TW201343649A - 經取代之苯基咪唑并吡唑類及其用途 - Google Patents

經取代之苯基咪唑并吡唑類及其用途 Download PDF

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Publication number
TW201343649A
TW201343649A TW102102567A TW102102567A TW201343649A TW 201343649 A TW201343649 A TW 201343649A TW 102102567 A TW102102567 A TW 102102567A TW 102102567 A TW102102567 A TW 102102567A TW 201343649 A TW201343649 A TW 201343649A
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TW
Taiwan
Prior art keywords
group
fluorine
methyl
mmol
alkyl
Prior art date
Application number
TW102102567A
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English (en)
Chinese (zh)
Inventor
法蘭克 蘇斯米爾
馬力歐 羅貝爾
席爾維亞 古羅恩瓦德
麥可 海特
柏恩德 巴契曼
約金 泰爾瑟
漢娜 喬瑞森
米藍尼 賀魯特
安傑 卡賀奈特
克雷曼斯 路斯堤戈
尼爾斯 林德納
Original Assignee
拜耳智慧財產有限公司
拜耳製藥股份有限公司
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47594775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW201343649(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 拜耳智慧財產有限公司, 拜耳製藥股份有限公司 filed Critical 拜耳智慧財產有限公司
Publication of TW201343649A publication Critical patent/TW201343649A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW102102567A 2012-01-25 2013-01-24 經取代之苯基咪唑并吡唑類及其用途 TW201343649A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12152515 2012-01-25

Publications (1)

Publication Number Publication Date
TW201343649A true TW201343649A (zh) 2013-11-01

Family

ID=47594775

Family Applications (1)

Application Number Title Priority Date Filing Date
TW102102567A TW201343649A (zh) 2012-01-25 2013-01-24 經取代之苯基咪唑并吡唑類及其用途

Country Status (30)

Country Link
US (2) US20150005288A1 (enExample)
EP (1) EP2807162B1 (enExample)
JP (1) JP6101290B2 (enExample)
KR (1) KR20140117582A (enExample)
CN (1) CN104411707B (enExample)
AP (1) AP2014007869A0 (enExample)
AR (1) AR089788A1 (enExample)
AU (1) AU2013211707A1 (enExample)
BR (1) BR112014018450A8 (enExample)
CA (1) CA2862163A1 (enExample)
CL (1) CL2014001959A1 (enExample)
CO (1) CO7101244A2 (enExample)
CR (1) CR20140362A (enExample)
CU (1) CU20140096A7 (enExample)
DO (1) DOP2014000173A (enExample)
EA (1) EA201491427A1 (enExample)
EC (1) ECSP14010868A (enExample)
ES (1) ES2639338T3 (enExample)
GT (1) GT201400161A (enExample)
IL (1) IL233652A0 (enExample)
MA (1) MA35877B1 (enExample)
MX (1) MX2014008893A (enExample)
PE (1) PE20142421A1 (enExample)
PH (1) PH12014501687A1 (enExample)
SG (1) SG11201404118XA (enExample)
TN (1) TN2014000320A1 (enExample)
TW (1) TW201343649A (enExample)
UY (1) UY34590A (enExample)
WO (1) WO2013110590A1 (enExample)
ZA (1) ZA201405392B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2862163A1 (en) * 2012-01-25 2013-08-01 Bayer Pharma Aktiengesellschaft Substituted phenylimidazopyrazoles and use thereof
CA3280124A1 (en) 2013-07-31 2025-10-31 Avalyn Pharma Inc. Aerosol imatinib compounds and uses thereof
US20180368404A1 (en) 2014-11-06 2018-12-27 Basf Se 3-pyridyl heterobicyclic compound for controlling invertebrate pests
BR112018007034B1 (pt) * 2015-10-08 2022-10-11 Fmc Corporation Composto, composição, método para controlar uma praga de invertebrados e semente revestida
PY1974629A (es) * 2018-09-13 2021-01-11 Syngenta Participations Ag Compuestos de azol-amida pesticidamente activos
CN109096195A (zh) * 2018-09-27 2018-12-28 上海雅本化学有限公司 一种艾曲波帕的制备方法
KR20220082835A (ko) * 2019-10-16 2022-06-17 바이엘 악티엔게젤샤프트 1,1'-디술판디일비스(4-플루오로-2-메틸-5-니트로벤졸)의 제조 방법
BR112022015110A2 (pt) * 2020-01-29 2022-11-08 Foghorn Therapeutics Inc Compostos e usos dos mesmos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0753730B2 (ja) * 1988-07-26 1995-06-07 三共株式会社 イミダゾピラゾール誘導体
UA80171C2 (en) * 2002-12-19 2007-08-27 Pfizer Prod Inc Pyrrolopyrimidine derivatives
US7419978B2 (en) * 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
KR101061599B1 (ko) * 2008-12-05 2011-09-02 한국과학기술연구원 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물
CA2765534C (en) * 2009-06-15 2018-09-18 Rigel Pharmaceuticals, Inc. Small molecule inhibitors of spleen tyrosine kinase (syk)
KR101116756B1 (ko) * 2009-10-27 2012-03-13 한국과학기술연구원 단백질 키나아제 저해활성을 갖는 신규의 1,6-치환된 인돌 화합물
CA2862163A1 (en) * 2012-01-25 2013-08-01 Bayer Pharma Aktiengesellschaft Substituted phenylimidazopyrazoles and use thereof

Also Published As

Publication number Publication date
WO2013110590A1 (de) 2013-08-01
GT201400161A (es) 2015-03-05
IL233652A0 (en) 2014-08-31
SG11201404118XA (en) 2014-10-30
ZA201405392B (en) 2015-12-23
US20130190290A1 (en) 2013-07-25
EP2807162B1 (de) 2017-06-07
ECSP14010868A (es) 2015-12-31
CA2862163A1 (en) 2013-08-01
EA201491427A1 (ru) 2015-01-30
TN2014000320A1 (en) 2015-12-21
US20150005288A1 (en) 2015-01-01
UY34590A (es) 2013-09-02
CL2014001959A1 (es) 2014-11-07
DOP2014000173A (es) 2014-08-31
CR20140362A (es) 2014-08-21
MA35877B1 (fr) 2014-12-01
EP2807162A1 (de) 2014-12-03
BR112014018450A8 (pt) 2017-07-11
AU2013211707A1 (en) 2014-08-07
PE20142421A1 (es) 2015-01-11
CU20140096A7 (es) 2015-02-26
JP6101290B2 (ja) 2017-03-22
KR20140117582A (ko) 2014-10-07
PH12014501687A1 (en) 2014-10-20
CO7101244A2 (es) 2014-10-31
AP2014007869A0 (en) 2014-08-31
US9394309B2 (en) 2016-07-19
BR112014018450A2 (enExample) 2017-06-20
HK1203198A1 (en) 2015-10-23
MX2014008893A (es) 2014-08-26
JP2015504904A (ja) 2015-02-16
CN104411707A (zh) 2015-03-11
CN104411707B (zh) 2017-03-01
AR089788A1 (es) 2014-09-17
ES2639338T3 (es) 2017-10-26

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