CA2872000A1 - Complement pathway modulators and uses thereof - Google Patents
Complement pathway modulators and uses thereof Download PDFInfo
- Publication number
- CA2872000A1 CA2872000A1 CA2872000A CA2872000A CA2872000A1 CA 2872000 A1 CA2872000 A1 CA 2872000A1 CA 2872000 A CA2872000 A CA 2872000A CA 2872000 A CA2872000 A CA 2872000A CA 2872000 A1 CA2872000 A1 CA 2872000A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- benzo
- indol
- carbonitrile
- imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US10849883B2 (en) | 2016-02-01 | 2020-12-01 | Biocryst Pharmaceuticals, Inc. | Benzopyrazole compounds and analogues thereof |
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| CN105849090A (zh) * | 2013-10-30 | 2016-08-10 | 诺华股份有限公司 | 2-苄基-苯并咪唑补体因子b抑制剂及其用途 |
| CN103755622A (zh) * | 2013-12-25 | 2014-04-30 | 华东理工大学 | 合成4,5,6,7-四氘代吲哚-3-乙酸的方法 |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| SG11201811491YA (en) * | 2016-06-27 | 2019-01-30 | Achillion Pharmaceuticals Inc | Quinazoline and indole compounds to treat medical disorders |
| CN110603252A (zh) | 2017-03-01 | 2019-12-20 | 艾其林医药公司 | 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物 |
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| US20230022157A1 (en) | 2018-08-20 | 2023-01-26 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| JP7443375B2 (ja) | 2018-09-06 | 2024-03-05 | アキリオン ファーマシューティカルズ， インコーポレーテッド | 医学的障害の治療のための大環状化合物 |
| WO2020051538A1 (en) | 2018-09-06 | 2020-03-12 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor d inhibitors |
| KR20210093855A (ko) | 2018-09-25 | 2021-07-28 | 아칠리온 파르마세우티칼스 인코포레이티드 | 보체 인자 d 억제제의 형태체 형태 |
| CN115362162A (zh) | 2020-02-20 | 2022-11-18 | 艾其林医药公司 | 用于治疗补体因子d介导的障碍的杂芳基化合物 |
| WO2021204801A1 (en) * | 2020-04-07 | 2021-10-14 | UCB Biopharma SRL | Difluorocyclohexyl derivatives as il-17 modulators |
| KR20230049115A (ko) | 2020-08-07 | 2023-04-12 | 상하이 메이유에 바이오테크 디벨롭먼트 컴퍼니 리미티드 | 보체 인자 b 억제제 및 이의 약학적 조성물, 제조 방법 및 용도 |
| WO2022028507A1 (zh) | 2020-08-07 | 2022-02-10 | 上海美悦生物科技发展有限公司 | 一种杂环类化合物、其制备方法及用途 |
| CN116437913A (zh) | 2020-09-23 | 2023-07-14 | 艾其林医药公司 | 用于治疗补体介导的病症的药物化合物 |
| CN120081822A (zh) * | 2021-06-03 | 2025-06-03 | 诺瓦提斯药物公司 | 经取代的吲哚化合物及其使用方法 |
| WO2023143293A1 (zh) | 2022-01-26 | 2023-08-03 | 上海美悦生物科技发展有限公司 | 补体因子b抑制剂的盐型、晶型及其制备方法和应用 |
| UY40204A (es) * | 2022-04-01 | 2023-10-31 | Novartis Ag | Inhibidores del Factor B del Complemento y Usos de los mismos |
| JP2025541667A (ja) | 2022-11-11 | 2025-12-23 | シャンハイ イーシェン バイオファーマシューティカル カンパニー リミテッド | ピペリジン置換安息香酸系化合物、その医薬組成物および使用 |
| WO2024141011A1 (zh) * | 2022-12-31 | 2024-07-04 | 深圳晶泰科技有限公司 | 补体因子b抑制剂及其药物组合物和应用 |
| IL325760A (en) | 2023-07-04 | 2026-03-01 | Sitala Bio Ltd | History of 2-(1H-indol-4-yl)methyl)-isoindoline as factor B inhibitors |
| CN121889385A (zh) | 2023-07-04 | 2026-04-17 | 希塔拉生物有限公司 | 作为因子b抑制剂的2-(1h-吲哚-4-基)甲基)2h-吲唑衍生物 |
| WO2025008516A2 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Novel compounds |
| WO2025008517A1 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Indole derivatives with factor b inhibitory activity |
| CN119371402A (zh) | 2023-07-26 | 2025-01-28 | 上海美悦生物科技发展有限公司 | 螺环烯基类或氮杂烯基类化合物及其药物组合物、制备方法和用途 |
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10849883B2 (en) | 2016-02-01 | 2020-12-01 | Biocryst Pharmaceuticals, Inc. | Benzopyrazole compounds and analogues thereof |
| US11559515B2 (en) | 2016-02-01 | 2023-01-24 | Biocryst Pharmaceuticals, Inc. | Indole compounds and analogues thereof |
| US12485109B2 (en) | 2016-02-01 | 2025-12-02 | Biocryst Pharmaceuticals, Inc. | Pyrrolo 12.3-dipyrimidine compounds and analogues thereof |
Also Published As
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| IL235362A0 (en) | 2014-12-31 |
| AU2013255470A1 (en) | 2014-11-13 |
| JP6180514B2 (ja) | 2017-08-16 |
| TN2014000449A1 (en) | 2016-03-30 |
| EP2855456B1 (en) | 2017-03-29 |
| JP2015515976A (ja) | 2015-06-04 |
| PH12014502462A1 (en) | 2014-12-22 |
| ES2630079T3 (es) | 2017-08-17 |
| TW201348199A (zh) | 2013-12-01 |
| EP2855456A1 (en) | 2015-04-08 |
| KR20150003903A (ko) | 2015-01-09 |
| HK1206017A1 (en) | 2015-12-31 |
| EA027113B1 (ru) | 2017-06-30 |
| PT2855456T (pt) | 2017-07-10 |
| AP2014008040A0 (en) | 2014-10-31 |
| CN104603127B (zh) | 2016-10-05 |
| PE20150623A1 (es) | 2015-05-17 |
| EA201492023A1 (ru) | 2015-03-31 |
| AU2013255470B2 (en) | 2015-09-17 |
| MX2014013428A (es) | 2015-02-04 |
| AR090945A1 (es) | 2014-12-17 |
| PL2855456T3 (pl) | 2017-09-29 |
| BR112014027359A2 (pt) | 2017-07-18 |
| WO2013164802A1 (en) | 2013-11-07 |
| CR20140508A (es) | 2015-03-13 |
| UY34781A (es) | 2013-12-31 |
| CL2014002919A1 (es) | 2015-07-03 |
| SG11201406973PA (en) | 2014-12-30 |
| CN104603127A (zh) | 2015-05-06 |
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| FZDE | Discontinued |
Effective date: 20190503 |