TW200911822A - Boron-containing small molecules - Google Patents

Boron-containing small molecules Download PDF

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Publication number
TW200911822A
TW200911822A TW097123257A TW97123257A TW200911822A TW 200911822 A TW200911822 A TW 200911822A TW 097123257 A TW097123257 A TW 097123257A TW 97123257 A TW97123257 A TW 97123257A TW 200911822 A TW200911822 A TW 200911822A
Authority
TW
Taiwan
Prior art keywords
group
compound
substituted
unsubstituted
exemplary embodiment
Prior art date
Application number
TW097123257A
Other languages
English (en)
Chinese (zh)
Inventor
Stephen J Baker
Vincent S Hernandez
Rashmi Sharma
James A Nieman
Tsutomu Akama
Yong-Kang Zhang
Jacob J Plattner
Michael Richard Kevin Alley
Rajeshwar Singh
Fernando Rock
Original Assignee
Anacor Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40156702&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200911822(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anacor Pharmaceuticals Inc filed Critical Anacor Pharmaceuticals Inc
Publication of TW200911822A publication Critical patent/TW200911822A/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW097123257A 2007-06-20 2008-06-20 Boron-containing small molecules TW200911822A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94529407P 2007-06-20 2007-06-20
US4117808P 2008-03-31 2008-03-31

Publications (1)

Publication Number Publication Date
TW200911822A true TW200911822A (en) 2009-03-16

Family

ID=40156702

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097123257A TW200911822A (en) 2007-06-20 2008-06-20 Boron-containing small molecules

Country Status (29)

Country Link
US (4) US7816344B2 (OSRAM)
EP (1) EP2164331B1 (OSRAM)
JP (3) JP5530923B2 (OSRAM)
KR (3) KR20150100945A (OSRAM)
CN (2) CN104017008A (OSRAM)
AR (1) AR067105A1 (OSRAM)
AU (1) AU2008265630B2 (OSRAM)
BR (1) BRPI0813450B8 (OSRAM)
CA (1) CA2692135C (OSRAM)
CL (1) CL2008001855A1 (OSRAM)
CO (1) CO6251209A2 (OSRAM)
CR (1) CR11224A (OSRAM)
DK (1) DK2164331T3 (OSRAM)
DO (1) DOP2009000281A (OSRAM)
EA (1) EA020530B1 (OSRAM)
ES (1) ES2655299T3 (OSRAM)
IL (1) IL202379A (OSRAM)
JO (1) JO3396B1 (OSRAM)
MA (1) MA31675B1 (OSRAM)
MX (1) MX347688B (OSRAM)
MY (1) MY162692A (OSRAM)
NO (1) NO2164331T3 (OSRAM)
NZ (1) NZ582706A (OSRAM)
PE (1) PE20090840A1 (OSRAM)
SG (1) SG182219A1 (OSRAM)
TW (1) TW200911822A (OSRAM)
UY (1) UY31171A1 (OSRAM)
WO (1) WO2008157726A1 (OSRAM)
ZA (2) ZA200909003B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12482208B2 (en) 2023-05-30 2025-11-25 Snap Inc. Mirroring 3D assets for virtual experiences

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE026021T2 (en) * 2005-02-16 2016-05-30 Anacor Pharmaceuticals Inc Biocidal boron phthalide (boronophthalide) compounds
CN106008583A (zh) 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
BRPI0708051A2 (pt) 2006-02-16 2011-05-17 Anacor Pharmaceuticals Inc moléculas pequenas contendo boro como agentes antiflamatórios
JP2009536660A (ja) 2006-05-02 2009-10-15 アナコール ファーマシューティカルズ,インコーポレイテッド 加水分解耐性ホウ素含有治療剤及びその使用方法
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
KR101672511B1 (ko) 2008-03-06 2016-11-03 아나코르 파마슈티칼스 인코포레이티드 소염제로써 붕소가 함유된 소분자
WO2009140309A2 (en) * 2008-05-12 2009-11-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
EP2348863A4 (en) * 2008-09-04 2012-03-07 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES
US8461336B2 (en) 2008-09-04 2013-06-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US9493489B2 (en) * 2008-10-15 2016-11-15 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
KR20110111407A (ko) * 2008-12-17 2011-10-11 아나코르 파마슈티칼스 인코포레이티드 (s)-3-아미노메틸-7-(3-히드록시-프로폭시)-3h-벤조〔c〕〔1,2〕옥사보롤-1-올의 다형태
WO2010132833A1 (en) * 2009-05-14 2010-11-18 The Regents Of The University Of Michigan Streptococcus vaccine compositions and methods of using the same
WO2011017125A1 (en) * 2009-07-28 2011-02-10 Anacor Pharmaceuticals, Inc. Trisubstituted boron-containing molecules
US9440994B2 (en) 2009-08-14 2016-09-13 Anacor Pharmaceuticals, Inc. Boron containing small molecules as antiprotozoal agents
WO2011019612A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011019616A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
US20110207701A1 (en) * 2009-08-19 2011-08-25 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011037731A1 (en) * 2009-09-25 2011-03-31 Anacor Pharmaceuticals, Inc. Boron containing small molecules
US8979820B2 (en) 2009-10-09 2015-03-17 Cynthia S. Bailey Method and apparatus for improving the appearance of nails affected by onychomycosis through the topical application of an aqueous solution containing boric acid and camphor or other terpenes
US9346834B2 (en) 2009-10-20 2016-05-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011060196A1 (en) * 2009-11-11 2011-05-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011094450A1 (en) 2010-01-27 2011-08-04 Anacor Pharmaceuticals, Inc Boron-containing small molecules
AP2012006482A0 (en) 2010-03-19 2012-10-31 Anacor Pharmacueticals Inc Boron-containing small molecules as anti-protozoalagent
WO2011127143A1 (en) * 2010-04-07 2011-10-13 Glaxosmithkline Llc Process for preparing benzoxaboroles
HRP20211762T1 (hr) * 2010-09-07 2022-02-18 Anacor Pharmaceuticals, Inc. Derivati benzoksaborola za liječenje bakterijskih infekcija
WO2013025975A1 (en) * 2011-08-17 2013-02-21 Glaxosmithkline Llc Combination treatments for hepatitis c
WO2013049424A1 (en) 2011-09-28 2013-04-04 Wisconsin Alumni Research Foundation Catalytic conversion of cellulose to fuels and chemicals using boronic acids
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
AR088669A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos
KR20140114380A (ko) * 2011-12-22 2014-09-26 미큐알엑스 파마슈티칼스, 인크. 항미생물 요법용 트리시클릭 붕소 화합물
US20150080342A1 (en) * 2012-04-14 2015-03-19 Anacor Pharmaceuticals, Inc. Benzoxaborole compounds and uses thereof
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
UY35287A (es) 2013-01-30 2014-08-29 Dow Agrosciences Llc Uso de benzoxaborolas como agentes antimicrobianos volátiles en carnes, plantas o partes de plantas.
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
US9452173B2 (en) 2013-01-31 2016-09-27 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9446131B2 (en) 2013-01-31 2016-09-20 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9433680B2 (en) 2013-01-31 2016-09-06 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
AP2015008638A0 (en) 2013-02-01 2015-08-31 Anacor Pharmaceuticals Inc Boron-containing small molecules as antiprotozoal agents
AU2014202928B1 (en) * 2013-06-05 2014-09-11 Agrofresh Inc. Compounds and compositions
KR101636431B1 (ko) * 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
EP3030519B1 (en) 2013-08-09 2022-01-05 Glaxosmithkline Intellectual Property (No. 2) Limited Tricyclic benzoxaborole compounds and uses thereof
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
RU2016137000A (ru) * 2014-02-17 2018-03-22 Зингента Партисипейшнс Аг Микробиоцидно активные бензоксаборолы
EP3164404B1 (en) * 2014-07-01 2019-04-03 Daiichi Sankyo Company, Limited Tricyclic benzoxaboroles as antibacterial agents
EP3212196A4 (en) * 2014-10-29 2018-07-11 Wisconsin Alumni Research Foundation Boronic acid inhibitors of hiv protease
MA41494B1 (fr) 2015-02-12 2020-10-28 Glaxosmithkline Ip No 2 Ltd Composés benzoxaborole substitués en position 4 et utilisations associées
CA2981773C (en) 2015-04-09 2022-03-15 The Penn State Research Foundation Synergistic benzoxaborole-containing anti-fungicidal composition
WO2017024022A1 (en) * 2015-08-06 2017-02-09 The Penn State Research Foundation Benzoxaborole-containing coating resistant to cellulose-supportable fungus
US10874679B2 (en) 2016-03-02 2020-12-29 Bill & Melinda Gates Foundation Boron-containing small molecules
US10611781B2 (en) 2016-03-02 2020-04-07 Bill And Melinda Gates Foundation Boron-containing small molecules
WO2017151489A1 (en) 2016-03-02 2017-09-08 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
EP3426029B1 (en) 2016-03-07 2023-08-30 AgroFresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
UA120999C2 (uk) 2016-05-12 2020-03-10 Анакор Фармасутікалз, Інк. Естери оксаборолу та їх використання
EP3609504A4 (en) 2017-03-01 2021-03-03 Anacor Pharmaceuticals, Inc. NEW OXABOROLE ANALOGUES AND USES OF THE LATEST
CN107090000B (zh) * 2017-04-27 2019-07-12 上海交通大学 一种苯并硼唑7位脂肪酸的衍生物及其制备与用途
CA3067372A1 (en) * 2017-06-13 2018-12-20 Veterinary Diagnostics Institute, Inc. System and procedure for stabilizing, storing and recovering blood samples
CA3120976A1 (en) 2017-11-30 2019-06-06 Boragen, Inc. Benzoxaborole compounds and formulations thereof
CA3120974A1 (en) * 2017-11-30 2019-06-06 Boragen, Inc. Combinatorial compositions of benzoxaboroles and biologic agents
AU2019325436B2 (en) * 2018-08-18 2023-10-26 5Metis, Inc. Solid forms of substituted benzoxaborole and compositions thereof
WO2020051575A1 (en) * 2018-09-07 2020-03-12 Boragen, Inc. Boron containing compounds and their uses
US11058695B2 (en) * 2019-11-08 2021-07-13 Myongji University Industry And Academia Cooperation Foundation Inhibitor of carbapenem-hydrolyzing class D beta-lactamases
US20230340530A1 (en) 2020-08-31 2023-10-26 Pfizer Inc. Methods of Protecting RNA
JP2025520237A (ja) * 2022-06-23 2025-07-03 ミクウルク ファーマシューティカルズ, インコーポレイテッド ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物
EP4384527A4 (en) * 2022-06-23 2025-09-03 Micurx Pharmaceuticals Inc PRODRUGS OF BORON COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2260336A (en) * 1939-10-16 1941-10-28 Dow Chemical Co Method of preparation of organic borates
GB1396904A (en) * 1972-08-11 1975-06-11 Ici Ltd Method for the control of micro-organisms
US5962498A (en) * 1986-06-11 1999-10-05 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
US5594151A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
GB9411587D0 (en) * 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5831046A (en) * 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
AU7995300A (en) * 1999-10-05 2001-05-10 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
WO2002006316A2 (en) * 2000-07-14 2002-01-24 Zycos, Inc. Alpha-msh related compounds and methods of use
US6537733B2 (en) * 2001-02-23 2003-03-25 Applied Materials, Inc. Method of depositing low dielectric constant silicon carbide layers
GB0117645D0 (en) * 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
DE10143979A1 (de) 2001-09-07 2003-03-27 Clariant Gmbh Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
WO2003033002A1 (en) * 2001-10-11 2003-04-24 Ono Pharmaceutical Co Intracellular calcium concentration increase inhibitors
WO2003059916A2 (en) 2002-01-10 2003-07-24 The Pennsylvania State Research Foundation Methods for the preparation of alkyl diaryl borinates and complexed diarylborinic acids
US7109354B2 (en) * 2002-05-28 2006-09-19 3-Dimensional Pharmaceuticals, Inc. Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
US7465836B2 (en) * 2003-06-16 2008-12-16 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
EP2335722B1 (en) * 2004-05-12 2019-03-13 The Brigham and Women's Hospital, Inc. Use of gelsolin to treat infections
HUE026021T2 (en) * 2005-02-16 2016-05-30 Anacor Pharmaceuticals Inc Biocidal boron phthalide (boronophthalide) compounds
CN106008583A (zh) * 2005-12-30 2016-10-12 安纳考尔医药公司 含硼的小分子
BRPI0708051A2 (pt) 2006-02-16 2011-05-17 Anacor Pharmaceuticals Inc moléculas pequenas contendo boro como agentes antiflamatórios
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
RU2008152367A (ru) 2006-06-12 2010-07-20 Анакор Фармасьютикалз, Инк. (Us) Соединения для лечения периодонтального заболевания
DE102006038471A1 (de) 2006-08-17 2008-04-10 Wala-Heilmittel Gmbh Platanencreme, Verfahren zu ihrer Herstellung und Verwendung
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
WO2009140309A2 (en) * 2008-05-12 2009-11-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12482208B2 (en) 2023-05-30 2025-11-25 Snap Inc. Mirroring 3D assets for virtual experiences

Also Published As

Publication number Publication date
CN101772302A (zh) 2010-07-07
JP5530923B2 (ja) 2014-06-25
EP2164331A1 (en) 2010-03-24
KR101578351B1 (ko) 2015-12-17
JP6570391B2 (ja) 2019-09-04
US8895534B2 (en) 2014-11-25
MY162692A (en) 2017-07-14
CL2008001855A1 (es) 2009-05-29
JP2010530881A (ja) 2010-09-16
US20180016285A1 (en) 2018-01-18
DK2164331T3 (da) 2018-01-29
NZ582706A (en) 2012-07-27
EP2164331A4 (en) 2011-09-07
US9796735B2 (en) 2017-10-24
JP2016040275A (ja) 2016-03-24
WO2008157726A1 (en) 2008-12-24
CN104017008A (zh) 2014-09-03
US7816344B2 (en) 2010-10-19
AU2008265630A1 (en) 2008-12-24
KR20160049025A (ko) 2016-05-04
CN101772302B (zh) 2014-05-07
PE20090840A1 (es) 2009-07-08
SG182219A1 (en) 2012-07-30
ES2655299T3 (es) 2018-02-19
CR11224A (es) 2010-06-28
CO6251209A2 (es) 2011-02-21
MA31675B1 (fr) 2010-09-01
CA2692135C (en) 2017-01-24
BRPI0813450A2 (pt) 2014-12-30
ZA200909003B (en) 2022-03-30
MX347688B (es) 2017-05-09
KR20150100945A (ko) 2015-09-02
EA200901617A1 (ru) 2010-06-30
BRPI0813450B1 (pt) 2019-05-07
AU2008265630B2 (en) 2013-06-20
JP2014148531A (ja) 2014-08-21
US10533021B2 (en) 2020-01-14
NO2164331T3 (OSRAM) 2018-04-28
JO3396B1 (ar) 2019-10-20
US20100292504A1 (en) 2010-11-18
IL202379A0 (en) 2010-06-30
KR101685656B1 (ko) 2016-12-12
EP2164331B1 (en) 2017-11-29
IL202379A (en) 2016-02-29
UY31171A1 (es) 2009-04-30
BRPI0813450B8 (pt) 2021-05-25
CA2692135A1 (en) 2008-12-24
EA020530B1 (ru) 2014-11-28
ZA201104573B (en) 2014-03-26
US20090227541A1 (en) 2009-09-10
KR20100051615A (ko) 2010-05-17
DOP2009000281A (es) 2010-07-31
US20150133402A1 (en) 2015-05-14
AR067105A1 (es) 2009-09-30

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