TW201233802A - Liquid viral formulations - Google Patents
Liquid viral formulations Download PDFInfo
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- TW201233802A TW201233802A TW100144333A TW100144333A TW201233802A TW 201233802 A TW201233802 A TW 201233802A TW 100144333 A TW100144333 A TW 100144333A TW 100144333 A TW100144333 A TW 100144333A TW 201233802 A TW201233802 A TW 201233802A
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- virus
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- viral composition
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- A61K39/15—Reoviridae, e.g. calf diarrhea virus
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- C12N2720/00011—Details
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- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
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- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12211—Orthoreovirus, e.g. mammalian orthoreovirus
- C12N2720/12232—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
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- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7803385B2 (en) * | 2007-03-12 | 2010-09-28 | Oncolytics Biotech Inc. | Reoviruses having modified sequences |
| AU2011336413B2 (en) | 2010-12-02 | 2015-01-22 | Oncolytics Biotech Inc. | Liquid viral formulations |
| MX349294B (es) * | 2010-12-02 | 2017-07-21 | Oncolytics Biotech Inc | Formulaciones virales liofilizadas. |
| CN103492557B (zh) * | 2011-04-29 | 2015-07-29 | 昂科利蒂克斯生物科技公司 | 使用凝胶渗透色谱法纯化病毒的方法 |
| AU2014364930B2 (en) | 2013-12-16 | 2017-06-15 | Massachusetts Institute Of Technology | Micromolded or 3-D printed pulsatile release vaccine formulations |
| SG11201604805XA (en) | 2013-12-16 | 2016-07-28 | Massachusetts Inst Technology | Fortified micronutrient salt formulations |
| WO2018204677A1 (en) * | 2017-05-04 | 2018-11-08 | Epicentrx, Inc. | Oncolytic adenovirus formulation |
| JP2021505610A (ja) * | 2017-12-05 | 2021-02-18 | アプライド ジェネティック テクノロジーズ コーポレイション | ウイルス粒子のための製剤最適化 |
| CA3104196A1 (en) * | 2018-07-11 | 2020-01-16 | Baxalta Incorporated | Aav compositions |
| CN113350343A (zh) * | 2020-03-06 | 2021-09-07 | 华南理工大学 | 右旋手性磷酸氯喹在制备治疗冠状病毒药物中的应用 |
| CN113350344A (zh) * | 2020-03-06 | 2021-09-07 | 华南理工大学 | 左旋手性磷酸氯喹在制备治疗冠状病毒药物中的应用 |
| IL298019A (en) | 2020-05-13 | 2023-01-01 | Massachusetts Inst Technology | Compositions of polymeric microdevices and their use in cancer immunotherapy |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2505657A1 (fr) | 1981-05-13 | 1982-11-19 | Pasteur Institut | Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation |
| US5626851A (en) | 1987-11-30 | 1997-05-06 | The Wistar Institute Of Anatomy And Biology | Rotavirus reassortant vaccine |
| US5096885A (en) | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| ATE148165T1 (de) | 1989-07-24 | 1997-02-15 | Bayer Ag | Stabilisierung von hochgereinigten proteinen |
| EP0713397B1 (en) | 1992-03-24 | 2002-12-11 | United Cancer Research Institute | Vaccine containing live virus |
| CA2075521C (en) | 1992-05-05 | 1995-11-28 | Kuniaki Koyama | Stabilized live vaccine |
| JPH09504429A (ja) | 1993-10-12 | 1997-05-06 | チロン ビアジーン,インコーポレイティド | 組換えウイルスの保存方法 |
| EP0757717B1 (en) | 1994-05-16 | 2006-05-31 | Merck & Co. Inc. | Papillomavirus vaccines |
| AU3125795A (en) | 1994-07-11 | 1996-02-09 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Attenuated human rotavirus vaccine |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| SI2275119T1 (sl) | 1995-07-27 | 2013-12-31 | Genentech, Inc. | Stabilna izotonična liofilizirana proteinska formulacija |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| GB9521806D0 (en) | 1995-10-25 | 1996-01-03 | Cortecs Ltd | Preservation methods |
| US6165773A (en) | 1995-10-25 | 2000-12-26 | Provalis Uk Limited | Methods of preserving viruses |
| FR2742756B1 (fr) | 1995-12-22 | 1998-04-03 | Pasteur Merieux Serums Vacc | Stabilisants pour vaccins vivants, vaccins les contenant et procedes pour leur preparation |
| FR2751343B1 (fr) | 1996-07-16 | 1998-12-18 | Transgene Sa | Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament |
| US6403098B1 (en) | 1996-09-26 | 2002-06-11 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| DE69738271T2 (de) | 1996-09-26 | 2008-08-28 | Merck & Co., Inc. | Rotavirus-impfstoff |
| US6616931B1 (en) | 1996-09-26 | 2003-09-09 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| US5932223A (en) * | 1996-09-26 | 1999-08-03 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| US7732129B1 (en) | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
| US20080261289A1 (en) | 1996-12-13 | 2008-10-23 | Schering-Plough Corporation | Compositions comprising viruses and methods for concentrating virus preparations |
| US6544769B1 (en) | 1996-12-13 | 2003-04-08 | Schering Corporation | Compostions comprising viruses and methods for concentrating virus preparations |
| US6051238A (en) | 1996-12-20 | 2000-04-18 | Merck & Co., Inc. | Stabilizers for lyophilized mumps vaccines |
| WO1998028000A1 (en) | 1996-12-20 | 1998-07-02 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
| US6290967B1 (en) | 1996-12-20 | 2001-09-18 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
| US6565831B1 (en) | 1999-02-24 | 2003-05-20 | Oncolytics Biotech Inc. | Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders |
| KR100912362B1 (ko) | 1998-02-17 | 2009-08-19 | 쉐링 코포레이션 | 바이러스 제제의 정제방법 |
| GB9808922D0 (en) | 1998-04-24 | 1998-06-24 | Cantab Pharmaceuticals Res Ltd | Virus preparations |
| KR100688434B1 (ko) | 1998-07-28 | 2007-03-09 | 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 | 다가의 인간-소의 로타바이러스 백신 |
| CN1062770C (zh) * | 1998-11-12 | 2001-03-07 | 卫生部长春生物制品研究所 | 甲肝-麻疹二联疫苗及其生产方法 |
| US6689600B1 (en) | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| EP1977764A1 (en) | 1998-11-16 | 2008-10-08 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
| US6225289B1 (en) | 1998-12-10 | 2001-05-01 | Genvec, Inc. | Methods and compositions for preserving adenoviral vectors |
| CA2368655A1 (en) | 1999-04-08 | 2000-10-19 | Gregory M. Glenn | Dry formulation for transcutaneous immunization |
| CN100406004C (zh) | 1999-08-24 | 2008-07-30 | 特瓦制药工业有限公司 | 疫苗组合物及其制药用途 |
| US6592869B2 (en) | 1999-08-24 | 2003-07-15 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
| TWI310688B (en) | 1999-10-29 | 2009-06-11 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
| US7456009B2 (en) * | 2000-03-07 | 2008-11-25 | Merck & Co., Inc. | Adenovirus formulations |
| CA2399321C (en) | 2000-03-07 | 2013-04-30 | Robert K. Evans | Adenovirus formulations |
| US20020120228A1 (en) | 2000-06-08 | 2002-08-29 | Yuh-Fun Maa | Powder compositions |
| EP1289494A2 (en) | 2000-06-08 | 2003-03-12 | Powderject Vaccines, Inc. | Powder compositions |
| US6689353B1 (en) * | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| TWI289158B (en) | 2000-08-10 | 2007-11-01 | Oncolytics Biotech Inc | Method of producing infectious reovirus |
| GB0020089D0 (en) | 2000-08-15 | 2000-10-04 | Smithkline Beecham Biolog | Vaccine Composition |
| ES2327103T3 (es) | 2000-09-25 | 2009-10-26 | Polymun Scientific Immunbiologische Forschung Gmbh | Vacuna viva de influenzavirus y procedimiento de fabricacion. |
| US20040033239A1 (en) | 2001-03-06 | 2004-02-19 | Evans Robert K | Adenovirus formulations |
| JP4087712B2 (ja) | 2001-03-16 | 2008-05-21 | オンコリティクス バイオテック, インコーポレイティッド | 細胞培養物からウイルスを抽出する方法 |
| JP2004532277A (ja) | 2001-06-08 | 2004-10-21 | パウダージェクト ワクチンズ,インコーポレーテッド | 噴霧凍結乾燥組成物 |
| GB0124710D0 (en) | 2001-10-15 | 2001-12-05 | Quadrant Healthcare Uk Ltd | Therapeutic composition |
| CN1607941A (zh) | 2001-11-19 | 2005-04-20 | 贝克顿迪肯森公司 | 粒状药物组合物 |
| EP1453537A1 (en) | 2001-12-12 | 2004-09-08 | FH Faulding & Co. Limited | Composition for viral preservation |
| US20030153065A1 (en) | 2002-01-14 | 2003-08-14 | Genvec, Inc. | Composition and method for maintaining non-enveloped viral vectors |
| MXPA04006995A (es) * | 2002-01-18 | 2005-07-13 | Schering Ag | Formulaciones estabilizadas de adenovirus. |
| WO2003087339A2 (en) | 2002-04-11 | 2003-10-23 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for pulmonary administration |
| US20040042972A1 (en) | 2002-04-11 | 2004-03-04 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
| CA2482448C (en) | 2002-04-11 | 2014-07-08 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by freeze dried foam |
| MXPA04010603A (es) | 2002-04-30 | 2004-12-13 | Oncolytics Biotech Inc | Metodos mejorados de purificacion viral. |
| TW200501981A (en) | 2002-11-01 | 2005-01-16 | Glaxosmithkline Biolog Sa | Drying method |
| US6752740B2 (en) | 2002-11-12 | 2004-06-22 | Jeffery T. Semmes | Continuously variable transmission |
| CN1745170A (zh) | 2002-12-17 | 2006-03-08 | 米迪缪尼疫苗股份有限公司 | 生物活性材料的高压喷雾干燥 |
| US6931888B2 (en) | 2003-02-07 | 2005-08-23 | Ferro Corporation | Lyophilization method and apparatus for producing particles |
| CA2522379C (en) | 2003-04-10 | 2012-10-23 | Chiron Corporation | The severe acute respiratory syndrome coronavirus |
| PL2272532T3 (pl) | 2003-09-02 | 2016-07-29 | Glaxosmithkline Biologicals Sa | Szczepionka rotawirusowa |
| WO2005052116A2 (en) | 2003-11-19 | 2005-06-09 | Merck & Co., Inc. | Preservative-containing virus formulations |
| CA2549197C (en) | 2003-12-17 | 2015-04-14 | Wyeth | Methods for producing storage stable viruses and immunogenic compositions thereof |
| WO2005066333A1 (en) | 2003-12-30 | 2005-07-21 | Aventis Pasteur, Inc. | Stabilizing compositions for recombinant viruses |
| GB0404586D0 (en) | 2004-03-01 | 2004-04-07 | Britannia Pharmaceuticals Ltd | Improvements in or relating to organic materials |
| CA2554018A1 (en) | 2004-03-04 | 2005-09-29 | Wyeth | Lyophilization method to improve excipient crystallization |
| AU2005249530B2 (en) | 2004-06-02 | 2012-04-12 | Victor Bronshtein | Preservation by vaporization |
| WO2006029467A1 (en) | 2004-09-16 | 2006-03-23 | Btf Pty Ltd | Rapid freeze drying process |
| AR050959A1 (es) | 2004-09-28 | 2006-12-06 | Alza Corp | Estabilizacion de agentes inmunologicamente activos adyuvados con alumbre |
| EP2769735B1 (en) * | 2004-10-06 | 2017-04-19 | MedImmune, LLC | Refrigerator-temperature stable influenza vaccine compositions |
| US7901921B2 (en) | 2004-10-22 | 2011-03-08 | Oncolytics Biotech Inc. | Viral purification methods |
| RU2458125C2 (ru) * | 2004-11-05 | 2012-08-10 | Веллстат Байолоджикс Корпорейшн | Способ стабилизации вируса ньюкаслской болезни для хранения в водном растворе и способ сохранения его стабильности |
| WO2006061708A2 (en) | 2004-12-09 | 2006-06-15 | Precimed S.A. | Surgical tool holder for facilitated sterilization |
| US20060141483A1 (en) * | 2004-12-23 | 2006-06-29 | Calton Gary J | Stabilization of viral compositions |
| KR20190062506A (ko) * | 2005-02-18 | 2019-06-05 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 조합 및 투여 방식, 및 조합 요법 |
| PT1954308E (pt) * | 2005-09-16 | 2011-11-03 | Merial Ltd | Estabilizadores para vacinas liofilizadas |
| CN1765181A (zh) * | 2005-10-19 | 2006-05-03 | 路兴波 | 高效抗病毒制剂 |
| SI2007883T1 (sl) | 2006-04-20 | 2012-02-29 | Wyeth Llc | Procesi äśiĺ äśenja za osamitev preäśiĺ äśenega virusa vezikularnega stomatitisa iz celiäśne kulture |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| EP1854478A1 (en) | 2006-05-12 | 2007-11-14 | Cytos Biotechnology AG | Nicotine-carrier vaccine formulation |
| EP1878791A1 (en) | 2006-07-11 | 2008-01-16 | Bia Separations D.O.O. | Method for influenza virus purification |
| EP2055311B1 (en) | 2006-08-07 | 2017-06-21 | The Chemo-Sero-Therapeutic Research Institute | Process for preparing live smallpox vaccine |
| KR20090060453A (ko) | 2006-09-25 | 2009-06-12 | 메디뮨 엘엘씨 | 안정화된 항체 제제 및 그것의 용도 |
| DK2099485T3 (en) | 2006-11-03 | 2018-05-22 | Alphavax Inc | Alphavirus and alphavirus replica particle formulations and associated methods |
| CL2007003209A1 (es) * | 2006-11-07 | 2008-05-09 | Acambis Inc | Composicion que comprende una vacuna de flavivirus vivos atenuados; composicion que comprende un producto farmaceutico derivado de virus o proteina; un metodo para la elaboracion de una composicion terapeutica que comprende liofilizar las composicion |
| CN101573137B (zh) * | 2006-12-27 | 2014-05-14 | 硕腾P有限责任公司 | 适用于治疗犬的犬病的疫苗 |
| WO2008106646A2 (en) | 2007-03-01 | 2008-09-04 | Introgen Therapeutics, Inc | Methods and formulations for topical gene therapy |
| US7803385B2 (en) * | 2007-03-12 | 2010-09-28 | Oncolytics Biotech Inc. | Reoviruses having modified sequences |
| GB0705245D0 (en) | 2007-03-19 | 2007-04-25 | Stabilitech Ltd | Stable biological products |
| EP2829282B1 (en) | 2007-03-22 | 2017-10-25 | The Regents of The University of Colorado, A Body Corporate | Method of preparing an immunologically-active adjuvant-bound dried vaccine composition |
| CN110478479B (zh) | 2007-04-06 | 2024-09-03 | 武田疫苗公司 | 用于活的减毒病毒的方法和组合物 |
| AR066649A1 (es) | 2007-05-21 | 2009-09-02 | Oncolytics Biotech Inc | Reovirus mutantes y metodos de elaboracion y uso de los mismos |
| EP2197283B1 (en) * | 2007-09-25 | 2013-07-17 | Aridis Pharmaceuticals | Formulations for preservation of rota virus |
| EP2630966B1 (en) * | 2007-10-12 | 2017-04-19 | Massachusetts Institute of Technology | Vaccine nanotechnology |
| WO2009056651A1 (en) | 2007-11-02 | 2009-05-07 | Cytos Biotechnology Ag | Angiotensin-carrier formulation |
| NZ585500A (en) | 2007-11-12 | 2012-06-29 | Theraclone Sciences Inc | Antibodies which bind to an epitope in the extracellular domain of the matrix 2 ectodomain polypeptide of an influenza virus |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| WO2009108689A1 (en) | 2008-02-25 | 2009-09-03 | Novavax, Inc. | Sugar glassified virus like particles (vlps) |
| WO2009133413A1 (en) | 2008-04-28 | 2009-11-05 | Novatech D.O.O. | Formulation based on micronized clinoptilolite as a therapeutic agent for removal of toxins, bacteria and viruses from organism |
| HRP20251316T1 (hr) * | 2009-09-03 | 2025-12-05 | Ablynx Nv | Stabilne formulacije polipeptida i njihova upotreba |
| AU2011336413B2 (en) | 2010-12-02 | 2015-01-22 | Oncolytics Biotech Inc. | Liquid viral formulations |
| MX349294B (es) * | 2010-12-02 | 2017-07-21 | Oncolytics Biotech Inc | Formulaciones virales liofilizadas. |
| CN103492557B (zh) * | 2011-04-29 | 2015-07-29 | 昂科利蒂克斯生物科技公司 | 使用凝胶渗透色谱法纯化病毒的方法 |
| JP6065096B2 (ja) | 2015-12-25 | 2017-01-25 | ダイキン工業株式会社 | 調湿装置 |
-
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- 2011-12-02 MX MX2013006170A patent/MX350932B/es active IP Right Grant
- 2011-12-02 WO PCT/US2011/063040 patent/WO2012075379A2/en not_active Ceased
- 2011-12-02 TW TW100144333A patent/TW201233802A/zh unknown
- 2011-12-02 KR KR1020137016881A patent/KR101875245B1/ko active Active
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2013
- 2013-05-29 IL IL226647A patent/IL226647A/en active IP Right Grant
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2015
- 2015-04-23 US US14/693,977 patent/US9610309B2/en active Active
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2016
- 2016-09-01 JP JP2016170630A patent/JP6639359B2/ja active Active
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2018
- 2018-04-10 JP JP2018075352A patent/JP2018123155A/ja not_active Withdrawn
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2019
- 2019-11-05 JP JP2019200490A patent/JP2020015770A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20150224155A1 (en) | 2015-08-13 |
| US20120141421A1 (en) | 2012-06-07 |
| EA201390810A1 (ru) | 2013-09-30 |
| JP2016199592A (ja) | 2016-12-01 |
| US9610309B2 (en) | 2017-04-04 |
| CN103347535A (zh) | 2013-10-09 |
| WO2012075379A3 (en) | 2012-08-16 |
| KR20130121899A (ko) | 2013-11-06 |
| MX350932B (es) | 2017-09-26 |
| CA2819246A1 (en) | 2012-06-07 |
| EP2646051A2 (en) | 2013-10-09 |
| JP2018123155A (ja) | 2018-08-09 |
| CA2819246C (en) | 2023-04-25 |
| WO2012075379A2 (en) | 2012-06-07 |
| JP2014502275A (ja) | 2014-01-30 |
| MX2013006170A (es) | 2013-12-02 |
| CN103347535B (zh) | 2015-11-25 |
| MX373096B (es) | 2020-04-27 |
| IL226647A (en) | 2017-07-31 |
| JP2020015770A (ja) | 2020-01-30 |
| AU2011336413A1 (en) | 2013-03-21 |
| AU2011336413B2 (en) | 2015-01-22 |
| US9045728B2 (en) | 2015-06-02 |
| JP6639359B2 (ja) | 2020-02-05 |
| JP6034798B2 (ja) | 2016-11-30 |
| SG190418A1 (en) | 2013-07-31 |
| KR101875245B1 (ko) | 2018-08-02 |
| EP2646051A4 (en) | 2014-05-28 |
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