TW200940524A - Quinoline compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor - Google Patents

Info

Publication number

TW200940524A

TW200940524A TW097133636A TW97133636A TW200940524A TW 200940524 A TW200940524 A TW 200940524A TW 097133636 A TW097133636 A TW 097133636A TW 97133636 A TW97133636 A TW 97133636A TW 200940524 A TW200940524 A TW 200940524A

Authority

TW

Taiwan

Prior art keywords

group

alkyl

compound

alkoxy

formula

Prior art date

2007-03-23

Links

• Espacenet
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• 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title claims abstract description 8
• 108091005435 5-HT6 receptors Proteins 0.000 title abstract description 16
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract description 11
• 229940076279 serotonin Drugs 0.000 title abstract description 3
• 150000001875 compounds Chemical class 0.000 claims abstract description 186
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 43
• 239000002253 acid Substances 0.000 claims abstract description 24
• 201000010099 disease Diseases 0.000 claims abstract description 24
• 229910052736 halogen Inorganic materials 0.000 claims abstract description 17
• 125000001424 substituent group Chemical group 0.000 claims abstract description 14
• 150000003839 salts Chemical class 0.000 claims abstract description 13
• 150000002367 halogens Chemical class 0.000 claims abstract description 12
• 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 12
• 125000003118 aryl group Chemical group 0.000 claims abstract description 10
• 150000001204 N-oxides Chemical class 0.000 claims abstract description 7
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 6
• 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims abstract description 3
• 229910052717 sulfur Inorganic materials 0.000 claims abstract description 3
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 2
• -1 quinoline compound Chemical class 0.000 claims description 180
• 125000000217 alkyl group Chemical group 0.000 claims description 83
• 239000001257 hydrogen Substances 0.000 claims description 41
• 229910052739 hydrogen Inorganic materials 0.000 claims description 41
• 125000003545 alkoxy group Chemical group 0.000 claims description 34
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• 238000009739 binding Methods 0.000 claims description 26
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 26
• SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 22
• 230000027455 binding Effects 0.000 claims description 22
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 20
• 125000004432 carbon atom Chemical group C* 0.000 claims description 18
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 17
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 13
• NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims description 12
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