TW200848047A - [6,5]-bicyclic GPR119 G protein-coupled receptor agonists - Google Patents

[6,5]-bicyclic GPR119 G protein-coupled receptor agonists Download PDF

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Publication number
TW200848047A
TW200848047A TW097116366A TW97116366A TW200848047A TW 200848047 A TW200848047 A TW 200848047A TW 097116366 A TW097116366 A TW 097116366A TW 97116366 A TW97116366 A TW 97116366A TW 200848047 A TW200848047 A TW 200848047A
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group
alkyl
aryl
heteroaryl
nr9r9
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TW097116366A
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Chinese (zh)
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John M Fevig
Dean A Wacker
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Bristol Myers Squibb Co
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
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    • AHUMAN NECESSITIES
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    • A61P27/02Ophthalmic agents
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    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
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TW097116366A 2007-05-04 2008-05-02 [6,5]-bicyclic GPR119 G protein-coupled receptor agonists TW200848047A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91595207P 2007-05-04 2007-05-04

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TW200848047A true TW200848047A (en) 2008-12-16

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TW097116366A TW200848047A (en) 2007-05-04 2008-05-02 [6,5]-bicyclic GPR119 G protein-coupled receptor agonists

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US (2) US8093257B2 (https=)
EP (1) EP2152707B1 (https=)
JP (1) JP2010526146A (https=)
CN (1) CN101668759A (https=)
AR (1) AR066438A1 (https=)
CL (1) CL2008001270A1 (https=)
ES (1) ES2388315T3 (https=)
PE (1) PE20090213A1 (https=)
TW (1) TW200848047A (https=)
WO (1) WO2008137436A1 (https=)

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US9174992B2 (en) 2012-02-29 2015-11-03 Amgen Inc. Heterobicyclic compounds

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9174992B2 (en) 2012-02-29 2015-11-03 Amgen Inc. Heterobicyclic compounds

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JP2010526146A (ja) 2010-07-29
ES2388315T3 (es) 2012-10-11
WO2008137436A1 (en) 2008-11-13
PE20090213A1 (es) 2009-02-28
US8093257B2 (en) 2012-01-10
CL2008001270A1 (es) 2008-09-12
AR066438A1 (es) 2009-08-19
CN101668759A (zh) 2010-03-10
US8476283B2 (en) 2013-07-02
EP2152707B1 (en) 2012-06-20
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