if it is a tablet, it can be prepared by mixing a powdery active ingredient and a pharmaceutically acceptable carrier component (excipient etc.) and directly compressing the mixture (direct compression method). The drop agent may be prepared by injecting it into a mold. Furthermore, among the solid agents, granules such as granules are available in various granulation methods (extrusion granulation method, pulverization granulation method, dry compaction granulation method, fluidized bed granulation method, rolling granulation method, high speed granulation method, The tablet may be prepared by appropriately combining the above granulation method and tableting method (wet tableting method etc.) (indirect compression method). Furthermore, the capsule can be prepared by filling a capsule (soft or hard capsule) with a powder (powder, granule, etc.) by a conventional method. Tablets may be coated to be sugar-coated tablets or film-coated tablets. Furthermore, the tablet may be a monolayer tablet or a laminated tablet such as a bilayer tablet. Each solution is dissolved or dispersed in an aqueous medium (purified water, heat purified water, ethanol-containing purified water, etc.) that is a carrier component, and heated, filtered, clothed or sterilized as necessary, and placed in a prescribed container. It can be prepared by filling and sterilizing.

  According to the supplement of the present invention, the immunity is improved and it contributes to the maintenance of the fundamental health of the body.

Claims (3)

An orally administered supplement,
It contains at least a component that improves immunity, and the component that improves immunity is derived from a natural living body grown under the conditions of pesticide-free or reduced pesticide. A supplement characterized by containing fish and shellfish and mushrooms in addition to those selected from the publication “Food with High Potential for Preventing Cancer” (Non-patent Document 1). The ingredients of the immunity enhancing ingredient are
The supplement according to claim 1, comprising garlic, cabbage, ginger, carrot, celery, soybean, seafood, mushrooms, and laver. The ingredients of the immunity enhancing ingredient are
The supplement according to claim 2, further comprising brown rice, tea, wheat, onion, tomato, eggplant, green pepper, broccoli, cauliflower, brussels sprouts, orange, grapefruit, and kale.

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