TW201141846A - Dimeric IAP inhibitors - Google Patents

Info

Publication number

TW201141846A

TW201141846A TW100106289A TW100106289A TW201141846A TW 201141846 A TW201141846 A TW 201141846A TW 100106289 A TW100106289 A TW 100106289A TW 100106289 A TW100106289 A TW 100106289A TW 201141846 A TW201141846 A TW 201141846A

Authority

TW

Taiwan

Prior art keywords

group

alkyl

phenyl

fluoro

independently selected

Prior art date

2010-02-25

Links

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• 239000003112 inhibitor Substances 0.000 title claims description 7
• 150000001875 compounds Chemical class 0.000 claims abstract description 166
• 230000006907 apoptotic process Effects 0.000 claims abstract description 10
• 125000000217 alkyl group Chemical group 0.000 claims description 149
• -1 -OH Chemical group 0.000 claims description 118
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• 150000003839 salts Chemical class 0.000 claims description 92
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 80
• 229910052757 nitrogen Inorganic materials 0.000 claims description 51
• 125000000623 heterocyclic group Chemical group 0.000 claims description 49
• 125000005842 heteroatom Chemical group 0.000 claims description 48
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 44
• 229910052739 hydrogen Chemical group 0.000 claims description 41
• 239000001257 hydrogen Chemical group 0.000 claims description 41
• 239000002253 acid Substances 0.000 claims description 35
• 239000000203 mixture Substances 0.000 claims description 35
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 29
• 238000011282 treatment Methods 0.000 claims description 29
• WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 28
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• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
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• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 3
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• NEQFBGHQPUXOFH-UHFFFAOYSA-N 4-(4-carboxyphenyl)benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC=C(C(O)=O)C=C1 NEQFBGHQPUXOFH-UHFFFAOYSA-N 0.000 claims description 3
• 125000006164 6-membered heteroaryl group Chemical group 0.000 claims description 3
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