TW201317255A - 具抗病毒活性之新穎樺木酸衍生物 - Google Patents
具抗病毒活性之新穎樺木酸衍生物 Download PDFInfo
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- TW201317255A TW201317255A TW101134558A TW101134558A TW201317255A TW 201317255 A TW201317255 A TW 201317255A TW 101134558 A TW101134558 A TW 101134558A TW 101134558 A TW101134558 A TW 101134558A TW 201317255 A TW201317255 A TW 201317255A
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- alkyl
- compound
- hiv
- pharmaceutically acceptable
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- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 12
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- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- SGOIRFVFHAKUTI-ZCFIWIBFSA-N tenofovir (anhydrous) Chemical compound N1=CN=C2N(C[C@@H](C)OCP(O)(O)=O)C=NC2=C1N SGOIRFVFHAKUTI-ZCFIWIBFSA-N 0.000 description 1
- JFVZFKDSXNQEJW-CQSZACIVSA-N tenofovir disoproxil Chemical compound N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N JFVZFKDSXNQEJW-CQSZACIVSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000005247 tetrazinyl group Chemical group N1=NN=NC(=C1)* 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 229960000838 tipranavir Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 description 1
- 125000004385 trihaloalkyl group Chemical group 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 229940111527 trizivir Drugs 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940087450 zerit Drugs 0.000 description 1
- 229940052255 ziagen Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161537099P | 2011-09-21 | 2011-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201317255A true TW201317255A (zh) | 2013-05-01 |
Family
ID=46964090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101134558A TW201317255A (zh) | 2011-09-21 | 2012-09-20 | 具抗病毒活性之新穎樺木酸衍生物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8754069B2 (OSRAM) |
| EP (1) | EP2758419B8 (OSRAM) |
| JP (1) | JP6100786B2 (OSRAM) |
| KR (1) | KR20140069167A (OSRAM) |
| CN (1) | CN103814042B (OSRAM) |
| AU (1) | AU2012312485B2 (OSRAM) |
| BR (1) | BR112014006559A2 (OSRAM) |
| CA (1) | CA2849475A1 (OSRAM) |
| EA (1) | EA023463B1 (OSRAM) |
| ES (1) | ES2611727T3 (OSRAM) |
| IL (1) | IL231421A (OSRAM) |
| MX (1) | MX2014002936A (OSRAM) |
| SG (1) | SG11201400331WA (OSRAM) |
| TW (1) | TW201317255A (OSRAM) |
| WO (1) | WO2013043778A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
| US10221208B2 (en) * | 2015-04-14 | 2019-03-05 | ViiV Healthcare UK (No.4) Limited | Methods of producing an HIV maturation inhibitor |
| WO2017017609A1 (en) | 2015-07-28 | 2017-02-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Betuin derivatives for preventing or treating hiv infections |
| CA2993758A1 (en) | 2015-07-28 | 2017-02-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Betuin derivatives for preventing or treating hiv infections |
| AU2016327169A1 (en) | 2015-09-24 | 2018-04-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Compounds with hiv maturation inhibitory activity |
| EP3405474A1 (en) | 2016-01-20 | 2018-11-28 | Glaxosmithkline Intellectual Property (No. 2) Limited | Amine derivatives of lupanes with hiv maturation inhibitory activity |
| EP3478661A1 (en) * | 2016-06-30 | 2019-05-08 | ViiV Healthcare UK (No.5) Limited | Aza-substituted inhibitors of human immunodeficiency virus replication |
| EP4321164A3 (en) | 2018-04-24 | 2024-04-17 | ViiV Healthcare UK (No.5) Limited | Compounds with hiv maturation inhibitory activity |
| AU2019292599B2 (en) * | 2018-06-29 | 2022-03-03 | Dfh Therapeutics | Triterpene amine derivatives |
| HRP20231582T1 (hr) * | 2019-02-11 | 2024-03-15 | Hetero Labs Limited | Novi derivati triterpena kao inhibitori hiv-a |
| EP4103579A4 (en) * | 2020-02-11 | 2024-05-01 | Hetero Labs Limited | NOVEL TRITEPENDENT DERIVATIVES AS HIV INHIBITORS |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US5869535A (en) | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
| US5962527A (en) | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
| US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| WO2004089357A2 (en) | 2003-04-02 | 2004-10-21 | Regents Of The University Of Minnesota | Anti-fungal formulation of triterpene and essential oil |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| MXPA06010592A (es) | 2004-03-17 | 2007-06-12 | Panacos Pharmaceuticals Inc | Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico. |
| TW200628161A (en) * | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| WO2008127364A2 (en) * | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
| US20110144069A1 (en) | 2006-10-16 | 2011-06-16 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
| EP2257567A1 (en) * | 2008-02-14 | 2010-12-08 | Virochem Pharma Inc. | Novel 17 beta lupane derivatives |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| MX2012013628A (es) | 2010-06-04 | 2012-12-17 | Bristol Myers Squibb Co | Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). |
| CN103038245B (zh) | 2010-06-04 | 2015-03-25 | 百时美施贵宝公司 | 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物 |
| US8846647B2 (en) | 2011-01-31 | 2014-09-30 | Bristol-Myers Squibb Company | C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity |
| RS54352B1 (sr) | 2011-01-31 | 2016-02-29 | Bristol-Myers Squibb Company | C-28 amini c-3 modifikovanih derivata betulinske kiseline kao inhibitori sazrevanja hiv-a |
-
2012
- 2012-09-20 BR BR112014006559A patent/BR112014006559A2/pt not_active IP Right Cessation
- 2012-09-20 SG SG11201400331WA patent/SG11201400331WA/en unknown
- 2012-09-20 KR KR1020147010087A patent/KR20140069167A/ko not_active Ceased
- 2012-09-20 EA EA201490643A patent/EA023463B1/ru not_active IP Right Cessation
- 2012-09-20 CA CA2849475A patent/CA2849475A1/en not_active Abandoned
- 2012-09-20 EP EP12766825.9A patent/EP2758419B8/en not_active Not-in-force
- 2012-09-20 AU AU2012312485A patent/AU2012312485B2/en not_active Ceased
- 2012-09-20 JP JP2014531936A patent/JP6100786B2/ja not_active Expired - Fee Related
- 2012-09-20 ES ES12766825.9T patent/ES2611727T3/es active Active
- 2012-09-20 CN CN201280046037.7A patent/CN103814042B/zh not_active Expired - Fee Related
- 2012-09-20 WO PCT/US2012/056186 patent/WO2013043778A1/en not_active Ceased
- 2012-09-20 MX MX2014002936A patent/MX2014002936A/es unknown
- 2012-09-20 US US13/623,165 patent/US8754069B2/en not_active Expired - Fee Related
- 2012-09-20 TW TW101134558A patent/TW201317255A/zh unknown
-
2014
- 2014-03-09 IL IL231421A patent/IL231421A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014002936A (es) | 2014-04-25 |
| IL231421A0 (en) | 2014-04-30 |
| CN103814042A (zh) | 2014-05-21 |
| JP2014526554A (ja) | 2014-10-06 |
| JP6100786B2 (ja) | 2017-03-22 |
| US20130072465A1 (en) | 2013-03-21 |
| EP2758419A1 (en) | 2014-07-30 |
| CN103814042B (zh) | 2015-08-19 |
| AU2012312485B2 (en) | 2016-09-01 |
| EP2758419B1 (en) | 2016-10-19 |
| CA2849475A1 (en) | 2013-03-28 |
| EA023463B1 (ru) | 2016-06-30 |
| SG11201400331WA (en) | 2014-08-28 |
| KR20140069167A (ko) | 2014-06-09 |
| AU2012312485A1 (en) | 2014-05-08 |
| ES2611727T3 (es) | 2017-05-10 |
| EP2758419B8 (en) | 2017-04-19 |
| BR112014006559A2 (pt) | 2017-03-28 |
| IL231421A (en) | 2015-11-30 |
| WO2013043778A1 (en) | 2013-03-28 |
| EA201490643A1 (ru) | 2014-06-30 |
| US8754069B2 (en) | 2014-06-17 |
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