TW201348199A - 補體路徑調節劑及其用途 - Google Patents
補體路徑調節劑及其用途 Download PDFInfo
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- TW201348199A TW201348199A TW102115970A TW102115970A TW201348199A TW 201348199 A TW201348199 A TW 201348199A TW 102115970 A TW102115970 A TW 102115970A TW 102115970 A TW102115970 A TW 102115970A TW 201348199 A TW201348199 A TW 201348199A
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- Prior art keywords
- methyl
- benzo
- carbonitrile
- imidazole
- methoxy
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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| CN105229003B (zh) * | 2013-03-14 | 2017-03-15 | 诺华股份有限公司 | 作为补体因子b抑制剂用于治疗眼科疾病的2‑(1h‑吲哚‑4‑基甲基)‑3h‑咪唑并[4,5‑b]吡啶‑6‑甲腈衍生物 |
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| CN105849090A (zh) | 2013-10-30 | 2016-08-10 | 诺华股份有限公司 | 2-苄基-苯并咪唑补体因子b抑制剂及其用途 |
| CN103755622A (zh) * | 2013-12-25 | 2014-04-30 | 华东理工大学 | 合成4,5,6,7-四氘代吲哚-3-乙酸的方法 |
| EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| TWI747873B (zh) | 2016-02-01 | 2021-12-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| CN109414441A (zh) | 2016-06-27 | 2019-03-01 | 艾其林医药公司 | 治疗医学障碍的喹唑啉和吲哚化合物 |
| KR102632860B1 (ko) | 2017-03-01 | 2024-02-02 | 아칠리온 파르마세우티칼스 인코포레이티드 | 의학적 장애의 치료를 위한 아릴, 헤테로아릴, 및 헤테로사이클릭 약학적 화합물 |
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| US20230022157A1 (en) | 2018-08-20 | 2023-01-26 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| US11814363B2 (en) | 2018-09-06 | 2023-11-14 | Achillion Pharmaceuticals, Inc. | Morphic forms of danicopan |
| EP3846803A4 (en) | 2018-09-06 | 2022-08-10 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| EP3856164B1 (en) | 2018-09-25 | 2024-08-07 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor d inhibitors |
| CN115362162A (zh) | 2020-02-20 | 2022-11-18 | 艾其林医药公司 | 用于治疗补体因子d介导的障碍的杂芳基化合物 |
| JP7682920B2 (ja) * | 2020-04-07 | 2025-05-26 | ユーシービー バイオファルマ エスアールエル | Ｉｌ－１７モジュレータとしてのジフルオロシクロヘキシル誘導体 |
| US20230331710A1 (en) | 2020-08-07 | 2023-10-19 | Shanghai Meiyue Biotech Development Co. Ltd | Heterocyclic compound, preparation method and use thereof |
| US20230286947A1 (en) * | 2020-08-07 | 2023-09-14 | Shanghai Meiyue Biotech Development Co. Ltd | Complement factor b inhibitor, and pharmaceutical composition, preparation method and use thereof |
| CA3193488A1 (en) | 2020-09-23 | 2022-03-31 | Jason Allan Wiles | Pharmaceutical compounds for the treatment of complement mediated disorders |
| MX2023014274A (es) * | 2021-06-03 | 2024-04-22 | Chinook Therapeutics Inc | Compuestos indol sustituidos y metodos de uso de los mismos. |
| EP4471021A4 (en) | 2022-01-26 | 2025-04-30 | Shanghai Meiyue Biotech Development Co., Ltd. | Salt type and crystal form of complement factor b inhibitor, and preparation method therefor and application thereof |
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| AU2024290587A1 (en) | 2023-07-04 | 2026-02-19 | Sitala Bio Ltd | 2-(1h-indol-4-yl)methyl)-isoindoline derivatives as factor b inhibitors |
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| TWI896250B (zh) | 2023-07-26 | 2025-09-01 | 大陸商上海美悦生物科技發展有限公司 | 螺環烯基類或氮雜烯基類化合物及其藥物組合物、製備方法和用途 |
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
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| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| GB8420919D0 (en) * | 1984-08-17 | 1984-09-19 | Beecham Group Plc | Compounds |
| DE19545464A1 (de) * | 1995-12-06 | 1997-06-12 | Bayer Ag | Benzimidazol-isoindoleninfarbstoffe |
| PT1249450E (pt) * | 2000-01-17 | 2008-01-02 | Teijin Pharma Ltd | Derivados de benzimidazole como inibidores de quimase humana |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
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| AU2007271188B2 (en) * | 2006-07-03 | 2012-11-01 | Proximagen Limited | Indoles as 5-HT6 modulators |
| JO3265B1 (ar) * | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| SMT202200074T1 (it) * | 2008-12-22 | 2022-03-21 | Chemocentryx Inc | Antagonisti di c5ar |
| AU2010216239B2 (en) * | 2009-02-18 | 2012-06-14 | Amgen Inc. | Indole/benzimidazole compounds as mTOR kinase inhibitors |
| EP2447263A1 (en) * | 2010-09-27 | 2012-05-02 | Bioprojet | Benzazole derivatives as histamine H4 receptor ligands |
| US8846656B2 (en) * | 2011-07-22 | 2014-09-30 | Novartis Ag | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators |
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| KR20150003903A (ko) | 2015-01-09 |
| AU2013255470B2 (en) | 2015-09-17 |
| SG11201406973PA (en) | 2014-12-30 |
| BR112014027359A2 (pt) | 2017-07-18 |
| AR090945A1 (es) | 2014-12-17 |
| AU2013255470A1 (en) | 2014-11-13 |
| UY34781A (es) | 2013-12-31 |
| EP2855456B1 (en) | 2017-03-29 |
| IL235362A0 (en) | 2014-12-31 |
| EA201492023A1 (ru) | 2015-03-31 |
| CR20140508A (es) | 2015-03-13 |
| PE20150623A1 (es) | 2015-05-17 |
| WO2013164802A1 (en) | 2013-11-07 |
| CN104603127A (zh) | 2015-05-06 |
| AP2014008040A0 (en) | 2014-10-31 |
| EP2855456A1 (en) | 2015-04-08 |
| ES2630079T3 (es) | 2017-08-17 |
| JP2015515976A (ja) | 2015-06-04 |
| PT2855456T (pt) | 2017-07-10 |
| CA2872000A1 (en) | 2013-11-07 |
| JP6180514B2 (ja) | 2017-08-16 |
| MX2014013428A (es) | 2015-02-04 |
| TN2014000449A1 (en) | 2016-03-30 |
| PH12014502462A1 (en) | 2014-12-22 |
| EA027113B1 (ru) | 2017-06-30 |
| PL2855456T3 (pl) | 2017-09-29 |
| CN104603127B (zh) | 2016-10-05 |
| CL2014002919A1 (es) | 2015-07-03 |
| HK1206017A1 (en) | 2015-12-31 |
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