JP6180514B2 - 補体経路モジュレーターおよびその使用 - Google Patents
補体経路モジュレーターおよびその使用 Download PDFInfo
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- JP6180514B2 JP6180514B2 JP2015509561A JP2015509561A JP6180514B2 JP 6180514 B2 JP6180514 B2 JP 6180514B2 JP 2015509561 A JP2015509561 A JP 2015509561A JP 2015509561 A JP2015509561 A JP 2015509561A JP 6180514 B2 JP6180514 B2 JP 6180514B2
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- Prior art keywords
- methyl
- benzo
- indol
- carbonitrile
- imidazole
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Landscapes
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2016526576A (ja) * | 2013-07-15 | 2016-09-05 | ノバルティス アーゲー | ピペリジニル−インドール誘導体および補体因子ｂ阻害剤としてのその使用 |
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| EP2970269B1 (en) * | 2013-03-14 | 2017-04-19 | Novartis AG | 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases |
| WO2015066241A1 (en) * | 2013-10-30 | 2015-05-07 | Novartis Ag | 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof |
| CN103755622A (zh) * | 2013-12-25 | 2014-04-30 | 华东理工大学 | 合成4,5,6,7-四氘代吲哚-3-乙酸的方法 |
| WO2017035408A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| TWI854164B (zh) | 2016-02-01 | 2024-09-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| EP3448389B1 (en) | 2016-06-27 | 2021-09-29 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
| CN110603252A (zh) | 2017-03-01 | 2019-12-20 | 艾其林医药公司 | 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物 |
| TWI873092B (zh) * | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| JP7538113B2 (ja) | 2018-08-20 | 2024-08-21 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 補体ｄ因子の医学的障害の治療のための医薬化合物 |
| EP3846803A4 (en) | 2018-09-06 | 2022-08-10 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| CA3114039A1 (en) | 2018-09-25 | 2020-04-02 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor d inhibitors |
| CN115362162A (zh) | 2020-02-20 | 2022-11-18 | 艾其林医药公司 | 用于治疗补体因子d介导的障碍的杂芳基化合物 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016526576A (ja) * | 2013-07-15 | 2016-09-05 | ノバルティス アーゲー | ピペリジニル−インドール誘導体および補体因子ｂ阻害剤としてのその使用 |
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| BR112014027359A2 (pt) | 2017-07-18 |
| KR20150003903A (ko) | 2015-01-09 |
| AU2013255470B2 (en) | 2015-09-17 |
| IL235362A0 (en) | 2014-12-31 |
| HK1206017A1 (en) | 2015-12-31 |
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| AU2013255470A1 (en) | 2014-11-13 |
| CR20140508A (es) | 2015-03-13 |
| JP2015515976A (ja) | 2015-06-04 |
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| UY34781A (es) | 2013-12-31 |
| TN2014000449A1 (en) | 2016-03-30 |
| PL2855456T3 (pl) | 2017-09-29 |
| CL2014002919A1 (es) | 2015-07-03 |
| CA2872000A1 (en) | 2013-11-07 |
| PH12014502462A1 (en) | 2014-12-22 |
| EP2855456A1 (en) | 2015-04-08 |
| SG11201406973PA (en) | 2014-12-30 |
| TW201348199A (zh) | 2013-12-01 |
| ES2630079T3 (es) | 2017-08-17 |
| WO2013164802A1 (en) | 2013-11-07 |
| CN104603127B (zh) | 2016-10-05 |
| EA027113B1 (ru) | 2017-06-30 |
| EA201492023A1 (ru) | 2015-03-31 |
| PE20150623A1 (es) | 2015-05-17 |
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