TW201035104A - Improved synthesis method for Temsirolimus and its similar compounds - Google Patents

Improved synthesis method for Temsirolimus and its similar compounds Download PDF

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Publication number
TW201035104A
TW201035104A TW098110170A TW98110170A TW201035104A TW 201035104 A TW201035104 A TW 201035104A TW 098110170 A TW098110170 A TW 098110170A TW 98110170 A TW98110170 A TW 98110170A TW 201035104 A TW201035104 A TW 201035104A
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TW
Taiwan
Prior art keywords
compound
sirolimus
bis
reaction
temsirolimus
Prior art date
Application number
TW098110170A
Other languages
English (en)
Chinese (zh)
Other versions
TWI360550B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
guang-zong Li
Ting-Hui Li
yan-shi Dong
jia-zhen Gao
Ci-Ai Li
Original Assignee
Chunghwa Chemical Synthesis & Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chunghwa Chemical Synthesis & Biotech Co Ltd filed Critical Chunghwa Chemical Synthesis & Biotech Co Ltd
Priority to TW098110170A priority Critical patent/TW201035104A/zh
Priority to US12/661,928 priority patent/US8258299B2/en
Publication of TW201035104A publication Critical patent/TW201035104A/zh
Application granted granted Critical
Publication of TWI360550B publication Critical patent/TWI360550B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/153—Ortho-condensed systems the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
TW098110170A 2009-03-27 2009-03-27 Improved synthesis method for Temsirolimus and its similar compounds TW201035104A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TW098110170A TW201035104A (en) 2009-03-27 2009-03-27 Improved synthesis method for Temsirolimus and its similar compounds
US12/661,928 US8258299B2 (en) 2009-03-27 2010-03-29 Process for preparation of temsirolimus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW098110170A TW201035104A (en) 2009-03-27 2009-03-27 Improved synthesis method for Temsirolimus and its similar compounds

Publications (2)

Publication Number Publication Date
TW201035104A true TW201035104A (en) 2010-10-01
TWI360550B TWI360550B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2012-03-21

Family

ID=42785052

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098110170A TW201035104A (en) 2009-03-27 2009-03-27 Improved synthesis method for Temsirolimus and its similar compounds

Country Status (2)

Country Link
US (1) US8258299B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW201035104A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103421023A (zh) * 2013-07-30 2013-12-04 福建省微生物研究所 一种替西罗莫司的合成工艺

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011092564A2 (en) * 2010-01-28 2011-08-04 Fresenius Kabi Oncology Ltd Process for the preparation of temsirolimus and its intermediates
CN103140494A (zh) 2010-08-04 2013-06-05 美利奴生命科学有限公司 制备具有抗增殖特性的新的42-o-（杂烷氧基烷基）雷帕霉素化合物的方法
KR20140013000A (ko) 2011-04-01 2014-02-04 산도즈 아게 C-42 위치에서 라파마이신의 위치선택적 아실화
EP2997977A1 (en) 2014-09-19 2016-03-23 Fundación de la Comunidad Valenciana Centro de Investigación Principe Felipe Specific mtor inhibitors in the treatment of x-linked adrenoleukodystrophy
CN107561170B (zh) * 2016-07-02 2021-07-30 山东新时代药业有限公司 一种坦西莫司中间体的分析检测方法
CN109485657A (zh) * 2018-12-24 2019-03-19 江苏卓和药业有限公司 一种替西罗莫司的纯化方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
US7097856B2 (en) * 2000-09-29 2006-08-29 The Regents Of The University Of California Dendrimeric support or carrier macromolecule

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103421023A (zh) * 2013-07-30 2013-12-04 福建省微生物研究所 一种替西罗莫司的合成工艺

Also Published As

Publication number Publication date
US20100249415A1 (en) 2010-09-30
TWI360550B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2012-03-21
US8258299B2 (en) 2012-09-04

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