TW201124160A - SiRNA compounds comprising terminal substitutions - Google Patents

SiRNA compounds comprising terminal substitutions Download PDF

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Publication number
TW201124160A
TW201124160A TW099141067A TW99141067A TW201124160A TW 201124160 A TW201124160 A TW 201124160A TW 099141067 A TW099141067 A TW 099141067A TW 99141067 A TW99141067 A TW 99141067A TW 201124160 A TW201124160 A TW 201124160A
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Taiwan
Prior art keywords
nucleic acid
double
acid molecule
modified
target
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TW099141067A
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English (en)
Chinese (zh)
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Sharon Avkin-Nachum
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Quark Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content

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TW099141067A 2009-11-26 2010-11-25 SiRNA compounds comprising terminal substitutions TW201124160A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26466809P 2009-11-26 2009-11-26
US29572110P 2010-01-17 2010-01-17
US37207210P 2010-08-09 2010-08-09

Publications (1)

Publication Number Publication Date
TW201124160A true TW201124160A (en) 2011-07-16

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Application Number Title Priority Date Filing Date
TW099141067A TW201124160A (en) 2009-11-26 2010-11-25 SiRNA compounds comprising terminal substitutions

Country Status (13)

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US (3) US8796239B2 (enExample)
EP (1) EP2504435B1 (enExample)
JP (1) JP2013511990A (enExample)
KR (1) KR20120102630A (enExample)
CN (1) CN102597239A (enExample)
AU (1) AU2010324658A1 (enExample)
CA (1) CA2776568A1 (enExample)
DK (1) DK2504435T3 (enExample)
ES (1) ES2759003T3 (enExample)
IL (1) IL218965A0 (enExample)
NZ (1) NZ599237A (enExample)
TW (1) TW201124160A (enExample)
WO (1) WO2011066475A1 (enExample)

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US20150152412A1 (en) 2015-06-04
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